PF3D7_0902800 (SERA9)

Aliases : SERA9

Description : SSF54001: Papain-like cysteine peptidase superfamily. Pfam domain(s): PF00112: Papain family cysteine protease.

Gene families : OG_01_0000019 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000019_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0902800
Cluster	P. falciparum: Cluster_31

Type	GO Term	Name	Evidence	Source
BP	GO:0002376	immune system process	None	Extended
BP	GO:0002377	immunoglobulin production	IDA	PlasmoDB
BP	GO:0002440	production of molecular mediator of immune response	None	Extended
BP	GO:0002682	regulation of immune system process	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
BP	GO:0006508	proteolysis	IEA	Interproscan predictions
BP	GO:0006508	proteolysis	IEA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008234	cysteine-type peptidase activity	IEA	Interproscan predictions
MF	GO:0008234	cysteine-type peptidase activity	IEA	PlasmoDB
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0048583	regulation of response to stimulus	None	Extended
BP	GO:0050776	regulation of immune response	TAS	PlasmoDB
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
BP	GO:0001505	regulation of neurotransmitter levels	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003677	DNA binding	IEP	Predicted GO
MF	GO:0003678	DNA helicase activity	IEP	Predicted GO
MF	GO:0003689	DNA clamp loader activity	IEP	Predicted GO
MF	GO:0003896	DNA primase activity	IEP	Predicted GO
MF	GO:0003998	acylphosphatase activity	IEP	Predicted GO
MF	GO:0004146	dihydrofolate reductase activity	IEP	Predicted GO
MF	GO:0004312	fatty acid synthase activity	IEP	Predicted GO
MF	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IEP	Predicted GO
MF	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	IEP	Predicted GO
MF	GO:0004354	glutamate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004386	helicase activity	IEP	Predicted GO
MF	GO:0004478	methionine adenosyltransferase activity	IEP	Predicted GO
MF	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	IEP	Predicted GO
MF	GO:0004656	procollagen-proline 4-dioxygenase activity	IEP	Predicted GO
MF	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEP	Predicted GO
MF	GO:0004791	thioredoxin-disulfide reductase activity	IEP	Predicted GO
MF	GO:0004799	thymidylate synthase activity	IEP	Predicted GO
MF	GO:0004825	methionine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005385	zinc ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005388	calcium-transporting ATPase activity	IEP	Predicted GO
MF	GO:0005488	binding	IEP	Predicted GO
MF	GO:0005506	iron ion binding	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
CC	GO:0005663	DNA replication factor C complex	IEP	Predicted GO
CC	GO:0005672	transcription factor TFIIA complex	IEP	Predicted GO
CC	GO:0005788	endoplasmic reticulum lumen	IEP	Predicted GO
CC	GO:0005887	integral component of plasma membrane	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006103	2-oxoglutarate metabolic process	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006231	dTMP biosynthetic process	IEP	Predicted GO
BP	GO:0006259	DNA metabolic process	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006268	DNA unwinding involved in DNA replication	IEP	Predicted GO
BP	GO:0006269	DNA replication, synthesis of RNA primer	IEP	Predicted GO
BP	GO:0006270	DNA replication initiation	IEP	Predicted GO
BP	GO:0006410	obsolete transcription, RNA-dependent	IEP	Predicted GO
BP	GO:0006431	methionyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006537	glutamate biosynthetic process	IEP	Predicted GO
BP	GO:0006544	glycine metabolic process	IEP	Predicted GO
BP	GO:0006545	glycine biosynthetic process	IEP	Predicted GO
BP	GO:0006556	S-adenosylmethionine biosynthetic process	IEP	Predicted GO
BP	GO:0006631	fatty acid metabolic process	IEP	Predicted GO
BP	GO:0006721	terpenoid metabolic process	IEP	Predicted GO
BP	GO:0006730	one-carbon metabolic process	IEP	Predicted GO
BP	GO:0006816	calcium ion transport	IEP	Predicted GO
BP	GO:0006829	zinc ion transport	IEP	Predicted GO
MF	GO:0008094	DNA-dependent ATPase activity	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008271	secondary active sulfate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0008272	sulfate transport	IEP	Predicted GO
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009070	serine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009084	glutamine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009124	nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009129	pyrimidine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009162	deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009176	pyrimidine deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009177	pyrimidine deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009265	2'-deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009394	2'-deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009396	folic acid-containing compound biosynthetic process	IEP	Predicted GO
CC	GO:0009536	plastid	IEP	Predicted GO
BP	GO:0009894	regulation of catabolic process	IEP	Predicted GO
BP	GO:0009987	cellular process	IEP	Predicted GO
BP	GO:0010035	response to inorganic substance	IEP	Predicted GO
BP	GO:0010038	response to metal ion	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
BP	GO:0015074	DNA integration	IEP	Predicted GO
MF	GO:0015075	ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015085	calcium ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015103	inorganic anion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015116	sulfate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015318	inorganic molecular entity transmembrane transporter activity	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
BP	GO:0016114	terpenoid biosynthetic process	IEP	Predicted GO
BP	GO:0016197	endosomal transport	IEP	Predicted GO
MF	GO:0016208	AMP binding	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
BP	GO:0016539	intein-mediated protein splicing	IEP	Predicted GO
MF	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	IEP	Predicted GO
MF	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	IEP	Predicted GO
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEP	Predicted GO
MF	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEP	Predicted GO
MF	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	IEP	Predicted GO
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
BP	GO:0018143	nucleic acid-protein covalent cross-linking	IEP	Predicted GO
BP	GO:0018144	RNA-protein covalent cross-linking	IEP	Predicted GO
BP	GO:0019692	deoxyribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019725	cellular homeostasis	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
MF	GO:0019798	procollagen-proline dioxygenase activity	IEP	Predicted GO
MF	GO:0019842	vitamin binding	IEP	Predicted GO
CC	GO:0020011	apicoplast	IEP	Predicted GO
BP	GO:0030001	metal ion transport	IEP	Predicted GO
MF	GO:0030246	carbohydrate binding	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
CC	GO:0030904	retromer complex	IEP	Predicted GO
BP	GO:0030908	protein splicing	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
MF	GO:0031079	obsolete picornain 3C activity	IEP	Predicted GO
CC	GO:0031226	intrinsic component of plasma membrane	IEP	Predicted GO
MF	GO:0031418	L-ascorbic acid binding	IEP	Predicted GO
BP	GO:0031497	chromatin assembly	IEP	Predicted GO
MF	GO:0031543	peptidyl-proline dioxygenase activity	IEP	Predicted GO
MF	GO:0031545	peptidyl-proline 4-dioxygenase activity	IEP	Predicted GO
CC	GO:0031974	membrane-enclosed lumen	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
MF	GO:0033170	protein-DNA loading ATPase activity	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
MF	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	IEP	Predicted GO
BP	GO:0042133	neurotransmitter metabolic process	IEP	Predicted GO
BP	GO:0042136	neurotransmitter biosynthetic process	IEP	Predicted GO
BP	GO:0042147	retrograde transport, endosome to Golgi	IEP	Predicted GO
BP	GO:0042176	regulation of protein catabolic process	IEP	Predicted GO
BP	GO:0042221	response to chemical	IEP	Predicted GO
MF	GO:0042393	histone binding	IEP	Predicted GO
BP	GO:0042493	response to drug	IEP	Predicted GO
CC	GO:0042555	MCM complex	IEP	Predicted GO
BP	GO:0042592	homeostatic process	IEP	Predicted GO
MF	GO:0042623	ATPase activity, coupled	IEP	Predicted GO
BP	GO:0043086	negative regulation of catalytic activity	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043233	organelle lumen	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0044092	negative regulation of molecular function	IEP	Predicted GO
BP	GO:0044237	cellular metabolic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044432	endoplasmic reticulum part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
BP	GO:0045454	cell redox homeostasis	IEP	Predicted GO
BP	GO:0046073	dTMP metabolic process	IEP	Predicted GO
BP	GO:0046385	deoxyribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
MF	GO:0046429	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	IEP	Predicted GO
BP	GO:0046500	S-adenosylmethionine metabolic process	IEP	Predicted GO
BP	GO:0046653	tetrahydrofolate metabolic process	IEP	Predicted GO
BP	GO:0046654	tetrahydrofolate biosynthetic process	IEP	Predicted GO
MF	GO:0046873	metal ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0048029	monosaccharide binding	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051095	regulation of helicase activity	IEP	Predicted GO
BP	GO:0051097	negative regulation of helicase activity	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
MF	GO:0051213	dioxygenase activity	IEP	Predicted GO
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Predicted GO
MF	GO:0051539	4 iron, 4 sulfur cluster binding	IEP	Predicted GO
MF	GO:0052592	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
BP	GO:0061025	membrane fusion	IEP	Predicted GO
BP	GO:0065008	regulation of biological quality	IEP	Predicted GO
CC	GO:0070013	intracellular organelle lumen	IEP	Predicted GO
BP	GO:0070838	divalent metal ion transport	IEP	Predicted GO
BP	GO:0072348	sulfur compound transport	IEP	Predicted GO
MF	GO:0072509	divalent inorganic cation transmembrane transporter activity	IEP	Predicted GO
BP	GO:0072511	divalent inorganic cation transport	IEP	Predicted GO
BP	GO:0090304	nucleic acid metabolic process	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
MF	GO:0097472	cyclin-dependent protein kinase activity	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Predicted GO
MF	GO:1901682	sulfur compound transmembrane transporter activity	IEP	Predicted GO
BP	GO:1905462	regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905463	negative regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905774	regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:1905775	negative regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000668	Peptidase_C1A_C	498	732

External Links

PlasmoDB	813307
PlasmoDB	PFI0135c

PF3D7_0902800 (SERA9)

Expression Profile

Co-expression Networks

Functional Annotation