PF3D7_1357900


Description : SSF51735: NAD(P)-binding domain superfamily, SSF48179: "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily". Pfam domain(s): PF14748: Pyrroline-5-carboxylate reductase dimerisation, PF03807: NADP oxidoreductase coenzyme F420-dependent.


Gene families : OG_01_0001497 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001497_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pfa RNA-seq: PF3D7_1357900
Cluster P. falciparum: Cluster_11

Target Alias Description ECC score Gene Family Method Actions
PBANKA_1134200 No alias SSF51735: NAD(P)-binding domain superfamily, SSF48179:... 0.04 Orthofinderv1.1.8

Type GO Term Name Evidence Source
MF GO:0004735 pyrroline-5-carboxylate reductase activity ISS PlasmoDB
MF GO:0004735 pyrroline-5-carboxylate reductase activity IEA PlasmoDB
BP GO:0006561 proline biosynthetic process ISS PlasmoDB
BP GO:0006561 proline biosynthetic process IEA PlasmoDB
BP GO:0055114 oxidation-reduction process IEA PlasmoDB
Type GO Term Name Evidence Source
CC GO:0000015 phosphopyruvate hydratase complex IEP Predicted GO
BP GO:0000045 autophagosome assembly IEP Predicted GO
BP GO:0000302 response to reactive oxygen species IEP Predicted GO
BP GO:0000304 response to singlet oxygen IEP Predicted GO
MF GO:0000774 adenyl-nucleotide exchange factor activity IEP Predicted GO
BP GO:0002253 activation of immune response IEP Predicted GO
BP GO:0002684 positive regulation of immune system process IEP Predicted GO
MF GO:0003735 structural constituent of ribosome IEP Predicted GO
MF GO:0004152 dihydroorotate dehydrogenase activity IEP Predicted GO
MF GO:0004164 diphthine synthase activity IEP Predicted GO
MF GO:0004347 glucose-6-phosphate isomerase activity IEP Predicted GO
MF GO:0004359 glutaminase activity IEP Predicted GO
MF GO:0004364 glutathione transferase activity IEP Predicted GO
MF GO:0004457 lactate dehydrogenase activity IEP Predicted GO
MF GO:0004459 L-lactate dehydrogenase activity IEP Predicted GO
MF GO:0004634 phosphopyruvate hydratase activity IEP Predicted GO
MF GO:0005087 Ran guanyl-nucleotide exchange factor activity IEP Predicted GO
MF GO:0005088 Ras guanyl-nucleotide exchange factor activity IEP Predicted GO
MF GO:0005198 structural molecule activity IEP Predicted GO
CC GO:0005575 cellular_component IEP Predicted GO
CC GO:0005622 intracellular IEP Predicted GO
CC GO:0005739 mitochondrion IEP Predicted GO
CC GO:0005742 mitochondrial outer membrane translocase complex IEP Predicted GO
CC GO:0005743 mitochondrial inner membrane IEP Predicted GO
CC GO:0005746 mitochondrial respirasome IEP Predicted GO
CC GO:0005759 mitochondrial matrix IEP Predicted GO
CC GO:0005840 ribosome IEP Predicted GO
CC GO:0005854 nascent polypeptide-associated complex IEP Predicted GO
BP GO:0005975 carbohydrate metabolic process IEP Predicted GO
BP GO:0005996 monosaccharide metabolic process IEP Predicted GO
BP GO:0006006 glucose metabolic process IEP Predicted GO
BP GO:0006081 cellular aldehyde metabolic process IEP Predicted GO
BP GO:0006090 pyruvate metabolic process IEP Predicted GO
BP GO:0006091 generation of precursor metabolites and energy IEP Predicted GO
BP GO:0006094 gluconeogenesis IEP Predicted GO
BP GO:0006096 glycolytic process IEP Predicted GO
BP GO:0006109 regulation of carbohydrate metabolic process IEP Predicted GO
BP GO:0006163 purine nucleotide metabolic process IEP Predicted GO
BP GO:0006164 purine nucleotide biosynthetic process IEP Predicted GO
BP GO:0006165 nucleoside diphosphate phosphorylation IEP Predicted GO
BP GO:0006412 translation IEP Predicted GO
BP GO:0006457 protein folding IEP Predicted GO
BP GO:0006518 peptide metabolic process IEP Predicted GO
BP GO:0006605 protein targeting IEP Predicted GO
BP GO:0006626 protein targeting to mitochondrion IEP Predicted GO
BP GO:0006732 coenzyme metabolic process IEP Predicted GO
BP GO:0006733 oxidoreduction coenzyme metabolic process IEP Predicted GO
BP GO:0006754 ATP biosynthetic process IEP Predicted GO
BP GO:0006757 ATP generation from ADP IEP Predicted GO
BP GO:0006839 mitochondrial transport IEP Predicted GO
BP GO:0006863 purine nucleobase transport IEP Predicted GO
MF GO:0008097 5S rRNA binding IEP Predicted GO
BP GO:0008614 pyridoxine metabolic process IEP Predicted GO
BP GO:0008615 pyridoxine biosynthetic process IEP Predicted GO
BP GO:0009059 macromolecule biosynthetic process IEP Predicted GO
BP GO:0009108 coenzyme biosynthetic process IEP Predicted GO
BP GO:0009132 nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009135 purine nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009141 nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009142 nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009144 purine nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009145 purine nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009150 purine ribonucleotide metabolic process IEP Predicted GO
BP GO:0009152 purine ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009166 nucleotide catabolic process IEP Predicted GO
BP GO:0009179 purine ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009185 ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009199 ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009201 ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009205 purine ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009259 ribonucleotide metabolic process IEP Predicted GO
BP GO:0009260 ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009266 response to temperature stimulus IEP Predicted GO
MF GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity IEP Predicted GO
BP GO:0009408 response to heat IEP Predicted GO
BP GO:0009628 response to abiotic stimulus IEP Predicted GO
BP GO:0010322 regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEP Predicted GO
BP GO:0010323 negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEP Predicted GO
BP GO:0010563 negative regulation of phosphorus metabolic process IEP Predicted GO
BP GO:0010565 regulation of cellular ketone metabolic process IEP Predicted GO
BP GO:0010675 regulation of cellular carbohydrate metabolic process IEP Predicted GO
BP GO:0010677 negative regulation of cellular carbohydrate metabolic process IEP Predicted GO
MF GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEP Predicted GO
BP GO:0015851 nucleobase transport IEP Predicted GO
BP GO:0015858 nucleoside transport IEP Predicted GO
CC GO:0015934 large ribosomal subunit IEP Predicted GO
CC GO:0015935 small ribosomal subunit IEP Predicted GO
BP GO:0016051 carbohydrate biosynthetic process IEP Predicted GO
BP GO:0016052 carbohydrate catabolic process IEP Predicted GO
MF GO:0016434 rRNA (cytosine) methyltransferase activity IEP Predicted GO
MF GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor IEP Predicted GO
MF GO:0016835 carbon-oxygen lyase activity IEP Predicted GO
MF GO:0016836 hydro-lyase activity IEP Predicted GO
BP GO:0017144 drug metabolic process IEP Predicted GO
MF GO:0019203 carbohydrate phosphatase activity IEP Predicted GO
BP GO:0019216 regulation of lipid metabolic process IEP Predicted GO
BP GO:0019318 hexose metabolic process IEP Predicted GO
BP GO:0019319 hexose biosynthetic process IEP Predicted GO
BP GO:0019359 nicotinamide nucleotide biosynthetic process IEP Predicted GO
BP GO:0019362 pyridine nucleotide metabolic process IEP Predicted GO
BP GO:0019363 pyridine nucleotide biosynthetic process IEP Predicted GO
BP GO:0019439 aromatic compound catabolic process IEP Predicted GO
BP GO:0019538 protein metabolic process IEP Predicted GO
BP GO:0019747 regulation of isoprenoid metabolic process IEP Predicted GO
MF GO:0019843 rRNA binding IEP Predicted GO
CC GO:0019866 organelle inner membrane IEP Predicted GO
CC GO:0020036 Maurer's cleft IEP Predicted GO
BP GO:0022613 ribonucleoprotein complex biogenesis IEP Predicted GO
CC GO:0022625 cytosolic large ribosomal subunit IEP Predicted GO
CC GO:0022627 cytosolic small ribosomal subunit IEP Predicted GO
BP GO:0030091 protein repair IEP Predicted GO
BP GO:0030150 protein import into mitochondrial matrix IEP Predicted GO
CC GO:0031090 organelle membrane IEP Predicted GO
CC GO:0031966 mitochondrial membrane IEP Predicted GO
CC GO:0031974 membrane-enclosed lumen IEP Predicted GO
CC GO:0031982 vesicle IEP Predicted GO
BP GO:0032238 adenosine transport IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033365 protein localization to organelle IEP Predicted GO
BP GO:0034404 nucleobase-containing small molecule biosynthetic process IEP Predicted GO
BP GO:0034613 cellular protein localization IEP Predicted GO
BP GO:0034641 cellular nitrogen compound metabolic process IEP Predicted GO
BP GO:0034645 cellular macromolecule biosynthetic process IEP Predicted GO
BP GO:0034655 nucleobase-containing compound catabolic process IEP Predicted GO
BP GO:0035915 pore formation in membrane of other organism IEP Predicted GO
MF GO:0036524 protein deglycase activity IEP Predicted GO
BP GO:0036525 protein deglycation IEP Predicted GO
BP GO:0042255 ribosome assembly IEP Predicted GO
BP GO:0042256 mature ribosome assembly IEP Predicted GO
BP GO:0042273 ribosomal large subunit biogenesis IEP Predicted GO
BP GO:0042822 pyridoxal phosphate metabolic process IEP Predicted GO
BP GO:0042823 pyridoxal phosphate biosynthetic process IEP Predicted GO
BP GO:0042866 pyruvate biosynthetic process IEP Predicted GO
MF GO:0043023 ribosomal large subunit binding IEP Predicted GO
BP GO:0043043 peptide biosynthetic process IEP Predicted GO
MF GO:0043139 5'-3' DNA helicase activity IEP Predicted GO
MF GO:0043141 ATP-dependent 5'-3' DNA helicase activity IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
CC GO:0043226 organelle IEP Predicted GO
CC GO:0043228 non-membrane-bounded organelle IEP Predicted GO
CC GO:0043229 intracellular organelle IEP Predicted GO
CC GO:0043230 extracellular organelle IEP Predicted GO
CC GO:0043232 intracellular non-membrane-bounded organelle IEP Predicted GO
CC GO:0043233 organelle lumen IEP Predicted GO
BP GO:0043603 cellular amide metabolic process IEP Predicted GO
BP GO:0043604 amide biosynthetic process IEP Predicted GO
BP GO:0044085 cellular component biogenesis IEP Predicted GO
CC GO:0044161 host cell cytoplasmic vesicle IEP Predicted GO
CC GO:0044217 other organism part IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
BP GO:0044267 cellular protein metabolic process IEP Predicted GO
BP GO:0044270 cellular nitrogen compound catabolic process IEP Predicted GO
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Predicted GO
CC GO:0044391 ribosomal subunit IEP Predicted GO
CC GO:0044421 extracellular region part IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044429 mitochondrial part IEP Predicted GO
CC GO:0044444 cytoplasmic part IEP Predicted GO
CC GO:0044445 cytosolic part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
CC GO:0044455 mitochondrial membrane part IEP Predicted GO
CC GO:0044464 cell part IEP Predicted GO
BP GO:0044657 pore formation in membrane of other organism during symbiotic interaction IEP Predicted GO
BP GO:0044658 pore formation in membrane of host by symbiont IEP Predicted GO
BP GO:0045827 negative regulation of isoprenoid metabolic process IEP Predicted GO
BP GO:0045833 negative regulation of lipid metabolic process IEP Predicted GO
BP GO:0045912 negative regulation of carbohydrate metabolic process IEP Predicted GO
BP GO:0045936 negative regulation of phosphate metabolic process IEP Predicted GO
BP GO:0046031 ADP metabolic process IEP Predicted GO
BP GO:0046034 ATP metabolic process IEP Predicted GO
BP GO:0046184 aldehyde biosynthetic process IEP Predicted GO
BP GO:0046364 monosaccharide biosynthetic process IEP Predicted GO
BP GO:0046390 ribose phosphate biosynthetic process IEP Predicted GO
BP GO:0046434 organophosphate catabolic process IEP Predicted GO
BP GO:0046496 nicotinamide nucleotide metabolic process IEP Predicted GO
BP GO:0046700 heterocycle catabolic process IEP Predicted GO
BP GO:0046890 regulation of lipid biosynthetic process IEP Predicted GO
BP GO:0046939 nucleotide phosphorylation IEP Predicted GO
BP GO:0048584 positive regulation of response to stimulus IEP Predicted GO
MF GO:0050308 sugar-phosphatase activity IEP Predicted GO
BP GO:0050778 positive regulation of immune response IEP Predicted GO
BP GO:0051055 negative regulation of lipid biosynthetic process IEP Predicted GO
MF GO:0051082 unfolded protein binding IEP Predicted GO
BP GO:0051186 cofactor metabolic process IEP Predicted GO
BP GO:0051188 cofactor biosynthetic process IEP Predicted GO
BP GO:0051673 membrane disruption in other organism IEP Predicted GO
BP GO:0052025 modification by symbiont of host cell membrane IEP Predicted GO
BP GO:0052043 modification by symbiont of host cellular component IEP Predicted GO
BP GO:0052111 modification by symbiont of host structure IEP Predicted GO
BP GO:0052185 modification of structure of other organism involved in symbiotic interaction IEP Predicted GO
BP GO:0052188 modification of cellular component in other organism involved in symbiotic interaction IEP Predicted GO
BP GO:0052332 modification by organism of membrane in other organism involved in symbiotic interaction IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
BP GO:0062012 regulation of small molecule metabolic process IEP Predicted GO
BP GO:0062014 negative regulation of small molecule metabolic process IEP Predicted GO
CC GO:0070013 intracellular organelle lumen IEP Predicted GO
CC GO:0070469 respirasome IEP Predicted GO
BP GO:0070585 protein localization to mitochondrion IEP Predicted GO
BP GO:0070727 cellular macromolecule localization IEP Predicted GO
BP GO:0070925 organelle assembly IEP Predicted GO
BP GO:0071071 regulation of phospholipid biosynthetic process IEP Predicted GO
BP GO:0071072 negative regulation of phospholipid biosynthetic process IEP Predicted GO
BP GO:0072330 monocarboxylic acid biosynthetic process IEP Predicted GO
BP GO:0072522 purine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072524 pyridine-containing compound metabolic process IEP Predicted GO
BP GO:0072525 pyridine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072594 establishment of protein localization to organelle IEP Predicted GO
BP GO:0072655 establishment of protein localization to mitochondrion IEP Predicted GO
BP GO:0090407 organophosphate biosynthetic process IEP Predicted GO
CC GO:0098799 outer mitochondrial membrane protein complex IEP Predicted GO
BP GO:1901292 nucleoside phosphate catabolic process IEP Predicted GO
BP GO:1901361 organic cyclic compound catabolic process IEP Predicted GO
BP GO:1901700 response to oxygen-containing compound IEP Predicted GO
CC GO:1903561 extracellular vesicle IEP Predicted GO
BP GO:1903725 regulation of phospholipid metabolic process IEP Predicted GO
BP GO:1903726 negative regulation of phospholipid metabolic process IEP Predicted GO
BP GO:1905037 autophagosome organization IEP Predicted GO
CC GO:1990904 ribonucleoprotein complex IEP Predicted GO
InterPro domains Description Start Stop
IPR029036 P5CR_dimer 155 259
IPR028939 P5C_Rdtase_cat_N 5 90
PlasmoDB 813846
PlasmoDB MAL13P1.284