PF3D7_1324900 (LDH)


Aliases : LDH

Description : SSF51735: NAD(P)-binding domain superfamily, SSF56327: "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal". Pfam domain(s): PF02866: "lactate/malate dehydrogenase, alpha/beta C-terminal domain", PF00056: "lactate/malate dehydrogenase, NAD binding domain".


Gene families : OG_01_0000387 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000387_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pfa RNA-seq: PF3D7_1324900
Cluster P. falciparum: Cluster_11

Target Alias Description ECC score Gene Family Method Actions
PBANKA_1340100 LDH SSF51735: NAD(P)-binding domain superfamily, SSF56327:... 0.2 Orthofinderv1.1.8

Type GO Term Name Evidence Source
MF GO:0003824 catalytic activity IEA PlasmoDB
MF GO:0004459 L-lactate dehydrogenase activity TAS PlasmoDB
MF GO:0005515 protein binding IPI PlasmoDB
CC GO:0005622 intracellular ISO PlasmoDB
BP GO:0005975 carbohydrate metabolic process IEA PlasmoDB
BP GO:0006096 glycolytic process TAS PlasmoDB
CC GO:0009986 cell surface RCA PlasmoDB
MF GO:0016491 oxidoreductase activity IEA Interproscan predictions
MF GO:0016491 oxidoreductase activity IEA PlasmoDB
MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA Interproscan predictions
MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA PlasmoDB
BP GO:0019752 carboxylic acid metabolic process IEA PlasmoDB
BP GO:0055114 oxidation-reduction process IEA Interproscan predictions
BP GO:0055114 oxidation-reduction process IEA PlasmoDB
CC GO:1903561 extracellular vesicle RCA PlasmoDB
Type GO Term Name Evidence Source
CC GO:0000015 phosphopyruvate hydratase complex IEP Predicted GO
BP GO:0000045 autophagosome assembly IEP Predicted GO
MF GO:0000287 magnesium ion binding IEP Predicted GO
MF GO:0000339 RNA cap binding IEP Predicted GO
BP GO:0000375 RNA splicing, via transesterification reactions IEP Predicted GO
BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile IEP Predicted GO
BP GO:0000398 mRNA splicing, via spliceosome IEP Predicted GO
BP GO:0001678 cellular glucose homeostasis IEP Predicted GO
CC GO:0002189 ribose phosphate diphosphokinase complex IEP Predicted GO
BP GO:0002253 activation of immune response IEP Predicted GO
BP GO:0002684 positive regulation of immune system process IEP Predicted GO
MF GO:0003676 nucleic acid binding IEP Predicted GO
MF GO:0003723 RNA binding IEP Predicted GO
MF GO:0003725 double-stranded RNA binding IEP Predicted GO
MF GO:0003729 mRNA binding IEP Predicted GO
MF GO:0003735 structural constituent of ribosome IEP Predicted GO
MF GO:0003746 translation elongation factor activity IEP Predicted GO
MF GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity IEP Predicted GO
MF GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEP Predicted GO
MF GO:0004396 hexokinase activity IEP Predicted GO
MF GO:0004618 phosphoglycerate kinase activity IEP Predicted GO
MF GO:0004619 phosphoglycerate mutase activity IEP Predicted GO
MF GO:0004634 phosphopyruvate hydratase activity IEP Predicted GO
MF GO:0004731 purine-nucleoside phosphorylase activity IEP Predicted GO
MF GO:0004735 pyrroline-5-carboxylate reductase activity IEP Predicted GO
MF GO:0004743 pyruvate kinase activity IEP Predicted GO
MF GO:0004749 ribose phosphate diphosphokinase activity IEP Predicted GO
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Predicted GO
MF GO:0004814 arginine-tRNA ligase activity IEP Predicted GO
MF GO:0004816 asparagine-tRNA ligase activity IEP Predicted GO
MF GO:0004824 lysine-tRNA ligase activity IEP Predicted GO
MF GO:0004828 serine-tRNA ligase activity IEP Predicted GO
MF GO:0005198 structural molecule activity IEP Predicted GO
MF GO:0005536 glucose binding IEP Predicted GO
CC GO:0005746 mitochondrial respirasome IEP Predicted GO
CC GO:0005829 cytosol IEP Predicted GO
CC GO:0005840 ribosome IEP Predicted GO
CC GO:0005956 protein kinase CK2 complex IEP Predicted GO
BP GO:0005996 monosaccharide metabolic process IEP Predicted GO
BP GO:0006006 glucose metabolic process IEP Predicted GO
BP GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEP Predicted GO
BP GO:0006094 gluconeogenesis IEP Predicted GO
BP GO:0006148 inosine catabolic process IEP Predicted GO
BP GO:0006152 purine nucleoside catabolic process IEP Predicted GO
BP GO:0006366 transcription by RNA polymerase II IEP Predicted GO
BP GO:0006397 mRNA processing IEP Predicted GO
BP GO:0006399 tRNA metabolic process IEP Predicted GO
BP GO:0006412 translation IEP Predicted GO
BP GO:0006414 translational elongation IEP Predicted GO
BP GO:0006418 tRNA aminoacylation for protein translation IEP Predicted GO
BP GO:0006420 arginyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006421 asparaginyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006430 lysyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006434 seryl-tRNA aminoacylation IEP Predicted GO
BP GO:0006449 regulation of translational termination IEP Predicted GO
BP GO:0006452 translational frameshifting IEP Predicted GO
BP GO:0006518 peptide metabolic process IEP Predicted GO
BP GO:0006520 cellular amino acid metabolic process IEP Predicted GO
BP GO:0006528 asparagine metabolic process IEP Predicted GO
BP GO:0006529 asparagine biosynthetic process IEP Predicted GO
BP GO:0006560 proline metabolic process IEP Predicted GO
BP GO:0006561 proline biosynthetic process IEP Predicted GO
MF GO:0008097 5S rRNA binding IEP Predicted GO
MF GO:0008135 translation factor activity, RNA binding IEP Predicted GO
MF GO:0008379 thioredoxin peroxidase activity IEP Predicted GO
BP GO:0008380 RNA splicing IEP Predicted GO
BP GO:0008652 cellular amino acid biosynthetic process IEP Predicted GO
BP GO:0009059 macromolecule biosynthetic process IEP Predicted GO
BP GO:0009067 aspartate family amino acid biosynthetic process IEP Predicted GO
BP GO:0009164 nucleoside catabolic process IEP Predicted GO
BP GO:0009891 positive regulation of biosynthetic process IEP Predicted GO
BP GO:0010557 positive regulation of macromolecule biosynthetic process IEP Predicted GO
BP GO:0010628 positive regulation of gene expression IEP Predicted GO
CC GO:0015934 large ribosomal subunit IEP Predicted GO
CC GO:0015935 small ribosomal subunit IEP Predicted GO
BP GO:0015959 diadenosine polyphosphate metabolic process IEP Predicted GO
BP GO:0015960 diadenosine polyphosphate biosynthetic process IEP Predicted GO
BP GO:0015965 diadenosine tetraphosphate metabolic process IEP Predicted GO
BP GO:0015966 diadenosine tetraphosphate biosynthetic process IEP Predicted GO
BP GO:0016051 carbohydrate biosynthetic process IEP Predicted GO
BP GO:0016070 RNA metabolic process IEP Predicted GO
BP GO:0016071 mRNA metabolic process IEP Predicted GO
CC GO:0016281 eukaryotic translation initiation factor 4F complex IEP Predicted GO
MF GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEP Predicted GO
MF GO:0016774 phosphotransferase activity, carboxyl group as acceptor IEP Predicted GO
MF GO:0016835 carbon-oxygen lyase activity IEP Predicted GO
MF GO:0016836 hydro-lyase activity IEP Predicted GO
MF GO:0016874 ligase activity IEP Predicted GO
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Predicted GO
MF GO:0019200 carbohydrate kinase activity IEP Predicted GO
BP GO:0019318 hexose metabolic process IEP Predicted GO
BP GO:0019319 hexose biosynthetic process IEP Predicted GO
BP GO:0019538 protein metabolic process IEP Predicted GO
MF GO:0019843 rRNA binding IEP Predicted GO
CC GO:0022625 cytosolic large ribosomal subunit IEP Predicted GO
CC GO:0022627 cytosolic small ribosomal subunit IEP Predicted GO
BP GO:0030091 protein repair IEP Predicted GO
MF GO:0030621 U4 snRNA binding IEP Predicted GO
BP GO:0031328 positive regulation of cellular biosynthetic process IEP Predicted GO
BP GO:0032270 positive regulation of cellular protein metabolic process IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033500 carbohydrate homeostasis IEP Predicted GO
MF GO:0033677 DNA/RNA helicase activity IEP Predicted GO
MF GO:0033679 3'-5' DNA/RNA helicase activity IEP Predicted GO
BP GO:0034250 positive regulation of cellular amide metabolic process IEP Predicted GO
MF GO:0034511 U3 snoRNA binding IEP Predicted GO
BP GO:0034645 cellular macromolecule biosynthetic process IEP Predicted GO
BP GO:0034656 nucleobase-containing small molecule catabolic process IEP Predicted GO
BP GO:0035915 pore formation in membrane of other organism IEP Predicted GO
MF GO:0036524 protein deglycase activity IEP Predicted GO
BP GO:0036525 protein deglycation IEP Predicted GO
BP GO:0042255 ribosome assembly IEP Predicted GO
BP GO:0042256 mature ribosome assembly IEP Predicted GO
BP GO:0042262 DNA protection IEP Predicted GO
BP GO:0042454 ribonucleoside catabolic process IEP Predicted GO
BP GO:0042593 glucose homeostasis IEP Predicted GO
MF GO:0043021 ribonucleoprotein complex binding IEP Predicted GO
MF GO:0043022 ribosome binding IEP Predicted GO
MF GO:0043023 ribosomal large subunit binding IEP Predicted GO
BP GO:0043038 amino acid activation IEP Predicted GO
BP GO:0043039 tRNA aminoacylation IEP Predicted GO
BP GO:0043043 peptide biosynthetic process IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
CC GO:0043228 non-membrane-bounded organelle IEP Predicted GO
CC GO:0043229 intracellular organelle IEP Predicted GO
CC GO:0043232 intracellular non-membrane-bounded organelle IEP Predicted GO
BP GO:0043243 positive regulation of protein complex disassembly IEP Predicted GO
BP GO:0043244 regulation of protein complex disassembly IEP Predicted GO
BP GO:0043603 cellular amide metabolic process IEP Predicted GO
BP GO:0043604 amide biosynthetic process IEP Predicted GO
MF GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity IEP Predicted GO
CC GO:0044161 host cell cytoplasmic vesicle IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
BP GO:0044267 cellular protein metabolic process IEP Predicted GO
CC GO:0044391 ribosomal subunit IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044444 cytoplasmic part IEP Predicted GO
CC GO:0044445 cytosolic part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
BP GO:0044657 pore formation in membrane of other organism during symbiotic interaction IEP Predicted GO
BP GO:0044658 pore formation in membrane of host by symbiont IEP Predicted GO
MF GO:0044877 protein-containing complex binding IEP Predicted GO
BP GO:0045727 positive regulation of translation IEP Predicted GO
BP GO:0045901 positive regulation of translational elongation IEP Predicted GO
BP GO:0045905 positive regulation of translational termination IEP Predicted GO
BP GO:0046102 inosine metabolic process IEP Predicted GO
BP GO:0046130 purine ribonucleoside catabolic process IEP Predicted GO
BP GO:0046364 monosaccharide biosynthetic process IEP Predicted GO
BP GO:0046391 5-phosphoribose 1-diphosphate metabolic process IEP Predicted GO
MF GO:0048029 monosaccharide binding IEP Predicted GO
BP GO:0048518 positive regulation of biological process IEP Predicted GO
BP GO:0048584 positive regulation of response to stimulus IEP Predicted GO
BP GO:0050778 positive regulation of immune response IEP Predicted GO
BP GO:0051247 positive regulation of protein metabolic process IEP Predicted GO
BP GO:0051260 protein homooligomerization IEP Predicted GO
BP GO:0051262 protein tetramerization IEP Predicted GO
BP GO:0051289 protein homotetramerization IEP Predicted GO
BP GO:0051673 membrane disruption in other organism IEP Predicted GO
BP GO:0052025 modification by symbiont of host cell membrane IEP Predicted GO
BP GO:0052043 modification by symbiont of host cellular component IEP Predicted GO
BP GO:0052111 modification by symbiont of host structure IEP Predicted GO
BP GO:0052185 modification of structure of other organism involved in symbiotic interaction IEP Predicted GO
BP GO:0052188 modification of cellular component in other organism involved in symbiotic interaction IEP Predicted GO
BP GO:0052332 modification by organism of membrane in other organism involved in symbiotic interaction IEP Predicted GO
CC GO:0061695 transferase complex, transferring phosphorus-containing groups IEP Predicted GO
CC GO:0070469 respirasome IEP Predicted GO
BP GO:0070925 organelle assembly IEP Predicted GO
BP GO:0090304 nucleic acid metabolic process IEP Predicted GO
MF GO:0097159 organic cyclic compound binding IEP Predicted GO
MF GO:0140098 catalytic activity, acting on RNA IEP Predicted GO
MF GO:0140101 catalytic activity, acting on a tRNA IEP Predicted GO
MF GO:1901363 heterocyclic compound binding IEP Predicted GO
BP GO:1901605 alpha-amino acid metabolic process IEP Predicted GO
BP GO:1901607 alpha-amino acid biosynthetic process IEP Predicted GO
BP GO:1901658 glycosyl compound catabolic process IEP Predicted GO
BP GO:1905037 autophagosome organization IEP Predicted GO
CC GO:1990904 ribonucleoprotein complex IEP Predicted GO
InterPro domains Description Start Stop
IPR022383 Lactate/malate_DH_C 153 310
IPR001236 Lactate/malate_DH_N 6 149
PlasmoDB 814112
PlasmoDB PF13_0141