PF3D7_1202900 (HMGB1)

Aliases : HMGB1

Description : SSF47095: High mobility group box domain superfamily. Pfam domain(s): PF00505: HMG (high mobility group) box.

Gene families : OG_01_0000080 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000080_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1202900
Cluster	P. falciparum: Cluster_31

Type	GO Term	Name	Evidence	Source
BP	GO:0001817	regulation of cytokine production	None	Extended
BP	GO:0001819	positive regulation of cytokine production	IDA	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IDA	PlasmoDB
CC	GO:0005694	chromosome	IDA	PlasmoDB
CC	GO:0005829	cytosol	IDA	PlasmoDB
BP	GO:0006355	regulation of transcription, DNA-templated	TAS	PlasmoDB
BP	GO:0008150	biological_process	None	Extended
MF	GO:0008301	DNA binding, bending	IDA	PlasmoDB
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043228	non-membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
CC	GO:0043232	intracellular non-membrane-bounded organelle	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0048518	positive regulation of biological process	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051239	regulation of multicellular organismal process	None	Extended
BP	GO:0051240	positive regulation of multicellular organismal process	None	Extended
BP	GO:0051252	regulation of RNA metabolic process	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1903506	regulation of nucleic acid-templated transcription	None	Extended
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	None	Extended
BP	GO:2001141	regulation of RNA biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000041	transition metal ion transport	IEP	Predicted GO
CC	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	IEP	Predicted GO
CC	GO:0000786	nucleosome	IEP	Predicted GO
MF	GO:0000993	RNA polymerase II complex binding	IEP	Predicted GO
MF	GO:0001098	basal transcription machinery binding	IEP	Predicted GO
MF	GO:0001099	basal RNA polymerase II transcription machinery binding	IEP	Predicted GO
BP	GO:0002376	immune system process	IEP	Predicted GO
BP	GO:0002377	immunoglobulin production	IEP	Predicted GO
BP	GO:0002440	production of molecular mediator of immune response	IEP	Predicted GO
BP	GO:0002682	regulation of immune system process	IEP	Predicted GO
MF	GO:0004831	tyrosine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005507	copper ion binding	IEP	Predicted GO
MF	GO:0005509	calcium ion binding	IEP	Predicted GO
MF	GO:0005515	protein binding	IEP	Predicted GO
CC	GO:0005758	mitochondrial intermembrane space	IEP	Predicted GO
CC	GO:0005813	centrosome	IEP	Predicted GO
CC	GO:0005838	proteasome regulatory particle	IEP	Predicted GO
BP	GO:0006325	chromatin organization	IEP	Predicted GO
BP	GO:0006333	chromatin assembly or disassembly	IEP	Predicted GO
BP	GO:0006334	nucleosome assembly	IEP	Predicted GO
BP	GO:0006354	DNA-templated transcription, elongation	IEP	Predicted GO
BP	GO:0006368	transcription elongation from RNA polymerase II promoter	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006437	tyrosyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006811	ion transport	IEP	Predicted GO
BP	GO:0006812	cation transport	IEP	Predicted GO
BP	GO:0006825	copper ion transport	IEP	Predicted GO
BP	GO:0006873	cellular ion homeostasis	IEP	Predicted GO
BP	GO:0006885	regulation of pH	IEP	Predicted GO
BP	GO:0006996	organelle organization	IEP	Predicted GO
BP	GO:0007035	vacuolar acidification	IEP	Predicted GO
BP	GO:0007264	small GTPase mediated signal transduction	IEP	Predicted GO
CC	GO:0008023	transcription elongation factor complex	IEP	Predicted GO
MF	GO:0008175	tRNA methyltransferase activity	IEP	Predicted GO
MF	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	IEP	Predicted GO
BP	GO:0016043	cellular component organization	IEP	Predicted GO
BP	GO:0016070	RNA metabolic process	IEP	Predicted GO
MF	GO:0016423	tRNA (guanine) methyltransferase activity	IEP	Predicted GO
CC	GO:0016469	proton-transporting two-sector ATPase complex	IEP	Predicted GO
CC	GO:0016471	vacuolar proton-transporting V-type ATPase complex	IEP	Predicted GO
MF	GO:0016530	metallochaperone activity	IEP	Predicted GO
MF	GO:0016531	copper chaperone activity	IEP	Predicted GO
BP	GO:0022607	cellular component assembly	IEP	Predicted GO
BP	GO:0030003	cellular cation homeostasis	IEP	Predicted GO
BP	GO:0030004	cellular monovalent inorganic cation homeostasis	IEP	Predicted GO
BP	GO:0030641	regulation of cellular pH	IEP	Predicted GO
CC	GO:0031970	organelle envelope lumen	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
BP	GO:0032774	RNA biosynthetic process	IEP	Predicted GO
CC	GO:0032993	protein-DNA complex	IEP	Predicted GO
CC	GO:0033176	proton-transporting V-type ATPase complex	IEP	Predicted GO
CC	GO:0033180	proton-transporting V-type ATPase, V1 domain	IEP	Predicted GO
CC	GO:0033646	host intracellular part	IEP	Predicted GO
CC	GO:0033655	host cell cytoplasm part	IEP	Predicted GO
BP	GO:0034622	cellular protein-containing complex assembly	IEP	Predicted GO
BP	GO:0034728	nucleosome organization	IEP	Predicted GO
BP	GO:0042592	homeostatic process	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
MF	GO:0043175	RNA polymerase core enzyme binding	IEP	Predicted GO
CC	GO:0043230	extracellular organelle	IEP	Predicted GO
BP	GO:0043248	proteasome assembly	IEP	Predicted GO
BP	GO:0043933	protein-containing complex subunit organization	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044427	chromosomal part	IEP	Predicted GO
CC	GO:0044437	vacuolar part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
CC	GO:0044815	DNA packaging complex	IEP	Predicted GO
BP	GO:0045851	pH reduction	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0046982	protein heterodimerization activity	IEP	Predicted GO
MF	GO:0046983	protein dimerization activity	IEP	Predicted GO
MF	GO:0048306	calcium-dependent protein binding	IEP	Predicted GO
BP	GO:0048878	chemical homeostasis	IEP	Predicted GO
BP	GO:0050776	regulation of immune response	IEP	Predicted GO
BP	GO:0050801	ion homeostasis	IEP	Predicted GO
BP	GO:0051276	chromosome organization	IEP	Predicted GO
BP	GO:0051452	intracellular pH reduction	IEP	Predicted GO
BP	GO:0051453	regulation of intracellular pH	IEP	Predicted GO
BP	GO:0055065	metal ion homeostasis	IEP	Predicted GO
BP	GO:0055067	monovalent inorganic cation homeostasis	IEP	Predicted GO
BP	GO:0055074	calcium ion homeostasis	IEP	Predicted GO
BP	GO:0055080	cation homeostasis	IEP	Predicted GO
BP	GO:0055082	cellular chemical homeostasis	IEP	Predicted GO
BP	GO:0065003	protein-containing complex assembly	IEP	Predicted GO
BP	GO:0065004	protein-DNA complex assembly	IEP	Predicted GO
BP	GO:0065008	regulation of biological quality	IEP	Predicted GO
MF	GO:0070063	RNA polymerase binding	IEP	Predicted GO
BP	GO:0070682	proteasome regulatory particle assembly	IEP	Predicted GO
BP	GO:0071824	protein-DNA complex subunit organization	IEP	Predicted GO
BP	GO:0071840	cellular component organization or biogenesis	IEP	Predicted GO
BP	GO:0072507	divalent inorganic cation homeostasis	IEP	Predicted GO
BP	GO:0090304	nucleic acid metabolic process	IEP	Predicted GO
BP	GO:0098771	inorganic ion homeostasis	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
MF	GO:0140104	molecular carrier activity	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR009071	HMG_box_dom	21	90

External Links

PlasmoDB	2277.t00029
PlasmoDB	811082
PlasmoDB	MAL12P1.29
PlasmoDB	PFL0145c

PF3D7_1202900 (HMGB1)

Expression Profile

Co-expression Networks

Functional Annotation