PF3D7_1010600 (eIF2beta)

Aliases : eIF2beta

Description : SSF75689: "Translation initiation factor IF2/IF5, zinc-binding", SSF100966: "Translation initiation factor IF2/IF5, N-terminal". Pfam domain(s): PF01873: Domain found in IF2B/IF5.

Gene families : OG_01_0001590 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001590_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1010600
Cluster	P. falciparum: Cluster_28

Type	GO Term	Name	Evidence	Source
BP	GO:0001731	formation of translation preinitiation complex	ISS	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003723	RNA binding	None	Extended
MF	GO:0003729	mRNA binding	ISS	PlasmoDB
MF	GO:0003743	translation initiation factor activity	ISS	PlasmoDB
MF	GO:0003743	translation initiation factor activity	IEA	Interproscan predictions
MF	GO:0003743	translation initiation factor activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IPI	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IDA	PlasmoDB
CC	GO:0005737	cytoplasm	IDA	PlasmoDB
CC	GO:0005850	eukaryotic translation initiation factor 2 complex	IDA	PlasmoDB
BP	GO:0006413	translational initiation	ISM	PlasmoDB
BP	GO:0006413	translational initiation	IEA	Interproscan predictions
BP	GO:0006413	translational initiation	IEA	PlasmoDB
MF	GO:0008135	translation factor activity, RNA binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
BP	GO:0022607	cellular component assembly	None	Extended
BP	GO:0022618	ribonucleoprotein complex assembly	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0034622	cellular protein-containing complex assembly	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043933	protein-containing complex subunit organization	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0065003	protein-containing complex assembly	None	Extended
BP	GO:0071826	ribonucleoprotein complex subunit organization	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000122	negative regulation of transcription by RNA polymerase II	IEP	Predicted GO
BP	GO:0000375	RNA splicing, via transesterification reactions	IEP	Predicted GO
BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	IEP	Predicted GO
BP	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IEP	Predicted GO
BP	GO:0000398	mRNA splicing, via spliceosome	IEP	Predicted GO
BP	GO:0000723	telomere maintenance	IEP	Predicted GO
MF	GO:0000900	translation repressor activity, mRNA regulatory element binding	IEP	Predicted GO
BP	GO:0002181	cytoplasmic translation	IEP	Predicted GO
MF	GO:0003697	single-stranded DNA binding	IEP	Predicted GO
MF	GO:0003714	transcription corepressor activity	IEP	Predicted GO
MF	GO:0003727	single-stranded RNA binding	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IEP	Predicted GO
MF	GO:0004749	ribose phosphate diphosphokinase activity	IEP	Predicted GO
MF	GO:0005198	structural molecule activity	IEP	Predicted GO
CC	GO:0005622	intracellular	IEP	Predicted GO
CC	GO:0005681	spliceosomal complex	IEP	Predicted GO
CC	GO:0005685	U1 snRNP	IEP	Predicted GO
CC	GO:0005840	ribosome	IEP	Predicted GO
CC	GO:0005853	eukaryotic translation elongation factor 1 complex	IEP	Predicted GO
CC	GO:0005956	protein kinase CK2 complex	IEP	Predicted GO
BP	GO:0006081	cellular aldehyde metabolic process	IEP	Predicted GO
BP	GO:0006098	pentose-phosphate shunt	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006166	purine ribonucleoside salvage	IEP	Predicted GO
BP	GO:0006396	RNA processing	IEP	Predicted GO
BP	GO:0006397	mRNA processing	IEP	Predicted GO
BP	GO:0006412	translation	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006518	peptide metabolic process	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0006733	oxidoreduction coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006739	NADP metabolic process	IEP	Predicted GO
BP	GO:0006807	nitrogen compound metabolic process	IEP	Predicted GO
MF	GO:0008097	5S rRNA binding	IEP	Predicted GO
MF	GO:0008143	poly(A) binding	IEP	Predicted GO
BP	GO:0008380	RNA splicing	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010468	regulation of gene expression	IEP	Predicted GO
CC	GO:0015934	large ribosomal subunit	IEP	Predicted GO
CC	GO:0015935	small ribosomal subunit	IEP	Predicted GO
BP	GO:0016070	RNA metabolic process	IEP	Predicted GO
BP	GO:0016071	mRNA metabolic process	IEP	Predicted GO
BP	GO:0016556	mRNA modification	IEP	Predicted GO
MF	GO:0016778	diphosphotransferase activity	IEP	Predicted GO
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	IEP	Predicted GO
CC	GO:0022625	cytosolic large ribosomal subunit	IEP	Predicted GO
CC	GO:0022627	cytosolic small ribosomal subunit	IEP	Predicted GO
MF	GO:0030371	translation repressor activity	IEP	Predicted GO
BP	GO:0031323	regulation of cellular metabolic process	IEP	Predicted GO
MF	GO:0031369	translation initiation factor binding	IEP	Predicted GO
BP	GO:0032200	telomere organization	IEP	Predicted GO
BP	GO:0032780	negative regulation of ATPase activity	IEP	Predicted GO
BP	GO:0034641	cellular nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0042162	telomeric DNA binding	IEP	Predicted GO
BP	GO:0043043	peptide biosynthetic process	IEP	Predicted GO
MF	GO:0043047	single-stranded telomeric DNA binding	IEP	Predicted GO
BP	GO:0043086	negative regulation of catalytic activity	IEP	Predicted GO
BP	GO:0043094	cellular metabolic compound salvage	IEP	Predicted GO
BP	GO:0043101	purine-containing compound salvage	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
BP	GO:0043174	nucleoside salvage	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043462	regulation of ATPase activity	IEP	Predicted GO
BP	GO:0043484	regulation of RNA splicing	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043604	amide biosynthetic process	IEP	Predicted GO
BP	GO:0044092	negative regulation of molecular function	IEP	Predicted GO
BP	GO:0044238	primary metabolic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044267	cellular protein metabolic process	IEP	Predicted GO
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Predicted GO
CC	GO:0044391	ribosomal subunit	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
MF	GO:0045182	translation regulator activity	IEP	Predicted GO
BP	GO:0045892	negative regulation of transcription, DNA-templated	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Predicted GO
BP	GO:0048024	regulation of mRNA splicing, via spliceosome	IEP	Predicted GO
BP	GO:0050684	regulation of mRNA processing	IEP	Predicted GO
BP	GO:0051156	glucose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0051252	regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0051253	negative regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0051262	protein tetramerization	IEP	Predicted GO
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0060249	anatomical structure homeostasis	IEP	Predicted GO
MF	GO:0070717	poly-purine tract binding	IEP	Predicted GO
BP	GO:0071704	organic substance metabolic process	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0080009	mRNA methylation	IEP	Predicted GO
MF	GO:0090079	translation regulator activity, nucleic acid binding	IEP	Predicted GO
BP	GO:0090304	nucleic acid metabolic process	IEP	Predicted GO
MF	GO:0098847	sequence-specific single stranded DNA binding	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1902679	negative regulation of RNA biosynthetic process	IEP	Predicted GO
BP	GO:1903311	regulation of mRNA metabolic process	IEP	Predicted GO
BP	GO:1903507	negative regulation of nucleic acid-templated transcription	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002735	Transl_init_fac_IF2/IF5	87	197

External Links

PlasmoDB	810261
PlasmoDB	PF10_0103

PF3D7_1010600 (eIF2beta)

Expression Profile

Co-expression Networks

Functional Annotation