PF3D7_0527200 (USP14)

Aliases : USP14

Description : SSF54001: Papain-like cysteine peptidase superfamily, SSF54236: Ubiquitin-like domain superfamily. Pfam domain(s): PF00240: Ubiquitin family, PF00443: Ubiquitin carboxyl-terminal hydrolase.

Gene families : OG_01_0001727 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001727_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0527200
Cluster	P. falciparum: Cluster_43

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004843	thiol-dependent ubiquitin-specific protease activity	IDA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IEA	Interproscan predictions
MF	GO:0005515	protein binding	IEA	PlasmoDB
BP	GO:0006464	cellular protein modification process	None	Extended
BP	GO:0006508	proteolysis	None	Extended
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008234	cysteine-type peptidase activity	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009057	macromolecule catabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016579	protein deubiquitination	IDA	PlasmoDB
BP	GO:0016579	protein deubiquitination	IEA	Interproscan predictions
BP	GO:0016579	protein deubiquitination	IEA	PlasmoDB
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
MF	GO:0019783	ubiquitin-like protein-specific protease activity	None	Extended
BP	GO:0019941	modification-dependent protein catabolic process	None	Extended
BP	GO:0036211	protein modification process	None	Extended
MF	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	Interproscan predictions
MF	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	PlasmoDB
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0043632	modification-dependent macromolecule catabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044265	cellular macromolecule catabolic process	None	Extended
BP	GO:0044267	cellular protein metabolic process	None	Extended
MF	GO:0044877	protein-containing complex binding	None	Extended
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
MF	GO:0070628	proteasome binding	IDA	PlasmoDB
BP	GO:0070646	protein modification by small protein removal	None	Extended
BP	GO:0070647	protein modification by small protein conjugation or removal	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0101005	ubiquitinyl hydrolase activity	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901575	organic substance catabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000036	acyl carrier activity	IEP	Predicted GO
BP	GO:0000041	transition metal ion transport	IEP	Predicted GO
MF	GO:0000234	phosphoethanolamine N-methyltransferase activity	IEP	Predicted GO
BP	GO:0000280	nuclear division	IEP	Predicted GO
CC	GO:0000502	proteasome complex	IEP	Predicted GO
MF	GO:0003909	DNA ligase activity	IEP	Predicted GO
MF	GO:0003911	DNA ligase (NAD+) activity	IEP	Predicted GO
MF	GO:0004000	adenosine deaminase activity	IEP	Predicted GO
MF	GO:0004017	adenylate kinase activity	IEP	Predicted GO
MF	GO:0004057	arginyltransferase activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004298	threonine-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004448	isocitrate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004602	glutathione peroxidase activity	IEP	Predicted GO
MF	GO:0004784	superoxide dismutase activity	IEP	Predicted GO
MF	GO:0004825	methionine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004839	ubiquitin activating enzyme activity	IEP	Predicted GO
MF	GO:0005310	dicarboxylic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005342	organic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005375	copper ion transmembrane transporter activity	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
CC	GO:0005798	Golgi-associated vesicle	IEP	Predicted GO
CC	GO:0005838	proteasome regulatory particle	IEP	Predicted GO
CC	GO:0005839	proteasome core complex	IEP	Predicted GO
CC	GO:0005956	protein kinase CK2 complex	IEP	Predicted GO
BP	GO:0006102	isocitrate metabolic process	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006275	regulation of DNA replication	IEP	Predicted GO
BP	GO:0006431	methionyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006627	protein processing involved in protein targeting to mitochondrion	IEP	Predicted GO
BP	GO:0006801	superoxide metabolic process	IEP	Predicted GO
BP	GO:0006825	copper ion transport	IEP	Predicted GO
BP	GO:0006835	dicarboxylic acid transport	IEP	Predicted GO
BP	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
BP	GO:0006979	response to oxidative stress	IEP	Predicted GO
MF	GO:0008081	phosphoric diester hydrolase activity	IEP	Predicted GO
MF	GO:0008168	methyltransferase activity	IEP	Predicted GO
MF	GO:0008170	N-methyltransferase activity	IEP	Predicted GO
MF	GO:0008379	thioredoxin peroxidase activity	IEP	Predicted GO
MF	GO:0008509	anion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0008514	organic anion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0008889	glycerophosphodiester phosphodiesterase activity	IEP	Predicted GO
MF	GO:0008914	leucyltransferase activity	IEP	Predicted GO
CC	GO:0009536	plastid	IEP	Predicted GO
MF	GO:0015075	ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015140	malate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015318	inorganic molecular entity transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015367	oxoglutarate:malate antiporter activity	IEP	Predicted GO
MF	GO:0015556	C4-dicarboxylate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015711	organic anion transport	IEP	Predicted GO
BP	GO:0015740	C4-dicarboxylate transport	IEP	Predicted GO
BP	GO:0015742	alpha-ketoglutarate transport	IEP	Predicted GO
BP	GO:0015743	malate transport	IEP	Predicted GO
BP	GO:0015849	organic acid transport	IEP	Predicted GO
MF	GO:0016209	antioxidant activity	IEP	Predicted GO
CC	GO:0016324	apical plasma membrane	IEP	Predicted GO
BP	GO:0016485	protein processing	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	IEP	Predicted GO
BP	GO:0016598	protein arginylation	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	IEP	Predicted GO
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Predicted GO
MF	GO:0016755	transferase activity, transferring amino-acyl groups	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
CC	GO:0017087	mitochondrial processing peptidase complex	IEP	Predicted GO
MF	GO:0019239	deaminase activity	IEP	Predicted GO
CC	GO:0019773	proteasome core complex, alpha-subunit complex	IEP	Predicted GO
CC	GO:0020011	apicoplast	IEP	Predicted GO
BP	GO:0030001	metal ion transport	IEP	Predicted GO
CC	GO:0030117	membrane coat	IEP	Predicted GO
CC	GO:0030120	vesicle coat	IEP	Predicted GO
CC	GO:0030134	COPII-coated ER to Golgi transport vesicle	IEP	Predicted GO
CC	GO:0030135	coated vesicle	IEP	Predicted GO
MF	GO:0030234	enzyme regulator activity	IEP	Predicted GO
MF	GO:0030337	DNA polymerase processivity factor activity	IEP	Predicted GO
MF	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0034982	mitochondrial protein processing	IEP	Predicted GO
BP	GO:0035434	copper ion transmembrane transport	IEP	Predicted GO
BP	GO:0042176	regulation of protein catabolic process	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044433	cytoplasmic vesicle part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
MF	GO:0044620	ACP phosphopantetheine attachment site binding	IEP	Predicted GO
BP	GO:0046777	protein autophosphorylation	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0046915	transition metal ion transmembrane transporter activity	IEP	Predicted GO
BP	GO:0046942	carboxylic acid transport	IEP	Predicted GO
MF	GO:0046943	carboxylic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
BP	GO:0048193	Golgi vesicle transport	IEP	Predicted GO
BP	GO:0048285	organelle fission	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051181	cofactor transport	IEP	Predicted GO
MF	GO:0051192	prosthetic group binding	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0070003	threonine-type peptidase activity	IEP	Predicted GO
MF	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	IEP	Predicted GO
MF	GO:0070402	NADPH binding	IEP	Predicted GO
BP	GO:0070481	nuclear-transcribed mRNA catabolic process, non-stop decay	IEP	Predicted GO
BP	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay	IEP	Predicted GO
BP	GO:0071025	RNA surveillance	IEP	Predicted GO
BP	GO:0072593	reactive oxygen species metabolic process	IEP	Predicted GO
CC	GO:0098590	plasma membrane region	IEP	Predicted GO
MF	GO:0098772	molecular function regulator	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
CC	GO:1905368	peptidase complex	IEP	Predicted GO
CC	GO:1905369	endopeptidase complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000626	Ubiquitin_dom	6	74
IPR001394	Peptidase_C19_UCH	110	567

External Links

PlasmoDB	813087
PlasmoDB	MAL5P1.271
PlasmoDB	PFE1355c

PF3D7_0527200 (USP14)

Expression Profile

Co-expression Networks

Functional Annotation