PF3D7_1209500 (PDEalpha)

Aliases : PDEalpha

Description : SSF109604: No description available. Pfam domain(s): PF00233: 3'5'-cyclic nucleotide phosphodiesterase.

Gene families : OG_01_0002465 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002465_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1209500
Cluster	P. falciparum: Cluster_20

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004112	cyclic-nucleotide phosphodiesterase activity	None	Extended
MF	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	Interproscan predictions
MF	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006163	purine nucleotide metabolic process	None	Extended
BP	GO:0006195	purine nucleotide catabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0007165	signal transduction	ISS	PlasmoDB
BP	GO:0007165	signal transduction	IEA	Interproscan predictions
BP	GO:0007165	signal transduction	IEA	PlasmoDB
MF	GO:0008081	phosphoric diester hydrolase activity	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009150	purine ribonucleotide metabolic process	None	Extended
BP	GO:0009154	purine ribonucleotide catabolic process	None	Extended
BP	GO:0009166	nucleotide catabolic process	None	Extended
BP	GO:0009187	cyclic nucleotide metabolic process	None	Extended
BP	GO:0009214	cyclic nucleotide catabolic process	None	Extended
BP	GO:0009259	ribonucleotide metabolic process	None	Extended
BP	GO:0009261	ribonucleotide catabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
CC	GO:0016020	membrane	IEA	PlasmoDB
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016788	hydrolase activity, acting on ester bonds	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
MF	GO:0019001	guanyl nucleotide binding	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019439	aromatic compound catabolic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
MF	GO:0030551	cyclic nucleotide binding	None	Extended
MF	GO:0030553	cGMP binding	IDA	PlasmoDB
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032561	guanyl ribonucleotide binding	None	Extended
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034654	nucleobase-containing compound biosynthetic process	None	Extended
BP	GO:0034655	nucleobase-containing compound catabolic process	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042578	phosphoric ester hydrolase activity	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044270	cellular nitrogen compound catabolic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046068	cGMP metabolic process	None	Extended
BP	GO:0046069	cGMP catabolic process	IDA	PlasmoDB
BP	GO:0046434	organophosphate catabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0046700	heterocycle catabolic process	None	Extended
MF	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IDA	PlasmoDB
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072521	purine-containing compound metabolic process	None	Extended
BP	GO:0072523	purine-containing compound catabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901136	carbohydrate derivative catabolic process	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901292	nucleoside phosphate catabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901361	organic cyclic compound catabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901565	organonitrogen compound catabolic process	None	Extended
BP	GO:1901575	organic substance catabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003919	FMN adenylyltransferase activity	IEP	Predicted GO
MF	GO:0003954	NADH dehydrogenase activity	IEP	Predicted GO
MF	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity	IEP	Predicted GO
MF	GO:0004140	dephospho-CoA kinase activity	IEP	Predicted GO
MF	GO:0004143	diacylglycerol kinase activity	IEP	Predicted GO
MF	GO:0004438	phosphatidylinositol-3-phosphatase activity	IEP	Predicted GO
CC	GO:0005792	obsolete microsome	IEP	Predicted GO
CC	GO:0005886	plasma membrane	IEP	Predicted GO
CC	GO:0005905	clathrin-coated pit	IEP	Predicted GO
BP	GO:0006304	DNA modification	IEP	Predicted GO
BP	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IEP	Predicted GO
MF	GO:0008137	NADH dehydrogenase (ubiquinone) activity	IEP	Predicted GO
CC	GO:0009986	cell surface	IEP	Predicted GO
MF	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	IEP	Predicted GO
MF	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IEP	Predicted GO
CC	GO:0019005	SCF ubiquitin ligase complex	IEP	Predicted GO
CC	GO:0020008	rhoptry	IEP	Predicted GO
CC	GO:0030119	AP-type membrane coat adaptor complex	IEP	Predicted GO
CC	GO:0030131	clathrin adaptor complex	IEP	Predicted GO
BP	GO:0030260	entry into host cell	IEP	Predicted GO
BP	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
CC	GO:0031226	intrinsic component of plasma membrane	IEP	Predicted GO
MF	GO:0031625	ubiquitin protein ligase binding	IEP	Predicted GO
MF	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	IEP	Predicted GO
MF	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	IEP	Predicted GO
MF	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	IEP	Predicted GO
MF	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity	IEP	Predicted GO
MF	GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IEP	Predicted GO
MF	GO:0044389	ubiquitin-like protein ligase binding	IEP	Predicted GO
BP	GO:0044409	entry into host	IEP	Predicted GO
CC	GO:0044425	membrane part	IEP	Predicted GO
CC	GO:0046658	anchored component of plasma membrane	IEP	Predicted GO
MF	GO:0048038	quinone binding	IEP	Predicted GO
MF	GO:0048039	ubiquinone binding	IEP	Predicted GO
MF	GO:0050136	NADH dehydrogenase (quinone) activity	IEP	Predicted GO
BP	GO:0050746	regulation of lipoprotein metabolic process	IEP	Predicted GO
BP	GO:0050748	negative regulation of lipoprotein metabolic process	IEP	Predicted GO
BP	GO:0051806	entry into cell of other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0051828	entry into other organism involved in symbiotic interaction	IEP	Predicted GO
MF	GO:0052744	phosphatidylinositol monophosphate phosphatase activity	IEP	Predicted GO
MF	GO:0052866	phosphatidylinositol phosphate phosphatase activity	IEP	Predicted GO
MF	GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	IEP	Predicted GO
BP	GO:1903059	regulation of protein lipidation	IEP	Predicted GO
BP	GO:1903060	negative regulation of protein lipidation	IEP	Predicted GO
CC	GO:1990225	rhoptry neck	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002073	PDEase_catalytic_dom	679	905
IPR002073	PDEase_catalytic_dom	1571	1797

External Links

PlasmoDB	2277.t00096
PlasmoDB	811148
PlasmoDB	MAL12P1.95
PlasmoDB	PFL0475w

PF3D7_1209500 (PDEalpha)

Expression Profile

Co-expression Networks

Functional Annotation