PF3D7_0614800 (NTHL1)

Aliases : NTHL1

Description : SSF48150: DNA glycosylase. Pfam domain(s): PF00730: HhH-GPD superfamily base excision DNA repair protein, PF00633: Helix-hairpin-helix motif.

Gene families : OG_01_0001676 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001676_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0614800
Cluster	P. falciparum: Cluster_1

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan predictions
MF	GO:0003677	DNA binding	IEA	PlasmoDB
MF	GO:0003824	catalytic activity	IEA	PlasmoDB
MF	GO:0004518	nuclease activity	None	Extended
MF	GO:0004519	endonuclease activity	ISS	PlasmoDB
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006281	DNA repair	ISS	PlasmoDB
BP	GO:0006281	DNA repair	IEA	PlasmoDB
BP	GO:0006284	base-excision repair	IEA	Interproscan predictions
BP	GO:0006284	base-excision repair	IEA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016788	hydrolase activity, acting on ester bonds	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
MF	GO:0051536	iron-sulfur cluster binding	None	Extended
MF	GO:0051539	4 iron, 4 sulfur cluster binding	IEA	PlasmoDB
MF	GO:0051540	metal cluster binding	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000375	RNA splicing, via transesterification reactions	IEP	Predicted GO
BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	IEP	Predicted GO
BP	GO:0000398	mRNA splicing, via spliceosome	IEP	Predicted GO
CC	GO:0000785	chromatin	IEP	Predicted GO
MF	GO:0003697	single-stranded DNA binding	IEP	Predicted GO
MF	GO:0004222	metalloendopeptidase activity	IEP	Predicted GO
MF	GO:0004576	oligosaccharyl transferase activity	IEP	Predicted GO
MF	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IEP	Predicted GO
MF	GO:0004611	phosphoenolpyruvate carboxykinase activity	IEP	Predicted GO
MF	GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	IEP	Predicted GO
MF	GO:0004774	succinate-CoA ligase activity	IEP	Predicted GO
MF	GO:0004775	succinate-CoA ligase (ADP-forming) activity	IEP	Predicted GO
MF	GO:0005507	copper ion binding	IEP	Predicted GO
CC	GO:0005681	spliceosomal complex	IEP	Predicted GO
CC	GO:0005739	mitochondrion	IEP	Predicted GO
CC	GO:0005759	mitochondrial matrix	IEP	Predicted GO
BP	GO:0005996	monosaccharide metabolic process	IEP	Predicted GO
BP	GO:0006006	glucose metabolic process	IEP	Predicted GO
BP	GO:0006094	gluconeogenesis	IEP	Predicted GO
BP	GO:0006104	succinyl-CoA metabolic process	IEP	Predicted GO
BP	GO:0006268	DNA unwinding involved in DNA replication	IEP	Predicted GO
BP	GO:0006333	chromatin assembly or disassembly	IEP	Predicted GO
BP	GO:0006334	nucleosome assembly	IEP	Predicted GO
BP	GO:0006397	mRNA processing	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006486	protein glycosylation	IEP	Predicted GO
BP	GO:0006487	protein N-linked glycosylation	IEP	Predicted GO
BP	GO:0006627	protein processing involved in protein targeting to mitochondrion	IEP	Predicted GO
BP	GO:0006637	acyl-CoA metabolic process	IEP	Predicted GO
CC	GO:0008250	oligosaccharyltransferase complex	IEP	Predicted GO
BP	GO:0008380	RNA splicing	IEP	Predicted GO
BP	GO:0008535	respiratory chain complex IV assembly	IEP	Predicted GO
MF	GO:0015035	protein disulfide oxidoreductase activity	IEP	Predicted GO
MF	GO:0015036	disulfide oxidoreductase activity	IEP	Predicted GO
MF	GO:0015037	peptide disulfide oxidoreductase activity	IEP	Predicted GO
MF	GO:0015038	glutathione disulfide oxidoreductase activity	IEP	Predicted GO
BP	GO:0016043	cellular component organization	IEP	Predicted GO
BP	GO:0016051	carbohydrate biosynthetic process	IEP	Predicted GO
CC	GO:0016272	prefoldin complex	IEP	Predicted GO
MF	GO:0016831	carboxy-lyase activity	IEP	Predicted GO
BP	GO:0017004	cytochrome complex assembly	IEP	Predicted GO
CC	GO:0017087	mitochondrial processing peptidase complex	IEP	Predicted GO
BP	GO:0019318	hexose metabolic process	IEP	Predicted GO
BP	GO:0019319	hexose biosynthetic process	IEP	Predicted GO
BP	GO:0022607	cellular component assembly	IEP	Predicted GO
BP	GO:0031497	chromatin assembly	IEP	Predicted GO
BP	GO:0032392	DNA geometric change	IEP	Predicted GO
BP	GO:0032508	DNA duplex unwinding	IEP	Predicted GO
BP	GO:0033865	nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034622	cellular protein-containing complex assembly	IEP	Predicted GO
BP	GO:0034728	nucleosome organization	IEP	Predicted GO
BP	GO:0034982	mitochondrial protein processing	IEP	Predicted GO
BP	GO:0035383	thioester metabolic process	IEP	Predicted GO
MF	GO:0042393	histone binding	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043413	macromolecule glycosylation	IEP	Predicted GO
BP	GO:0043933	protein-containing complex subunit organization	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044429	mitochondrial part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
BP	GO:0046364	monosaccharide biosynthetic process	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0051082	unfolded protein binding	IEP	Predicted GO
BP	GO:0065003	protein-containing complex assembly	IEP	Predicted GO
BP	GO:0065004	protein-DNA complex assembly	IEP	Predicted GO
BP	GO:0070085	glycosylation	IEP	Predicted GO
BP	GO:0071824	protein-DNA complex subunit organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003265	HhH-GPD_domain	249	382
IPR000445	HhH_motif	314	342

External Links

PlasmoDB	2270.t00038
PlasmoDB	3885808
PlasmoDB	MAL6P1.278
PlasmoDB	PFF0715c

PF3D7_0614800 (NTHL1)

Expression Profile

Co-expression Networks

Functional Annotation