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Heatmap: Cluster_49 (P. berghei)

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Gene
Asexual: SRP099925
Asexual, PbSR-MG KO: SRP109709
10 hpi, ab libitum: SRP059210
10 hpi, diet restriction: SRP059210
10 hpi, ab libitum, kin KO: SRP059210
10 hpi, diet restriction, kin KO: SRP059210
16 hpi, WT: ERP004868
16 hpi, CL: ERP004868
Trophozoite, 16 hpi: SRP027529
Schizont, predicted: ERP021229
Schizont, WT: SRP073801
Schizont, 22 hpi: SRP027529
Schizont: ERP004598
Schizont, ap2-g KO: SRP073801
Schizont, ap2-g2 KO: SRP073801
Schizont, ap2-l KO: SRP073801
Schizont, ap2-o KO: SRP073801
Schizont, ap2-o2 KO: SRP073801
Schizont, ap2-o3 KO: SRP073801
Schizont, ap2-o4 KO: SRP073801
Schizont, ap2-sp KO: SRP073801
Schizont, ap2-sp2 KO: SRP073801
Schizont, ap2-sp3 KO: SRP073801
Schizont, PBANKA_131970 KO: SRP073801
Schizont, ppm2 KO: ERP004598
Schizont, ppm5 KO: ERP004598
Gametocyte, WT: SRP073801
Gametocyte: SRP027529
Gametocyte: ERP004598
Gametocyte (male): SRP099925
Gametocyte (female): SRP099925
Gametocyte ap2-o KO: SRP073801
Gametocyte ap2-o2 KO: SRP073801
Gametocyte ap2-o3 KO: SRP073801
Gametocyte, ppm5 KO: ERP004598
Gametocyte (male), PbSR-MG KO: SRP109709
Gametocyte (female), PbSR-MG KO: SRP109709
Ookinete, WT: SRP073801
Ookinete, WT: ERP004740
Ookinete ap2-o KO: SRP073801
Ookinete ap2-o2 KO: SRP073801
Ookinete ap2-o3 KO: SRP073801
Ookinete, mutant: ERP004740
36.34 33.27 246.57 248.9 126.13 85.89 19.47 13.34 108.94 46.87 405.96 96.67 58.4 656.53 443.73 302.99 302.14 343.37 381.04 328.01 147.54 205.0 217.95 274.33 70.85 51.4 123.5 43.96 20.05 32.9 15.41 165.54 218.24 163.46 18.98 28.53 9.72 81.32 8.52 193.75 220.28 40.98 4.68
5.04 3.01 75.29 90.77 62.59 30.86 6.85 7.88 14.31 1.87 212.03 31.33 10.1 541.76 318.8 162.56 687.05 282.13 272.25 261.84 85.46 112.16 132.96 168.39 13.22 8.47 22.8 12.21 1.82 4.07 2.77 38.84 69.03 33.44 2.37 4.54 2.23 25.66 6.77 73.43 57.15 17.3 4.76
48.2 42.39 115.3 112.84 64.19 45.32 45.62 37.14 74.22 10.19 148.59 106.37 83.72 210.83 215.32 90.73 182.2 128.49 157.01 123.98 77.09 101.39 107.88 120.34 119.34 65.98 80.48 68.76 64.31 43.49 39.78 101.58 98.46 86.31 44.47 41.21 42.22 62.76 20.79 76.89 94.51 29.76 23.76
26.92 24.13 133.29 144.02 91.5 71.89 25.16 10.83 113.55 0.0 242.47 73.33 22.62 384.79 282.97 180.79 402.77 268.4 277.23 251.76 143.75 163.69 174.06 193.54 30.82 23.94 156.93 69.78 8.35 43.84 17.51 173.19 250.92 198.86 12.51 49.19 7.97 88.13 15.48 176.33 165.8 44.5 20.45
1.6 2.78 20.76 20.74 7.68 4.84 0.57 0.73 4.58 0.04 50.07 2.94 6.47 158.57 147.0 6.63 316.84 10.1 34.07 51.83 2.64 17.96 10.99 24.75 33.84 2.23 4.99 2.15 0.95 1.73 0.12 6.65 10.42 7.97 0.95 0.83 0.12 6.24 0.9 15.2 19.94 2.61 0.43
51.3 38.57 185.47 223.51 121.26 76.65 50.63 36.05 131.08 1.69 231.0 109.13 42.96 458.99 371.08 359.46 617.55 286.78 283.27 262.61 178.85 220.9 229.66 244.87 63.13 45.77 203.28 92.9 10.29 85.58 28.1 289.47 351.34 348.61 19.16 103.22 8.78 129.9 42.47 176.96 192.76 88.59 58.55
9.33 10.82 217.21 308.48 137.81 88.93 5.2 3.8 93.88 5.48 399.0 162.87 15.82 744.52 402.19 263.83 752.57 439.46 461.64 502.73 178.19 205.6 256.47 346.78 17.94 12.56 125.79 65.87 3.8 11.5 5.35 156.42 175.74 128.41 5.21 13.23 3.64 28.29 2.63 111.07 114.16 16.18 3.12
16.18 21.64 207.06 134.0 155.64 92.16 159.5 169.22 165.51 131.09 614.15 118.46 117.48 818.76 562.17 402.13 1138.59 616.14 684.51 525.67 573.47 427.34 512.25 495.85 83.08 92.59 732.17 964.1 214.34 106.94 126.45 787.0 704.93 535.32 150.29 111.2 118.49 146.01 164.31 490.45 357.35 74.6 84.76
PBANKA_0521700 (ApiAP2)
 21.66 24.14 161.62 119.52 124.84 71.28 39.09 80.02 122.89 294.68 311.45 79.31 114.13 935.11 751.31 135.89 830.98 322.76 495.31 370.25 70.91 130.86 179.26 255.57 135.76 59.85 42.99 56.6 22.2 23.79 15.04 82.96 50.78 44.5 13.61 24.62 13.61 58.0 169.21 146.79 109.02 28.42 49.04
0.31 0.31 3.89 5.62 0.7 0.76 0.87 11.96 13.73 340.21 86.27 153.16 12.5 56.65 142.76 11.1 2486.99 6.0 14.6 650.29 0.81 4.97 4.97 11.0 73.6 13.59 14.57 16.32 1.54 0.72 0.4 38.06 13.51 10.59 0.85 0.32 0.23 13.96 3.28 153.5 15.43 2.17 1.06
16.51 17.46 79.31 111.26 57.74 39.67 68.23 32.25 41.72 38.45 138.92 53.15 22.87 217.97 181.42 146.49 253.74 133.8 132.67 176.75 78.78 90.08 105.52 130.93 34.74 22.6 71.26 31.17 7.7 29.44 12.31 116.65 105.25 107.83 11.36 34.59 3.4 137.89 44.78 157.62 174.86 71.92 64.18
14.52 10.6 31.14 10.85 13.41 5.07 245.19 465.75 14.17 9.16 500.04 157.04 62.94 479.63 287.74 245.68 413.55 406.79 578.28 500.44 583.06 241.91 313.28 360.42 66.63 67.79 706.73 872.47 92.64 316.04 153.43 347.15 1152.44 763.41 124.42 383.82 86.2 639.2 93.21 511.96 659.76 311.67 64.39
84.7 80.04 246.16 284.61 144.19 118.11 36.84 34.95 188.59 0.0 272.58 52.97 59.89 265.33 194.66 203.66 296.02 318.79 308.99 209.94 139.26 152.41 160.56 191.65 60.73 64.58 150.69 63.34 12.4 71.01 28.77 223.7 249.49 212.48 22.53 68.77 17.95 125.86 44.76 266.23 205.58 70.47 37.11
2.43 3.42 14.87 13.32 14.76 6.11 28.82 47.64 9.74 0.0 323.56 123.0 66.38 452.83 253.86 193.02 569.39 279.49 334.95 359.94 394.67 207.85 232.04 272.61 55.8 79.98 369.21 421.52 70.69 22.41 122.27 258.74 569.83 504.0 120.45 25.74 177.81 110.43 36.48 185.5 187.49 116.64 18.94
8.26 6.3 52.29 71.35 28.78 24.08 0.29 2.53 20.71 18.27 306.76 80.0 38.01 1003.04 625.62 19.03 1093.18 27.36 612.73 527.51 105.52 143.54 21.44 19.54 33.23 20.63 61.88 16.64 5.68 14.3 4.21 70.45 81.08 90.55 6.18 21.39 1.41 22.45 4.14 152.11 26.73 10.26 1.06
52.66 49.25 120.26 80.03 70.94 40.01 146.15 77.19 69.09 87.09 310.11 69.09 87.68 461.8 468.97 221.86 206.56 251.73 209.12 321.0 186.46 211.9 190.0 217.69 96.41 78.02 171.38 64.55 50.29 102.55 42.69 288.66 279.04 286.78 55.64 114.3 22.03 259.78 182.41 191.2 361.67 218.36 109.3
26.64 18.16 49.98 38.9 27.86 19.64 92.33 142.27 26.34 22.83 384.66 107.17 130.04 897.1 626.89 300.75 772.18 366.97 525.11 443.12 237.55 223.52 250.83 276.55 164.18 84.32 271.28 183.76 146.66 430.96 202.12 367.95 474.96 466.75 123.89 406.18 48.36 176.9 121.17 137.47 261.95 136.2 92.92
51.32 45.27 149.4 147.38 124.1 78.6 57.52 24.13 81.81 18.8 178.12 48.05 46.52 307.06 223.65 136.89 190.24 203.09 184.06 146.7 117.86 106.64 110.52 117.45 54.87 44.84 97.12 55.07 10.54 42.11 21.17 96.64 128.72 95.72 20.2 59.01 16.6 137.25 43.02 94.41 179.4 60.43 34.56
35.65 32.1 188.83 213.63 122.97 120.05 14.3 18.32 121.81 24.46 326.12 119.26 40.53 474.89 303.12 200.08 514.86 335.86 385.92 269.47 132.05 166.54 191.04 223.19 54.42 39.56 68.42 33.28 10.81 14.79 9.84 43.18 71.7 39.54 15.47 12.69 10.88 56.53 10.13 176.51 119.89 29.3 9.13
1.14 1.46 28.34 59.67 19.0 18.8 3.83 15.64 13.3 14.39 226.16 91.45 35.33 1576.51 833.11 225.42 1991.01 613.24 926.16 242.78 127.5 200.63 286.1 432.65 56.8 29.67 11.21 14.45 3.61 2.34 0.55 33.54 65.55 43.42 5.01 2.17 0.22 15.24 4.67 200.09 122.66 13.3 3.05
6.66 5.79 13.79 7.61 7.99 6.5 0.85 1.31 12.27 0.0 38.0 16.82 5.24 24.55 52.83 25.95 29.07 44.74 40.01 27.63 15.11 26.24 24.61 29.57 7.52 6.04 21.0 2.8 2.13 7.63 3.23 31.62 64.08 36.3 3.27 6.24 0.91 6.32 0.33 16.92 30.04 2.9 0.08
35.2 30.14 75.82 90.2 47.94 57.03 172.89 180.64 103.93 5.36 246.38 75.81 114.08 371.77 293.16 148.7 300.35 198.44 231.75 306.15 172.43 161.25 171.05 194.34 160.41 91.42 203.27 99.98 55.65 149.81 63.42 217.27 312.93 272.87 62.6 182.1 25.98 220.24 114.46 244.3 259.25 195.33 93.06
7.26 6.63 22.49 37.08 11.65 15.29 0.0 1.07 16.18 0.0 18.87 0.0 24.52 47.71 120.81 9.01 96.29 21.09 33.76 35.61 1.55 23.07 13.58 6.56 89.92 12.06 2.98 4.54 3.05 10.46 3.1 4.6 7.2 5.89 1.91 10.07 0.56 2.76 0.71 6.39 2.45 4.14 0.8
15.03 14.88 41.0 46.72 13.16 19.15 1.26 0.12 26.3 0.0 37.25 1.81 93.5 173.82 355.99 15.13 236.6 41.67 100.95 146.41 3.99 41.54 21.01 16.4 224.51 31.6 2.32 5.58 3.45 8.21 2.66 1.39 3.89 3.64 1.37 4.4 0.78 1.32 0.26 5.27 4.8 4.03 0.19
15.62 12.2 50.67 46.13 47.13 29.32 55.46 55.36 34.84 0.0 240.86 45.76 57.31 301.78 317.77 167.33 466.35 235.88 223.99 311.18 239.87 191.1 180.81 191.48 51.78 53.5 196.03 109.49 60.86 21.25 112.05 239.59 225.15 197.16 64.74 26.11 169.53 99.52 56.32 213.1 119.85 103.92 22.64
39.79 35.12 50.2 33.84 34.74 16.04 128.83 227.14 32.5 0.0 408.77 116.42 164.08 717.12 691.89 340.33 674.35 370.03 501.52 389.24 301.62 266.34 272.36 255.68 234.39 139.79 345.24 211.51 157.69 615.8 256.22 407.04 453.5 493.88 187.83 733.09 83.83 211.87 108.73 245.89 259.1 285.19 64.9
24.94 30.84 228.15 465.68 148.93 127.16 19.01 28.33 136.52 7.8 231.46 205.11 20.74 368.28 282.55 153.26 419.22 231.71 287.62 232.21 90.97 110.79 163.65 207.66 32.28 20.98 70.57 41.07 3.82 19.61 7.66 97.48 92.42 79.54 6.02 21.56 5.36 49.63 13.92 313.22 107.42 13.59 5.42
37.8 32.6 251.64 262.19 176.87 118.09 24.0 21.94 88.05 423.77 406.53 110.59 146.79 830.18 682.48 314.84 952.11 445.35 497.28 478.23 408.49 324.06 377.55 427.44 153.1 108.95 496.08 418.61 176.61 89.24 191.5 653.87 552.46 349.2 159.7 102.84 228.43 42.77 18.33 137.14 96.29 25.01 12.72
0.6 4.91 22.62 34.05 29.08 8.35 1.59 2.11 1.37 4.92 204.58 86.2 17.9 327.97 317.28 84.87 429.6 202.39 264.21 203.53 150.56 92.9 159.33 209.28 16.53 12.51 369.44 189.41 26.38 4.48 32.38 714.78 268.07 117.02 23.0 4.59 48.96 8.07 15.53 79.37 29.29 2.85 3.6
17.32 17.42 42.71 23.43 47.54 23.45 929.96 235.07 10.13 0.0 317.53 376.71 182.94 110.03 195.02 358.94 192.9 157.08 257.9 387.85 610.42 421.22 406.9 380.32 146.04 232.44 867.22 652.22 340.25 114.41 538.97 815.5 696.75 699.91 492.34 128.46 723.52 569.38 530.87 318.87 432.35 248.61 807.09
5.38 0.55 6.79 1.25 6.74 44.69 0.54 0.96 378.04 0.0 75.15 278.32 28.68 174.23 93.46 41.61 104.76 114.54 132.09 35.55 28.16 39.04 36.01 29.61 31.03 31.26 28.66 61.14 19.98 54.5 20.85 21.68 63.56 61.96 32.24 24.13 3.22 15.51 0.2 10.32 24.31 19.04 0.0
20.68 16.04 77.08 58.62 65.53 50.47 98.58 70.6 48.17 0.43 139.76 17.33 16.63 187.89 170.25 133.23 242.69 139.37 146.37 116.56 72.24 90.04 82.79 97.71 13.01 18.57 64.53 38.23 6.04 15.26 9.16 82.63 90.68 87.07 11.72 20.71 9.36 126.74 66.41 121.95 127.39 135.9 64.6
65.14 70.17 481.79 629.67 235.9 189.72 34.42 27.22 241.65 0.25 467.26 370.65 131.93 895.88 557.01 312.34 833.1 497.23 557.88 393.47 197.53 273.75 331.76 407.6 179.26 98.28 90.31 71.7 35.24 30.99 16.18 123.55 105.38 89.98 30.45 30.86 13.88 43.44 35.19 275.38 158.6 19.33 21.03
1.44 0.85 2.82 1.26 2.3 0.96 5.23 4.78 1.58 0.0 40.45 12.61 17.07 53.84 50.44 27.72 37.69 36.25 47.9 12.16 22.46 28.36 26.33 23.23 44.51 15.33 11.98 20.8 11.08 38.16 10.8 18.68 46.91 29.22 8.48 41.07 2.98 17.15 1.04 20.38 45.03 10.87 2.28
37.35 35.77 152.57 174.32 96.77 89.81 112.49 95.58 80.72 38.77 183.66 140.65 43.64 175.53 230.88 152.39 226.48 183.91 158.91 161.45 109.87 174.34 177.1 179.45 54.96 47.62 63.06 37.07 17.51 30.14 16.4 88.53 67.39 63.53 19.63 26.18 15.65 157.1 91.02 121.58 130.77 137.12 62.75
36.5 22.67 129.42 148.64 91.71 82.92 10.43 20.26 45.8 550.98 333.1 50.71 267.62 844.3 604.36 271.64 769.38 351.97 408.82 487.02 433.04 218.6 272.31 237.07 326.5 253.64 624.58 672.38 309.12 44.0 452.61 432.88 402.13 297.01 371.72 47.26 633.17 47.6 7.7 69.23 86.56 81.9 5.43
108.98 118.17 121.92 151.62 221.46 199.2 433.78 189.87 108.78 146.93 215.21 82.06 283.44 444.35 452.2 175.94 388.36 228.53 216.03 206.68 100.6 139.22 131.58 137.62 366.68 223.52 99.46 89.29 185.77 229.56 179.16 115.69 107.14 91.94 147.97 207.31 176.43 130.63 121.17 104.33 132.68 76.56 311.18
6.8 7.25 23.07 15.82 28.27 10.74 292.36 237.58 9.33 0.0 346.65 86.26 202.69 519.95 422.45 286.44 619.69 273.48 332.53 342.15 600.58 269.13 297.78 265.6 177.73 242.21 805.35 888.4 286.73 23.06 572.26 689.04 747.02 466.24 491.26 17.65 780.18 434.04 417.14 177.07 384.45 235.39 508.03
10.92 11.77 68.77 29.1 54.06 18.06 69.91 98.16 49.73 39.73 139.25 18.22 13.25 286.96 228.8 89.91 408.6 185.55 153.41 122.09 93.45 73.45 86.32 98.39 11.65 13.96 113.93 67.83 13.88 15.14 14.29 142.75 167.34 125.35 17.79 23.02 14.16 93.25 46.3 180.68 112.98 87.67 28.14
7.51 6.76 95.94 68.29 95.54 52.16 9.58 6.4 36.17 0.0 111.31 12.47 5.29 132.61 137.15 74.98 201.1 102.93 92.01 87.88 34.21 62.41 55.76 70.09 4.79 5.57 19.46 12.43 1.14 4.17 1.43 35.86 37.44 57.16 1.45 4.0 1.08 53.23 9.19 106.69 77.69 72.58 7.6
2.47 1.69 9.14 4.81 7.11 2.68 22.31 20.65 4.38 0.0 102.41 23.66 26.55 111.69 120.13 75.49 69.16 65.57 76.95 86.18 143.07 69.08 79.26 90.05 20.79 29.33 142.98 126.38 39.05 13.37 36.22 114.09 153.48 110.93 53.39 12.23 52.0 71.46 15.56 76.97 107.23 45.78 7.06
0.86 0.62 5.37 2.17 4.24 1.27 3.79 7.94 2.14 0.0 38.33 17.37 3.82 31.19 54.51 21.34 47.44 27.32 33.58 51.77 37.39 23.49 27.89 32.11 4.72 3.93 48.63 29.3 5.77 4.39 7.32 55.6 44.54 29.79 6.98 4.59 7.39 12.53 3.91 36.44 26.65 8.35 1.66
29.32 30.5 98.94 119.75 33.18 22.35 0.0 1.31 50.46 0.0 64.49 5.43 198.31 239.65 417.31 27.2 363.15 105.08 230.34 44.92 13.97 41.98 38.94 47.59 478.09 75.87 2.79 9.48 7.53 13.88 3.99 4.42 7.23 10.04 3.83 12.2 2.82 4.81 0.26 11.08 14.27 11.29 0.0
12.59 11.16 59.42 95.28 39.61 24.28 2.63 1.07 22.92 0.0 42.08 7.23 75.75 92.1 188.27 14.57 176.45 51.18 83.73 50.05 6.97 26.61 19.84 29.77 232.61 45.4 8.58 10.6 9.1 13.51 5.82 10.08 8.77 19.32 10.47 10.17 4.66 5.46 0.71 9.48 9.78 14.78 0.8
94.12 92.1 309.67 301.54 202.39 136.31 73.24 98.14 294.38 0.0 265.23 165.0 112.62 530.43 354.4 144.49 584.29 262.9 381.89 165.85 155.72 119.67 158.18 169.45 145.02 94.0 172.12 216.59 89.16 61.58 64.17 277.67 235.88 223.18 69.87 68.07 76.52 63.09 73.69 177.11 87.91 34.66 63.54
230.81 216.22 319.65 356.49 149.34 139.75 327.32 216.96 269.55 922.3 551.73 198.8 477.59 1004.88 629.49 510.27 852.55 480.32 473.29 791.63 817.39 507.69 570.92 537.4 477.61 422.81 1245.71 1071.06 652.61 197.42 629.89 788.79 835.19 974.94 635.45 190.59 825.69 441.62 356.15 414.14 424.04 465.72 441.68
1.31 0.92 11.72 12.75 6.49 2.65 12.84 24.21 1.06 0.0 75.44 60.84 10.0 109.42 141.73 51.09 146.19 73.15 93.45 105.4 71.84 61.26 82.47 97.43 14.76 9.27 85.05 27.58 8.14 1.35 6.58 126.95 74.86 67.83 9.45 0.9 10.22 28.06 20.28 153.24 50.25 17.12 6.71
1.99 5.73 24.35 25.85 39.02 11.79 81.65 115.66 4.33 0.0 968.61 109.22 283.76 1362.39 871.16 435.76 1540.2 850.06 1146.09 624.75 983.06 469.42 539.64 563.88 207.15 280.32 1228.07 1253.42 597.75 29.15 504.1 973.42 1091.82 1164.09 600.38 29.13 701.04 225.8 126.46 602.83 408.61 370.54 51.76
10.5 8.66 59.43 58.14 51.18 41.39 23.28 27.71 55.28 0.0 89.55 26.27 6.71 111.69 97.78 64.14 141.96 91.74 74.36 74.5 45.27 51.39 47.37 54.46 6.0 7.27 29.91 20.2 2.53 8.97 4.82 30.98 41.64 37.39 4.56 10.62 3.88 47.58 15.33 57.72 61.29 52.13 16.68
668.19 713.42 715.81 472.3 1173.29 789.74 1172.84 1301.12 472.99 9094.72 2955.89 801.31 1748.21 5780.35 6345.88 2493.05 4191.16 3041.21 2302.05 5119.56 2652.5 2087.32 2164.51 1947.12 2186.21 1395.2 3083.33 1281.1 2605.23 3161.42 2224.26 4964.74 4013.19 5278.37 3058.07 3760.26 1947.42 3227.43 1653.66 4372.16 3093.83 1825.49 2232.82
12.69 10.68 212.26 248.58 156.19 92.36 33.34 32.17 64.2 0.0 313.01 60.24 20.11 472.2 338.37 207.58 556.34 344.14 331.8 318.81 221.11 185.88 214.83 233.88 27.01 17.84 354.68 80.64 14.2 15.98 9.62 503.87 434.41 366.68 11.61 16.79 8.11 147.78 24.16 440.31 220.85 83.45 26.87

Details

Raw expression values (TPM normalized), Green cells indicate low expression and red high. (Dark gray cells indicate missing values)