PF3D7_0207700 (SERA4)

Aliases : SERA4

Description : SSF54001: Papain-like cysteine peptidase superfamily. Pfam domain(s): PF00112: Papain family cysteine protease.

Gene families : OG_01_0000019 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000019_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0207700
Cluster	P. falciparum: Cluster_17

Target	Alias	Description	ECC score	Gene Family Method
PBANKA_0304800	SERA4	SSF54001: Papain-like cysteine peptidase superfamily....	0.03	Orthofinderv1.1.8
PBANKA_0305000	SERA2	SSF54001: Papain-like cysteine peptidase superfamily....	0.03	Orthofinderv1.1.8
PBANKA_0305100	SERA1	SSF54001: Papain-like cysteine peptidase superfamily....	0.03	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
BP	GO:0002376	immune system process	None	Extended
BP	GO:0002377	immunoglobulin production	IDA	PlasmoDB
BP	GO:0002440	production of molecular mediator of immune response	None	Extended
BP	GO:0002682	regulation of immune system process	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006508	proteolysis	ISS	PlasmoDB
BP	GO:0006508	proteolysis	IEA	Interproscan predictions
BP	GO:0006508	proteolysis	IEA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008234	cysteine-type peptidase activity	ISS	PlasmoDB
MF	GO:0008234	cysteine-type peptidase activity	IEA	Interproscan predictions
MF	GO:0008234	cysteine-type peptidase activity	IEA	PlasmoDB
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
CC	GO:0020003	symbiont-containing vacuole	IDA	PlasmoDB
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
CC	GO:0033655	host cell cytoplasm part	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043230	extracellular organelle	None	Extended
CC	GO:0044217	other organism part	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
CC	GO:0044421	extracellular region part	None	Extended
BP	GO:0048583	regulation of response to stimulus	None	Extended
BP	GO:0050776	regulation of immune response	TAS	PlasmoDB
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
CC	GO:0065010	extracellular membrane-bounded organelle	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
CC	GO:0000808	origin recognition complex	IEP	Predicted GO
BP	GO:0001817	regulation of cytokine production	IEP	Predicted GO
BP	GO:0001819	positive regulation of cytokine production	IEP	Predicted GO
MF	GO:0001882	nucleoside binding	IEP	Predicted GO
MF	GO:0001883	purine nucleoside binding	IEP	Predicted GO
MF	GO:0003677	DNA binding	IEP	Predicted GO
MF	GO:0003756	protein disulfide isomerase activity	IEP	Predicted GO
MF	GO:0003924	GTPase activity	IEP	Predicted GO
MF	GO:0004176	ATP-dependent peptidase activity	IEP	Predicted GO
MF	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	IEP	Predicted GO
MF	GO:0004402	histone acetyltransferase activity	IEP	Predicted GO
MF	GO:0004427	inorganic diphosphatase activity	IEP	Predicted GO
MF	GO:0004619	phosphoglycerate mutase activity	IEP	Predicted GO
MF	GO:0004674	protein serine/threonine kinase activity	IEP	Predicted GO
MF	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEP	Predicted GO
MF	GO:0004774	succinate-CoA ligase activity	IEP	Predicted GO
MF	GO:0004775	succinate-CoA ligase (ADP-forming) activity	IEP	Predicted GO
MF	GO:0005326	neurotransmitter transporter activity	IEP	Predicted GO
MF	GO:0005328	neurotransmitter:sodium symporter activity	IEP	Predicted GO
MF	GO:0005338	nucleotide-sugar transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005459	UDP-galactose transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005488	binding	IEP	Predicted GO
MF	GO:0005509	calcium ion binding	IEP	Predicted GO
MF	GO:0005516	calmodulin binding	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
MF	GO:0005525	GTP binding	IEP	Predicted GO
CC	GO:0005664	nuclear origin of replication recognition complex	IEP	Predicted GO
CC	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006104	succinyl-CoA metabolic process	IEP	Predicted GO
BP	GO:0006259	DNA metabolic process	IEP	Predicted GO
BP	GO:0006268	DNA unwinding involved in DNA replication	IEP	Predicted GO
BP	GO:0006270	DNA replication initiation	IEP	Predicted GO
BP	GO:0006325	chromatin organization	IEP	Predicted GO
BP	GO:0006410	obsolete transcription, RNA-dependent	IEP	Predicted GO
BP	GO:0006471	protein ADP-ribosylation	IEP	Predicted GO
BP	GO:0006662	glycerol ether metabolic process	IEP	Predicted GO
BP	GO:0006732	coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006793	phosphorus metabolic process	IEP	Predicted GO
BP	GO:0006796	phosphate-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006836	neurotransmitter transport	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008301	DNA binding, bending	IEP	Predicted GO
CC	GO:0008540	proteasome regulatory particle, base subcomplex	IEP	Predicted GO
MF	GO:0008841	dihydrofolate synthase activity	IEP	Predicted GO
CC	GO:0009368	endopeptidase Clp complex	IEP	Predicted GO
CC	GO:0009376	HslUV protease complex	IEP	Predicted GO
BP	GO:0009396	folic acid-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0009987	cellular process	IEP	Predicted GO
MF	GO:0015081	sodium ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015293	symporter activity	IEP	Predicted GO
MF	GO:0015294	solute:cation symporter activity	IEP	Predicted GO
MF	GO:0015370	solute:sodium symporter activity	IEP	Predicted GO
BP	GO:0016043	cellular component organization	IEP	Predicted GO
BP	GO:0016310	phosphorylation	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
MF	GO:0016757	transferase activity, transferring glycosyl groups	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016853	isomerase activity	IEP	Predicted GO
MF	GO:0016860	intramolecular oxidoreductase activity	IEP	Predicted GO
MF	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	IEP	Predicted GO
MF	GO:0016868	intramolecular transferase activity, phosphotransferases	IEP	Predicted GO
MF	GO:0016881	acid-amino acid ligase activity	IEP	Predicted GO
MF	GO:0017076	purine nucleotide binding	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
MF	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	IEP	Predicted GO
BP	GO:0018105	peptidyl-serine phosphorylation	IEP	Predicted GO
BP	GO:0018143	nucleic acid-protein covalent cross-linking	IEP	Predicted GO
BP	GO:0018144	RNA-protein covalent cross-linking	IEP	Predicted GO
BP	GO:0018209	peptidyl-serine modification	IEP	Predicted GO
BP	GO:0018904	ether metabolic process	IEP	Predicted GO
MF	GO:0019001	guanyl nucleotide binding	IEP	Predicted GO
BP	GO:0019725	cellular homeostasis	IEP	Predicted GO
BP	GO:0030163	protein catabolic process	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
MF	GO:0031079	obsolete picornain 3C activity	IEP	Predicted GO
CC	GO:0031410	cytoplasmic vesicle	IEP	Predicted GO
CC	GO:0031597	cytosolic proteasome complex	IEP	Predicted GO
CC	GO:0031974	membrane-enclosed lumen	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
MF	GO:0032549	ribonucleoside binding	IEP	Predicted GO
MF	GO:0032550	purine ribonucleoside binding	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
MF	GO:0032555	purine ribonucleotide binding	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Predicted GO
BP	GO:0032879	regulation of localization	IEP	Predicted GO
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Predicted GO
BP	GO:0035890	exit from host	IEP	Predicted GO
BP	GO:0035891	exit from host cell	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
BP	GO:0040011	locomotion	IEP	Predicted GO
CC	GO:0042555	MCM complex	IEP	Predicted GO
BP	GO:0042592	homeostatic process	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
CC	GO:0043233	organelle lumen	IEP	Predicted GO
BP	GO:0043248	proteasome assembly	IEP	Predicted GO
CC	GO:0043264	extracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0045454	cell redox homeostasis	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0048306	calcium-dependent protein binding	IEP	Predicted GO
BP	GO:0048878	chemical homeostasis	IEP	Predicted GO
BP	GO:0050794	regulation of cellular process	IEP	Predicted GO
BP	GO:0050801	ion homeostasis	IEP	Predicted GO
BP	GO:0051049	regulation of transport	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051239	regulation of multicellular organismal process	IEP	Predicted GO
BP	GO:0051240	positive regulation of multicellular organismal process	IEP	Predicted GO
BP	GO:0051276	chromosome organization	IEP	Predicted GO
BP	GO:0052126	movement in host environment	IEP	Predicted GO
BP	GO:0052192	movement in environment of other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0055065	metal ion homeostasis	IEP	Predicted GO
BP	GO:0055074	calcium ion homeostasis	IEP	Predicted GO
BP	GO:0055080	cation homeostasis	IEP	Predicted GO
BP	GO:0060627	regulation of vesicle-mediated transport	IEP	Predicted GO
MF	GO:0061733	peptide-lysine-N-acetyltransferase activity	IEP	Predicted GO
BP	GO:0065008	regulation of biological quality	IEP	Predicted GO
CC	GO:0070013	intracellular organelle lumen	IEP	Predicted GO
BP	GO:0070682	proteasome regulatory particle assembly	IEP	Predicted GO
BP	GO:0071344	diphosphate metabolic process	IEP	Predicted GO
BP	GO:0071840	cellular component organization or biogenesis	IEP	Predicted GO
BP	GO:0072507	divalent inorganic cation homeostasis	IEP	Predicted GO
CC	GO:0085026	tubovesicular membrane network	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
MF	GO:0097367	carbohydrate derivative binding	IEP	Predicted GO
MF	GO:0097472	cyclin-dependent protein kinase activity	IEP	Predicted GO
CC	GO:0097708	intracellular vesicle	IEP	Predicted GO
BP	GO:0098771	inorganic ion homeostasis	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000668	Peptidase_C1A_C	484	703

External Links

PlasmoDB	812669
PlasmoDB	PF02_0073
PlasmoDB	PFB0345c

PF3D7_0207700 (SERA4)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation