PF3D7_1124500 (pdhA)

Aliases : pdhA

Description : SSF52518: Thiamin diphosphate-binding fold. Pfam domain(s): PF00676: Dehydrogenase E1 component.

Gene families : OG_01_0002700 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002700_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1124500
Cluster	P. falciparum: Cluster_32

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004738	pyruvate dehydrogenase activity	None	Extended
MF	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	ISS	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006084	acetyl-CoA metabolic process	None	Extended
BP	GO:0006085	acetyl-CoA biosynthetic process	None	Extended
BP	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	IC	PlasmoDB
BP	GO:0006090	pyruvate metabolic process	None	Extended
BP	GO:0006099	tricarboxylic acid cycle	ISS	PlasmoDB
BP	GO:0006101	citrate metabolic process	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006163	purine nucleotide metabolic process	None	Extended
BP	GO:0006164	purine nucleotide biosynthetic process	None	Extended
BP	GO:0006629	lipid metabolic process	None	Extended
BP	GO:0006631	fatty acid metabolic process	None	Extended
BP	GO:0006633	fatty acid biosynthetic process	TAS	PlasmoDB
BP	GO:0006637	acyl-CoA metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006790	sulfur compound metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	IEA	PlasmoDB
BP	GO:0008610	lipid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009108	coenzyme biosynthetic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009150	purine ribonucleotide metabolic process	None	Extended
BP	GO:0009152	purine ribonucleotide biosynthetic process	None	Extended
BP	GO:0009165	nucleotide biosynthetic process	None	Extended
BP	GO:0009259	ribonucleotide metabolic process	None	Extended
BP	GO:0009260	ribonucleotide biosynthetic process	None	Extended
CC	GO:0009536	plastid	None	Extended
BP	GO:0009987	cellular process	None	Extended
CC	GO:0016020	membrane	ISS	PlasmoDB
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA	Interproscan predictions
MF	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA	PlasmoDB
MF	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	None	Extended
BP	GO:0016999	antibiotic metabolic process	None	Extended
BP	GO:0017144	drug metabolic process	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
CC	GO:0020011	apicoplast	IDA	PlasmoDB
BP	GO:0032787	monocarboxylic acid metabolic process	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0033865	nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0033866	nucleoside bisphosphate biosynthetic process	None	Extended
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034030	ribonucleoside bisphosphate biosynthetic process	None	Extended
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034033	purine nucleoside bisphosphate biosynthetic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034654	nucleobase-containing compound biosynthetic process	None	Extended
BP	GO:0035383	thioester metabolic process	None	Extended
BP	GO:0035384	thioester biosynthetic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0043603	cellular amide metabolic process	None	Extended
BP	GO:0043604	amide biosynthetic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044255	cellular lipid metabolic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044272	sulfur compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
CC	GO:0045254	pyruvate dehydrogenase complex	ISS	PlasmoDB
BP	GO:0046390	ribose phosphate biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0051188	cofactor biosynthetic process	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0071616	acyl-CoA biosynthetic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072330	monocarboxylic acid biosynthetic process	None	Extended
BP	GO:0072350	tricarboxylic acid metabolic process	None	Extended
BP	GO:0072521	purine-containing compound metabolic process	None	Extended
BP	GO:0072522	purine-containing compound biosynthetic process	None	Extended
BP	GO:0090407	organophosphate biosynthetic process	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901137	carbohydrate derivative biosynthetic process	None	Extended
BP	GO:1901293	nucleoside phosphate biosynthetic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
CC	GO:1902494	catalytic complex	None	Extended
CC	GO:1990204	oxidoreductase complex	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000338	protein deneddylation	IEP	Predicted GO
BP	GO:0001505	regulation of neurotransmitter levels	IEP	Predicted GO
MF	GO:0003684	damaged DNA binding	IEP	Predicted GO
MF	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	IEP	Predicted GO
MF	GO:0004047	aminomethyltransferase activity	IEP	Predicted GO
MF	GO:0004112	cyclic-nucleotide phosphodiesterase activity	IEP	Predicted GO
MF	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEP	Predicted GO
MF	GO:0004484	mRNA guanylyltransferase activity	IEP	Predicted GO
MF	GO:0004520	endodeoxyribonuclease activity	IEP	Predicted GO
MF	GO:0004536	deoxyribonuclease activity	IEP	Predicted GO
MF	GO:0004843	thiol-dependent ubiquitin-specific protease activity	IEP	Predicted GO
BP	GO:0006289	nucleotide-excision repair	IEP	Predicted GO
BP	GO:0006370	7-methylguanosine mRNA capping	IEP	Predicted GO
BP	GO:0006512	obsolete ubiquitin cycle	IEP	Predicted GO
BP	GO:0006544	glycine metabolic process	IEP	Predicted GO
BP	GO:0006546	glycine catabolic process	IEP	Predicted GO
MF	GO:0008081	phosphoric diester hydrolase activity	IEP	Predicted GO
MF	GO:0008192	RNA guanylyltransferase activity	IEP	Predicted GO
BP	GO:0009063	cellular amino acid catabolic process	IEP	Predicted GO
BP	GO:0009069	serine family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009071	serine family amino acid catabolic process	IEP	Predicted GO
BP	GO:0009187	cyclic nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009452	7-methylguanosine RNA capping	IEP	Predicted GO
BP	GO:0009890	negative regulation of biosynthetic process	IEP	Predicted GO
CC	GO:0010494	cytoplasmic stress granule	IEP	Predicted GO
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0015095	magnesium ion transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015693	magnesium ion transport	IEP	Predicted GO
BP	GO:0016054	organic acid catabolic process	IEP	Predicted GO
BP	GO:0016579	protein deubiquitination	IEP	Predicted GO
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
BP	GO:0017148	negative regulation of translation	IEP	Predicted GO
MF	GO:0019783	ubiquitin-like protein-specific protease activity	IEP	Predicted GO
MF	GO:0030551	cyclic nucleotide binding	IEP	Predicted GO
MF	GO:0030552	cAMP binding	IEP	Predicted GO
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	Predicted GO
BP	GO:0032269	negative regulation of cellular protein metabolic process	IEP	Predicted GO
BP	GO:0034249	negative regulation of cellular amide metabolic process	IEP	Predicted GO
CC	GO:0035770	ribonucleoprotein granule	IEP	Predicted GO
BP	GO:0036260	RNA capping	IEP	Predicted GO
MF	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEP	Predicted GO
CC	GO:0036464	cytoplasmic ribonucleoprotein granule	IEP	Predicted GO
BP	GO:0042133	neurotransmitter metabolic process	IEP	Predicted GO
BP	GO:0042135	neurotransmitter catabolic process	IEP	Predicted GO
BP	GO:0042737	drug catabolic process	IEP	Predicted GO
BP	GO:0044282	small molecule catabolic process	IEP	Predicted GO
BP	GO:0046395	carboxylic acid catabolic process	IEP	Predicted GO
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051248	negative regulation of protein metabolic process	IEP	Predicted GO
MF	GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	IEP	Predicted GO
MF	GO:0070568	guanylyltransferase activity	IEP	Predicted GO
MF	GO:0070569	uridylyltransferase activity	IEP	Predicted GO
BP	GO:0070646	protein modification by small protein removal	IEP	Predicted GO
BP	GO:0070838	divalent metal ion transport	IEP	Predicted GO
BP	GO:0072511	divalent inorganic cation transport	IEP	Predicted GO
MF	GO:0101005	ubiquitinyl hydrolase activity	IEP	Predicted GO
BP	GO:1901606	alpha-amino acid catabolic process	IEP	Predicted GO
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001017	DH_E1	200	529

External Links

PlasmoDB	810803
PlasmoDB	PF11_0256

PF3D7_1124500 (pdhA)

Expression Profile

Co-expression Networks

Functional Annotation