PF3D7_1235600 (SHMT)


Aliases : SHMT

Description : SSF53383: Pyridoxal phosphate-dependent transferase. Pfam domain(s): PF00464: Serine hydroxymethyltransferase.


Gene families : OG_01_0003287 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0003287_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pfa RNA-seq: PF3D7_1235600
Cluster P. falciparum: Cluster_10

Target Alias Description ECC score Gene Family Method Actions
PBANKA_1450200 SHMT SSF53383: Pyridoxal phosphate-dependent transferase.... 0.1 Orthofinderv1.1.8

Type GO Term Name Evidence Source
MF GO:0004372 glycine hydroxymethyltransferase activity TAS PlasmoDB
MF GO:0004372 glycine hydroxymethyltransferase activity IEA PlasmoDB
CC GO:0005737 cytoplasm IDA PlasmoDB
CC GO:0005739 mitochondrion IDA PlasmoDB
BP GO:0006730 one-carbon metabolic process TAS PlasmoDB
BP GO:0019264 glycine biosynthetic process from serine IEA PlasmoDB
CC GO:0020011 apicoplast IDA PlasmoDB
MF GO:0030170 pyridoxal phosphate binding IEA PlasmoDB
BP GO:0035999 tetrahydrofolate interconversion IEA PlasmoDB
BP GO:0070178 D-serine metabolic process IDA PlasmoDB
Type GO Term Name Evidence Source
BP GO:0000041 transition metal ion transport IEP Predicted GO
MF GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity IEP Predicted GO
MF GO:0000234 phosphoethanolamine N-methyltransferase activity IEP Predicted GO
CC GO:0000315 organellar large ribosomal subunit IEP Predicted GO
CC GO:0000502 proteasome complex IEP Predicted GO
MF GO:0003677 DNA binding IEP Predicted GO
MF GO:0003689 DNA clamp loader activity IEP Predicted GO
MF GO:0003756 protein disulfide isomerase activity IEP Predicted GO
MF GO:0003909 DNA ligase activity IEP Predicted GO
MF GO:0003911 DNA ligase (NAD+) activity IEP Predicted GO
MF GO:0003998 acylphosphatase activity IEP Predicted GO
MF GO:0004013 adenosylhomocysteinase activity IEP Predicted GO
MF GO:0004129 cytochrome-c oxidase activity IEP Predicted GO
MF GO:0004170 dUTP diphosphatase activity IEP Predicted GO
MF GO:0004175 endopeptidase activity IEP Predicted GO
MF GO:0004298 threonine-type endopeptidase activity IEP Predicted GO
MF GO:0004354 glutamate dehydrogenase (NADP+) activity IEP Predicted GO
MF GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity IEP Predicted GO
MF GO:0004392 heme oxygenase (decyclizing) activity IEP Predicted GO
MF GO:0004602 glutathione peroxidase activity IEP Predicted GO
MF GO:0004784 superoxide dismutase activity IEP Predicted GO
MF GO:0004791 thioredoxin-disulfide reductase activity IEP Predicted GO
MF GO:0005215 transporter activity IEP Predicted GO
MF GO:0005342 organic acid transmembrane transporter activity IEP Predicted GO
MF GO:0005375 copper ion transmembrane transporter activity IEP Predicted GO
MF GO:0005385 zinc ion transmembrane transporter activity IEP Predicted GO
MF GO:0005483 soluble NSF attachment protein activity IEP Predicted GO
CC GO:0005663 DNA replication factor C complex IEP Predicted GO
CC GO:0005672 transcription factor TFIIA complex IEP Predicted GO
CC GO:0005740 mitochondrial envelope IEP Predicted GO
CC GO:0005762 mitochondrial large ribosomal subunit IEP Predicted GO
CC GO:0005787 signal peptidase complex IEP Predicted GO
CC GO:0005788 endoplasmic reticulum lumen IEP Predicted GO
CC GO:0005813 centrosome IEP Predicted GO
CC GO:0005815 microtubule organizing center IEP Predicted GO
CC GO:0005838 proteasome regulatory particle IEP Predicted GO
CC GO:0005839 proteasome core complex IEP Predicted GO
BP GO:0006108 malate metabolic process IEP Predicted GO
BP GO:0006116 NADH oxidation IEP Predicted GO
BP GO:0006127 glycerophosphate shuttle IEP Predicted GO
BP GO:0006163 purine nucleotide metabolic process IEP Predicted GO
BP GO:0006164 purine nucleotide biosynthetic process IEP Predicted GO
BP GO:0006183 GTP biosynthetic process IEP Predicted GO
BP GO:0006228 UTP biosynthetic process IEP Predicted GO
BP GO:0006259 DNA metabolic process IEP Predicted GO
BP GO:0006260 DNA replication IEP Predicted GO
BP GO:0006270 DNA replication initiation IEP Predicted GO
BP GO:0006271 DNA strand elongation involved in DNA replication IEP Predicted GO
BP GO:0006272 leading strand elongation IEP Predicted GO
BP GO:0006275 regulation of DNA replication IEP Predicted GO
BP GO:0006465 signal peptide processing IEP Predicted GO
BP GO:0006505 GPI anchor metabolic process IEP Predicted GO
BP GO:0006506 GPI anchor biosynthetic process IEP Predicted GO
BP GO:0006508 proteolysis IEP Predicted GO
BP GO:0006511 ubiquitin-dependent protein catabolic process IEP Predicted GO
BP GO:0006537 glutamate biosynthetic process IEP Predicted GO
BP GO:0006643 membrane lipid metabolic process IEP Predicted GO
BP GO:0006644 phospholipid metabolic process IEP Predicted GO
BP GO:0006650 glycerophospholipid metabolic process IEP Predicted GO
BP GO:0006661 phosphatidylinositol biosynthetic process IEP Predicted GO
BP GO:0006664 glycolipid metabolic process IEP Predicted GO
BP GO:0006734 NADH metabolic process IEP Predicted GO
BP GO:0006753 nucleoside phosphate metabolic process IEP Predicted GO
BP GO:0006754 ATP biosynthetic process IEP Predicted GO
BP GO:0006778 porphyrin-containing compound metabolic process IEP Predicted GO
BP GO:0006784 heme a biosynthetic process IEP Predicted GO
BP GO:0006787 porphyrin-containing compound catabolic process IEP Predicted GO
BP GO:0006801 superoxide metabolic process IEP Predicted GO
BP GO:0006811 ion transport IEP Predicted GO
BP GO:0006812 cation transport IEP Predicted GO
BP GO:0006829 zinc ion transport IEP Predicted GO
BP GO:0006835 dicarboxylic acid transport IEP Predicted GO
BP GO:0006979 response to oxidative stress IEP Predicted GO
MF GO:0008121 ubiquinol-cytochrome-c reductase activity IEP Predicted GO
MF GO:0008233 peptidase activity IEP Predicted GO
MF GO:0008324 cation transmembrane transporter activity IEP Predicted GO
MF GO:0008509 anion transmembrane transporter activity IEP Predicted GO
MF GO:0008514 organic anion transmembrane transporter activity IEP Predicted GO
CC GO:0008540 proteasome regulatory particle, base subcomplex IEP Predicted GO
BP GO:0008610 lipid biosynthetic process IEP Predicted GO
BP GO:0008654 phospholipid biosynthetic process IEP Predicted GO
MF GO:0008897 holo-[acyl-carrier-protein] synthase activity IEP Predicted GO
MF GO:0009055 electron transfer activity IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009057 macromolecule catabolic process IEP Predicted GO
BP GO:0009059 macromolecule biosynthetic process IEP Predicted GO
BP GO:0009117 nucleotide metabolic process IEP Predicted GO
BP GO:0009141 nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009142 nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009144 purine nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009145 purine nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009150 purine ribonucleotide metabolic process IEP Predicted GO
BP GO:0009152 purine ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009165 nucleotide biosynthetic process IEP Predicted GO
BP GO:0009199 ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009201 ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009205 purine ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009247 glycolipid biosynthetic process IEP Predicted GO
BP GO:0009259 ribonucleotide metabolic process IEP Predicted GO
BP GO:0009260 ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0010038 response to metal ion IEP Predicted GO
MF GO:0015002 heme-copper terminal oxidase activity IEP Predicted GO
MF GO:0015075 ion transmembrane transporter activity IEP Predicted GO
MF GO:0015077 monovalent inorganic cation transmembrane transporter activity IEP Predicted GO
MF GO:0015078 proton transmembrane transporter activity IEP Predicted GO
MF GO:0015140 malate transmembrane transporter activity IEP Predicted GO
MF GO:0015318 inorganic molecular entity transmembrane transporter activity IEP Predicted GO
MF GO:0015367 oxoglutarate:malate antiporter activity IEP Predicted GO
MF GO:0015556 C4-dicarboxylate transmembrane transporter activity IEP Predicted GO
BP GO:0015711 organic anion transport IEP Predicted GO
BP GO:0015740 C4-dicarboxylate transport IEP Predicted GO
BP GO:0015742 alpha-ketoglutarate transport IEP Predicted GO
BP GO:0015743 malate transport IEP Predicted GO
BP GO:0015849 organic acid transport IEP Predicted GO
BP GO:0015985 energy coupled proton transport, down electrochemical gradient IEP Predicted GO
BP GO:0015986 ATP synthesis coupled proton transport IEP Predicted GO
BP GO:0016043 cellular component organization IEP Predicted GO
MF GO:0016209 antioxidant activity IEP Predicted GO
BP GO:0016485 protein processing IEP Predicted GO
MF GO:0016491 oxidoreductase activity IEP Predicted GO
MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEP Predicted GO
MF GO:0016675 oxidoreductase activity, acting on a heme group of donors IEP Predicted GO
MF GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor IEP Predicted GO
MF GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors IEP Predicted GO
MF GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor IEP Predicted GO
MF GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor IEP Predicted GO
MF GO:0016787 hydrolase activity IEP Predicted GO
MF GO:0016802 trialkylsulfonium hydrolase activity IEP Predicted GO
MF GO:0016860 intramolecular oxidoreductase activity IEP Predicted GO
MF GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds IEP Predicted GO
MF GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEP Predicted GO
CC GO:0019005 SCF ubiquitin ligase complex IEP Predicted GO
BP GO:0019438 aromatic compound biosynthetic process IEP Predicted GO
BP GO:0019538 protein metabolic process IEP Predicted GO
BP GO:0019637 organophosphate metabolic process IEP Predicted GO
BP GO:0019674 NAD metabolic process IEP Predicted GO
BP GO:0019693 ribose phosphate metabolic process IEP Predicted GO
CC GO:0019773 proteasome core complex, alpha-subunit complex IEP Predicted GO
CC GO:0019774 proteasome core complex, beta-subunit complex IEP Predicted GO
BP GO:0019941 modification-dependent protein catabolic process IEP Predicted GO
BP GO:0022607 cellular component assembly IEP Predicted GO
BP GO:0022616 DNA strand elongation IEP Predicted GO
MF GO:0022857 transmembrane transporter activity IEP Predicted GO
MF GO:0022890 inorganic cation transmembrane transporter activity IEP Predicted GO
CC GO:0030134 COPII-coated ER to Golgi transport vesicle IEP Predicted GO
BP GO:0030163 protein catabolic process IEP Predicted GO
MF GO:0030234 enzyme regulator activity IEP Predicted GO
MF GO:0030337 DNA polymerase processivity factor activity IEP Predicted GO
CC GO:0031974 membrane-enclosed lumen IEP Predicted GO
MF GO:0032552 deoxyribonucleotide binding IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033013 tetrapyrrole metabolic process IEP Predicted GO
BP GO:0033015 tetrapyrrole catabolic process IEP Predicted GO
MF GO:0033170 protein-DNA loading ATPase activity IEP Predicted GO
BP GO:0034220 ion transmembrane transport IEP Predicted GO
BP GO:0034308 primary alcohol metabolic process IEP Predicted GO
BP GO:0034622 cellular protein-containing complex assembly IEP Predicted GO
BP GO:0034645 cellular macromolecule biosynthetic process IEP Predicted GO
BP GO:0035434 copper ion transmembrane transport IEP Predicted GO
BP GO:0042167 heme catabolic process IEP Predicted GO
BP GO:0042168 heme metabolic process IEP Predicted GO
BP GO:0042440 pigment metabolic process IEP Predicted GO
CC GO:0042555 MCM complex IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
CC GO:0043233 organelle lumen IEP Predicted GO
BP GO:0043248 proteasome assembly IEP Predicted GO
CC GO:0043626 PCNA complex IEP Predicted GO
BP GO:0043632 modification-dependent macromolecule catabolic process IEP Predicted GO
BP GO:0043648 dicarboxylic acid metabolic process IEP Predicted GO
BP GO:0043933 protein-containing complex subunit organization IEP Predicted GO
BP GO:0044248 cellular catabolic process IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
BP GO:0044265 cellular macromolecule catabolic process IEP Predicted GO
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044429 mitochondrial part IEP Predicted GO
CC GO:0044432 endoplasmic reticulum part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
CC GO:0044796 DNA polymerase processivity factor complex IEP Predicted GO
BP GO:0045017 glycerolipid biosynthetic process IEP Predicted GO
BP GO:0045116 protein neddylation IEP Predicted GO
CC GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) IEP Predicted GO
BP GO:0045454 cell redox homeostasis IEP Predicted GO
BP GO:0046034 ATP metabolic process IEP Predicted GO
BP GO:0046039 GTP metabolic process IEP Predicted GO
BP GO:0046051 UTP metabolic process IEP Predicted GO
BP GO:0046149 pigment catabolic process IEP Predicted GO
BP GO:0046160 heme a metabolic process IEP Predicted GO
BP GO:0046390 ribose phosphate biosynthetic process IEP Predicted GO
BP GO:0046467 membrane lipid biosynthetic process IEP Predicted GO
BP GO:0046474 glycerophospholipid biosynthetic process IEP Predicted GO
BP GO:0046486 glycerolipid metabolic process IEP Predicted GO
MF GO:0046915 transition metal ion transmembrane transporter activity IEP Predicted GO
BP GO:0046942 carboxylic acid transport IEP Predicted GO
MF GO:0046943 carboxylic acid transmembrane transporter activity IEP Predicted GO
BP GO:0051052 regulation of DNA metabolic process IEP Predicted GO
BP GO:0051382 kinetochore assembly IEP Predicted GO
BP GO:0051383 kinetochore organization IEP Predicted GO
BP GO:0051603 proteolysis involved in cellular protein catabolic process IEP Predicted GO
BP GO:0055085 transmembrane transport IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
BP GO:0055114 oxidation-reduction process IEP Predicted GO
BP GO:0061025 membrane fusion IEP Predicted GO
BP GO:0065003 protein-containing complex assembly IEP Predicted GO
MF GO:0070003 threonine-type peptidase activity IEP Predicted GO
MF GO:0070011 peptidase activity, acting on L-amino acid peptides IEP Predicted GO
CC GO:0070013 intracellular organelle lumen IEP Predicted GO
BP GO:0070682 proteasome regulatory particle assembly IEP Predicted GO
BP GO:0071840 cellular component organization or biogenesis IEP Predicted GO
BP GO:0072521 purine-containing compound metabolic process IEP Predicted GO
BP GO:0072522 purine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072593 reactive oxygen species metabolic process IEP Predicted GO
BP GO:0090407 organophosphate biosynthetic process IEP Predicted GO
BP GO:0098655 cation transmembrane transport IEP Predicted GO
BP GO:0098660 inorganic ion transmembrane transport IEP Predicted GO
BP GO:0098662 inorganic cation transmembrane transport IEP Predicted GO
MF GO:0098772 molecular function regulator IEP Predicted GO
CC GO:0098796 membrane protein complex IEP Predicted GO
CC GO:0098798 mitochondrial protein complex IEP Predicted GO
MF GO:0140096 catalytic activity, acting on a protein IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901137 carbohydrate derivative biosynthetic process IEP Predicted GO
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Predicted GO
BP GO:1901565 organonitrogen compound catabolic process IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
CC GO:1902494 catalytic complex IEP Predicted GO
BP GO:1903509 liposaccharide metabolic process IEP Predicted GO
CC GO:1905368 peptidase complex IEP Predicted GO
CC GO:1905369 endopeptidase complex IEP Predicted GO
CC GO:1990204 oxidoreductase complex IEP Predicted GO
InterPro domains Description Start Stop
IPR039429 SHMT-like_dom 7 393
PlasmoDB 2277.t00344
PlasmoDB 811396
PlasmoDB MAL12P1.342
PlasmoDB PFL1720w