PF3D7_0924300 (TPK)

Aliases : TPK

Description : SSF63862: "Thiamin pyrophosphokinase, thiamin-binding domain superfamily", SSF63999: "Thiamin pyrophosphokinase, catalytic domain superfamily". Pfam domain(s): PF04263: "Thiamin pyrophosphokinase, catalytic domain", PF04265: "Thiamin pyrophosphokinase, vitamin B1 binding domain".

Gene families : OG_01_0002614 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002614_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0924300
Cluster	P. falciparum: Cluster_18

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004788	thiamine diphosphokinase activity	IEA	Interproscan predictions
MF	GO:0004788	thiamine diphosphokinase activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005829	cytosol	IDA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006766	vitamin metabolic process	None	Extended
BP	GO:0006767	water-soluble vitamin metabolic process	None	Extended
BP	GO:0006772	thiamine metabolic process	IEA	PlasmoDB
BP	GO:0006790	sulfur compound metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009108	coenzyme biosynthetic process	None	Extended
BP	GO:0009229	thiamine diphosphate biosynthetic process	IEA	Interproscan predictions
BP	GO:0009229	thiamine diphosphate biosynthetic process	IEA	PlasmoDB
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016778	diphosphotransferase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0017144	drug metabolic process	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
MF	GO:0019842	vitamin binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0030975	thiamine binding	IEA	Interproscan predictions
MF	GO:0030975	thiamine binding	IEA	PlasmoDB
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042357	thiamine diphosphate metabolic process	None	Extended
BP	GO:0042723	thiamine-containing compound metabolic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044272	sulfur compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0051188	cofactor biosynthetic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072527	pyrimidine-containing compound metabolic process	None	Extended
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	None	Extended
BP	GO:0090407	organophosphate biosynthetic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
MF	GO:1901681	sulfur compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000338	protein deneddylation	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0003987	acetate-CoA ligase activity	IEP	Predicted GO
MF	GO:0004484	mRNA guanylyltransferase activity	IEP	Predicted GO
MF	GO:0004605	phosphatidate cytidylyltransferase activity	IEP	Predicted GO
MF	GO:0004721	phosphoprotein phosphatase activity	IEP	Predicted GO
MF	GO:0004730	pseudouridylate synthase activity	IEP	Predicted GO
MF	GO:0004857	enzyme inhibitor activity	IEP	Predicted GO
MF	GO:0004864	protein phosphatase inhibitor activity	IEP	Predicted GO
MF	GO:0004865	protein serine/threonine phosphatase inhibitor activity	IEP	Predicted GO
MF	GO:0005371	tricarboxylate secondary active transmembrane transporter activity	IEP	Predicted GO
CC	GO:0005669	transcription factor TFIID complex	IEP	Predicted GO
CC	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	IEP	Predicted GO
CC	GO:0005849	mRNA cleavage factor complex	IEP	Predicted GO
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006370	7-methylguanosine mRNA capping	IEP	Predicted GO
BP	GO:0006378	mRNA polyadenylation	IEP	Predicted GO
BP	GO:0006379	mRNA cleavage	IEP	Predicted GO
BP	GO:0006470	protein dephosphorylation	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006842	tricarboxylic acid transport	IEP	Predicted GO
BP	GO:0006843	mitochondrial citrate transmembrane transport	IEP	Predicted GO
MF	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEP	Predicted GO
MF	GO:0008192	RNA guanylyltransferase activity	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009452	7-methylguanosine RNA capping	IEP	Predicted GO
BP	GO:0009742	brassinosteroid mediated signaling pathway	IEP	Predicted GO
BP	GO:0009755	hormone-mediated signaling pathway	IEP	Predicted GO
BP	GO:0009966	regulation of signal transduction	IEP	Predicted GO
BP	GO:0010646	regulation of cell communication	IEP	Predicted GO
BP	GO:0010921	regulation of phosphatase activity	IEP	Predicted GO
MF	GO:0015142	tricarboxylic acid transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015746	citrate transport	IEP	Predicted GO
BP	GO:0016070	RNA metabolic process	IEP	Predicted GO
BP	GO:0016073	snRNA metabolic process	IEP	Predicted GO
BP	GO:0016180	snRNA processing	IEP	Predicted GO
BP	GO:0016311	dephosphorylation	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
MF	GO:0016788	hydrolase activity, acting on ester bonds	IEP	Predicted GO
MF	GO:0016791	phosphatase activity	IEP	Predicted GO
MF	GO:0016882	cyclo-ligase activity	IEP	Predicted GO
MF	GO:0019208	phosphatase regulator activity	IEP	Predicted GO
MF	GO:0019212	phosphatase inhibitor activity	IEP	Predicted GO
MF	GO:0019888	protein phosphatase regulator activity	IEP	Predicted GO
BP	GO:0023051	regulation of signaling	IEP	Predicted GO
MF	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	IEP	Predicted GO
BP	GO:0031123	RNA 3'-end processing	IEP	Predicted GO
BP	GO:0031124	mRNA 3'-end processing	IEP	Predicted GO
BP	GO:0034220	ion transmembrane transport	IEP	Predicted GO
BP	GO:0034472	snRNA 3'-end processing	IEP	Predicted GO
BP	GO:0034477	U6 snRNA 3'-end processing	IEP	Predicted GO
BP	GO:0035303	regulation of dephosphorylation	IEP	Predicted GO
BP	GO:0035304	regulation of protein dephosphorylation	IEP	Predicted GO
BP	GO:0035674	tricarboxylic acid transmembrane transport	IEP	Predicted GO
BP	GO:0036260	RNA capping	IEP	Predicted GO
MF	GO:0042578	phosphoric ester hydrolase activity	IEP	Predicted GO
BP	GO:0042891	antibiotic transport	IEP	Predicted GO
MF	GO:0043139	5'-3' DNA helicase activity	IEP	Predicted GO
MF	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
BP	GO:0043401	steroid hormone mediated signaling pathway	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043628	ncRNA 3'-end processing	IEP	Predicted GO
BP	GO:0043666	regulation of phosphoprotein phosphatase activity	IEP	Predicted GO
BP	GO:0044238	primary metabolic process	IEP	Predicted GO
BP	GO:0044267	cellular protein metabolic process	IEP	Predicted GO
CC	GO:0044451	nucleoplasm part	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046653	tetrahydrofolate metabolic process	IEP	Predicted GO
MF	GO:0070567	cytidylyltransferase activity	IEP	Predicted GO
MF	GO:0070568	guanylyltransferase activity	IEP	Predicted GO
BP	GO:0098656	anion transmembrane transport	IEP	Predicted GO
BP	GO:1903825	organic acid transmembrane transport	IEP	Predicted GO
BP	GO:1905039	carboxylic acid transmembrane transport	IEP	Predicted GO
BP	GO:1990546	mitochondrial tricarboxylic acid transmembrane transport	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR007371	TPK_catalytic	113	310
IPR007373	Thiamin_PyroPKinase_B1-bd	326	390

External Links

PlasmoDB	813519
PlasmoDB	PFI1195c

PF3D7_0924300 (TPK)

Expression Profile

Co-expression Networks

Functional Annotation