PF3D7_0409600 (RPA1)

Aliases : RPA1

Description : SSF50249: "Nucleic acid-binding, OB-fold". Pfam domain(s): PF16900: Replication protein A OB domain, PF01336: OB-fold nucleic acid binding domain, PF08646: Replication factor-A C terminal domain.

Gene families : OG_01_0000319 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000319_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0409600
Cluster	P. falciparum: Cluster_43

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1007200	RPA1	SSF50249: Nucleic acid-binding, OB-fold. Pfam domain(s):...	0.06	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	IEA	Interproscan predictions
MF	GO:0003676	nucleic acid binding	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005662	DNA replication factor A complex	ISS	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IDA	PlasmoDB
BP	GO:0006261	DNA-dependent DNA replication	IDA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044422	organelle part	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044427	chromosomal part	None	Extended
CC	GO:0044428	nuclear part	None	Extended
CC	GO:0044446	intracellular organelle part	None	Extended
CC	GO:0044454	nuclear chromosome part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051052	regulation of DNA metabolic process	TAS	PlasmoDB
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000151	ubiquitin ligase complex	IEP	Predicted GO
CC	GO:0000775	chromosome, centromeric region	IEP	Predicted GO
CC	GO:0000776	kinetochore	IEP	Predicted GO
MF	GO:0004438	phosphatidylinositol-3-phosphatase activity	IEP	Predicted GO
MF	GO:0004789	thiamine-phosphate diphosphorylase activity	IEP	Predicted GO
MF	GO:0004843	thiol-dependent ubiquitin-specific protease activity	IEP	Predicted GO
MF	GO:0005506	iron ion binding	IEP	Predicted GO
CC	GO:0005768	endosome	IEP	Predicted GO
BP	GO:0006721	terpenoid metabolic process	IEP	Predicted GO
BP	GO:0006772	thiamine metabolic process	IEP	Predicted GO
BP	GO:0007059	chromosome segregation	IEP	Predicted GO
MF	GO:0008270	zinc ion binding	IEP	Predicted GO
BP	GO:0009110	vitamin biosynthetic process	IEP	Predicted GO
BP	GO:0009228	thiamine biosynthetic process	IEP	Predicted GO
CC	GO:0015629	actin cytoskeleton	IEP	Predicted GO
BP	GO:0016114	terpenoid biosynthetic process	IEP	Predicted GO
MF	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	IEP	Predicted GO
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Predicted GO
MF	GO:0016791	phosphatase activity	IEP	Predicted GO
MF	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	IEP	Predicted GO
CC	GO:0019005	SCF ubiquitin ligase complex	IEP	Predicted GO
MF	GO:0019207	kinase regulator activity	IEP	Predicted GO
MF	GO:0019887	protein kinase regulator activity	IEP	Predicted GO
CC	GO:0030127	COPII vesicle coat	IEP	Predicted GO
BP	GO:0030258	lipid modification	IEP	Predicted GO
CC	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	IEP	Predicted GO
MF	GO:0031072	heat shock protein binding	IEP	Predicted GO
BP	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEP	Predicted GO
CC	GO:0031262	Ndc80 complex	IEP	Predicted GO
CC	GO:0031461	cullin-RING ubiquitin ligase complex	IEP	Predicted GO
MF	GO:0031625	ubiquitin protein ligase binding	IEP	Predicted GO
MF	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	IEP	Predicted GO
MF	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	IEP	Predicted GO
MF	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	IEP	Predicted GO
BP	GO:0042364	water-soluble vitamin biosynthetic process	IEP	Predicted GO
MF	GO:0042578	phosphoric ester hydrolase activity	IEP	Predicted GO
BP	GO:0042723	thiamine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0042724	thiamine-containing compound biosynthetic process	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
MF	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity	IEP	Predicted GO
MF	GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IEP	Predicted GO
MF	GO:0044389	ubiquitin-like protein ligase binding	IEP	Predicted GO
MF	GO:0046429	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	IEP	Predicted GO
BP	GO:0046839	phospholipid dephosphorylation	IEP	Predicted GO
BP	GO:0046856	phosphatidylinositol dephosphorylation	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0046914	transition metal ion binding	IEP	Predicted GO
MF	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IEP	Predicted GO
MF	GO:0051539	4 iron, 4 sulfur cluster binding	IEP	Predicted GO
MF	GO:0052592	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor	IEP	Predicted GO
MF	GO:0052744	phosphatidylinositol monophosphate phosphatase activity	IEP	Predicted GO
MF	GO:0052866	phosphatidylinositol phosphate phosphatase activity	IEP	Predicted GO
BP	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	IEP	Predicted GO
MF	GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR004365	NA-bd_OB_tRNA	697	781
IPR031657	REPA_OB_2	805	905
IPR013955	Rep_factor-A_C	966	1117

External Links

PlasmoDB	812392
PlasmoDB	MAL4P2.32
PlasmoDB	PFD0470c
PlasmoDB	PFD0475c

PF3D7_0409600 (RPA1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation