PF3D7_1366500 (NDK)

Aliases : NDK

Description : SSF54919: Nucleoside diphosphate kinase-like domain superfamily. Pfam domain(s): PF00334: Nucleoside diphosphate kinase.

Gene families : OG_01_0001535 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001535_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1366500
Cluster	P. falciparum: Cluster_10

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1142400	No alias	SSF54919: Nucleoside diphosphate kinase-like domain...	0.06	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0000287	magnesium ion binding	IDA	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004550	nucleoside diphosphate kinase activity	IDA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	ISS	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006163	purine nucleotide metabolic process	None	Extended
BP	GO:0006164	purine nucleotide biosynthetic process	None	Extended
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEA	PlasmoDB
BP	GO:0006183	GTP biosynthetic process	ISS	PlasmoDB
BP	GO:0006220	pyrimidine nucleotide metabolic process	None	Extended
BP	GO:0006221	pyrimidine nucleotide biosynthetic process	None	Extended
BP	GO:0006228	UTP biosynthetic process	ISS	PlasmoDB
BP	GO:0006241	CTP biosynthetic process	ISS	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009116	nucleoside metabolic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009119	ribonucleoside metabolic process	None	Extended
BP	GO:0009132	nucleoside diphosphate metabolic process	None	Extended
BP	GO:0009141	nucleoside triphosphate metabolic process	None	Extended
BP	GO:0009142	nucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009144	purine nucleoside triphosphate metabolic process	None	Extended
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009147	pyrimidine nucleoside triphosphate metabolic process	None	Extended
BP	GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009150	purine ribonucleotide metabolic process	None	Extended
BP	GO:0009152	purine ribonucleotide biosynthetic process	None	Extended
BP	GO:0009163	nucleoside biosynthetic process	None	Extended
BP	GO:0009165	nucleotide biosynthetic process	None	Extended
BP	GO:0009199	ribonucleoside triphosphate metabolic process	None	Extended
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	None	Extended
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009208	pyrimidine ribonucleoside triphosphate metabolic process	None	Extended
BP	GO:0009209	pyrimidine ribonucleoside triphosphate biosynthetic process	None	Extended
BP	GO:0009218	pyrimidine ribonucleotide metabolic process	None	Extended
BP	GO:0009220	pyrimidine ribonucleotide biosynthetic process	None	Extended
BP	GO:0009259	ribonucleotide metabolic process	None	Extended
BP	GO:0009260	ribonucleotide biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016301	kinase activity	None	Extended
BP	GO:0016310	phosphorylation	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016776	phosphotransferase activity, phosphate group as acceptor	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
MF	GO:0019205	nucleobase-containing compound kinase activity	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032552	deoxyribonucleotide binding	ISS	PlasmoDB
MF	GO:0032553	ribonucleotide binding	ISS	PlasmoDB
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034654	nucleobase-containing compound biosynthetic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042278	purine nucleoside metabolic process	None	Extended
BP	GO:0042451	purine nucleoside biosynthetic process	None	Extended
BP	GO:0042455	ribonucleoside biosynthetic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046036	CTP metabolic process	None	Extended
BP	GO:0046039	GTP metabolic process	None	Extended
BP	GO:0046051	UTP metabolic process	None	Extended
BP	GO:0046128	purine ribonucleoside metabolic process	None	Extended
BP	GO:0046129	purine ribonucleoside biosynthetic process	None	Extended
BP	GO:0046390	ribose phosphate biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
BP	GO:0046939	nucleotide phosphorylation	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072521	purine-containing compound metabolic process	None	Extended
BP	GO:0072522	purine-containing compound biosynthetic process	None	Extended
BP	GO:0072527	pyrimidine-containing compound metabolic process	None	Extended
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	None	Extended
BP	GO:0090407	organophosphate biosynthetic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
BP	GO:1901068	guanosine-containing compound metabolic process	None	Extended
BP	GO:1901070	guanosine-containing compound biosynthetic process	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901137	carbohydrate derivative biosynthetic process	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901293	nucleoside phosphate biosynthetic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901657	glycosyl compound metabolic process	None	Extended
BP	GO:1901659	glycosyl compound biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000151	ubiquitin ligase complex	IEP	Predicted GO
MF	GO:0000213	tRNA-intron endonuclease activity	IEP	Predicted GO
CC	GO:0000214	tRNA-intron endonuclease complex	IEP	Predicted GO
CC	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	IEP	Predicted GO
CC	GO:0000315	organellar large ribosomal subunit	IEP	Predicted GO
BP	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	IEP	Predicted GO
CC	GO:0000502	proteasome complex	IEP	Predicted GO
BP	GO:0003006	developmental process involved in reproduction	IEP	Predicted GO
MF	GO:0003689	DNA clamp loader activity	IEP	Predicted GO
MF	GO:0003998	acylphosphatase activity	IEP	Predicted GO
MF	GO:0004013	adenosylhomocysteinase activity	IEP	Predicted GO
MF	GO:0004170	dUTP diphosphatase activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004298	threonine-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	IEP	Predicted GO
MF	GO:0004354	glutamate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004372	glycine hydroxymethyltransferase activity	IEP	Predicted GO
MF	GO:0004392	heme oxygenase (decyclizing) activity	IEP	Predicted GO
MF	GO:0004784	superoxide dismutase activity	IEP	Predicted GO
MF	GO:0004791	thioredoxin-disulfide reductase activity	IEP	Predicted GO
MF	GO:0005310	dicarboxylic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005483	soluble NSF attachment protein activity	IEP	Predicted GO
CC	GO:0005663	DNA replication factor C complex	IEP	Predicted GO
CC	GO:0005672	transcription factor TFIIA complex	IEP	Predicted GO
CC	GO:0005739	mitochondrion	IEP	Predicted GO
CC	GO:0005756	mitochondrial proton-transporting ATP synthase, central stalk	IEP	Predicted GO
CC	GO:0005762	mitochondrial large ribosomal subunit	IEP	Predicted GO
CC	GO:0005787	signal peptidase complex	IEP	Predicted GO
CC	GO:0005839	proteasome core complex	IEP	Predicted GO
CC	GO:0005868	cytoplasmic dynein complex	IEP	Predicted GO
BP	GO:0006108	malate metabolic process	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006271	DNA strand elongation involved in DNA replication	IEP	Predicted GO
BP	GO:0006272	leading strand elongation	IEP	Predicted GO
BP	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006458	'de novo' protein folding	IEP	Predicted GO
BP	GO:0006465	signal peptide processing	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0006537	glutamate biosynthetic process	IEP	Predicted GO
BP	GO:0006545	glycine biosynthetic process	IEP	Predicted GO
BP	GO:0006563	L-serine metabolic process	IEP	Predicted GO
BP	GO:0006662	glycerol ether metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006787	porphyrin-containing compound catabolic process	IEP	Predicted GO
BP	GO:0006801	superoxide metabolic process	IEP	Predicted GO
BP	GO:0006835	dicarboxylic acid transport	IEP	Predicted GO
BP	GO:0006979	response to oxidative stress	IEP	Predicted GO
BP	GO:0007530	sex determination	IEP	Predicted GO
MF	GO:0008121	ubiquinol-cytochrome-c reductase activity	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	Predicted GO
MF	GO:0009055	electron transfer activity	IEP	Predicted GO
BP	GO:0009056	catabolic process	IEP	Predicted GO
BP	GO:0009057	macromolecule catabolic process	IEP	Predicted GO
BP	GO:0009070	serine family amino acid biosynthetic process	IEP	Predicted GO
CC	GO:0009376	HslUV protease complex	IEP	Predicted GO
BP	GO:0010038	response to metal ion	IEP	Predicted GO
MF	GO:0015035	protein disulfide oxidoreductase activity	IEP	Predicted GO
MF	GO:0015036	disulfide oxidoreductase activity	IEP	Predicted GO
MF	GO:0015140	malate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015367	oxoglutarate:malate antiporter activity	IEP	Predicted GO
MF	GO:0015556	C4-dicarboxylate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015740	C4-dicarboxylate transport	IEP	Predicted GO
BP	GO:0015742	alpha-ketoglutarate transport	IEP	Predicted GO
BP	GO:0015743	malate transport	IEP	Predicted GO
BP	GO:0015985	energy coupled proton transport, down electrochemical gradient	IEP	Predicted GO
BP	GO:0015986	ATP synthesis coupled proton transport	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
MF	GO:0016209	antioxidant activity	IEP	Predicted GO
CC	GO:0016272	prefoldin complex	IEP	Predicted GO
BP	GO:0016485	protein processing	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	IEP	Predicted GO
MF	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IEP	Predicted GO
MF	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	IEP	Predicted GO
MF	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	IEP	Predicted GO
MF	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	IEP	Predicted GO
MF	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	IEP	Predicted GO
MF	GO:0016787	hydrolase activity	IEP	Predicted GO
MF	GO:0016801	hydrolase activity, acting on ether bonds	IEP	Predicted GO
MF	GO:0016802	trialkylsulfonium hydrolase activity	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	IEP	Predicted GO
MF	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
BP	GO:0018904	ether metabolic process	IEP	Predicted GO
CC	GO:0019005	SCF ubiquitin ligase complex	IEP	Predicted GO
MF	GO:0019153	protein-disulfide reductase (glutathione) activity	IEP	Predicted GO
BP	GO:0019264	glycine biosynthetic process from serine	IEP	Predicted GO
BP	GO:0019430	removal of superoxide radicals	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
BP	GO:0019725	cellular homeostasis	IEP	Predicted GO
CC	GO:0019773	proteasome core complex, alpha-subunit complex	IEP	Predicted GO
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0022616	DNA strand elongation	IEP	Predicted GO
MF	GO:0030508	obsolete thiol-disulfide exchange intermediate activity	IEP	Predicted GO
CC	GO:0031090	organelle membrane	IEP	Predicted GO
CC	GO:0031597	cytosolic proteasome complex	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0033015	tetrapyrrole catabolic process	IEP	Predicted GO
MF	GO:0033170	protein-DNA loading ATPase activity	IEP	Predicted GO
CC	GO:0035145	exon-exon junction complex	IEP	Predicted GO
BP	GO:0035999	tetrahydrofolate interconversion	IEP	Predicted GO
BP	GO:0042136	neurotransmitter biosynthetic process	IEP	Predicted GO
BP	GO:0042167	heme catabolic process	IEP	Predicted GO
BP	GO:0042592	homeostatic process	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Predicted GO
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0044248	cellular catabolic process	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044429	mitochondrial part	IEP	Predicted GO
CC	GO:0044432	endoplasmic reticulum part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
CC	GO:0044455	mitochondrial membrane part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
BP	GO:0045116	protein neddylation	IEP	Predicted GO
CC	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	IEP	Predicted GO
CC	GO:0045269	proton-transporting ATP synthase, central stalk	IEP	Predicted GO
BP	GO:0045454	cell redox homeostasis	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046149	pigment catabolic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0046416	D-amino acid metabolic process	IEP	Predicted GO
BP	GO:0046653	tetrahydrofolate metabolic process	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051181	cofactor transport	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051187	cofactor catabolic process	IEP	Predicted GO
BP	GO:0051382	kinetochore assembly	IEP	Predicted GO
BP	GO:0051383	kinetochore organization	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
BP	GO:0061025	membrane fusion	IEP	Predicted GO
BP	GO:0065008	regulation of biological quality	IEP	Predicted GO
MF	GO:0070003	threonine-type peptidase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0070178	D-serine metabolic process	IEP	Predicted GO
BP	GO:0072593	reactive oxygen species metabolic process	IEP	Predicted GO
BP	GO:0098754	detoxification	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
CC	GO:0098798	mitochondrial protein complex	IEP	Predicted GO
CC	GO:0098800	inner mitochondrial membrane protein complex	IEP	Predicted GO
BP	GO:0098869	cellular oxidant detoxification	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
BP	GO:1901575	organic substance catabolic process	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Predicted GO
CC	GO:1902494	catalytic complex	IEP	Predicted GO
BP	GO:1902600	proton transmembrane transport	IEP	Predicted GO
CC	GO:1905368	peptidase complex	IEP	Predicted GO
CC	GO:1905369	endopeptidase complex	IEP	Predicted GO
CC	GO:1990229	iron-sulfur cluster assembly complex	IEP	Predicted GO
BP	GO:1990748	cellular detoxification	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR034907	NDK-like_dom	2	135

External Links

PlasmoDB	814308
PlasmoDB	PF13_0349

PF3D7_1366500 (NDK)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation