Heatmap: Cluster_3 (P. falciparum)

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(Values are log2 transformed ratios of a genes expression in a sample divided by the mean expression level)

Gene
Ring, WT: ERP021698
Ring, WT: ERP107326
Ring, WT: SRP048710
Ring, early, 40-5 hpi: SRP055417
Ring, medium, 2-10 hpi: SRP055417
Ring, late, 7-15 hpi: SRP055417
Ring, 10 hpi: SRP073610
Ring, 20 hpi: SRP073610
Ring: SRP090611
Ring, early, 40-5 hpi: SRP118379
Ring, medium, 2-10 hpi: SRP118379
Ring, late 7-15 hpi: SRP118379
Ring, 8-10 hpi: ERP010738
Ring, sodium L-lactate treatment: ERP107326
Ring, BLM helicase KO: ERP021698
Ring, WRN helicase KO: ERP021698
Ring, DHA-treated: SRP048710
Trophozoite, 28-30 hpi: ERP010738
Trophozoite, 24 hpi (predicted): ERP021229
Trophozoite, 32 hpi (predicted): ERP021229
Trophozoite, 40 hpi (predicted): ERP021229
Trophozoite, WT: ERP021698
Trophozoite: SRP009370
Trophozoite, WT: SRP048710
Trophozoite, early, 12-20 hpi: SRP055417
Trophozoite, late, 17-25 hpi: SRP055417
Trophozoite: SRP072137
Trophozoite, 30 hpi: SRP073610
Trophozoite, early, 12-20 hpi: SRP118379
Trophozoite, late, 17-25 hpi: SRP118379
Trophozoite, DHA-treated: SRP048710
Trophozoite, BLM helicase KO: ERP021698
Trophozoite, WRN helicase KO: ERP021698
Schizont, 40 hpi (predicted): ERP021229
Schizonts, WT: ERP021698
Schizont: ERP103955
Schizont: SRP009370
Schizont, WT: SRP014155
Schizont, WT: SRP048710
Schizont, early, 22-30 hpi: SRP055417
Schizont, medium, 27-35 hpi: SRP055417
Schizont, late, 32-40 hpi: SRP055417
Schizont: SRP072137
Schizont, 40 hpi: SRP073610
Schizont, early, 22-30 hpi: SRP118379
Schizont, medium, 27-35 hpi: SRP118379
Schizont, late, 32-40 hpi: SRP118379
Schizont: SRP143373
Schizont, 3D7C8-WT: SRP162789
Schizont, 3D7-WT: SRP162789
Schizont, DHA-treated: SRP048710
Schizonts, BLM helicase KO: ERP021698
Schizonts, WRN helicase KO: ERP021698
Schizont, induced halofuginone resistance: SRP014155
Schizont, 3D7-Sir2a-E1: SRP162789
Schizont, 3D7-Sir2a-G1: SRP162789
Gametocyte (male) (predicted): ERP021229
Gametocyte (male): SRP067125
Gametocyte (male): SRP069075
Gametocyte (female) (predicted): ERP021229
Gametocyte (female): SRP067125
Gametocyte (female): SRP069075
Sporozoite: SRP033414
-0.47 -1.84 -2.73 -0.98 -2.94 -3.97 -3.73 -3.63 -5.07 0.31 -1.17 -2.76 -3.11 -1.78 0.05 0.13 -7.68 -0.91 -3.76 0.87 -2.77 0.97 -0.13 -2.49 -3.23 -2.59 -0.03 0.95 -1.71 -0.07 -3.44 0.82 0.89 -1.34 0.68 1.92 -0.03 -0.76 -1.24 0.05 0.86 0.07 -0.9 -0.61 1.48 1.55 0.91 -0.3 0.51 0.88 -2.52 0.58 0.71 -0.88 1.26 -0.29 - 2.03 0.91 -0.02 0.37 0.79 0.3
0.91 0.39 -3.05 -3.98 -2.35 -1.36 -2.31 -0.44 -3.97 -2.57 -1.11 -0.23 -0.64 0.03 1.21 1.11 -4.82 0.93 - -5.04 -2.71 2.25 -1.22 -2.48 -1.26 -0.07 -0.43 0.48 0.51 0.74 -3.02 2.55 2.24 - 0.62 1.56 -2.15 -0.59 -1.8 0.04 -0.09 -0.94 -2.12 -1.43 1.11 -0.14 0.29 -1.18 0.01 -0.25 -2.45 0.89 0.91 -0.96 0.53 -0.3 - -0.73 0.24 -2.18 -0.87 -0.01 -3.97
1.38 -1.05 -2.61 -3.02 -4.98 -4.59 -5.09 -1.88 - -1.26 -2.41 -4.37 -4.92 -1.14 1.83 1.23 -6.55 -0.06 - - -6.9 2.26 -2.07 -2.25 -3.94 0.69 0.35 0.64 0.13 1.88 -3.41 2.58 2.22 - 0.69 0.64 -3.67 -0.91 -0.78 0.79 -0.06 -1.48 -1.79 -2.88 1.76 0.4 0.38 -0.75 -1.29 -1.61 -3.48 0.86 0.81 -0.42 -1.22 -1.7 - 0.74 -0.03 -1.15 0.72 -0.05 -
0.6 -1.01 -4.2 -1.64 -3.05 -3.25 -3.6 -2.74 -4.44 -0.26 -1.47 -2.18 -0.92 -0.6 1.0 0.74 -7.18 -0.25 - -8.02 -3.35 1.95 -0.55 -1.97 -3.31 -1.54 -1.83 0.73 -1.8 -0.19 -2.58 2.02 1.88 -0.43 1.58 1.39 -1.08 -0.59 -2.71 -0.23 0.55 -0.18 -1.93 -0.61 1.41 0.85 0.53 -1.55 0.22 -0.23 -2.84 1.8 1.7 -0.76 0.19 -0.33 - 1.6 -1.23 -1.81 0.18 -1.24 0.93
1.88 -2.39 -2.14 -1.09 -1.75 -0.96 -1.0 -1.35 -0.39 0.14 0.06 0.01 1.0 -2.03 1.64 1.69 -2.97 -1.21 -10.75 -9.82 -9.27 1.57 -5.1 -2.61 -1.79 -1.46 -0.64 -1.01 0.05 -0.21 -2.38 1.47 1.51 -4.93 1.53 2.86 -5.98 -4.3 -2.22 -1.31 -0.61 -0.08 -0.52 -0.55 0.25 0.0 0.28 -3.41 0.61 0.34 -2.33 1.48 1.49 -4.35 -0.06 0.48 -7.12 0.31 -2.79 -8.53 -1.34 -2.62 -0.52
-0.1 -4.71 -3.32 -1.52 -3.17 -3.49 -2.64 -2.49 -7.05 0.06 -1.26 -2.41 -1.41 -4.54 0.48 0.29 -6.58 -0.44 -0.59 -1.09 0.58 0.62 -0.89 -2.78 -3.86 -0.97 -4.04 -0.21 -1.75 -0.22 -2.53 0.83 0.57 -7.12 1.99 2.56 0.38 1.28 -1.33 -1.0 -0.35 1.2 -1.53 1.12 0.01 0.84 1.94 -1.69 -0.16 -0.36 -2.25 2.21 2.21 0.7 -0.27 -0.69 -5.26 0.41 -1.96 -1.99 -0.77 -1.6 -0.69
0.69 -1.8 -1.12 -2.69 -1.26 -0.11 -0.32 0.02 -4.01 -2.14 -0.48 0.54 -1.45 -1.64 1.32 1.22 -1.83 -0.66 - -1.26 - 1.29 -1.47 -1.65 -0.28 0.7 -0.85 0.76 1.02 0.93 -3.01 1.5 1.39 - 0.89 1.61 -5.02 0.62 -2.36 0.37 0.7 1.26 -1.23 0.25 1.45 1.44 1.05 -1.75 -0.85 -1.22 -2.37 1.07 1.02 -0.41 -0.41 -0.92 - -0.06 -2.47 -9.06 -1.02 -2.49 -2.94
1.05 -2.21 -2.75 -1.83 -1.4 0.24 -0.23 0.4 -3.66 -0.73 0.88 1.47 -3.62 -2.08 1.21 1.1 - -2.5 - -2.8 -0.14 1.27 -2.95 -2.58 0.06 -0.18 -2.75 -0.96 1.6 0.72 -2.28 1.37 1.15 -5.92 1.18 2.17 -1.91 -1.1 -1.09 -1.26 -0.75 -0.14 -1.88 -1.12 0.76 0.08 0.83 -2.58 -0.01 0.63 -3.72 1.24 1.34 -1.73 0.43 -0.37 - 1.27 -0.89 -3.34 -1.44 -1.26 0.23
-0.09 -0.44 -2.79 -4.3 -3.95 -2.49 -3.96 -1.06 -3.54 -2.18 -2.87 -1.25 -2.75 -0.49 0.22 0.02 -3.94 0.56 -3.49 1.86 -1.75 1.19 -0.7 -1.23 -2.1 -0.51 0.64 0.16 0.14 0.89 -1.1 1.21 1.19 -5.29 0.31 2.1 -1.85 0.71 -1.05 -0.26 0.22 -0.03 -0.1 -1.21 1.26 1.22 0.72 -0.77 0.85 0.34 -1.68 0.55 0.46 -0.16 1.0 -0.01 - -0.76 -0.93 -0.78 -0.71 -0.89 1.9
PF3D7_0516100 (ATPase1)
0.4 -3.18 -2.64 -2.48 -3.59 -3.37 -3.87 -2.1 -4.14 -1.34 -1.95 -2.51 -1.89 -2.99 0.81 0.73 -3.03 -0.23 -7.01 0.23 -1.04 1.67 -0.72 -0.68 -3.62 -1.79 -1.21 0.65 -2.25 -0.39 -1.74 1.68 1.57 -6.59 0.67 1.59 -0.92 0.22 -0.72 -0.42 0.85 0.61 -1.28 -0.71 1.08 1.5 0.9 -0.61 1.04 0.58 -1.55 0.93 0.77 -0.0 1.14 0.42 0.98 -0.3 0.52 -0.92 0.54 0.5 -3.78
1.13 -0.81 -2.95 -3.44 -4.35 -3.52 -4.09 -1.39 -5.19 -1.56 -2.22 -2.25 -2.95 -0.78 1.21 1.14 -4.25 -1.67 - 1.05 - 2.24 -1.54 -1.51 -3.35 -0.35 -0.89 0.48 -0.69 0.7 -0.79 2.3 2.13 -0.57 0.84 1.42 -2.74 -0.8 -0.97 -0.0 0.22 -0.31 -1.57 -1.28 1.3 0.88 0.37 -0.87 -0.02 -0.46 -2.4 0.92 1.01 -1.19 0.53 -0.31 - -0.46 0.59 -0.39 -0.11 0.38 -0.62
2.29 -1.76 -2.07 -0.99 -1.47 -0.61 -0.59 -0.93 -2.75 -0.1 -0.5 -0.27 -4.16 -1.78 1.02 1.1 -3.55 -2.16 - -5.37 -5.44 1.76 -3.91 -2.85 -1.51 -0.24 -0.92 -0.56 0.3 0.24 -2.23 1.04 1.02 -5.13 2.02 2.81 -5.39 -2.19 -1.24 -0.34 -0.08 0.12 -0.95 -0.64 0.74 0.04 0.34 -2.82 -0.05 0.39 -2.21 2.01 1.84 -1.88 0.08 -0.18 -6.23 -0.36 -3.07 -3.31 -0.82 -2.86 -0.31
-0.11 -0.23 -5.19 -3.53 -4.46 -4.3 -6.87 -2.51 -5.39 -2.06 -2.36 -2.78 -1.87 -0.2 0.91 0.3 -7.39 -0.36 - -1.04 -1.18 1.82 -0.99 -2.97 -4.62 -0.79 0.04 0.78 -2.35 0.96 -1.59 1.99 1.67 0.05 0.66 1.66 -1.86 0.23 -2.6 0.42 0.26 -0.97 -1.68 -2.04 1.56 0.87 0.92 -1.78 0.49 -0.23 -3.77 1.14 0.89 0.28 0.48 -0.3 - 2.0 0.56 -0.44 0.76 0.41 -3.18
0.45 -0.72 -3.71 -2.97 -3.85 -2.91 -4.25 -1.67 -3.29 -1.14 -3.03 -1.36 -4.54 -0.88 0.8 0.57 -4.4 -2.65 - -0.08 -2.15 0.75 -0.32 -1.18 -1.32 0.15 -0.45 0.33 0.26 1.21 -0.98 1.04 0.65 - -0.57 0.48 -2.61 -0.14 -1.17 0.23 0.44 0.31 -1.33 -0.31 1.36 1.23 0.67 -1.16 0.54 0.69 -1.82 0.01 -0.41 -1.21 1.05 0.57 0.87 2.48 0.66 -0.81 0.95 0.45 1.31
1.11 -0.53 -0.13 -0.88 -3.3 -3.79 -2.55 -3.36 1.0 -0.23 -1.64 -3.03 3.56 -0.24 1.51 1.96 0.66 0.45 - - -1.41 -0.5 -0.43 -4.34 -4.32 -4.65 -1.6 -2.51 -3.79 -2.87 -0.84 -0.06 -0.11 - 1.41 -2.13 -0.32 -1.68 -3.22 -2.99 -1.72 -0.53 0.62 -0.14 -1.7 -1.08 0.38 -1.0 -1.0 0.62 -2.86 1.6 1.36 -1.32 0.21 -0.49 - 0.74 1.08 -4.88 0.05 0.84 -0.81
0.4 0.67 -0.48 0.43 -1.27 -0.88 -1.48 -0.22 -2.42 0.7 -0.24 -0.12 -0.8 0.61 0.3 0.5 -1.72 0.27 -5.26 -4.21 -1.57 0.26 -1.28 -1.59 -0.92 -0.21 -0.52 -0.44 0.61 0.86 -0.25 0.38 0.31 -5.05 1.14 1.14 -2.09 0.38 -0.19 -0.5 -0.23 0.29 0.08 -0.17 0.78 0.92 0.98 0.03 0.02 0.33 -0.75 1.01 1.27 0.91 0.4 -0.04 -3.42 -0.58 0.23 -3.52 -0.11 0.3 -1.75
0.22 0.22 -3.38 -3.75 -5.51 -5.82 -6.54 -1.35 -6.02 -2.67 -4.06 -4.55 -1.4 0.24 0.62 0.7 - 1.28 - - -3.1 2.46 -1.27 -1.96 -4.09 -0.24 -0.85 1.09 -1.47 1.0 -2.59 2.64 2.36 -1.63 0.81 1.68 -2.0 -0.97 -1.45 0.59 0.56 -0.75 -2.32 -1.5 1.84 0.86 0.38 -1.56 0.15 -0.49 -3.44 1.08 0.91 -0.73 0.15 -0.47 - 0.63 -1.35 -6.19 -1.63 -0.94 -2.26
1.18 -2.36 -1.72 -1.83 -1.7 -1.61 -1.11 -2.51 -3.39 -0.59 -0.81 -0.53 -1.13 -2.67 1.48 1.39 -3.63 -1.3 - -8.84 -1.35 1.21 -1.33 -1.38 -2.25 -2.02 -1.87 -0.34 -1.3 -0.59 -2.04 1.34 1.27 -1.36 1.2 2.38 -0.84 0.4 -0.9 -0.88 0.09 0.65 -1.19 0.12 0.18 0.88 0.92 -0.11 -0.52 -0.31 -1.59 1.39 1.2 0.56 0.37 -0.46 - 1.08 0.99 -1.26 -0.13 0.98 -1.41
0.42 -0.94 -5.25 -2.44 -3.92 -3.16 -4.47 -0.33 -4.84 -1.4 -2.39 -1.33 -2.14 -0.93 0.6 0.56 -5.81 -1.46 -1.79 -0.91 -0.34 1.41 -0.8 -2.22 -1.85 0.69 -0.23 1.39 0.48 1.92 -3.36 1.41 1.34 0.33 0.32 1.48 -2.51 0.41 -2.39 1.23 1.07 -0.08 -2.26 -1.16 2.46 1.4 1.05 -2.31 -0.01 -0.39 -3.32 0.49 0.34 0.21 -0.09 -0.68 - 0.43 -1.38 -4.22 -3.19 -1.27 -0.13
-1.16 -2.2 -4.53 -3.51 -4.85 -5.22 -5.0 -4.36 -6.03 -1.96 -2.77 -3.9 -2.9 -2.11 -0.59 -0.5 -5.84 0.64 -3.22 0.9 -1.19 1.36 -0.79 -2.34 -5.79 -1.55 -0.88 1.02 -3.66 0.29 -2.38 1.32 1.26 -4.12 0.37 1.53 -0.6 0.5 -1.8 0.29 1.02 0.4 -2.01 -0.4 1.57 1.46 0.87 -1.23 0.78 0.39 -2.21 0.42 0.49 0.34 0.61 -0.21 1.04 2.98 -0.93 -0.46 0.74 -0.99 -5.82
0.48 -1.05 -3.65 -2.26 -2.63 -1.38 -2.01 -1.29 -5.34 -1.66 -1.11 -1.55 -2.5 -0.86 1.06 0.69 -4.79 -1.06 - -0.33 -4.2 2.02 -0.02 -1.36 -1.78 -0.85 -1.56 0.56 -0.15 -0.1 -2.63 2.07 1.96 -0.44 1.86 1.8 -1.77 0.15 -2.06 -0.17 0.53 0.77 -0.77 0.04 0.45 0.71 0.65 -2.14 0.54 -1.0 -4.46 1.83 1.9 -0.9 -0.32 0.19 - 0.12 -1.45 -5.19 -0.91 -1.82 -0.97
0.17 -0.9 - -5.5 -5.95 -6.56 -3.44 -2.73 -8.48 -2.16 -3.39 -3.15 -4.7 -0.77 0.9 0.57 - -1.56 - -1.49 -1.84 2.54 -0.32 -1.95 -5.27 -0.92 0.37 0.98 -1.32 0.8 -2.03 2.61 2.34 - 0.81 1.52 -3.92 0.01 -3.16 0.42 0.74 -0.19 -1.55 -1.55 2.04 1.18 1.01 -1.74 0.82 -0.41 -5.31 0.88 1.03 -0.37 0.39 0.04 - 0.6 -1.58 -2.78 -1.51 -1.27 -5.01
1.0 -1.73 -2.26 -2.83 -2.96 -3.16 -2.39 -3.23 -6.07 -0.69 -0.84 -2.39 -1.24 -1.77 1.72 1.35 -2.85 1.08 - -3.11 - 1.54 -1.6 -0.04 -3.32 -3.11 -0.63 0.42 -1.89 -0.73 0.05 1.57 1.58 -1.06 0.96 1.1 -1.33 0.33 -0.82 -0.56 0.53 -0.21 -1.71 -0.82 1.5 0.98 0.72 -0.82 0.38 -0.63 -1.4 1.2 1.15 0.55 0.27 0.32 - 0.7 0.73 -2.23 0.47 0.58 -1.22
1.39 -1.26 -3.07 -3.64 -3.68 -3.29 -3.24 -1.89 -5.49 -2.47 -2.11 -2.87 -3.94 -1.12 1.84 1.64 -2.65 -0.8 - - - 2.25 -1.87 -2.9 -2.7 -2.24 -1.7 0.82 -1.35 0.27 -2.23 2.24 2.17 - 0.93 1.1 -5.23 -0.29 -2.07 -0.15 0.22 -0.61 -2.21 -1.6 1.39 0.7 0.57 -1.76 -0.68 -1.4 -4.04 1.03 1.25 -0.75 -0.35 -0.91 2.16 1.7 -0.03 -1.97 -2.01 -0.1 -3.15
-1.18 -2.8 -0.34 -2.74 -3.95 -3.49 -3.69 -1.67 -3.92 -1.64 -1.75 -1.99 -2.17 -2.79 0.0 -0.46 -1.24 1.88 - -0.67 -9.26 1.37 -1.14 -0.33 -3.53 -1.77 0.46 1.4 -2.67 0.11 -1.5 1.48 1.31 - -0.08 1.15 -3.21 -0.81 0.72 0.7 1.29 -0.25 -0.55 -0.77 1.85 1.21 0.23 -0.25 1.06 -0.01 -1.03 0.4 0.05 -0.94 0.92 0.44 - 0.23 1.1 -1.39 1.34 0.89 -0.52
-2.2 -4.58 -2.58 -5.47 - - - -6.21 - -0.66 -4.04 -4.12 -2.67 -4.13 -0.2 -0.1 -3.72 -1.76 - - -4.63 -2.25 -0.87 -3.52 -5.92 - - -3.98 -4.32 -2.97 - -1.79 -2.77 -3.78 -2.05 -0.4 -0.16 2.24 - -3.57 -4.03 -4.23 -0.95 -3.95 -4.36 -2.36 0.41 -1.04 -2.51 -1.02 -2.16 -1.66 -1.35 2.54 -0.49 -2.81 - 5.18 0.61 -4.47 -0.33 0.51 -
1.22 -0.09 -2.24 -3.87 -4.2 -4.39 -5.24 -2.16 -3.42 -1.75 -2.44 -3.3 -2.66 0.03 1.43 1.23 -6.77 -0.09 - - -5.86 2.21 -1.03 -0.65 -3.77 -0.65 0.92 0.63 -1.18 0.9 -1.18 2.32 2.03 -4.61 0.64 0.99 -1.97 0.04 -0.93 0.31 0.28 -1.12 -1.23 -2.0 1.77 0.48 0.37 -0.56 0.56 -0.99 -3.04 1.06 0.74 -0.28 -0.12 -0.23 - -1.93 0.51 -1.72 0.47 0.44 -0.89
-0.13 -2.91 - -5.34 - - -5.13 - - - -3.91 - -2.22 -3.1 1.61 0.16 - 1.12 - - - -0.04 - - -4.79 -3.04 -2.01 - -3.19 -0.72 - 1.28 0.08 - 0.26 2.82 - -0.21 - -1.57 0.16 0.74 -2.03 - 1.84 1.79 2.21 -1.01 - -6.1 - 1.27 0.06 -0.35 -5.15 - - 3.53 1.71 - -2.61 2.5 -
0.6 -2.02 - -3.87 - - - - - - -2.43 - -2.07 -2.91 0.98 1.73 - 0.73 - - - 0.04 - - -4.31 -1.56 -1.51 -3.96 - 1.3 - 0.41 0.17 - -0.15 2.77 - 0.68 - 1.03 1.42 1.46 -2.51 -2.35 2.42 2.37 3.01 -2.48 -3.31 -3.81 -1.36 1.46 0.08 1.48 -3.38 -5.23 - - -0.15 - -1.14 1.07 -2.05
0.24 -2.85 -2.79 -2.54 -3.67 -3.28 -2.52 -3.84 -8.15 -1.47 -2.1 -3.05 -3.05 -2.73 0.86 0.47 -4.77 -0.35 - -2.59 -2.22 2.29 -0.6 0.04 -4.13 -1.54 -0.8 0.73 -2.82 -0.52 -0.85 2.28 2.18 -8.08 1.45 1.27 -1.65 0.19 -1.37 0.17 0.92 0.43 -0.63 0.32 1.18 0.82 0.87 -0.75 0.75 -0.19 -2.06 1.59 1.54 -0.99 0.73 0.47 - 0.9 -0.89 -4.16 -0.63 -1.19 -3.87
1.35 -0.41 -1.42 -1.23 -0.87 -0.38 -0.02 -1.09 -3.27 0.37 0.86 0.43 -0.0 -0.65 1.38 1.25 -3.94 -0.26 -3.77 0.82 -5.3 1.59 -1.26 -1.96 -1.4 -0.69 -1.73 -0.61 0.29 0.09 -1.59 1.74 1.5 - 1.49 1.04 -3.0 -0.56 -2.64 -0.89 -0.51 -0.66 -1.69 -1.33 0.59 0.11 0.39 -1.41 0.08 -0.56 -4.03 1.6 1.67 -0.91 -0.08 -0.49 0.97 -0.06 -0.59 -2.62 -1.44 -0.51 -3.22
0.42 -3.61 -2.41 -0.37 0.28 0.77 0.19 0.99 -2.11 0.16 0.09 -0.03 -1.27 -3.45 0.52 0.41 -3.29 -1.36 - -6.37 -3.02 0.48 -4.91 -2.86 0.35 1.22 0.14 1.63 -0.05 0.26 -2.06 0.62 0.48 -3.13 0.16 1.38 -3.24 -1.83 -1.67 1.5 1.44 0.76 -0.73 0.84 0.15 -0.1 0.26 -2.71 0.85 -0.15 -2.53 0.15 0.17 -1.48 0.12 0.98 -6.94 0.26 -0.98 -3.56 0.35 -1.14 1.57
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Details

Dark gray cells indicate values where the raw expression is zero (cannot be log-transformed). Blue cells indicate samples where the expression of the gene is below average and red cells indicate the gene is expressed above average in the sample. White cells are average.