PF3D7_0624000 (HK)

Aliases : HK

Description : SSF53067: No description available. Pfam domain(s): PF00349: Hexokinase, PF03727: Hexokinase.

Gene families : OG_01_0000335 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000335_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0624000
Cluster	P. falciparum: Cluster_11

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1122900	HK	SSF53067: 20-02-2019. Pfam domain(s): PF03727:...	0.07	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
BP	GO:0001678	cellular glucose homeostasis	IEA	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004396	hexokinase activity	IDA	PlasmoDB
MF	GO:0004396	hexokinase activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
MF	GO:0005536	glucose binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005829	cytosol	IDA	PlasmoDB
BP	GO:0005975	carbohydrate metabolic process	IEA	Interproscan predictions
BP	GO:0005975	carbohydrate metabolic process	IEA	PlasmoDB
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006090	pyruvate metabolic process	None	Extended
BP	GO:0006091	generation of precursor metabolites and energy	None	Extended
BP	GO:0006096	glycolytic process	IDA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006163	purine nucleotide metabolic process	None	Extended
BP	GO:0006164	purine nucleotide biosynthetic process	None	Extended
BP	GO:0006165	nucleoside diphosphate phosphorylation	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006733	oxidoreduction coenzyme metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006754	ATP biosynthetic process	None	Extended
BP	GO:0006757	ATP generation from ADP	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009108	coenzyme biosynthetic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009132	nucleoside diphosphate metabolic process	None	Extended
BP	GO:0009135	purine nucleoside diphosphate metabolic process	None	Extended
BP	GO:0009141	nucleoside triphosphate metabolic process	None	Extended
BP	GO:0009142	nucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009144	purine nucleoside triphosphate metabolic process	None	Extended
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009150	purine ribonucleotide metabolic process	None	Extended
BP	GO:0009152	purine ribonucleotide biosynthetic process	None	Extended
BP	GO:0009165	nucleotide biosynthetic process	None	Extended
BP	GO:0009166	nucleotide catabolic process	None	Extended
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	None	Extended
BP	GO:0009185	ribonucleoside diphosphate metabolic process	None	Extended
BP	GO:0009199	ribonucleoside triphosphate metabolic process	None	Extended
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	None	Extended
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009259	ribonucleotide metabolic process	None	Extended
BP	GO:0009260	ribonucleotide biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016052	carbohydrate catabolic process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016301	kinase activity	None	Extended
BP	GO:0016310	phosphorylation	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	Interproscan predictions
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	PlasmoDB
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0017144	drug metabolic process	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
MF	GO:0019200	carbohydrate kinase activity	None	Extended
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	None	Extended
BP	GO:0019362	pyridine nucleotide metabolic process	None	Extended
BP	GO:0019363	pyridine nucleotide biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019439	aromatic compound catabolic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
BP	GO:0019725	cellular homeostasis	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0030246	carbohydrate binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0032787	monocarboxylic acid metabolic process	None	Extended
BP	GO:0033500	carbohydrate homeostasis	None	Extended
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034654	nucleobase-containing compound biosynthetic process	None	Extended
BP	GO:0034655	nucleobase-containing compound catabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042493	response to drug	IMP	PlasmoDB
BP	GO:0042592	homeostatic process	None	Extended
BP	GO:0042593	glucose homeostasis	None	Extended
BP	GO:0042866	pyruvate biosynthetic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044270	cellular nitrogen compound catabolic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046031	ADP metabolic process	None	Extended
BP	GO:0046034	ATP metabolic process	None	Extended
BP	GO:0046390	ribose phosphate biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0046434	organophosphate catabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0046496	nicotinamide nucleotide metabolic process	None	Extended
BP	GO:0046700	heterocycle catabolic process	None	Extended
BP	GO:0046939	nucleotide phosphorylation	None	Extended
MF	GO:0048029	monosaccharide binding	None	Extended
BP	GO:0048878	chemical homeostasis	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0051188	cofactor biosynthetic process	None	Extended
BP	GO:0055082	cellular chemical homeostasis	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0065008	regulation of biological quality	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072330	monocarboxylic acid biosynthetic process	None	Extended
BP	GO:0072521	purine-containing compound metabolic process	None	Extended
BP	GO:0072522	purine-containing compound biosynthetic process	None	Extended
BP	GO:0072524	pyridine-containing compound metabolic process	None	Extended
BP	GO:0072525	pyridine-containing compound biosynthetic process	None	Extended
BP	GO:0090407	organophosphate biosynthetic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901137	carbohydrate derivative biosynthetic process	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901292	nucleoside phosphate catabolic process	None	Extended
BP	GO:1901293	nucleoside phosphate biosynthetic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901361	organic cyclic compound catabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901575	organic substance catabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0000287	magnesium ion binding	IEP	Predicted GO
MF	GO:0001882	nucleoside binding	IEP	Predicted GO
MF	GO:0001883	purine nucleoside binding	IEP	Predicted GO
BP	GO:0003006	developmental process involved in reproduction	IEP	Predicted GO
MF	GO:0003725	double-stranded RNA binding	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0003746	translation elongation factor activity	IEP	Predicted GO
MF	GO:0004013	adenosylhomocysteinase activity	IEP	Predicted GO
MF	GO:0004017	adenylate kinase activity	IEP	Predicted GO
MF	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	IEP	Predicted GO
MF	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004298	threonine-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IEP	Predicted GO
MF	GO:0004448	isocitrate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004457	lactate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004459	L-lactate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004601	peroxidase activity	IEP	Predicted GO
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IEP	Predicted GO
MF	GO:0004618	phosphoglycerate kinase activity	IEP	Predicted GO
MF	GO:0004731	purine-nucleoside phosphorylase activity	IEP	Predicted GO
MF	GO:0004743	pyruvate kinase activity	IEP	Predicted GO
MF	GO:0004784	superoxide dismutase activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004824	lysine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004825	methionine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004828	serine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004839	ubiquitin activating enzyme activity	IEP	Predicted GO
MF	GO:0005310	dicarboxylic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005525	GTP binding	IEP	Predicted GO
CC	GO:0005622	intracellular	IEP	Predicted GO
CC	GO:0005789	endoplasmic reticulum membrane	IEP	Predicted GO
CC	GO:0005839	proteasome core complex	IEP	Predicted GO
CC	GO:0005850	eukaryotic translation initiation factor 2 complex	IEP	Predicted GO
CC	GO:0005956	protein kinase CK2 complex	IEP	Predicted GO
BP	GO:0006102	isocitrate metabolic process	IEP	Predicted GO
BP	GO:0006148	inosine catabolic process	IEP	Predicted GO
BP	GO:0006152	purine nucleoside catabolic process	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006430	lysyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006431	methionyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006434	seryl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006493	protein O-linked glycosylation	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006528	asparagine metabolic process	IEP	Predicted GO
BP	GO:0006529	asparagine biosynthetic process	IEP	Predicted GO
BP	GO:0006801	superoxide metabolic process	IEP	Predicted GO
BP	GO:0006835	dicarboxylic acid transport	IEP	Predicted GO
BP	GO:0006979	response to oxidative stress	IEP	Predicted GO
BP	GO:0007530	sex determination	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008379	thioredoxin peroxidase activity	IEP	Predicted GO
MF	GO:0008452	RNA ligase activity	IEP	Predicted GO
BP	GO:0009057	macromolecule catabolic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009164	nucleoside catabolic process	IEP	Predicted GO
MF	GO:0015140	malate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015367	oxoglutarate:malate antiporter activity	IEP	Predicted GO
MF	GO:0015556	C4-dicarboxylate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015740	C4-dicarboxylate transport	IEP	Predicted GO
BP	GO:0015742	alpha-ketoglutarate transport	IEP	Predicted GO
BP	GO:0015743	malate transport	IEP	Predicted GO
BP	GO:0015959	diadenosine polyphosphate metabolic process	IEP	Predicted GO
BP	GO:0015960	diadenosine polyphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0015965	diadenosine tetraphosphate metabolic process	IEP	Predicted GO
BP	GO:0015966	diadenosine tetraphosphate biosynthetic process	IEP	Predicted GO
MF	GO:0016209	antioxidant activity	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IEP	Predicted GO
MF	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	IEP	Predicted GO
MF	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	IEP	Predicted GO
MF	GO:0016757	transferase activity, transferring glycosyl groups	IEP	Predicted GO
MF	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	IEP	Predicted GO
MF	GO:0016787	hydrolase activity	IEP	Predicted GO
MF	GO:0016801	hydrolase activity, acting on ether bonds	IEP	Predicted GO
MF	GO:0016802	trialkylsulfonium hydrolase activity	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
MF	GO:0019001	guanyl nucleotide binding	IEP	Predicted GO
CC	GO:0019005	SCF ubiquitin ligase complex	IEP	Predicted GO
MF	GO:0019153	protein-disulfide reductase (glutathione) activity	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
CC	GO:0019773	proteasome core complex, alpha-subunit complex	IEP	Predicted GO
CC	GO:0019774	proteasome core complex, beta-subunit complex	IEP	Predicted GO
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0022414	reproductive process	IEP	Predicted GO
CC	GO:0022627	cytosolic small ribosomal subunit	IEP	Predicted GO
BP	GO:0030163	protein catabolic process	IEP	Predicted GO
CC	GO:0031461	cullin-RING ubiquitin ligase complex	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
MF	GO:0032549	ribonucleoside binding	IEP	Predicted GO
MF	GO:0032550	purine ribonucleoside binding	IEP	Predicted GO
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0034656	nucleobase-containing small molecule catabolic process	IEP	Predicted GO
CC	GO:0035145	exon-exon junction complex	IEP	Predicted GO
BP	GO:0042262	DNA protection	IEP	Predicted GO
BP	GO:0042454	ribonucleoside catabolic process	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
CC	GO:0043230	extracellular organelle	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043604	amide biosynthetic process	IEP	Predicted GO
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Predicted GO
MF	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Predicted GO
CC	GO:0044391	ribosomal subunit	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
BP	GO:0045116	protein neddylation	IEP	Predicted GO
BP	GO:0046102	inosine metabolic process	IEP	Predicted GO
BP	GO:0046130	purine ribonucleoside catabolic process	IEP	Predicted GO
MF	GO:0050661	NADP binding	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051181	cofactor transport	IEP	Predicted GO
BP	GO:0051260	protein homooligomerization	IEP	Predicted GO
BP	GO:0051262	protein tetramerization	IEP	Predicted GO
MF	GO:0051287	NAD binding	IEP	Predicted GO
BP	GO:0051289	protein homotetramerization	IEP	Predicted GO
BP	GO:0051382	kinetochore assembly	IEP	Predicted GO
BP	GO:0051383	kinetochore organization	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
MF	GO:0051920	peroxiredoxin activity	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
BP	GO:0065003	protein-containing complex assembly	IEP	Predicted GO
MF	GO:0070003	threonine-type peptidase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0072523	purine-containing compound catabolic process	IEP	Predicted GO
BP	GO:0072593	reactive oxygen species metabolic process	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
BP	GO:1901565	organonitrogen compound catabolic process	IEP	Predicted GO
BP	GO:1901658	glycosyl compound catabolic process	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR022672	Hexokinase_N	33	251
IPR022673	Hexokinase_C	262	482

External Links

PlasmoDB	2270.t00126
PlasmoDB	3885912
PlasmoDB	MAL6P1.189
PlasmoDB	PFF1155w

PF3D7_0624000 (HK)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation