PF3D7_0302600 (ABCB4)

Aliases : ABCB4

Description : SSF52540: P-loop containing nucleoside triphosphate hydrolase, SSF90123: "ABC transporter type 1, transmembrane domain superfamily". Pfam domain(s): PF00664: ABC transporter transmembrane region, PF00005: ABC transporter.

Gene families : OG_01_0003440 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0003440_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0302600
Cluster	P. falciparum: Cluster_41

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_0401200	ABCB4	SSF52540: P-loop containing nucleoside triphosphate...	0.03	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005215	transporter activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006810	transport	None	Extended
BP	GO:0006855	drug transmembrane transport	ISS	PlasmoDB
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
CC	GO:0009536	plastid	None	Extended
MF	GO:0015238	drug transmembrane transporter activity	ISS	PlasmoDB
MF	GO:0015399	primary active transmembrane transporter activity	None	Extended
MF	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	None	Extended
BP	GO:0015893	drug transport	None	Extended
CC	GO:0016021	integral component of membrane	ISS	PlasmoDB
CC	GO:0016021	integral component of membrane	IEA	Interproscan predictions
CC	GO:0016021	integral component of membrane	IEA	PlasmoDB
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	IEA	Interproscan predictions
MF	GO:0016887	ATPase activity	IEA	PlasmoDB
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
CC	GO:0020011	apicoplast	IDA	PlasmoDB
MF	GO:0022804	active transmembrane transporter activity	None	Extended
MF	GO:0022857	transmembrane transporter activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
CC	GO:0031224	intrinsic component of membrane	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042493	response to drug	IDA	PlasmoDB
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	ISS	PlasmoDB
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	Interproscan predictions
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	PlasmoDB
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
MF	GO:0043492	ATPase activity, coupled to movement of substances	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044425	membrane part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0055085	transmembrane transport	IEA	Interproscan predictions
BP	GO:0055085	transmembrane transport	IEA	PlasmoDB
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000287	magnesium ion binding	IEP	Predicted GO
BP	GO:0000723	telomere maintenance	IEP	Predicted GO
MF	GO:0003690	double-stranded DNA binding	IEP	Predicted GO
MF	GO:0003721	telomerase RNA reverse transcriptase activity	IEP	Predicted GO
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Predicted GO
MF	GO:0003896	DNA primase activity	IEP	Predicted GO
MF	GO:0003964	RNA-directed DNA polymerase activity	IEP	Predicted GO
MF	GO:0004179	obsolete membrane alanyl aminopeptidase activity	IEP	Predicted GO
MF	GO:0004518	nuclease activity	IEP	Predicted GO
MF	GO:0004523	RNA-DNA hybrid ribonuclease activity	IEP	Predicted GO
MF	GO:0004527	exonuclease activity	IEP	Predicted GO
MF	GO:0004540	ribonuclease activity	IEP	Predicted GO
MF	GO:0004576	oligosaccharyl transferase activity	IEP	Predicted GO
MF	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004831	tyrosine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004832	valine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005324	long-chain fatty acid transporter activity	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006097	glyoxylate cycle	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006259	DNA metabolic process	IEP	Predicted GO
BP	GO:0006278	RNA-dependent DNA biosynthetic process	IEP	Predicted GO
BP	GO:0006302	double-strand break repair	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006427	histidyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006437	tyrosyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006438	valyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006487	protein N-linked glycosylation	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006665	sphingolipid metabolic process	IEP	Predicted GO
BP	GO:0006721	terpenoid metabolic process	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0007004	telomere maintenance via telomerase	IEP	Predicted GO
MF	GO:0008408	3'-5' exonuclease activity	IEP	Predicted GO
MF	GO:0008661	1-deoxy-D-xylulose-5-phosphate synthase activity	IEP	Predicted GO
BP	GO:0010243	response to organonitrogen compound	IEP	Predicted GO
BP	GO:0010498	proteasomal protein catabolic process	IEP	Predicted GO
BP	GO:0010564	regulation of cell cycle process	IEP	Predicted GO
BP	GO:0010833	telomere maintenance via telomere lengthening	IEP	Predicted GO
BP	GO:0015074	DNA integration	IEP	Predicted GO
BP	GO:0016114	terpenoid biosynthetic process	IEP	Predicted GO
CC	GO:0016234	inclusion body	IEP	Predicted GO
BP	GO:0016441	posttranscriptional gene silencing	IEP	Predicted GO
BP	GO:0016458	gene silencing	IEP	Predicted GO
MF	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
BP	GO:0018196	peptidyl-asparagine modification	IEP	Predicted GO
BP	GO:0018279	protein N-linked glycosylation via asparagine	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
MF	GO:0030145	manganese ion binding	IEP	Predicted GO
BP	GO:0030433	ubiquitin-dependent ERAD pathway	IEP	Predicted GO
CC	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
BP	GO:0032196	transposition	IEP	Predicted GO
BP	GO:0032200	telomere organization	IEP	Predicted GO
BP	GO:0032202	telomere assembly	IEP	Predicted GO
BP	GO:0032203	telomere formation via telomerase	IEP	Predicted GO
BP	GO:0033554	cellular response to stress	IEP	Predicted GO
MF	GO:0034061	DNA polymerase activity	IEP	Predicted GO
BP	GO:0034976	response to endoplasmic reticulum stress	IEP	Predicted GO
BP	GO:0036503	ERAD pathway	IEP	Predicted GO
BP	GO:0040029	regulation of gene expression, epigenetic	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEP	Predicted GO
CC	GO:0043190	ATP-binding cassette (ABC) transporter complex	IEP	Predicted GO
MF	GO:0043295	glutathione binding	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0044237	cellular metabolic process	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
BP	GO:0046487	glyoxylate metabolic process	IEP	Predicted GO
MF	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IEP	Predicted GO
BP	GO:0051716	cellular response to stimulus	IEP	Predicted GO
BP	GO:0060249	anatomical structure homeostasis	IEP	Predicted GO
BP	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	IEP	Predicted GO
BP	GO:0071897	DNA biosynthetic process	IEP	Predicted GO
MF	GO:0072341	modified amino acid binding	IEP	Predicted GO
BP	GO:0090304	nucleic acid metabolic process	IEP	Predicted GO
CC	GO:0098533	ATPase dependent transmembrane transport complex	IEP	Predicted GO
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
MF	GO:1900750	oligopeptide binding	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO
BP	GO:1901698	response to nitrogen compound	IEP	Predicted GO
CC	GO:1990229	iron-sulfur cluster assembly complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR011527	ABC1_TM_dom	172	440
IPR003439	ABC_transporter-like	996	1293

External Links

PlasmoDB	814343
PlasmoDB	MAL3P1.7
PlasmoDB	PFC0125w

PF3D7_0302600 (ABCB4)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation