PF3D7_0812400 (KARalpha)

Aliases : KARalpha

Description : SSF48371: Armadillo-type fold. Pfam domain(s): PF01749: Importin beta binding domain, PF16186: Atypical Arm repeat, PF00514: Armadillo/beta-catenin-like repeat.

Gene families : OG_01_0002102 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002102_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0812400
Cluster	P. falciparum: Cluster_28

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005488	binding	IEA	PlasmoDB
MF	GO:0005515	protein binding	IEA	Interproscan predictions
MF	GO:0005515	protein binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	PlasmoDB
CC	GO:0005643	nuclear pore	TAS	PlasmoDB
CC	GO:0005737	cytoplasm	IEA	PlasmoDB
BP	GO:0006606	protein import into nucleus	IEA	Interproscan predictions
BP	GO:0006606	protein import into nucleus	IEA	PlasmoDB
BP	GO:0006607	NLS-bearing protein import into nucleus	IDA	PlasmoDB
BP	GO:0006810	transport	None	Extended
BP	GO:0006886	intracellular protein transport	None	Extended
BP	GO:0006913	nucleocytoplasmic transport	None	Extended
BP	GO:0006913	nucleocytoplasmic transport	TAS	PlasmoDB
BP	GO:0008104	protein localization	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0015031	protein transport	None	Extended
BP	GO:0015833	peptide transport	None	Extended
BP	GO:0017038	protein import	None	Extended
MF	GO:0019904	protein domain specific binding	IDA	PlasmoDB
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0033036	macromolecule localization	None	Extended
BP	GO:0033365	protein localization to organelle	None	Extended
BP	GO:0034504	protein localization to nucleus	None	Extended
BP	GO:0034613	cellular protein localization	None	Extended
BP	GO:0042886	amide transport	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
CC	GO:0044422	organelle part	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044428	nuclear part	None	Extended
CC	GO:0044446	intracellular organelle part	None	Extended
CC	GO:0044464	cell part	None	Extended
CC	GO:0044613	nuclear pore central transport channel	IC	PlasmoDB
BP	GO:0045184	establishment of protein localization	None	Extended
BP	GO:0046907	intracellular transport	None	Extended
MF	GO:0046982	protein heterodimerization activity	TAS	PlasmoDB
MF	GO:0046983	protein dimerization activity	None	Extended
BP	GO:0051169	nuclear transport	None	Extended
BP	GO:0051170	import into nucleus	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0051641	cellular localization	None	Extended
BP	GO:0051649	establishment of localization in cell	None	Extended
MF	GO:0061608	nuclear import signal receptor activity	IEA	Interproscan predictions
MF	GO:0061608	nuclear import signal receptor activity	IEA	PlasmoDB
BP	GO:0070727	cellular macromolecule localization	None	Extended
BP	GO:0071702	organic substance transport	None	Extended
BP	GO:0071705	nitrogen compound transport	None	Extended
BP	GO:0072594	establishment of protein localization to organelle	None	Extended
MF	GO:0140104	molecular carrier activity	None	Extended
MF	GO:0140142	nucleocytoplasmic carrier activity	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
MF	GO:0003682	chromatin binding	IEP	Predicted GO
MF	GO:0003824	catalytic activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004298	threonine-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004448	isocitrate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004467	long-chain fatty acid-CoA ligase activity	IEP	Predicted GO
MF	GO:0004594	pantothenate kinase activity	IEP	Predicted GO
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IEP	Predicted GO
MF	GO:0005085	guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0005087	Ran guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0005088	Ras guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0005337	nucleoside transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005345	purine nucleobase transmembrane transporter activity	IEP	Predicted GO
CC	GO:0005839	proteasome core complex	IEP	Predicted GO
CC	GO:0005956	protein kinase CK2 complex	IEP	Predicted GO
BP	GO:0006081	cellular aldehyde metabolic process	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006098	pentose-phosphate shunt	IEP	Predicted GO
BP	GO:0006099	tricarboxylic acid cycle	IEP	Predicted GO
BP	GO:0006101	citrate metabolic process	IEP	Predicted GO
BP	GO:0006102	isocitrate metabolic process	IEP	Predicted GO
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0006732	coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006739	NADP metabolic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006793	phosphorus metabolic process	IEP	Predicted GO
BP	GO:0006796	phosphate-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006863	purine nucleobase transport	IEP	Predicted GO
BP	GO:0007059	chromosome segregation	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
BP	GO:0008152	metabolic process	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008536	Ran GTPase binding	IEP	Predicted GO
BP	GO:0009056	catabolic process	IEP	Predicted GO
BP	GO:0009057	macromolecule catabolic process	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009266	response to temperature stimulus	IEP	Predicted GO
BP	GO:0009408	response to heat	IEP	Predicted GO
BP	GO:0009987	cellular process	IEP	Predicted GO
MF	GO:0015205	nucleobase transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015211	purine nucleoside transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015645	fatty acid ligase activity	IEP	Predicted GO
BP	GO:0015851	nucleobase transport	IEP	Predicted GO
BP	GO:0015858	nucleoside transport	IEP	Predicted GO
BP	GO:0015860	purine nucleoside transmembrane transport	IEP	Predicted GO
BP	GO:0015931	nucleobase-containing compound transport	IEP	Predicted GO
MF	GO:0015932	nucleobase-containing compound transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015936	coenzyme A metabolic process	IEP	Predicted GO
BP	GO:0015937	coenzyme A biosynthetic process	IEP	Predicted GO
MF	GO:0016208	AMP binding	IEP	Predicted GO
MF	GO:0016301	kinase activity	IEP	Predicted GO
MF	GO:0016405	CoA-ligase activity	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEP	Predicted GO
MF	GO:0016877	ligase activity, forming carbon-sulfur bonds	IEP	Predicted GO
MF	GO:0016878	acid-thiol ligase activity	IEP	Predicted GO
BP	GO:0016999	antibiotic metabolic process	IEP	Predicted GO
MF	GO:0017016	Ras GTPase binding	IEP	Predicted GO
BP	GO:0019637	organophosphate metabolic process	IEP	Predicted GO
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	IEP	Predicted GO
BP	GO:0019693	ribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0019773	proteasome core complex, alpha-subunit complex	IEP	Predicted GO
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
MF	GO:0031267	small GTPase binding	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
BP	GO:0033865	nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0033866	nucleoside bisphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034030	ribonucleoside bisphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034033	purine nucleoside bisphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0035690	cellular response to drug	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
BP	GO:0042221	response to chemical	IEP	Predicted GO
BP	GO:0042493	response to drug	IEP	Predicted GO
CC	GO:0043230	extracellular organelle	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Predicted GO
BP	GO:0044237	cellular metabolic process	IEP	Predicted GO
BP	GO:0044238	primary metabolic process	IEP	Predicted GO
BP	GO:0044248	cellular catabolic process	IEP	Predicted GO
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
CC	GO:0044421	extracellular region part	IEP	Predicted GO
BP	GO:0046777	protein autophosphorylation	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
MF	GO:0050661	NADP binding	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
MF	GO:0051020	GTPase binding	IEP	Predicted GO
BP	GO:0051156	glucose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
MF	GO:0051287	NAD binding	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0070003	threonine-type peptidase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0070887	cellular response to chemical stimulus	IEP	Predicted GO
BP	GO:0071704	organic substance metabolic process	IEP	Predicted GO
BP	GO:0072350	tricarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0072530	purine-containing compound transmembrane transport	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
BP	GO:1901135	carbohydrate derivative metabolic process	IEP	Predicted GO
BP	GO:1901264	carbohydrate derivative transport	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
MF	GO:1901505	carbohydrate derivative transmembrane transporter activity	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
BP	GO:1901575	organic substance catabolic process	IEP	Predicted GO
BP	GO:1901642	nucleoside transmembrane transport	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002652	Importin-a_IBB	8	112
IPR000225	Armadillo	258	290
IPR000225	Armadillo	335	374
IPR000225	Armadillo	209	249
IPR000225	Armadillo	125	164
IPR000225	Armadillo	379	415
IPR000225	Armadillo	166	205
IPR032413	Arm_3	473	517

External Links

PlasmoDB	2655286
PlasmoDB	PF08_0087

PF3D7_0812400 (KARalpha)

Expression Profile

Co-expression Networks

Functional Annotation