PF3D7_0619500 (ACS12)

Aliases : ACS12

Description : SSF52518: Thiamin diphosphate-binding fold, SSF52467: DHS-like NAD/FAD-binding domain superfamily, SSF56801: No description available. Pfam domain(s): PF00501: AMP-binding enzyme, PF02776: "Thiamine pyrophosphate enzyme, N-terminal TPP binding domain", PF02775: "Thiamine pyrophosphate enzyme, C-terminal TPP binding domain", PF00205: "Thiamine pyrophosphate enzyme, central domain".

Gene families : OG_01_0003989 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0003989_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0619500
Cluster	P. falciparum: Cluster_14

Type	GO Term	Name	Evidence	Source
MF	GO:0000287	magnesium ion binding	IEA	Interproscan predictions
MF	GO:0000287	magnesium ion binding	IEA	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	IEA	Interproscan predictions
MF	GO:0003824	catalytic activity	IEA	PlasmoDB
MF	GO:0005215	transporter activity	None	Extended
MF	GO:0005319	lipid transporter activity	None	Extended
MF	GO:0005324	long-chain fatty acid transporter activity	ISS	PlasmoDB
MF	GO:0005488	binding	None	Extended
BP	GO:0005975	carbohydrate metabolic process	None	Extended
BP	GO:0006081	cellular aldehyde metabolic process	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006097	glyoxylate cycle	ISS	PlasmoDB
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	IEA	PlasmoDB
BP	GO:0009987	cellular process	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0019842	vitamin binding	None	Extended
MF	GO:0030976	thiamine pyrophosphate binding	IEA	Interproscan predictions
MF	GO:0030976	thiamine pyrophosphate binding	IEA	PlasmoDB
BP	GO:0032787	monocarboxylic acid metabolic process	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044262	cellular carbohydrate metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046487	glyoxylate metabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
MF	GO:1901681	sulfur compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0001505	regulation of neurotransmitter levels	IEP	Predicted GO
MF	GO:0001786	phosphatidylserine binding	IEP	Predicted GO
MF	GO:0004519	endonuclease activity	IEP	Predicted GO
MF	GO:0004523	RNA-DNA hybrid ribonuclease activity	IEP	Predicted GO
MF	GO:0005085	guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0005088	Ras guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0005504	fatty acid binding	IEP	Predicted GO
CC	GO:0005960	glycine cleavage complex	IEP	Predicted GO
BP	GO:0006302	double-strand break repair	IEP	Predicted GO
BP	GO:0006544	glycine metabolic process	IEP	Predicted GO
BP	GO:0006546	glycine catabolic process	IEP	Predicted GO
BP	GO:0006855	drug transmembrane transport	IEP	Predicted GO
MF	GO:0008270	zinc ion binding	IEP	Predicted GO
MF	GO:0008289	lipid binding	IEP	Predicted GO
BP	GO:0009063	cellular amino acid catabolic process	IEP	Predicted GO
BP	GO:0009069	serine family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009071	serine family amino acid catabolic process	IEP	Predicted GO
MF	GO:0010314	phosphatidylinositol-5-phosphate binding	IEP	Predicted GO
BP	GO:0015074	DNA integration	IEP	Predicted GO
BP	GO:0015893	drug transport	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
BP	GO:0016054	organic acid catabolic process	IEP	Predicted GO
MF	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IEP	Predicted GO
MF	GO:0016929	SUMO-specific protease activity	IEP	Predicted GO
MF	GO:0017112	Rab guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0017137	Rab GTPase binding	IEP	Predicted GO
BP	GO:0019464	glycine decarboxylation via glycine cleavage system	IEP	Predicted GO
MF	GO:0030145	manganese ion binding	IEP	Predicted GO
MF	GO:0031405	lipoic acid binding	IEP	Predicted GO
MF	GO:0031406	carboxylic acid binding	IEP	Predicted GO
BP	GO:0032196	transposition	IEP	Predicted GO
MF	GO:0032266	phosphatidylinositol-3-phosphate binding	IEP	Predicted GO
MF	GO:0033293	monocarboxylic acid binding	IEP	Predicted GO
MF	GO:0035091	phosphatidylinositol binding	IEP	Predicted GO
BP	GO:0042133	neurotransmitter metabolic process	IEP	Predicted GO
BP	GO:0042135	neurotransmitter catabolic process	IEP	Predicted GO
BP	GO:0042737	drug catabolic process	IEP	Predicted GO
BP	GO:0043085	positive regulation of catalytic activity	IEP	Predicted GO
BP	GO:0043087	regulation of GTPase activity	IEP	Predicted GO
MF	GO:0043177	organic acid binding	IEP	Predicted GO
BP	GO:0043547	positive regulation of GTPase activity	IEP	Predicted GO
BP	GO:0044093	positive regulation of molecular function	IEP	Predicted GO
BP	GO:0044282	small molecule catabolic process	IEP	Predicted GO
BP	GO:0046395	carboxylic acid catabolic process	IEP	Predicted GO
MF	GO:0046914	transition metal ion binding	IEP	Predicted GO
CC	GO:0048471	perinuclear region of cytoplasm	IEP	Predicted GO
BP	GO:0051336	regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051345	positive regulation of hydrolase activity	IEP	Predicted GO
MF	GO:0072341	modified amino acid binding	IEP	Predicted GO
BP	GO:1901606	alpha-amino acid catabolic process	IEP	Predicted GO
MF	GO:1901981	phosphatidylinositol phosphate binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000873	AMP-dep_Synth/Lig	26	507
IPR011766	TPP_enzyme-bd_C	1220	1361
IPR012001	Thiamin_PyroP_enz_TPP-bd_dom	666	837
IPR012000	Thiamin_PyroP_enz_cen_dom	880	979

External Links

PlasmoDB	2270.t00084
PlasmoDB	3885943
PlasmoDB	MAL6P1.231
PlasmoDB	PFF0945c

PF3D7_0619500 (ACS12)

Expression Profile

Co-expression Networks

Functional Annotation