PF3D7_1204300 (EIF5A)


Aliases : EIF5A

Description : SSF50249: "Nucleic acid-binding, OB-fold", SSF50104: Translation protein SH3-like domain superfamily. Pfam domain(s): PF01287: "Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold".


Gene families : OG_01_0000765 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000765_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pfa RNA-seq: PF3D7_1204300
Cluster P. falciparum: Cluster_11

Target Alias Description ECC score Gene Family Method Actions
PBANKA_0603200 EIF5A SSF50249: Nucleic acid-binding, OB-fold, SSF50104:... 0.16 Orthofinderv1.1.8

Type GO Term Name Evidence Source
MF GO:0003723 RNA binding IEA Interproscan predictions
MF GO:0003723 RNA binding IEA PlasmoDB
MF GO:0003743 translation initiation factor activity ISS PlasmoDB
MF GO:0003746 translation elongation factor activity IEA Interproscan predictions
MF GO:0003746 translation elongation factor activity IEA PlasmoDB
BP GO:0006413 translational initiation ISS PlasmoDB
BP GO:0006452 translational frameshifting IEA Interproscan predictions
BP GO:0006452 translational frameshifting IEA PlasmoDB
MF GO:0043022 ribosome binding IEA Interproscan predictions
MF GO:0043022 ribosome binding IEA PlasmoDB
BP GO:0045901 positive regulation of translational elongation IEA Interproscan predictions
BP GO:0045901 positive regulation of translational elongation IEA PlasmoDB
BP GO:0045905 positive regulation of translational termination IEA Interproscan predictions
BP GO:0045905 positive regulation of translational termination IEA PlasmoDB
Type GO Term Name Evidence Source
CC GO:0000015 phosphopyruvate hydratase complex IEP Predicted GO
MF GO:0000036 acyl carrier activity IEP Predicted GO
BP GO:0000045 autophagosome assembly IEP Predicted GO
CC GO:0000178 exosome (RNase complex) IEP Predicted GO
MF GO:0000295 adenine nucleotide transmembrane transporter activity IEP Predicted GO
BP GO:0002253 activation of immune response IEP Predicted GO
BP GO:0002684 positive regulation of immune system process IEP Predicted GO
MF GO:0003725 double-stranded RNA binding IEP Predicted GO
MF GO:0003735 structural constituent of ribosome IEP Predicted GO
MF GO:0004000 adenosine deaminase activity IEP Predicted GO
MF GO:0004017 adenylate kinase activity IEP Predicted GO
MF GO:0004364 glutathione transferase activity IEP Predicted GO
MF GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEP Predicted GO
MF GO:0004422 hypoxanthine phosphoribosyltransferase activity IEP Predicted GO
MF GO:0004457 lactate dehydrogenase activity IEP Predicted GO
MF GO:0004459 L-lactate dehydrogenase activity IEP Predicted GO
MF GO:0004634 phosphopyruvate hydratase activity IEP Predicted GO
MF GO:0004731 purine-nucleoside phosphorylase activity IEP Predicted GO
MF GO:0004743 pyruvate kinase activity IEP Predicted GO
MF GO:0004784 superoxide dismutase activity IEP Predicted GO
MF GO:0004807 triose-phosphate isomerase activity IEP Predicted GO
MF GO:0004824 lysine-tRNA ligase activity IEP Predicted GO
MF GO:0005102 signaling receptor binding IEP Predicted GO
MF GO:0005125 cytokine activity IEP Predicted GO
MF GO:0005198 structural molecule activity IEP Predicted GO
MF GO:0005346 purine ribonucleotide transmembrane transporter activity IEP Predicted GO
MF GO:0005347 ATP transmembrane transporter activity IEP Predicted GO
MF GO:0005471 ATP:ADP antiporter activity IEP Predicted GO
CC GO:0005575 cellular_component IEP Predicted GO
CC GO:0005622 intracellular IEP Predicted GO
CC GO:0005739 mitochondrion IEP Predicted GO
CC GO:0005742 mitochondrial outer membrane translocase complex IEP Predicted GO
CC GO:0005746 mitochondrial respirasome IEP Predicted GO
CC GO:0005829 cytosol IEP Predicted GO
CC GO:0005840 ribosome IEP Predicted GO
CC GO:0005853 eukaryotic translation elongation factor 1 complex IEP Predicted GO
CC GO:0005956 protein kinase CK2 complex IEP Predicted GO
BP GO:0005975 carbohydrate metabolic process IEP Predicted GO
BP GO:0005996 monosaccharide metabolic process IEP Predicted GO
BP GO:0006006 glucose metabolic process IEP Predicted GO
BP GO:0006082 organic acid metabolic process IEP Predicted GO
BP GO:0006090 pyruvate metabolic process IEP Predicted GO
BP GO:0006091 generation of precursor metabolites and energy IEP Predicted GO
BP GO:0006094 gluconeogenesis IEP Predicted GO
BP GO:0006096 glycolytic process IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006148 inosine catabolic process IEP Predicted GO
BP GO:0006152 purine nucleoside catabolic process IEP Predicted GO
BP GO:0006163 purine nucleotide metabolic process IEP Predicted GO
BP GO:0006164 purine nucleotide biosynthetic process IEP Predicted GO
BP GO:0006165 nucleoside diphosphate phosphorylation IEP Predicted GO
BP GO:0006166 purine ribonucleoside salvage IEP Predicted GO
BP GO:0006412 translation IEP Predicted GO
BP GO:0006430 lysyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006457 protein folding IEP Predicted GO
BP GO:0006518 peptide metabolic process IEP Predicted GO
BP GO:0006633 fatty acid biosynthetic process IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006732 coenzyme metabolic process IEP Predicted GO
BP GO:0006733 oxidoreduction coenzyme metabolic process IEP Predicted GO
BP GO:0006753 nucleoside phosphate metabolic process IEP Predicted GO
BP GO:0006754 ATP biosynthetic process IEP Predicted GO
BP GO:0006757 ATP generation from ADP IEP Predicted GO
BP GO:0006793 phosphorus metabolic process IEP Predicted GO
BP GO:0006796 phosphate-containing compound metabolic process IEP Predicted GO
BP GO:0006801 superoxide metabolic process IEP Predicted GO
BP GO:0006807 nitrogen compound metabolic process IEP Predicted GO
BP GO:0006839 mitochondrial transport IEP Predicted GO
BP GO:0006863 purine nucleobase transport IEP Predicted GO
BP GO:0006979 response to oxidative stress IEP Predicted GO
BP GO:0007006 mitochondrial membrane organization IEP Predicted GO
BP GO:0007007 inner mitochondrial membrane organization IEP Predicted GO
MF GO:0008379 thioredoxin peroxidase activity IEP Predicted GO
MF GO:0008565 protein transporter activity IEP Predicted GO
BP GO:0008610 lipid biosynthetic process IEP Predicted GO
MF GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009108 coenzyme biosynthetic process IEP Predicted GO
BP GO:0009116 nucleoside metabolic process IEP Predicted GO
BP GO:0009117 nucleotide metabolic process IEP Predicted GO
BP GO:0009119 ribonucleoside metabolic process IEP Predicted GO
BP GO:0009132 nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009135 purine nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009141 nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009142 nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009144 purine nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009145 purine nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009150 purine ribonucleotide metabolic process IEP Predicted GO
BP GO:0009152 purine ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009164 nucleoside catabolic process IEP Predicted GO
BP GO:0009165 nucleotide biosynthetic process IEP Predicted GO
BP GO:0009166 nucleotide catabolic process IEP Predicted GO
BP GO:0009179 purine ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009185 ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009199 ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009201 ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009205 purine ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009259 ribonucleotide metabolic process IEP Predicted GO
BP GO:0009260 ribonucleotide biosynthetic process IEP Predicted GO
CC GO:0009986 cell surface IEP Predicted GO
MF GO:0015215 nucleotide transmembrane transporter activity IEP Predicted GO
MF GO:0015216 purine nucleotide transmembrane transporter activity IEP Predicted GO
MF GO:0015217 ADP transmembrane transporter activity IEP Predicted GO
MF GO:0015605 organophosphate ester transmembrane transporter activity IEP Predicted GO
BP GO:0015851 nucleobase transport IEP Predicted GO
BP GO:0015858 nucleoside transport IEP Predicted GO
MF GO:0015932 nucleobase-containing compound transmembrane transporter activity IEP Predicted GO
CC GO:0015934 large ribosomal subunit IEP Predicted GO
CC GO:0015935 small ribosomal subunit IEP Predicted GO
BP GO:0015959 diadenosine polyphosphate metabolic process IEP Predicted GO
BP GO:0015960 diadenosine polyphosphate biosynthetic process IEP Predicted GO
BP GO:0015965 diadenosine tetraphosphate metabolic process IEP Predicted GO
BP GO:0015966 diadenosine tetraphosphate biosynthetic process IEP Predicted GO
BP GO:0016043 cellular component organization IEP Predicted GO
BP GO:0016051 carbohydrate biosynthetic process IEP Predicted GO
BP GO:0016052 carbohydrate catabolic process IEP Predicted GO
BP GO:0016053 organic acid biosynthetic process IEP Predicted GO
MF GO:0016209 antioxidant activity IEP Predicted GO
BP GO:0016310 phosphorylation IEP Predicted GO
MF GO:0016491 oxidoreductase activity IEP Predicted GO
MF GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEP Predicted GO
MF GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor IEP Predicted GO
MF GO:0016757 transferase activity, transferring glycosyl groups IEP Predicted GO
MF GO:0016763 transferase activity, transferring pentosyl groups IEP Predicted GO
BP GO:0017144 drug metabolic process IEP Predicted GO
BP GO:0018130 heterocycle biosynthetic process IEP Predicted GO
CC GO:0019005 SCF ubiquitin ligase complex IEP Predicted GO
MF GO:0019239 deaminase activity IEP Predicted GO
BP GO:0019318 hexose metabolic process IEP Predicted GO
BP GO:0019319 hexose biosynthetic process IEP Predicted GO
BP GO:0019359 nicotinamide nucleotide biosynthetic process IEP Predicted GO
BP GO:0019362 pyridine nucleotide metabolic process IEP Predicted GO
BP GO:0019363 pyridine nucleotide biosynthetic process IEP Predicted GO
BP GO:0019438 aromatic compound biosynthetic process IEP Predicted GO
BP GO:0019439 aromatic compound catabolic process IEP Predicted GO
BP GO:0019538 protein metabolic process IEP Predicted GO
BP GO:0019637 organophosphate metabolic process IEP Predicted GO
BP GO:0019693 ribose phosphate metabolic process IEP Predicted GO
BP GO:0019752 carboxylic acid metabolic process IEP Predicted GO
BP GO:0022607 cellular component assembly IEP Predicted GO
CC GO:0022625 cytosolic large ribosomal subunit IEP Predicted GO
CC GO:0022627 cytosolic small ribosomal subunit IEP Predicted GO
CC GO:0030133 transport vesicle IEP Predicted GO
CC GO:0030141 secretory granule IEP Predicted GO
CC GO:0030532 small nuclear ribonucleoprotein complex IEP Predicted GO
MF GO:0030545 receptor regulator activity IEP Predicted GO
CC GO:0031982 vesicle IEP Predicted GO
BP GO:0032238 adenosine transport IEP Predicted GO
BP GO:0032787 monocarboxylic acid metabolic process IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033365 protein localization to organelle IEP Predicted GO
BP GO:0034404 nucleobase-containing small molecule biosynthetic process IEP Predicted GO
BP GO:0034622 cellular protein-containing complex assembly IEP Predicted GO
BP GO:0034641 cellular nitrogen compound metabolic process IEP Predicted GO
BP GO:0034654 nucleobase-containing compound biosynthetic process IEP Predicted GO
BP GO:0034655 nucleobase-containing compound catabolic process IEP Predicted GO
BP GO:0034656 nucleobase-containing small molecule catabolic process IEP Predicted GO
BP GO:0034975 protein folding in endoplasmic reticulum IEP Predicted GO
BP GO:0042262 DNA protection IEP Predicted GO
BP GO:0042278 purine nucleoside metabolic process IEP Predicted GO
BP GO:0042454 ribonucleoside catabolic process IEP Predicted GO
BP GO:0042866 pyruvate biosynthetic process IEP Predicted GO
BP GO:0043043 peptide biosynthetic process IEP Predicted GO
BP GO:0043101 purine-containing compound salvage IEP Predicted GO
BP GO:0043174 nucleoside salvage IEP Predicted GO
CC GO:0043226 organelle IEP Predicted GO
CC GO:0043228 non-membrane-bounded organelle IEP Predicted GO
CC GO:0043229 intracellular organelle IEP Predicted GO
CC GO:0043232 intracellular non-membrane-bounded organelle IEP Predicted GO
BP GO:0043248 proteasome assembly IEP Predicted GO
BP GO:0043436 oxoacid metabolic process IEP Predicted GO
BP GO:0043603 cellular amide metabolic process IEP Predicted GO
BP GO:0043604 amide biosynthetic process IEP Predicted GO
MF GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity IEP Predicted GO
BP GO:0043933 protein-containing complex subunit organization IEP Predicted GO
BP GO:0044238 primary metabolic process IEP Predicted GO
BP GO:0044248 cellular catabolic process IEP Predicted GO
BP GO:0044267 cellular protein metabolic process IEP Predicted GO
BP GO:0044270 cellular nitrogen compound catabolic process IEP Predicted GO
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Predicted GO
BP GO:0044281 small molecule metabolic process IEP Predicted GO
BP GO:0044283 small molecule biosynthetic process IEP Predicted GO
CC GO:0044391 ribosomal subunit IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044429 mitochondrial part IEP Predicted GO
CC GO:0044444 cytoplasmic part IEP Predicted GO
CC GO:0044445 cytosolic part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
CC GO:0044455 mitochondrial membrane part IEP Predicted GO
CC GO:0044464 cell part IEP Predicted GO
MF GO:0044620 ACP phosphopantetheine attachment site binding IEP Predicted GO
BP GO:0045039 protein import into mitochondrial inner membrane IEP Predicted GO
BP GO:0045116 protein neddylation IEP Predicted GO
BP GO:0046031 ADP metabolic process IEP Predicted GO
BP GO:0046034 ATP metabolic process IEP Predicted GO
BP GO:0046102 inosine metabolic process IEP Predicted GO
BP GO:0046128 purine ribonucleoside metabolic process IEP Predicted GO
BP GO:0046130 purine ribonucleoside catabolic process IEP Predicted GO
BP GO:0046364 monosaccharide biosynthetic process IEP Predicted GO
BP GO:0046390 ribose phosphate biosynthetic process IEP Predicted GO
BP GO:0046394 carboxylic acid biosynthetic process IEP Predicted GO
BP GO:0046434 organophosphate catabolic process IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
BP GO:0046496 nicotinamide nucleotide metabolic process IEP Predicted GO
BP GO:0046700 heterocycle catabolic process IEP Predicted GO
BP GO:0046777 protein autophosphorylation IEP Predicted GO
BP GO:0046939 nucleotide phosphorylation IEP Predicted GO
MF GO:0048018 receptor ligand activity IEP Predicted GO
BP GO:0048584 positive regulation of response to stimulus IEP Predicted GO
BP GO:0050778 positive regulation of immune response IEP Predicted GO
BP GO:0051186 cofactor metabolic process IEP Predicted GO
BP GO:0051188 cofactor biosynthetic process IEP Predicted GO
MF GO:0051192 prosthetic group binding IEP Predicted GO
BP GO:0051260 protein homooligomerization IEP Predicted GO
BP GO:0051262 protein tetramerization IEP Predicted GO
BP GO:0051289 protein homotetramerization IEP Predicted GO
BP GO:0051382 kinetochore assembly IEP Predicted GO
BP GO:0051383 kinetochore organization IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
BP GO:0055114 oxidation-reduction process IEP Predicted GO
BP GO:0065003 protein-containing complex assembly IEP Predicted GO
CC GO:0070469 respirasome IEP Predicted GO
BP GO:0070585 protein localization to mitochondrion IEP Predicted GO
BP GO:0070925 organelle assembly IEP Predicted GO
BP GO:0071840 cellular component organization or biogenesis IEP Predicted GO
BP GO:0072330 monocarboxylic acid biosynthetic process IEP Predicted GO
BP GO:0072521 purine-containing compound metabolic process IEP Predicted GO
BP GO:0072522 purine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072524 pyridine-containing compound metabolic process IEP Predicted GO
BP GO:0072525 pyridine-containing compound biosynthetic process IEP Predicted GO
CC GO:0072546 ER membrane protein complex IEP Predicted GO
BP GO:0072593 reactive oxygen species metabolic process IEP Predicted GO
BP GO:0072594 establishment of protein localization to organelle IEP Predicted GO
BP GO:0072655 establishment of protein localization to mitochondrion IEP Predicted GO
BP GO:0090151 establishment of protein localization to mitochondrial membrane IEP Predicted GO
BP GO:0090407 organophosphate biosynthetic process IEP Predicted GO
CC GO:0097525 spliceosomal snRNP complex IEP Predicted GO
MF GO:0098772 molecular function regulator IEP Predicted GO
CC GO:0098799 outer mitochondrial membrane protein complex IEP Predicted GO
CC GO:0099503 secretory vesicle IEP Predicted GO
MF GO:0106130 purine phosphoribosyltransferase activity IEP Predicted GO
CC GO:0120114 Sm-like protein family complex IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901137 carbohydrate derivative biosynthetic process IEP Predicted GO
BP GO:1901292 nucleoside phosphate catabolic process IEP Predicted GO
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
BP GO:1901361 organic cyclic compound catabolic process IEP Predicted GO
BP GO:1901362 organic cyclic compound biosynthetic process IEP Predicted GO
MF GO:1901505 carbohydrate derivative transmembrane transporter activity IEP Predicted GO
BP GO:1901564 organonitrogen compound metabolic process IEP Predicted GO
BP GO:1901566 organonitrogen compound biosynthetic process IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
BP GO:1901657 glycosyl compound metabolic process IEP Predicted GO
BP GO:1901658 glycosyl compound catabolic process IEP Predicted GO
CC GO:1902494 catalytic complex IEP Predicted GO
CC GO:1903561 extracellular vesicle IEP Predicted GO
BP GO:1905037 autophagosome organization IEP Predicted GO
CC GO:1905354 exoribonuclease complex IEP Predicted GO
CC GO:1990904 ribonucleoprotein complex IEP Predicted GO
InterPro domains Description Start Stop
IPR020189 Transl_elong_IF5A_C 83 157
PlasmoDB 2277.t00042
PlasmoDB 811095
PlasmoDB MAL12P1.42
PlasmoDB PFL0210c