PF3D7_1213700 (RPB8)

Aliases : RPB8

Description : SSF50249: "Nucleic acid-binding, OB-fold". Pfam domain(s): PF03870: RNA polymerase Rpb8.

Gene families : OG_01_0002119 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002119_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1213700
Cluster	P. falciparum: Cluster_4

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1429500	RPB8	SSF50249: Nucleic acid-binding, OB-fold. Pfam domain(s):...	0.05	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	ISS	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006351	transcription, DNA-templated	IEA	Interproscan predictions
BP	GO:0006351	transcription, DNA-templated	IEA	PlasmoDB
BP	GO:0006352	DNA-templated transcription, initiation	ISS	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016779	nucleotidyltransferase activity	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0032774	RNA biosynthetic process	None	Extended
MF	GO:0034062	5'-3' RNA polymerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0034654	nucleobase-containing compound biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
BP	GO:0097659	nucleic acid-templated transcription	None	Extended
MF	GO:0097747	RNA polymerase activity	None	Extended
MF	GO:0140098	catalytic activity, acting on RNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
BP	GO:0000122	negative regulation of transcription by RNA polymerase II	IEP	Predicted GO
MF	GO:0000175	3'-5'-exoribonuclease activity	IEP	Predicted GO
CC	GO:0000178	exosome (RNase complex)	IEP	Predicted GO
BP	GO:0000375	RNA splicing, via transesterification reactions	IEP	Predicted GO
BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	IEP	Predicted GO
BP	GO:0000380	alternative mRNA splicing, via spliceosome	IEP	Predicted GO
BP	GO:0000398	mRNA splicing, via spliceosome	IEP	Predicted GO
CC	GO:0000408	EKC/KEOPS complex	IEP	Predicted GO
CC	GO:0000428	DNA-directed RNA polymerase complex	IEP	Predicted GO
BP	GO:0001906	cell killing	IEP	Predicted GO
BP	GO:0002181	cytoplasmic translation	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003714	transcription corepressor activity	IEP	Predicted GO
MF	GO:0003725	double-stranded RNA binding	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IEP	Predicted GO
MF	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	IEP	Predicted GO
MF	GO:0004462	lactoylglutathione lyase activity	IEP	Predicted GO
MF	GO:0004526	ribonuclease P activity	IEP	Predicted GO
MF	GO:0004540	ribonuclease activity	IEP	Predicted GO
MF	GO:0004549	tRNA-specific ribonuclease activity	IEP	Predicted GO
MF	GO:0004551	nucleotide diphosphatase activity	IEP	Predicted GO
MF	GO:0004590	orotidine-5'-phosphate decarboxylase activity	IEP	Predicted GO
MF	GO:0004817	cysteine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005198	structural molecule activity	IEP	Predicted GO
CC	GO:0005665	RNA polymerase II, core complex	IEP	Predicted GO
CC	GO:0005688	U6 snRNP	IEP	Predicted GO
CC	GO:0005730	nucleolus	IEP	Predicted GO
CC	GO:0005732	small nucleolar ribonucleoprotein complex	IEP	Predicted GO
CC	GO:0005840	ribosome	IEP	Predicted GO
CC	GO:0005853	eukaryotic translation elongation factor 1 complex	IEP	Predicted GO
BP	GO:0006072	glycerol-3-phosphate metabolic process	IEP	Predicted GO
BP	GO:0006206	pyrimidine nucleobase metabolic process	IEP	Predicted GO
BP	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	IEP	Predicted GO
BP	GO:0006220	pyrimidine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006221	pyrimidine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006366	transcription by RNA polymerase II	IEP	Predicted GO
BP	GO:0006396	RNA processing	IEP	Predicted GO
BP	GO:0006397	mRNA processing	IEP	Predicted GO
BP	GO:0006412	translation	IEP	Predicted GO
BP	GO:0006423	cysteinyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006518	peptide metabolic process	IEP	Predicted GO
BP	GO:0006749	glutathione metabolic process	IEP	Predicted GO
BP	GO:0008380	RNA splicing	IEP	Predicted GO
BP	GO:0008593	regulation of Notch signaling pathway	IEP	Predicted GO
MF	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	IEP	Predicted GO
CC	GO:0009331	glycerol-3-phosphate dehydrogenase complex	IEP	Predicted GO
BP	GO:0009966	regulation of signal transduction	IEP	Predicted GO
BP	GO:0009967	positive regulation of signal transduction	IEP	Predicted GO
BP	GO:0010646	regulation of cell communication	IEP	Predicted GO
BP	GO:0010647	positive regulation of cell communication	IEP	Predicted GO
CC	GO:0015934	large ribosomal subunit	IEP	Predicted GO
BP	GO:0016071	mRNA metabolic process	IEP	Predicted GO
MF	GO:0016846	carbon-sulfur lyase activity	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
BP	GO:0019835	cytolysis	IEP	Predicted GO
BP	GO:0019856	pyrimidine nucleobase biosynthetic process	IEP	Predicted GO
CC	GO:0022625	cytosolic large ribosomal subunit	IEP	Predicted GO
CC	GO:0022627	cytosolic small ribosomal subunit	IEP	Predicted GO
BP	GO:0023051	regulation of signaling	IEP	Predicted GO
BP	GO:0023056	positive regulation of signaling	IEP	Predicted GO
CC	GO:0030532	small nuclear ribonucleoprotein complex	IEP	Predicted GO
CC	GO:0030677	ribonuclease P complex	IEP	Predicted GO
CC	GO:0030684	preribosome	IEP	Predicted GO
CC	GO:0030880	RNA polymerase complex	IEP	Predicted GO
BP	GO:0031640	killing of cells of other organism	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0042255	ribosome assembly	IEP	Predicted GO
BP	GO:0043043	peptide biosynthetic process	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043604	amide biosynthetic process	IEP	Predicted GO
BP	GO:0044179	hemolysis in other organism	IEP	Predicted GO
BP	GO:0044267	cellular protein metabolic process	IEP	Predicted GO
BP	GO:0044364	disruption of cells of other organism	IEP	Predicted GO
CC	GO:0044391	ribosomal subunit	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044428	nuclear part	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
CC	GO:0044451	nucleoplasm part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
BP	GO:0044764	multi-organism cellular process	IEP	Predicted GO
BP	GO:0045747	positive regulation of Notch signaling pathway	IEP	Predicted GO
BP	GO:0045892	negative regulation of transcription, DNA-templated	IEP	Predicted GO
BP	GO:0046112	nucleobase biosynthetic process	IEP	Predicted GO
BP	GO:0046168	glycerol-3-phosphate catabolic process	IEP	Predicted GO
MF	GO:0046983	protein dimerization activity	IEP	Predicted GO
BP	GO:0048584	positive regulation of response to stimulus	IEP	Predicted GO
BP	GO:0051253	negative regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0051715	cytolysis in other organism	IEP	Predicted GO
BP	GO:0052646	alditol phosphate metabolic process	IEP	Predicted GO
CC	GO:0055029	nuclear DNA-directed RNA polymerase complex	IEP	Predicted GO
CC	GO:0061695	transferase complex, transferring phosphorus-containing groups	IEP	Predicted GO
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	IEP	Predicted GO
CC	GO:0097525	spliceosomal snRNP complex	IEP	Predicted GO
CC	GO:0120114	Sm-like protein family complex	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
CC	GO:1902494	catalytic complex	IEP	Predicted GO
BP	GO:1902679	negative regulation of RNA biosynthetic process	IEP	Predicted GO
BP	GO:1903507	negative regulation of nucleic acid-templated transcription	IEP	Predicted GO
CC	GO:1905354	exoribonuclease complex	IEP	Predicted GO
CC	GO:1990234	transferase complex	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR005570	RNA_pol_Rpb8	8	136

External Links

PlasmoDB	2277.t00134
PlasmoDB	811186
PlasmoDB	MAL12P1.133
PlasmoDB	PFL0665c

PF3D7_1213700 (RPB8)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation