PF3D7_0626800 (PyrK)


Aliases : PyrK

Description : SSF50800: "Pyruvate kinase-like, insert domain superfamily", SSF52935: "Pyruvate kinase, C-terminal domain superfamily", SSF51621: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily. Pfam domain(s): PF00224: "Pyruvate kinase, barrel domain", PF02887: "Pyruvate kinase, alpha/beta domain".


Gene families : OG_01_0001454 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001454_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pfa RNA-seq: PF3D7_0626800
Cluster P. falciparum: Cluster_11

Target Alias Description ECC score Gene Family Method Actions
PBANKA_1125600 No alias SSF50800: Pyruvate kinase-like, insert domain... 0.18 Orthofinderv1.1.8

Type GO Term Name Evidence Source
MF GO:0000287 magnesium ion binding IEA Interproscan predictions
MF GO:0000287 magnesium ion binding IEA PlasmoDB
MF GO:0003824 catalytic activity IEA PlasmoDB
MF GO:0004743 pyruvate kinase activity IDA PlasmoDB
MF GO:0004743 pyruvate kinase activity IEA Interproscan predictions
MF GO:0004743 pyruvate kinase activity IEA PlasmoDB
BP GO:0006096 glycolytic process ISS PlasmoDB
BP GO:0006096 glycolytic process IEA Interproscan predictions
BP GO:0006096 glycolytic process IEA PlasmoDB
MF GO:0030955 potassium ion binding IEA Interproscan predictions
MF GO:0030955 potassium ion binding IEA PlasmoDB
BP GO:0051289 protein homotetramerization EXP PlasmoDB
Type GO Term Name Evidence Source
CC GO:0000015 phosphopyruvate hydratase complex IEP Predicted GO
BP GO:0000045 autophagosome assembly IEP Predicted GO
MF GO:0000166 nucleotide binding IEP Predicted GO
CC GO:0000178 exosome (RNase complex) IEP Predicted GO
MF GO:0000295 adenine nucleotide transmembrane transporter activity IEP Predicted GO
MF GO:0000339 RNA cap binding IEP Predicted GO
BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile IEP Predicted GO
BP GO:0000398 mRNA splicing, via spliceosome IEP Predicted GO
BP GO:0001678 cellular glucose homeostasis IEP Predicted GO
MF GO:0001882 nucleoside binding IEP Predicted GO
MF GO:0001883 purine nucleoside binding IEP Predicted GO
CC GO:0002189 ribose phosphate diphosphokinase complex IEP Predicted GO
BP GO:0002253 activation of immune response IEP Predicted GO
BP GO:0002684 positive regulation of immune system process IEP Predicted GO
MF GO:0003676 nucleic acid binding IEP Predicted GO
MF GO:0003723 RNA binding IEP Predicted GO
MF GO:0003725 double-stranded RNA binding IEP Predicted GO
MF GO:0003735 structural constituent of ribosome IEP Predicted GO
MF GO:0003743 translation initiation factor activity IEP Predicted GO
MF GO:0003746 translation elongation factor activity IEP Predicted GO
MF GO:0003872 6-phosphofructokinase activity IEP Predicted GO
MF GO:0003924 GTPase activity IEP Predicted GO
MF GO:0004017 adenylate kinase activity IEP Predicted GO
MF GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity IEP Predicted GO
MF GO:0004364 glutathione transferase activity IEP Predicted GO
MF GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEP Predicted GO
MF GO:0004396 hexokinase activity IEP Predicted GO
MF GO:0004457 lactate dehydrogenase activity IEP Predicted GO
MF GO:0004459 L-lactate dehydrogenase activity IEP Predicted GO
MF GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity IEP Predicted GO
MF GO:0004618 phosphoglycerate kinase activity IEP Predicted GO
MF GO:0004619 phosphoglycerate mutase activity IEP Predicted GO
MF GO:0004634 phosphopyruvate hydratase activity IEP Predicted GO
MF GO:0004731 purine-nucleoside phosphorylase activity IEP Predicted GO
MF GO:0004749 ribose phosphate diphosphokinase activity IEP Predicted GO
MF GO:0004784 superoxide dismutase activity IEP Predicted GO
MF GO:0004802 transketolase activity IEP Predicted GO
MF GO:0004807 triose-phosphate isomerase activity IEP Predicted GO
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Predicted GO
MF GO:0004816 asparagine-tRNA ligase activity IEP Predicted GO
MF GO:0004824 lysine-tRNA ligase activity IEP Predicted GO
MF GO:0004828 serine-tRNA ligase activity IEP Predicted GO
MF GO:0005198 structural molecule activity IEP Predicted GO
MF GO:0005346 purine ribonucleotide transmembrane transporter activity IEP Predicted GO
MF GO:0005347 ATP transmembrane transporter activity IEP Predicted GO
MF GO:0005471 ATP:ADP antiporter activity IEP Predicted GO
MF GO:0005525 GTP binding IEP Predicted GO
MF GO:0005536 glucose binding IEP Predicted GO
CC GO:0005575 cellular_component IEP Predicted GO
CC GO:0005622 intracellular IEP Predicted GO
CC GO:0005746 mitochondrial respirasome IEP Predicted GO
CC GO:0005829 cytosol IEP Predicted GO
CC GO:0005832 chaperonin-containing T-complex IEP Predicted GO
CC GO:0005840 ribosome IEP Predicted GO
CC GO:0005850 eukaryotic translation initiation factor 2 complex IEP Predicted GO
CC GO:0005853 eukaryotic translation elongation factor 1 complex IEP Predicted GO
CC GO:0005956 protein kinase CK2 complex IEP Predicted GO
BP GO:0005996 monosaccharide metabolic process IEP Predicted GO
BP GO:0006002 fructose 6-phosphate metabolic process IEP Predicted GO
BP GO:0006006 glucose metabolic process IEP Predicted GO
BP GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEP Predicted GO
BP GO:0006081 cellular aldehyde metabolic process IEP Predicted GO
BP GO:0006094 gluconeogenesis IEP Predicted GO
BP GO:0006098 pentose-phosphate shunt IEP Predicted GO
BP GO:0006148 inosine catabolic process IEP Predicted GO
BP GO:0006152 purine nucleoside catabolic process IEP Predicted GO
BP GO:0006166 purine ribonucleoside salvage IEP Predicted GO
BP GO:0006412 translation IEP Predicted GO
BP GO:0006413 translational initiation IEP Predicted GO
BP GO:0006414 translational elongation IEP Predicted GO
BP GO:0006418 tRNA aminoacylation for protein translation IEP Predicted GO
BP GO:0006421 asparaginyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006430 lysyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006434 seryl-tRNA aminoacylation IEP Predicted GO
BP GO:0006449 regulation of translational termination IEP Predicted GO
BP GO:0006452 translational frameshifting IEP Predicted GO
BP GO:0006457 protein folding IEP Predicted GO
BP GO:0006518 peptide metabolic process IEP Predicted GO
BP GO:0006520 cellular amino acid metabolic process IEP Predicted GO
BP GO:0006528 asparagine metabolic process IEP Predicted GO
BP GO:0006529 asparagine biosynthetic process IEP Predicted GO
BP GO:0006739 NADP metabolic process IEP Predicted GO
BP GO:0006801 superoxide metabolic process IEP Predicted GO
BP GO:0006979 response to oxidative stress IEP Predicted GO
MF GO:0008135 translation factor activity, RNA binding IEP Predicted GO
MF GO:0008379 thioredoxin peroxidase activity IEP Predicted GO
MF GO:0008443 phosphofructokinase activity IEP Predicted GO
BP GO:0009059 macromolecule biosynthetic process IEP Predicted GO
BP GO:0009067 aspartate family amino acid biosynthetic process IEP Predicted GO
BP GO:0009116 nucleoside metabolic process IEP Predicted GO
BP GO:0009119 ribonucleoside metabolic process IEP Predicted GO
BP GO:0009164 nucleoside catabolic process IEP Predicted GO
BP GO:0009891 positive regulation of biosynthetic process IEP Predicted GO
CC GO:0009986 cell surface IEP Predicted GO
BP GO:0010557 positive regulation of macromolecule biosynthetic process IEP Predicted GO
BP GO:0010628 positive regulation of gene expression IEP Predicted GO
MF GO:0015215 nucleotide transmembrane transporter activity IEP Predicted GO
MF GO:0015216 purine nucleotide transmembrane transporter activity IEP Predicted GO
MF GO:0015217 ADP transmembrane transporter activity IEP Predicted GO
MF GO:0015605 organophosphate ester transmembrane transporter activity IEP Predicted GO
CC GO:0015934 large ribosomal subunit IEP Predicted GO
CC GO:0015935 small ribosomal subunit IEP Predicted GO
BP GO:0015959 diadenosine polyphosphate metabolic process IEP Predicted GO
BP GO:0015960 diadenosine polyphosphate biosynthetic process IEP Predicted GO
BP GO:0015965 diadenosine tetraphosphate metabolic process IEP Predicted GO
BP GO:0015966 diadenosine tetraphosphate biosynthetic process IEP Predicted GO
BP GO:0016051 carbohydrate biosynthetic process IEP Predicted GO
MF GO:0016209 antioxidant activity IEP Predicted GO
CC GO:0016281 eukaryotic translation initiation factor 4F complex IEP Predicted GO
MF GO:0016301 kinase activity IEP Predicted GO
MF GO:0016491 oxidoreductase activity IEP Predicted GO
MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEP Predicted GO
MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEP Predicted GO
MF GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEP Predicted GO
MF GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEP Predicted GO
MF GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor IEP Predicted GO
MF GO:0016744 transferase activity, transferring aldehyde or ketonic groups IEP Predicted GO
MF GO:0016774 phosphotransferase activity, carboxyl group as acceptor IEP Predicted GO
MF GO:0016778 diphosphotransferase activity IEP Predicted GO
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Predicted GO
MF GO:0017076 purine nucleotide binding IEP Predicted GO
MF GO:0019001 guanyl nucleotide binding IEP Predicted GO
MF GO:0019153 protein-disulfide reductase (glutathione) activity IEP Predicted GO
MF GO:0019200 carbohydrate kinase activity IEP Predicted GO
BP GO:0019318 hexose metabolic process IEP Predicted GO
BP GO:0019319 hexose biosynthetic process IEP Predicted GO
BP GO:0019538 protein metabolic process IEP Predicted GO
BP GO:0019682 glyceraldehyde-3-phosphate metabolic process IEP Predicted GO
BP GO:0019725 cellular homeostasis IEP Predicted GO
CC GO:0022625 cytosolic large ribosomal subunit IEP Predicted GO
CC GO:0022627 cytosolic small ribosomal subunit IEP Predicted GO
MF GO:0030621 U4 snRNA binding IEP Predicted GO
BP GO:0031328 positive regulation of cellular biosynthetic process IEP Predicted GO
CC GO:0031982 vesicle IEP Predicted GO
BP GO:0032270 positive regulation of cellular protein metabolic process IEP Predicted GO
MF GO:0032549 ribonucleoside binding IEP Predicted GO
MF GO:0032550 purine ribonucleoside binding IEP Predicted GO
MF GO:0032553 ribonucleotide binding IEP Predicted GO
MF GO:0032555 purine ribonucleotide binding IEP Predicted GO
MF GO:0032561 guanyl ribonucleotide binding IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033500 carbohydrate homeostasis IEP Predicted GO
MF GO:0033677 DNA/RNA helicase activity IEP Predicted GO
MF GO:0033679 3'-5' DNA/RNA helicase activity IEP Predicted GO
BP GO:0034250 positive regulation of cellular amide metabolic process IEP Predicted GO
MF GO:0034511 U3 snoRNA binding IEP Predicted GO
BP GO:0034645 cellular macromolecule biosynthetic process IEP Predicted GO
BP GO:0034656 nucleobase-containing small molecule catabolic process IEP Predicted GO
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Predicted GO
MF GO:0036094 small molecule binding IEP Predicted GO
BP GO:0042221 response to chemical IEP Predicted GO
BP GO:0042262 DNA protection IEP Predicted GO
BP GO:0042278 purine nucleoside metabolic process IEP Predicted GO
BP GO:0042454 ribonucleoside catabolic process IEP Predicted GO
BP GO:0042493 response to drug IEP Predicted GO
BP GO:0042592 homeostatic process IEP Predicted GO
BP GO:0042593 glucose homeostasis IEP Predicted GO
BP GO:0043038 amino acid activation IEP Predicted GO
BP GO:0043039 tRNA aminoacylation IEP Predicted GO
BP GO:0043043 peptide biosynthetic process IEP Predicted GO
BP GO:0043101 purine-containing compound salvage IEP Predicted GO
MF GO:0043168 anion binding IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
BP GO:0043174 nucleoside salvage IEP Predicted GO
CC GO:0043226 organelle IEP Predicted GO
CC GO:0043228 non-membrane-bounded organelle IEP Predicted GO
CC GO:0043229 intracellular organelle IEP Predicted GO
CC GO:0043230 extracellular organelle IEP Predicted GO
CC GO:0043232 intracellular non-membrane-bounded organelle IEP Predicted GO
BP GO:0043243 positive regulation of protein complex disassembly IEP Predicted GO
BP GO:0043244 regulation of protein complex disassembly IEP Predicted GO
BP GO:0043603 cellular amide metabolic process IEP Predicted GO
BP GO:0043604 amide biosynthetic process IEP Predicted GO
MF GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
BP GO:0044267 cellular protein metabolic process IEP Predicted GO
CC GO:0044391 ribosomal subunit IEP Predicted GO
CC GO:0044421 extracellular region part IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044444 cytoplasmic part IEP Predicted GO
CC GO:0044445 cytosolic part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
CC GO:0044464 cell part IEP Predicted GO
BP GO:0045727 positive regulation of translation IEP Predicted GO
BP GO:0045901 positive regulation of translational elongation IEP Predicted GO
BP GO:0045905 positive regulation of translational termination IEP Predicted GO
BP GO:0046102 inosine metabolic process IEP Predicted GO
BP GO:0046128 purine ribonucleoside metabolic process IEP Predicted GO
BP GO:0046130 purine ribonucleoside catabolic process IEP Predicted GO
BP GO:0046364 monosaccharide biosynthetic process IEP Predicted GO
BP GO:0046391 5-phosphoribose 1-diphosphate metabolic process IEP Predicted GO
BP GO:0046777 protein autophosphorylation IEP Predicted GO
MF GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity IEP Predicted GO
MF GO:0048029 monosaccharide binding IEP Predicted GO
BP GO:0048518 positive regulation of biological process IEP Predicted GO
BP GO:0048584 positive regulation of response to stimulus IEP Predicted GO
MF GO:0050661 NADP binding IEP Predicted GO
BP GO:0050778 positive regulation of immune response IEP Predicted GO
MF GO:0051082 unfolded protein binding IEP Predicted GO
BP GO:0051156 glucose 6-phosphate metabolic process IEP Predicted GO
BP GO:0051247 positive regulation of protein metabolic process IEP Predicted GO
BP GO:0055114 oxidation-reduction process IEP Predicted GO
CC GO:0070469 respirasome IEP Predicted GO
BP GO:0072593 reactive oxygen species metabolic process IEP Predicted GO
MF GO:0097159 organic cyclic compound binding IEP Predicted GO
MF GO:0097367 carbohydrate derivative binding IEP Predicted GO
CC GO:0101031 chaperone complex IEP Predicted GO
MF GO:0140098 catalytic activity, acting on RNA IEP Predicted GO
MF GO:1901265 nucleoside phosphate binding IEP Predicted GO
MF GO:1901363 heterocyclic compound binding IEP Predicted GO
BP GO:1901657 glycosyl compound metabolic process IEP Predicted GO
BP GO:1901658 glycosyl compound catabolic process IEP Predicted GO
CC GO:1903561 extracellular vesicle IEP Predicted GO
BP GO:1905037 autophagosome organization IEP Predicted GO
CC GO:1905354 exoribonuclease complex IEP Predicted GO
CC GO:1990904 ribonucleoprotein complex IEP Predicted GO
InterPro domains Description Start Stop
IPR015793 Pyrv_Knase_brl 37 376
IPR015795 Pyrv_Knase_C 395 508
PlasmoDB 2270.t00155
PlasmoDB 3885761
PlasmoDB MAL6P1.160
PlasmoDB PFF1300w