PF3D7_1355100 (MCM6)

Aliases : MCM6

Description : SSF50249: "Nucleic acid-binding, OB-fold", SSF52540: P-loop containing nucleoside triphosphate hydrolase. Pfam domain(s): PF00493: MCM P-loop domain, PF14551: MCM N-terminal domain, PF17207: MCM OB domain, PF18263: MCM6 C-terminal winged-helix domain, PF17855: MCM AAA-lid domain.

Gene families : OG_01_0001483 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001483_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1355100
Cluster	P. falciparum: Cluster_31

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1131600	MCM6	SSF50249: Nucleic acid-binding, OB-fold, SSF52540:...	0.17	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	ISS	PlasmoDB
MF	GO:0003677	DNA binding	IEA	Interproscan predictions
MF	GO:0003677	DNA binding	IEA	PlasmoDB
MF	GO:0003678	DNA helicase activity	IEA	PlasmoDB
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004386	helicase activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IPI	PlasmoDB
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	PlasmoDB
CC	GO:0005737	cytoplasm	IDA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	PlasmoDB
BP	GO:0006270	DNA replication initiation	ISS	PlasmoDB
BP	GO:0006270	DNA replication initiation	IEA	Interproscan predictions
BP	GO:0006270	DNA replication initiation	IEA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008094	DNA-dependent ATPase activity	ISS	PlasmoDB
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
CC	GO:0042555	MCM complex	IEA	PlasmoDB
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000278	mitotic cell cycle	IEP	Predicted GO
CC	GO:0000796	condensin complex	IEP	Predicted GO
CC	GO:0000932	P-body	IEP	Predicted GO
BP	GO:0001505	regulation of neurotransmitter levels	IEP	Predicted GO
BP	GO:0002376	immune system process	IEP	Predicted GO
BP	GO:0002377	immunoglobulin production	IEP	Predicted GO
BP	GO:0002440	production of molecular mediator of immune response	IEP	Predicted GO
BP	GO:0002682	regulation of immune system process	IEP	Predicted GO
MF	GO:0003689	DNA clamp loader activity	IEP	Predicted GO
MF	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	IEP	Predicted GO
MF	GO:0004372	glycine hydroxymethyltransferase activity	IEP	Predicted GO
MF	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	IEP	Predicted GO
MF	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEP	Predicted GO
MF	GO:0004791	thioredoxin-disulfide reductase activity	IEP	Predicted GO
MF	GO:0004825	methionine-tRNA ligase activity	IEP	Predicted GO
CC	GO:0005663	DNA replication factor C complex	IEP	Predicted GO
CC	GO:0005750	mitochondrial respiratory chain complex III	IEP	Predicted GO
CC	GO:0005762	mitochondrial large ribosomal subunit	IEP	Predicted GO
CC	GO:0005814	centriole	IEP	Predicted GO
CC	GO:0005838	proteasome regulatory particle	IEP	Predicted GO
CC	GO:0005971	ribonucleoside-diphosphate reductase complex	IEP	Predicted GO
BP	GO:0006072	glycerol-3-phosphate metabolic process	IEP	Predicted GO
BP	GO:0006103	2-oxoglutarate metabolic process	IEP	Predicted GO
BP	GO:0006116	NADH oxidation	IEP	Predicted GO
BP	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	IEP	Predicted GO
BP	GO:0006127	glycerophosphate shuttle	IEP	Predicted GO
BP	GO:0006268	DNA unwinding involved in DNA replication	IEP	Predicted GO
BP	GO:0006271	DNA strand elongation involved in DNA replication	IEP	Predicted GO
BP	GO:0006272	leading strand elongation	IEP	Predicted GO
BP	GO:0006323	DNA packaging	IEP	Predicted GO
BP	GO:0006402	mRNA catabolic process	IEP	Predicted GO
BP	GO:0006431	methionyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0006544	glycine metabolic process	IEP	Predicted GO
BP	GO:0006545	glycine biosynthetic process	IEP	Predicted GO
BP	GO:0006563	L-serine metabolic process	IEP	Predicted GO
BP	GO:0006730	one-carbon metabolic process	IEP	Predicted GO
BP	GO:0006734	NADH metabolic process	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
BP	GO:0006996	organelle organization	IEP	Predicted GO
BP	GO:0007017	microtubule-based process	IEP	Predicted GO
BP	GO:0007049	cell cycle	IEP	Predicted GO
BP	GO:0007051	spindle organization	IEP	Predicted GO
BP	GO:0007052	mitotic spindle organization	IEP	Predicted GO
BP	GO:0007076	mitotic chromosome condensation	IEP	Predicted GO
MF	GO:0008121	ubiquinol-cytochrome-c reductase activity	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008234	cysteine-type peptidase activity	IEP	Predicted GO
CC	GO:0008540	proteasome regulatory particle, base subcomplex	IEP	Predicted GO
MF	GO:0009055	electron transfer activity	IEP	Predicted GO
BP	GO:0009056	catabolic process	IEP	Predicted GO
BP	GO:0009057	macromolecule catabolic process	IEP	Predicted GO
BP	GO:0009070	serine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009186	deoxyribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009266	response to temperature stimulus	IEP	Predicted GO
CC	GO:0009331	glycerol-3-phosphate dehydrogenase complex	IEP	Predicted GO
BP	GO:0009408	response to heat	IEP	Predicted GO
BP	GO:0009628	response to abiotic stimulus	IEP	Predicted GO
BP	GO:0009894	regulation of catabolic process	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
BP	GO:0016043	cellular component organization	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	IEP	Predicted GO
MF	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEP	Predicted GO
MF	GO:0016651	oxidoreductase activity, acting on NAD(P)H	IEP	Predicted GO
MF	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEP	Predicted GO
MF	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	IEP	Predicted GO
MF	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	IEP	Predicted GO
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Predicted GO
MF	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	IEP	Predicted GO
MF	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	IEP	Predicted GO
MF	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	IEP	Predicted GO
MF	GO:0019207	kinase regulator activity	IEP	Predicted GO
BP	GO:0019264	glycine biosynthetic process from serine	IEP	Predicted GO
BP	GO:0019674	NAD metabolic process	IEP	Predicted GO
MF	GO:0019842	vitamin binding	IEP	Predicted GO
MF	GO:0019887	protein kinase regulator activity	IEP	Predicted GO
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0022402	cell cycle process	IEP	Predicted GO
BP	GO:0022616	DNA strand elongation	IEP	Predicted GO
CC	GO:0030127	COPII vesicle coat	IEP	Predicted GO
BP	GO:0030163	protein catabolic process	IEP	Predicted GO
MF	GO:0030170	pyridoxal phosphate binding	IEP	Predicted GO
MF	GO:0030234	enzyme regulator activity	IEP	Predicted GO
BP	GO:0030261	chromosome condensation	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
BP	GO:0031497	chromatin assembly	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
MF	GO:0033170	protein-DNA loading ATPase activity	IEP	Predicted GO
BP	GO:0034308	primary alcohol metabolic process	IEP	Predicted GO
CC	GO:0035770	ribonucleoprotein granule	IEP	Predicted GO
BP	GO:0035999	tetrahydrofolate interconversion	IEP	Predicted GO
CC	GO:0036464	cytoplasmic ribonucleoprotein granule	IEP	Predicted GO
BP	GO:0040011	locomotion	IEP	Predicted GO
BP	GO:0042133	neurotransmitter metabolic process	IEP	Predicted GO
BP	GO:0042136	neurotransmitter biosynthetic process	IEP	Predicted GO
BP	GO:0042176	regulation of protein catabolic process	IEP	Predicted GO
MF	GO:0042393	histone binding	IEP	Predicted GO
BP	GO:0043086	negative regulation of catalytic activity	IEP	Predicted GO
CC	GO:0043186	P granule	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Predicted GO
BP	GO:0044092	negative regulation of molecular function	IEP	Predicted GO
BP	GO:0044248	cellular catabolic process	IEP	Predicted GO
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Predicted GO
CC	GO:0044427	chromosomal part	IEP	Predicted GO
CC	GO:0044429	mitochondrial part	IEP	Predicted GO
CC	GO:0044450	microtubule organizing center part	IEP	Predicted GO
CC	GO:0045275	respiratory chain complex III	IEP	Predicted GO
BP	GO:0046416	D-amino acid metabolic process	IEP	Predicted GO
BP	GO:0046653	tetrahydrofolate metabolic process	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
MF	GO:0048256	flap endonuclease activity	IEP	Predicted GO
BP	GO:0048519	negative regulation of biological process	IEP	Predicted GO
BP	GO:0048583	regulation of response to stimulus	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0050776	regulation of immune response	IEP	Predicted GO
BP	GO:0051095	regulation of helicase activity	IEP	Predicted GO
BP	GO:0051097	negative regulation of helicase activity	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051276	chromosome organization	IEP	Predicted GO
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
BP	GO:0052646	alditol phosphate metabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0061731	ribonucleoside-diphosphate reductase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
CC	GO:0070069	cytochrome complex	IEP	Predicted GO
BP	GO:0070178	D-serine metabolic process	IEP	Predicted GO
BP	GO:0070682	proteasome regulatory particle assembly	IEP	Predicted GO
BP	GO:0071103	DNA conformation change	IEP	Predicted GO
BP	GO:0071840	cellular component organization or biogenesis	IEP	Predicted GO
MF	GO:0098772	molecular function regulator	IEP	Predicted GO
CC	GO:0098798	mitochondrial protein complex	IEP	Predicted GO
BP	GO:1901575	organic substance catabolic process	IEP	Predicted GO
CC	GO:1902494	catalytic complex	IEP	Predicted GO
BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	IEP	Predicted GO
BP	GO:1903047	mitotic cell cycle process	IEP	Predicted GO
BP	GO:1905462	regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905463	negative regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905774	regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:1905775	negative regulation of DNA helicase activity	IEP	Predicted GO
CC	GO:1990204	oxidoreductase complex	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001208	MCM_dom	425	645
IPR027925	MCM_N	73	201
IPR033762	MCM_OB	210	338

External Links

PlasmoDB	814255
PlasmoDB	PF13_0291

PF3D7_1355100 (MCM6)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation