PF3D7_1115700 (FP2A)

Aliases : FP2A

Description : SSF54001: Papain-like cysteine peptidase superfamily. Pfam domain(s): PF08246: Cathepsin propeptide inhibitor domain (I29), PF00112: Papain family cysteine protease.

Gene families : OG_01_0000031 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000031_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1115700
Cluster	P. falciparum: Cluster_11

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_0932400	BP2	SSF54001: Papain-like cysteine peptidase superfamily....	0.09	Orthofinderv1.1.8
PBANKA_1321700	BP1	SSF54001: Papain-like cysteine peptidase superfamily....	0.09	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
CC	GO:0000323	lytic vacuole	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004175	endopeptidase activity	None	Extended
MF	GO:0004197	cysteine-type endopeptidase activity	ISS	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IPI	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005764	lysosome	None	Extended
CC	GO:0005767	secondary lysosome	None	Extended
CC	GO:0005773	vacuole	None	Extended
BP	GO:0006508	proteolysis	ISS	PlasmoDB
BP	GO:0006508	proteolysis	IEA	Interproscan predictions
BP	GO:0006508	proteolysis	IEA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008234	cysteine-type peptidase activity	IEA	Interproscan predictions
MF	GO:0008234	cysteine-type peptidase activity	IEA	PlasmoDB
CC	GO:0016020	membrane	IEA	PlasmoDB
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
CC	GO:0020020	food vacuole	IDA	PlasmoDB
CC	GO:0030139	endocytic vesicle	None	Extended
CC	GO:0031410	cytoplasmic vesicle	None	Extended
CC	GO:0031982	vesicle	None	Extended
CC	GO:0032010	phagolysosome	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
CC	GO:0045335	phagocytic vesicle	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
CC	GO:0097708	intracellular vesicle	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000295	adenine nucleotide transmembrane transporter activity	IEP	Predicted GO
MF	GO:0000774	adenyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0003688	DNA replication origin binding	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0003746	translation elongation factor activity	IEP	Predicted GO
MF	GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	IEP	Predicted GO
MF	GO:0004019	adenylosuccinate synthase activity	IEP	Predicted GO
MF	GO:0004152	dihydroorotate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004156	dihydropteroate synthase activity	IEP	Predicted GO
MF	GO:0004177	aminopeptidase activity	IEP	Predicted GO
MF	GO:0004347	glucose-6-phosphate isomerase activity	IEP	Predicted GO
MF	GO:0004364	glutathione transferase activity	IEP	Predicted GO
MF	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	IEP	Predicted GO
MF	GO:0004588	orotate phosphoribosyltransferase activity	IEP	Predicted GO
MF	GO:0004735	pyrroline-5-carboxylate reductase activity	IEP	Predicted GO
MF	GO:0005198	structural molecule activity	IEP	Predicted GO
MF	GO:0005337	nucleoside transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005346	purine ribonucleotide transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005347	ATP transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005471	ATP:ADP antiporter activity	IEP	Predicted GO
CC	GO:0005622	intracellular	IEP	Predicted GO
CC	GO:0005739	mitochondrion	IEP	Predicted GO
CC	GO:0005743	mitochondrial inner membrane	IEP	Predicted GO
CC	GO:0005746	mitochondrial respirasome	IEP	Predicted GO
CC	GO:0005758	mitochondrial intermembrane space	IEP	Predicted GO
CC	GO:0005829	cytosol	IEP	Predicted GO
CC	GO:0005832	chaperonin-containing T-complex	IEP	Predicted GO
CC	GO:0005840	ribosome	IEP	Predicted GO
CC	GO:0005853	eukaryotic translation elongation factor 1 complex	IEP	Predicted GO
CC	GO:0005854	nascent polypeptide-associated complex	IEP	Predicted GO
BP	GO:0006072	glycerol-3-phosphate metabolic process	IEP	Predicted GO
BP	GO:0006094	gluconeogenesis	IEP	Predicted GO
BP	GO:0006167	AMP biosynthetic process	IEP	Predicted GO
BP	GO:0006206	pyrimidine nucleobase metabolic process	IEP	Predicted GO
BP	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	IEP	Predicted GO
BP	GO:0006412	translation	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006458	'de novo' protein folding	IEP	Predicted GO
BP	GO:0006518	peptide metabolic process	IEP	Predicted GO
BP	GO:0006560	proline metabolic process	IEP	Predicted GO
BP	GO:0006561	proline biosynthetic process	IEP	Predicted GO
BP	GO:0006761	dihydrofolate biosynthetic process	IEP	Predicted GO
BP	GO:0006839	mitochondrial transport	IEP	Predicted GO
BP	GO:0006863	purine nucleobase transport	IEP	Predicted GO
BP	GO:0007005	mitochondrion organization	IEP	Predicted GO
BP	GO:0007006	mitochondrial membrane organization	IEP	Predicted GO
BP	GO:0007007	inner mitochondrial membrane organization	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
MF	GO:0008235	metalloexopeptidase activity	IEP	Predicted GO
MF	GO:0008237	metallopeptidase activity	IEP	Predicted GO
MF	GO:0008238	exopeptidase activity	IEP	Predicted GO
MF	GO:0008565	protein transporter activity	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009084	glutamine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009124	nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009126	purine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009156	ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009161	ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009167	purine ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
CC	GO:0009331	glycerol-3-phosphate dehydrogenase complex	IEP	Predicted GO
BP	GO:0009396	folic acid-containing compound biosynthetic process	IEP	Predicted GO
CC	GO:0009986	cell surface	IEP	Predicted GO
BP	GO:0009987	cellular process	IEP	Predicted GO
MF	GO:0015215	nucleotide transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015216	purine nucleotide transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015217	ADP transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015605	organophosphate ester transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015851	nucleobase transport	IEP	Predicted GO
BP	GO:0015858	nucleoside transport	IEP	Predicted GO
MF	GO:0015932	nucleobase-containing compound transmembrane transporter activity	IEP	Predicted GO
CC	GO:0015934	large ribosomal subunit	IEP	Predicted GO
CC	GO:0015935	small ribosomal subunit	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	IEP	Predicted GO
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	IEP	Predicted GO
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEP	Predicted GO
MF	GO:0016778	diphosphotransferase activity	IEP	Predicted GO
MF	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
BP	GO:0018130	heterocycle biosynthetic process	IEP	Predicted GO
BP	GO:0019319	hexose biosynthetic process	IEP	Predicted GO
BP	GO:0019856	pyrimidine nucleobase biosynthetic process	IEP	Predicted GO
CC	GO:0019866	organelle inner membrane	IEP	Predicted GO
CC	GO:0022625	cytosolic large ribosomal subunit	IEP	Predicted GO
CC	GO:0022627	cytosolic small ribosomal subunit	IEP	Predicted GO
MF	GO:0030145	manganese ion binding	IEP	Predicted GO
BP	GO:0030150	protein import into mitochondrial matrix	IEP	Predicted GO
CC	GO:0031090	organelle membrane	IEP	Predicted GO
CC	GO:0031966	mitochondrial membrane	IEP	Predicted GO
CC	GO:0031970	organelle envelope lumen	IEP	Predicted GO
CC	GO:0031974	membrane-enclosed lumen	IEP	Predicted GO
BP	GO:0032238	adenosine transport	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0033365	protein localization to organelle	IEP	Predicted GO
BP	GO:0034613	cellular protein localization	IEP	Predicted GO
BP	GO:0034641	cellular nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0042802	identical protein binding	IEP	Predicted GO
MF	GO:0042803	protein homodimerization activity	IEP	Predicted GO
BP	GO:0043043	peptide biosynthetic process	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043233	organelle lumen	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043604	amide biosynthetic process	IEP	Predicted GO
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Predicted GO
CC	GO:0043657	host cell	IEP	Predicted GO
CC	GO:0044216	other organism cell	IEP	Predicted GO
BP	GO:0044237	cellular metabolic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044267	cellular protein metabolic process	IEP	Predicted GO
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
CC	GO:0044391	ribosomal subunit	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044429	mitochondrial part	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
BP	GO:0044743	protein transmembrane import into intracellular organelle	IEP	Predicted GO
BP	GO:0045039	protein import into mitochondrial inner membrane	IEP	Predicted GO
BP	GO:0046033	AMP metabolic process	IEP	Predicted GO
BP	GO:0046112	nucleobase biosynthetic process	IEP	Predicted GO
BP	GO:0046168	glycerol-3-phosphate catabolic process	IEP	Predicted GO
BP	GO:0046364	monosaccharide biosynthetic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0046434	organophosphate catabolic process	IEP	Predicted GO
BP	GO:0046452	dihydrofolate metabolic process	IEP	Predicted GO
MF	GO:0046983	protein dimerization activity	IEP	Predicted GO
MF	GO:0051082	unfolded protein binding	IEP	Predicted GO
BP	GO:0051083	'de novo' cotranslational protein folding	IEP	Predicted GO
BP	GO:0052646	alditol phosphate metabolic process	IEP	Predicted GO
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0060590	ATPase regulator activity	IEP	Predicted GO
BP	GO:0065002	intracellular protein transmembrane transport	IEP	Predicted GO
CC	GO:0070013	intracellular organelle lumen	IEP	Predicted GO
CC	GO:0070469	respirasome	IEP	Predicted GO
BP	GO:0070585	protein localization to mitochondrion	IEP	Predicted GO
BP	GO:0070727	cellular macromolecule localization	IEP	Predicted GO
BP	GO:0071806	protein transmembrane transport	IEP	Predicted GO
BP	GO:0072594	establishment of protein localization to organelle	IEP	Predicted GO
BP	GO:0072655	establishment of protein localization to mitochondrion	IEP	Predicted GO
BP	GO:0090151	establishment of protein localization to mitochondrial membrane	IEP	Predicted GO
CC	GO:0101031	chaperone complex	IEP	Predicted GO
BP	GO:1901135	carbohydrate derivative metabolic process	IEP	Predicted GO
BP	GO:1901264	carbohydrate derivative transport	IEP	Predicted GO
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Predicted GO
MF	GO:1901505	carbohydrate derivative transmembrane transporter activity	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO
BP	GO:1990542	mitochondrial transmembrane transport	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR013201	Prot_inhib_I29	165	222
IPR000668	Peptidase_C1A_C	264	481

External Links

PlasmoDB	810712
PlasmoDB	PF11_0165

PF3D7_1115700 (FP2A)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation