PF3D7_1251300 (TMK)

Aliases : TMK

Description : SSF52540: P-loop containing nucleoside triphosphate hydrolase. Pfam domain(s): PF02223: Thymidylate kinase.

Gene families : OG_01_0002248 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002248_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1251300
Cluster	P. falciparum: Cluster_28

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004798	thymidylate kinase activity	IDA	PlasmoDB
MF	GO:0004798	thymidylate kinase activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006220	pyrimidine nucleotide metabolic process	None	Extended
BP	GO:0006221	pyrimidine nucleotide biosynthetic process	None	Extended
BP	GO:0006227	dUDP biosynthetic process	IDA	PlasmoDB
BP	GO:0006233	dTDP biosynthetic process	IEA	PlasmoDB
BP	GO:0006235	dTTP biosynthetic process	IDA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009132	nucleoside diphosphate metabolic process	None	Extended
BP	GO:0009133	nucleoside diphosphate biosynthetic process	None	Extended
BP	GO:0009138	pyrimidine nucleoside diphosphate metabolic process	None	Extended
BP	GO:0009139	pyrimidine nucleoside diphosphate biosynthetic process	None	Extended
BP	GO:0009141	nucleoside triphosphate metabolic process	None	Extended
BP	GO:0009142	nucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009147	pyrimidine nucleoside triphosphate metabolic process	None	Extended
BP	GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009165	nucleotide biosynthetic process	None	Extended
BP	GO:0009186	deoxyribonucleoside diphosphate metabolic process	None	Extended
BP	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process	None	Extended
BP	GO:0009196	pyrimidine deoxyribonucleoside diphosphate metabolic process	None	Extended
BP	GO:0009197	pyrimidine deoxyribonucleoside diphosphate biosynthetic process	None	Extended
BP	GO:0009200	deoxyribonucleoside triphosphate metabolic process	None	Extended
BP	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009211	pyrimidine deoxyribonucleoside triphosphate metabolic process	None	Extended
BP	GO:0009212	pyrimidine deoxyribonucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	None	Extended
BP	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	None	Extended
BP	GO:0009262	deoxyribonucleotide metabolic process	None	Extended
BP	GO:0009263	deoxyribonucleotide biosynthetic process	None	Extended
BP	GO:0009265	2'-deoxyribonucleotide biosynthetic process	None	Extended
BP	GO:0009394	2'-deoxyribonucleotide metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016301	kinase activity	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016776	phosphotransferase activity, phosphate group as acceptor	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
MF	GO:0019205	nucleobase-containing compound kinase activity	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019692	deoxyribose phosphate metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034654	nucleobase-containing compound biosynthetic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042493	response to drug	IDA	PlasmoDB
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046072	dTDP metabolic process	None	Extended
BP	GO:0046075	dTTP metabolic process	None	Extended
BP	GO:0046077	dUDP metabolic process	None	Extended
BP	GO:0046385	deoxyribose phosphate biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0050145	nucleoside monophosphate kinase activity	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072527	pyrimidine-containing compound metabolic process	None	Extended
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	None	Extended
BP	GO:0090407	organophosphate biosynthetic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901137	carbohydrate derivative biosynthetic process	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901293	nucleoside phosphate biosynthetic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006099	tricarboxylic acid cycle	IEP	Predicted GO
BP	GO:0006101	citrate metabolic process	IEP	Predicted GO
BP	GO:0006633	fatty acid biosynthetic process	IEP	Predicted GO
BP	GO:0008064	regulation of actin polymerization or depolymerization	IEP	Predicted GO
CC	GO:0008290	F-actin capping protein complex	IEP	Predicted GO
BP	GO:0009106	lipoate metabolic process	IEP	Predicted GO
BP	GO:0009107	lipoate biosynthetic process	IEP	Predicted GO
CC	GO:0009536	plastid	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016615	malate dehydrogenase activity	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016782	transferase activity, transferring sulfur-containing groups	IEP	Predicted GO
MF	GO:0016783	sulfurtransferase activity	IEP	Predicted GO
MF	GO:0016992	lipoate synthase activity	IEP	Predicted GO
BP	GO:0016999	antibiotic metabolic process	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0020011	apicoplast	IEP	Predicted GO
MF	GO:0030060	L-malate dehydrogenase activity	IEP	Predicted GO
BP	GO:0030832	regulation of actin filament length	IEP	Predicted GO
BP	GO:0030833	regulation of actin filament polymerization	IEP	Predicted GO
BP	GO:0030834	regulation of actin filament depolymerization	IEP	Predicted GO
BP	GO:0030835	negative regulation of actin filament depolymerization	IEP	Predicted GO
BP	GO:0030837	negative regulation of actin filament polymerization	IEP	Predicted GO
BP	GO:0031333	negative regulation of protein complex assembly	IEP	Predicted GO
BP	GO:0032271	regulation of protein polymerization	IEP	Predicted GO
BP	GO:0032272	negative regulation of protein polymerization	IEP	Predicted GO
BP	GO:0032535	regulation of cellular component size	IEP	Predicted GO
BP	GO:0032956	regulation of actin cytoskeleton organization	IEP	Predicted GO
BP	GO:0032970	regulation of actin filament-based process	IEP	Predicted GO
BP	GO:0033043	regulation of organelle organization	IEP	Predicted GO
BP	GO:0043242	negative regulation of protein complex disassembly	IEP	Predicted GO
BP	GO:0043244	regulation of protein complex disassembly	IEP	Predicted GO
BP	GO:0043254	regulation of protein complex assembly	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0044087	regulation of cellular component biogenesis	IEP	Predicted GO
BP	GO:0044272	sulfur compound biosynthetic process	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
MF	GO:0044877	protein-containing complex binding	IEP	Predicted GO
BP	GO:0048519	negative regulation of biological process	IEP	Predicted GO
BP	GO:0048523	negative regulation of cellular process	IEP	Predicted GO
MF	GO:0051015	actin filament binding	IEP	Predicted GO
BP	GO:0051016	barbed-end actin filament capping	IEP	Predicted GO
BP	GO:0051128	regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051493	regulation of cytoskeleton organization	IEP	Predicted GO
BP	GO:0051494	negative regulation of cytoskeleton organization	IEP	Predicted GO
MF	GO:0051536	iron-sulfur cluster binding	IEP	Predicted GO
MF	GO:0051539	4 iron, 4 sulfur cluster binding	IEP	Predicted GO
MF	GO:0051540	metal cluster binding	IEP	Predicted GO
BP	GO:0051693	actin filament capping	IEP	Predicted GO
BP	GO:0072350	tricarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0090066	regulation of anatomical structure size	IEP	Predicted GO
BP	GO:0110053	regulation of actin filament organization	IEP	Predicted GO
BP	GO:1901879	regulation of protein depolymerization	IEP	Predicted GO
BP	GO:1901880	negative regulation of protein depolymerization	IEP	Predicted GO
BP	GO:1902903	regulation of supramolecular fiber organization	IEP	Predicted GO
BP	GO:1902904	negative regulation of supramolecular fiber organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR039430	Thymidylate_kin_like_dom	13	191

External Links

PlasmoDB	2277.t00493
PlasmoDB	811545
PlasmoDB	MAL12P1.490
PlasmoDB	PFL2465c

PF3D7_1251300 (TMK)

Expression Profile

Co-expression Networks

Functional Annotation