PF3D7_1345700 (IDH)


Aliases : IDH

Description : SSF53659: No description available. Pfam domain(s): PF00180: Isocitrate/isopropylmalate dehydrogenase.


Gene families : OG_01_0000395 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000395_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pfa RNA-seq: PF3D7_1345700
Cluster P. falciparum: Cluster_43

Target Alias Description ECC score Gene Family Method Actions
PBANKA_1358600 IDH SSF53659: 20-02-2019. Pfam domain(s): PF00180:... 0.03 Orthofinderv1.1.8

Type GO Term Name Evidence Source
MF GO:0000287 magnesium ion binding IEA PlasmoDB
MF GO:0004450 isocitrate dehydrogenase (NADP+) activity ISS PlasmoDB
MF GO:0004450 isocitrate dehydrogenase (NADP+) activity IEA PlasmoDB
CC GO:0005739 mitochondrion IDA PlasmoDB
BP GO:0006099 tricarboxylic acid cycle IMP PlasmoDB
BP GO:0006102 isocitrate metabolic process ISS PlasmoDB
BP GO:0006102 isocitrate metabolic process IEA PlasmoDB
MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA Interproscan predictions
MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA PlasmoDB
MF GO:0051287 NAD binding IEA PlasmoDB
BP GO:0055114 oxidation-reduction process IEA Interproscan predictions
BP GO:0055114 oxidation-reduction process IEA PlasmoDB
Type GO Term Name Evidence Source
MF GO:0000036 acyl carrier activity IEP Predicted GO
MF GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEP Predicted GO
MF GO:0000234 phosphoethanolamine N-methyltransferase activity IEP Predicted GO
CC GO:0000502 proteasome complex IEP Predicted GO
BP GO:0001678 cellular glucose homeostasis IEP Predicted GO
MF GO:0003677 DNA binding IEP Predicted GO
MF GO:0003689 DNA clamp loader activity IEP Predicted GO
MF GO:0003909 DNA ligase activity IEP Predicted GO
MF GO:0003911 DNA ligase (NAD+) activity IEP Predicted GO
MF GO:0003998 acylphosphatase activity IEP Predicted GO
MF GO:0004000 adenosine deaminase activity IEP Predicted GO
MF GO:0004019 adenylosuccinate synthase activity IEP Predicted GO
MF GO:0004170 dUTP diphosphatase activity IEP Predicted GO
MF GO:0004175 endopeptidase activity IEP Predicted GO
MF GO:0004222 metalloendopeptidase activity IEP Predicted GO
MF GO:0004298 threonine-type endopeptidase activity IEP Predicted GO
MF GO:0004396 hexokinase activity IEP Predicted GO
MF GO:0004602 glutathione peroxidase activity IEP Predicted GO
MF GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity IEP Predicted GO
MF GO:0004731 purine-nucleoside phosphorylase activity IEP Predicted GO
MF GO:0004784 superoxide dismutase activity IEP Predicted GO
MF GO:0004791 thioredoxin-disulfide reductase activity IEP Predicted GO
MF GO:0004807 triose-phosphate isomerase activity IEP Predicted GO
MF GO:0004825 methionine-tRNA ligase activity IEP Predicted GO
MF GO:0004839 ubiquitin activating enzyme activity IEP Predicted GO
MF GO:0005342 organic acid transmembrane transporter activity IEP Predicted GO
MF GO:0005483 soluble NSF attachment protein activity IEP Predicted GO
MF GO:0005515 protein binding IEP Predicted GO
MF GO:0005527 macrolide binding IEP Predicted GO
MF GO:0005528 FK506 binding IEP Predicted GO
MF GO:0005536 glucose binding IEP Predicted GO
CC GO:0005622 intracellular IEP Predicted GO
CC GO:0005663 DNA replication factor C complex IEP Predicted GO
CC GO:0005743 mitochondrial inner membrane IEP Predicted GO
CC GO:0005829 cytosol IEP Predicted GO
CC GO:0005839 proteasome core complex IEP Predicted GO
BP GO:0006081 cellular aldehyde metabolic process IEP Predicted GO
BP GO:0006091 generation of precursor metabolites and energy IEP Predicted GO
BP GO:0006096 glycolytic process IEP Predicted GO
BP GO:0006098 pentose-phosphate shunt IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006148 inosine catabolic process IEP Predicted GO
BP GO:0006152 purine nucleoside catabolic process IEP Predicted GO
BP GO:0006163 purine nucleotide metabolic process IEP Predicted GO
BP GO:0006164 purine nucleotide biosynthetic process IEP Predicted GO
BP GO:0006167 AMP biosynthetic process IEP Predicted GO
BP GO:0006260 DNA replication IEP Predicted GO
BP GO:0006271 DNA strand elongation involved in DNA replication IEP Predicted GO
BP GO:0006272 leading strand elongation IEP Predicted GO
BP GO:0006431 methionyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006457 protein folding IEP Predicted GO
BP GO:0006458 'de novo' protein folding IEP Predicted GO
BP GO:0006508 proteolysis IEP Predicted GO
BP GO:0006511 ubiquitin-dependent protein catabolic process IEP Predicted GO
BP GO:0006607 NLS-bearing protein import into nucleus IEP Predicted GO
BP GO:0006627 protein processing involved in protein targeting to mitochondrion IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006733 oxidoreduction coenzyme metabolic process IEP Predicted GO
BP GO:0006739 NADP metabolic process IEP Predicted GO
BP GO:0006753 nucleoside phosphate metabolic process IEP Predicted GO
BP GO:0006754 ATP biosynthetic process IEP Predicted GO
BP GO:0006757 ATP generation from ADP IEP Predicted GO
BP GO:0006784 heme a biosynthetic process IEP Predicted GO
BP GO:0006793 phosphorus metabolic process IEP Predicted GO
BP GO:0006796 phosphate-containing compound metabolic process IEP Predicted GO
BP GO:0006801 superoxide metabolic process IEP Predicted GO
BP GO:0006807 nitrogen compound metabolic process IEP Predicted GO
BP GO:0006835 dicarboxylic acid transport IEP Predicted GO
BP GO:0006839 mitochondrial transport IEP Predicted GO
BP GO:0006950 response to stress IEP Predicted GO
BP GO:0006979 response to oxidative stress IEP Predicted GO
MF GO:0008168 methyltransferase activity IEP Predicted GO
MF GO:0008170 N-methyltransferase activity IEP Predicted GO
MF GO:0008233 peptidase activity IEP Predicted GO
MF GO:0008509 anion transmembrane transporter activity IEP Predicted GO
MF GO:0008514 organic anion transmembrane transporter activity IEP Predicted GO
BP GO:0008535 respiratory chain complex IV assembly IEP Predicted GO
BP GO:0008610 lipid biosynthetic process IEP Predicted GO
MF GO:0008641 ubiquitin-like modifier activating enzyme activity IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009057 macromolecule catabolic process IEP Predicted GO
BP GO:0009058 biosynthetic process IEP Predicted GO
BP GO:0009117 nucleotide metabolic process IEP Predicted GO
BP GO:0009123 nucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009124 nucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009126 purine nucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009127 purine nucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009135 purine nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009141 nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009142 nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009144 purine nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009145 purine nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009150 purine ribonucleotide metabolic process IEP Predicted GO
BP GO:0009152 purine ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009156 ribonucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009161 ribonucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009164 nucleoside catabolic process IEP Predicted GO
BP GO:0009165 nucleotide biosynthetic process IEP Predicted GO
BP GO:0009167 purine ribonucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009179 purine ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009185 ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009199 ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009201 ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009205 purine ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009259 ribonucleotide metabolic process IEP Predicted GO
BP GO:0009260 ribonucleotide biosynthetic process IEP Predicted GO
CC GO:0009536 plastid IEP Predicted GO
BP GO:0010033 response to organic substance IEP Predicted GO
BP GO:0010243 response to organonitrogen compound IEP Predicted GO
BP GO:0010498 proteasomal protein catabolic process IEP Predicted GO
BP GO:0010564 regulation of cell cycle process IEP Predicted GO
MF GO:0015140 malate transmembrane transporter activity IEP Predicted GO
MF GO:0015367 oxoglutarate:malate antiporter activity IEP Predicted GO
MF GO:0015556 C4-dicarboxylate transmembrane transporter activity IEP Predicted GO
BP GO:0015711 organic anion transport IEP Predicted GO
BP GO:0015740 C4-dicarboxylate transport IEP Predicted GO
BP GO:0015742 alpha-ketoglutarate transport IEP Predicted GO
BP GO:0015743 malate transport IEP Predicted GO
BP GO:0015849 organic acid transport IEP Predicted GO
BP GO:0016052 carbohydrate catabolic process IEP Predicted GO
MF GO:0016209 antioxidant activity IEP Predicted GO
CC GO:0016272 prefoldin complex IEP Predicted GO
MF GO:0016462 pyrophosphatase activity IEP Predicted GO
BP GO:0016485 protein processing IEP Predicted GO
MF GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor IEP Predicted GO
MF GO:0016741 transferase activity, transferring one-carbon groups IEP Predicted GO
MF GO:0016787 hydrolase activity IEP Predicted GO
MF GO:0016817 hydrolase activity, acting on acid anhydrides IEP Predicted GO
MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEP Predicted GO
MF GO:0016874 ligase activity IEP Predicted GO
BP GO:0017004 cytochrome complex assembly IEP Predicted GO
BP GO:0017038 protein import IEP Predicted GO
BP GO:0017062 respiratory chain complex III assembly IEP Predicted GO
CC GO:0017087 mitochondrial processing peptidase complex IEP Predicted GO
CC GO:0019005 SCF ubiquitin ligase complex IEP Predicted GO
MF GO:0019239 deaminase activity IEP Predicted GO
BP GO:0019359 nicotinamide nucleotide biosynthetic process IEP Predicted GO
BP GO:0019362 pyridine nucleotide metabolic process IEP Predicted GO
BP GO:0019363 pyridine nucleotide biosynthetic process IEP Predicted GO
BP GO:0019439 aromatic compound catabolic process IEP Predicted GO
BP GO:0019538 protein metabolic process IEP Predicted GO
BP GO:0019637 organophosphate metabolic process IEP Predicted GO
BP GO:0019682 glyceraldehyde-3-phosphate metabolic process IEP Predicted GO
BP GO:0019693 ribose phosphate metabolic process IEP Predicted GO
CC GO:0019773 proteasome core complex, alpha-subunit complex IEP Predicted GO
CC GO:0019866 organelle inner membrane IEP Predicted GO
BP GO:0019941 modification-dependent protein catabolic process IEP Predicted GO
MF GO:0019948 SUMO activating enzyme activity IEP Predicted GO
CC GO:0020011 apicoplast IEP Predicted GO
BP GO:0022607 cellular component assembly IEP Predicted GO
BP GO:0022616 DNA strand elongation IEP Predicted GO
BP GO:0030163 protein catabolic process IEP Predicted GO
MF GO:0030337 DNA polymerase processivity factor activity IEP Predicted GO
BP GO:0030433 ubiquitin-dependent ERAD pathway IEP Predicted GO
MF GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IEP Predicted GO
CC GO:0031090 organelle membrane IEP Predicted GO
CC GO:0031966 mitochondrial membrane IEP Predicted GO
BP GO:0032446 protein modification by small protein conjugation IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033108 mitochondrial respiratory chain complex assembly IEP Predicted GO
MF GO:0033170 protein-DNA loading ATPase activity IEP Predicted GO
BP GO:0033500 carbohydrate homeostasis IEP Predicted GO
BP GO:0034551 mitochondrial respiratory chain complex III assembly IEP Predicted GO
BP GO:0034622 cellular protein-containing complex assembly IEP Predicted GO
BP GO:0034641 cellular nitrogen compound metabolic process IEP Predicted GO
BP GO:0034655 nucleobase-containing compound catabolic process IEP Predicted GO
BP GO:0034656 nucleobase-containing small molecule catabolic process IEP Predicted GO
BP GO:0034976 response to endoplasmic reticulum stress IEP Predicted GO
BP GO:0034982 mitochondrial protein processing IEP Predicted GO
BP GO:0036503 ERAD pathway IEP Predicted GO
BP GO:0042026 protein refolding IEP Predicted GO
BP GO:0042221 response to chemical IEP Predicted GO
BP GO:0042454 ribonucleoside catabolic process IEP Predicted GO
BP GO:0042493 response to drug IEP Predicted GO
BP GO:0042593 glucose homeostasis IEP Predicted GO
BP GO:0042866 pyruvate biosynthetic process IEP Predicted GO
BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEP Predicted GO
MF GO:0043168 anion binding IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
BP GO:0043632 modification-dependent macromolecule catabolic process IEP Predicted GO
BP GO:0043933 protein-containing complex subunit organization IEP Predicted GO
BP GO:0044248 cellular catabolic process IEP Predicted GO
BP GO:0044249 cellular biosynthetic process IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
BP GO:0044265 cellular macromolecule catabolic process IEP Predicted GO
BP GO:0044270 cellular nitrogen compound catabolic process IEP Predicted GO
CC GO:0044427 chromosomal part IEP Predicted GO
CC GO:0044429 mitochondrial part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
MF GO:0044620 ACP phosphopantetheine attachment site binding IEP Predicted GO
BP GO:0045116 protein neddylation IEP Predicted GO
CC GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) IEP Predicted GO
BP GO:0046031 ADP metabolic process IEP Predicted GO
BP GO:0046033 AMP metabolic process IEP Predicted GO
BP GO:0046034 ATP metabolic process IEP Predicted GO
BP GO:0046102 inosine metabolic process IEP Predicted GO
BP GO:0046130 purine ribonucleoside catabolic process IEP Predicted GO
BP GO:0046160 heme a metabolic process IEP Predicted GO
BP GO:0046390 ribose phosphate biosynthetic process IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
BP GO:0046496 nicotinamide nucleotide metabolic process IEP Predicted GO
BP GO:0046700 heterocycle catabolic process IEP Predicted GO
BP GO:0046942 carboxylic acid transport IEP Predicted GO
MF GO:0046943 carboxylic acid transmembrane transporter activity IEP Predicted GO
MF GO:0046982 protein heterodimerization activity IEP Predicted GO
MF GO:0046983 protein dimerization activity IEP Predicted GO
MF GO:0048029 monosaccharide binding IEP Predicted GO
MF GO:0050661 NADP binding IEP Predicted GO
BP GO:0050794 regulation of cellular process IEP Predicted GO
BP GO:0051131 chaperone-mediated protein complex assembly IEP Predicted GO
BP GO:0051156 glucose 6-phosphate metabolic process IEP Predicted GO
MF GO:0051192 prosthetic group binding IEP Predicted GO
BP GO:0051382 kinetochore assembly IEP Predicted GO
BP GO:0051383 kinetochore organization IEP Predicted GO
BP GO:0051603 proteolysis involved in cellular protein catabolic process IEP Predicted GO
BP GO:0051726 regulation of cell cycle IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
MF GO:0061608 nuclear import signal receptor activity IEP Predicted GO
BP GO:0065003 protein-containing complex assembly IEP Predicted GO
MF GO:0070003 threonine-type peptidase activity IEP Predicted GO
MF GO:0070011 peptidase activity, acting on L-amino acid peptides IEP Predicted GO
BP GO:0070070 proton-transporting V-type ATPase complex assembly IEP Predicted GO
BP GO:0070071 proton-transporting two-sector ATPase complex assembly IEP Predicted GO
BP GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly IEP Predicted GO
MF GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEP Predicted GO
MF GO:0070402 NADPH binding IEP Predicted GO
MF GO:0070628 proteasome binding IEP Predicted GO
BP GO:0070647 protein modification by small protein conjugation or removal IEP Predicted GO
BP GO:0071702 organic substance transport IEP Predicted GO
BP GO:0072330 monocarboxylic acid biosynthetic process IEP Predicted GO
BP GO:0072521 purine-containing compound metabolic process IEP Predicted GO
BP GO:0072522 purine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072524 pyridine-containing compound metabolic process IEP Predicted GO
BP GO:0072593 reactive oxygen species metabolic process IEP Predicted GO
BP GO:0090407 organophosphate biosynthetic process IEP Predicted GO
CC GO:0098798 mitochondrial protein complex IEP Predicted GO
MF GO:0140096 catalytic activity, acting on a protein IEP Predicted GO
MF GO:0140104 molecular carrier activity IEP Predicted GO
MF GO:0140110 transcription regulator activity IEP Predicted GO
MF GO:0140142 nucleocytoplasmic carrier activity IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
BP GO:1901361 organic cyclic compound catabolic process IEP Predicted GO
BP GO:1901564 organonitrogen compound metabolic process IEP Predicted GO
BP GO:1901565 organonitrogen compound catabolic process IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
BP GO:1901576 organic substance biosynthetic process IEP Predicted GO
BP GO:1901658 glycosyl compound catabolic process IEP Predicted GO
BP GO:1901698 response to nitrogen compound IEP Predicted GO
CC GO:1905368 peptidase complex IEP Predicted GO
CC GO:1905369 endopeptidase complex IEP Predicted GO
InterPro domains Description Start Stop
IPR024084 IsoPropMal-DH-like_dom 35 426
PlasmoDB 814208
PlasmoDB PF13_0242