PF3D7_0705400 (MCM7)

Aliases : MCM7

Description : SSF52540: P-loop containing nucleoside triphosphate hydrolase, SSF50249: "Nucleic acid-binding, OB-fold". Pfam domain(s): PF00493: MCM P-loop domain, PF17207: MCM OB domain, PF17855: MCM AAA-lid domain, PF14551: MCM N-terminal domain.

Gene families : OG_01_0000941 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000941_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0705400
Cluster	P. falciparum: Cluster_17

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_0803100	MCM7	SSF50249: Nucleic acid-binding, OB-fold, SSF52540:...	0.1	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan predictions
MF	GO:0003677	DNA binding	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IPI	PlasmoDB
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005737	cytoplasm	IDA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	PlasmoDB
BP	GO:0006270	DNA replication initiation	IEA	Interproscan predictions
BP	GO:0006270	DNA replication initiation	IEA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000491	small nucleolar ribonucleoprotein complex assembly	IEP	Predicted GO
BP	GO:0000492	box C/D snoRNP assembly	IEP	Predicted GO
CC	GO:0000775	chromosome, centromeric region	IEP	Predicted GO
CC	GO:0000808	origin recognition complex	IEP	Predicted GO
BP	GO:0002376	immune system process	IEP	Predicted GO
BP	GO:0002377	immunoglobulin production	IEP	Predicted GO
BP	GO:0002440	production of molecular mediator of immune response	IEP	Predicted GO
BP	GO:0002682	regulation of immune system process	IEP	Predicted GO
MF	GO:0003688	DNA replication origin binding	IEP	Predicted GO
MF	GO:0003689	DNA clamp loader activity	IEP	Predicted GO
MF	GO:0003690	double-stranded DNA binding	IEP	Predicted GO
MF	GO:0003824	catalytic activity	IEP	Predicted GO
MF	GO:0004529	exodeoxyribonuclease activity	IEP	Predicted GO
MF	GO:0004536	deoxyribonuclease activity	IEP	Predicted GO
MF	GO:0004690	cyclic nucleotide-dependent protein kinase activity	IEP	Predicted GO
MF	GO:0004692	cGMP-dependent protein kinase activity	IEP	Predicted GO
MF	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEP	Predicted GO
MF	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEP	Predicted GO
MF	GO:0004842	ubiquitin-protein transferase activity	IEP	Predicted GO
CC	GO:0005663	DNA replication factor C complex	IEP	Predicted GO
CC	GO:0005664	nuclear origin of replication recognition complex	IEP	Predicted GO
CC	GO:0005694	chromosome	IEP	Predicted GO
CC	GO:0005783	endoplasmic reticulum	IEP	Predicted GO
CC	GO:0005856	cytoskeleton	IEP	Predicted GO
CC	GO:0005871	kinesin complex	IEP	Predicted GO
CC	GO:0005971	ribonucleoside-diphosphate reductase complex	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006793	phosphorus metabolic process	IEP	Predicted GO
BP	GO:0006796	phosphate-containing compound metabolic process	IEP	Predicted GO
MF	GO:0008017	microtubule binding	IEP	Predicted GO
MF	GO:0008092	cytoskeletal protein binding	IEP	Predicted GO
MF	GO:0008234	cysteine-type peptidase activity	IEP	Predicted GO
MF	GO:0008296	3'-5'-exodeoxyribonuclease activity	IEP	Predicted GO
MF	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	IEP	Predicted GO
MF	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009165	nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009186	deoxyribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009262	deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009894	regulation of catabolic process	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
MF	GO:0015631	tubulin binding	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Predicted GO
MF	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	IEP	Predicted GO
MF	GO:0016787	hydrolase activity	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016887	ATPase activity	IEP	Predicted GO
MF	GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
MF	GO:0019787	ubiquitin-like protein transferase activity	IEP	Predicted GO
CC	GO:0019898	extrinsic component of membrane	IEP	Predicted GO
CC	GO:0031262	Ndc80 complex	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
MF	GO:0033170	protein-DNA loading ATPase activity	IEP	Predicted GO
BP	GO:0035890	exit from host	IEP	Predicted GO
BP	GO:0040011	locomotion	IEP	Predicted GO
MF	GO:0042162	telomeric DNA binding	IEP	Predicted GO
BP	GO:0042176	regulation of protein catabolic process	IEP	Predicted GO
CC	GO:0042555	MCM complex	IEP	Predicted GO
CC	GO:0042575	DNA polymerase complex	IEP	Predicted GO
BP	GO:0043086	negative regulation of catalytic activity	IEP	Predicted GO
MF	GO:0043565	sequence-specific DNA binding	IEP	Predicted GO
CC	GO:0043625	delta DNA polymerase complex	IEP	Predicted GO
BP	GO:0044092	negative regulation of molecular function	IEP	Predicted GO
CC	GO:0044427	chromosomal part	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
CC	GO:0044454	nuclear chromosome part	IEP	Predicted GO
MF	GO:0048256	flap endonuclease activity	IEP	Predicted GO
BP	GO:0048583	regulation of response to stimulus	IEP	Predicted GO
BP	GO:0050776	regulation of immune response	IEP	Predicted GO
BP	GO:0051095	regulation of helicase activity	IEP	Predicted GO
BP	GO:0051097	negative regulation of helicase activity	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051246	regulation of protein metabolic process	IEP	Predicted GO
BP	GO:0051276	chromosome organization	IEP	Predicted GO
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051726	regulation of cell cycle	IEP	Predicted GO
BP	GO:0052126	movement in host environment	IEP	Predicted GO
BP	GO:0052192	movement in environment of other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0060089	molecular transducer activity	IEP	Predicted GO
MF	GO:0061731	ribonucleoside-diphosphate reductase activity	IEP	Predicted GO
BP	GO:0090407	organophosphate biosynthetic process	IEP	Predicted GO
CC	GO:0097255	R2TP complex	IEP	Predicted GO
MF	GO:0097472	cyclin-dependent protein kinase activity	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Predicted GO
BP	GO:1901137	carbohydrate derivative biosynthetic process	IEP	Predicted GO
BP	GO:1901293	nucleoside phosphate biosynthetic process	IEP	Predicted GO
CC	GO:1902494	catalytic complex	IEP	Predicted GO
BP	GO:1905462	regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905463	negative regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905774	regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:1905775	negative regulation of DNA helicase activity	IEP	Predicted GO
CC	GO:1990204	oxidoreductase complex	IEP	Predicted GO
MF	GO:1990837	sequence-specific double-stranded DNA binding	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR033762	MCM_OB	209	337
IPR001208	MCM_dom	380	600
IPR027925	MCM_N	35	126

External Links

PlasmoDB	2655059
PlasmoDB	PF07_0023

PF3D7_0705400 (MCM7)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation