PF3D7_1410600 (eIF2gamma)


Aliases : eIF2gamma

Description : SSF52540: P-loop containing nucleoside triphosphate hydrolase, SSF50465: "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal", SSF50447: "Translation protein, beta-barrel domain superfamily". Pfam domain(s): PF03144: Elongation factor Tu domain 2, PF00009: Elongation factor Tu GTP binding domain, PF09173: "Initiation factor eIF2 gamma, C terminal".


Gene families : OG_01_0001327 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001327_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pfa RNA-seq: PF3D7_1410600
Cluster P. falciparum: Cluster_34

Target Alias Description ECC score Gene Family Method Actions
PBANKA_1031900 eIF2gamma SSF50447: Translation protein, beta-barrel domain... 0.09 Orthofinderv1.1.8

Type GO Term Name Evidence Source
MF GO:0003743 translation initiation factor activity ISS PlasmoDB
MF GO:0003924 GTPase activity IEA Interproscan predictions
MF GO:0003924 GTPase activity IEA PlasmoDB
MF GO:0005515 protein binding IPI PlasmoDB
MF GO:0005525 GTP binding ISS PlasmoDB
MF GO:0005525 GTP binding IEA Interproscan predictions
MF GO:0005525 GTP binding IEA PlasmoDB
CC GO:0005850 eukaryotic translation initiation factor 2 complex ISS PlasmoDB
BP GO:0006413 translational initiation ISS PlasmoDB
Type GO Term Name Evidence Source
MF GO:0000182 rDNA binding IEP Predicted GO
MF GO:0000287 magnesium ion binding IEP Predicted GO
MF GO:0000339 RNA cap binding IEP Predicted GO
BP GO:0000375 RNA splicing, via transesterification reactions IEP Predicted GO
BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile IEP Predicted GO
BP GO:0000380 alternative mRNA splicing, via spliceosome IEP Predicted GO
BP GO:0000398 mRNA splicing, via spliceosome IEP Predicted GO
CC GO:0000428 DNA-directed RNA polymerase complex IEP Predicted GO
MF GO:0000900 translation repressor activity, mRNA regulatory element binding IEP Predicted GO
BP GO:0001678 cellular glucose homeostasis IEP Predicted GO
BP GO:0001731 formation of translation preinitiation complex IEP Predicted GO
MF GO:0003677 DNA binding IEP Predicted GO
MF GO:0003727 single-stranded RNA binding IEP Predicted GO
MF GO:0003729 mRNA binding IEP Predicted GO
MF GO:0003735 structural constituent of ribosome IEP Predicted GO
MF GO:0003746 translation elongation factor activity IEP Predicted GO
MF GO:0003872 6-phosphofructokinase activity IEP Predicted GO
MF GO:0003899 DNA-directed 5'-3' RNA polymerase activity IEP Predicted GO
MF GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity IEP Predicted GO
MF GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IEP Predicted GO
MF GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEP Predicted GO
MF GO:0004396 hexokinase activity IEP Predicted GO
MF GO:0004551 nucleotide diphosphatase activity IEP Predicted GO
MF GO:0004619 phosphoglycerate mutase activity IEP Predicted GO
MF GO:0004743 pyruvate kinase activity IEP Predicted GO
MF GO:0004749 ribose phosphate diphosphokinase activity IEP Predicted GO
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Predicted GO
MF GO:0004824 lysine-tRNA ligase activity IEP Predicted GO
MF GO:0004827 proline-tRNA ligase activity IEP Predicted GO
MF GO:0004828 serine-tRNA ligase activity IEP Predicted GO
MF GO:0005198 structural molecule activity IEP Predicted GO
MF GO:0005536 glucose binding IEP Predicted GO
CC GO:0005634 nucleus IEP Predicted GO
CC GO:0005665 RNA polymerase II, core complex IEP Predicted GO
CC GO:0005681 spliceosomal complex IEP Predicted GO
CC GO:0005682 U5 snRNP IEP Predicted GO
CC GO:0005685 U1 snRNP IEP Predicted GO
CC GO:0005732 small nucleolar ribonucleoprotein complex IEP Predicted GO
CC GO:0005829 cytosol IEP Predicted GO
CC GO:0005840 ribosome IEP Predicted GO
CC GO:0005853 eukaryotic translation elongation factor 1 complex IEP Predicted GO
BP GO:0005975 carbohydrate metabolic process IEP Predicted GO
BP GO:0006002 fructose 6-phosphate metabolic process IEP Predicted GO
BP GO:0006082 organic acid metabolic process IEP Predicted GO
BP GO:0006090 pyruvate metabolic process IEP Predicted GO
BP GO:0006091 generation of precursor metabolites and energy IEP Predicted GO
BP GO:0006096 glycolytic process IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006163 purine nucleotide metabolic process IEP Predicted GO
BP GO:0006164 purine nucleotide biosynthetic process IEP Predicted GO
BP GO:0006165 nucleoside diphosphate phosphorylation IEP Predicted GO
BP GO:0006166 purine ribonucleoside salvage IEP Predicted GO
BP GO:0006351 transcription, DNA-templated IEP Predicted GO
BP GO:0006366 transcription by RNA polymerase II IEP Predicted GO
BP GO:0006396 RNA processing IEP Predicted GO
BP GO:0006397 mRNA processing IEP Predicted GO
BP GO:0006412 translation IEP Predicted GO
BP GO:0006414 translational elongation IEP Predicted GO
BP GO:0006418 tRNA aminoacylation for protein translation IEP Predicted GO
BP GO:0006430 lysyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006433 prolyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006434 seryl-tRNA aminoacylation IEP Predicted GO
BP GO:0006518 peptide metabolic process IEP Predicted GO
BP GO:0006520 cellular amino acid metabolic process IEP Predicted GO
BP GO:0006528 asparagine metabolic process IEP Predicted GO
BP GO:0006529 asparagine biosynthetic process IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006732 coenzyme metabolic process IEP Predicted GO
BP GO:0006733 oxidoreduction coenzyme metabolic process IEP Predicted GO
BP GO:0006753 nucleoside phosphate metabolic process IEP Predicted GO
BP GO:0006754 ATP biosynthetic process IEP Predicted GO
BP GO:0006757 ATP generation from ADP IEP Predicted GO
BP GO:0006793 phosphorus metabolic process IEP Predicted GO
BP GO:0006796 phosphate-containing compound metabolic process IEP Predicted GO
BP GO:0006807 nitrogen compound metabolic process IEP Predicted GO
MF GO:0008187 poly-pyrimidine tract binding IEP Predicted GO
BP GO:0008380 RNA splicing IEP Predicted GO
MF GO:0008443 phosphofructokinase activity IEP Predicted GO
MF GO:0008452 RNA ligase activity IEP Predicted GO
MF GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009058 biosynthetic process IEP Predicted GO
BP GO:0009059 macromolecule biosynthetic process IEP Predicted GO
BP GO:0009066 aspartate family amino acid metabolic process IEP Predicted GO
BP GO:0009067 aspartate family amino acid biosynthetic process IEP Predicted GO
BP GO:0009108 coenzyme biosynthetic process IEP Predicted GO
BP GO:0009117 nucleotide metabolic process IEP Predicted GO
BP GO:0009132 nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009135 purine nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009141 nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009142 nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009144 purine nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009145 purine nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009150 purine ribonucleotide metabolic process IEP Predicted GO
BP GO:0009152 purine ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009165 nucleotide biosynthetic process IEP Predicted GO
BP GO:0009166 nucleotide catabolic process IEP Predicted GO
BP GO:0009179 purine ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009185 ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009199 ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009201 ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009205 purine ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009259 ribonucleotide metabolic process IEP Predicted GO
BP GO:0009260 ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009891 positive regulation of biosynthetic process IEP Predicted GO
BP GO:0010468 regulation of gene expression IEP Predicted GO
BP GO:0010557 positive regulation of macromolecule biosynthetic process IEP Predicted GO
BP GO:0010628 positive regulation of gene expression IEP Predicted GO
CC GO:0015934 large ribosomal subunit IEP Predicted GO
CC GO:0015935 small ribosomal subunit IEP Predicted GO
BP GO:0015959 diadenosine polyphosphate metabolic process IEP Predicted GO
BP GO:0015960 diadenosine polyphosphate biosynthetic process IEP Predicted GO
BP GO:0015965 diadenosine tetraphosphate metabolic process IEP Predicted GO
BP GO:0015966 diadenosine tetraphosphate biosynthetic process IEP Predicted GO
BP GO:0016052 carbohydrate catabolic process IEP Predicted GO
BP GO:0016053 organic acid biosynthetic process IEP Predicted GO
BP GO:0016070 RNA metabolic process IEP Predicted GO
BP GO:0016071 mRNA metabolic process IEP Predicted GO
CC GO:0016281 eukaryotic translation initiation factor 4F complex IEP Predicted GO
BP GO:0016310 phosphorylation IEP Predicted GO
MF GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEP Predicted GO
MF GO:0016772 transferase activity, transferring phosphorus-containing groups IEP Predicted GO
MF GO:0016778 diphosphotransferase activity IEP Predicted GO
MF GO:0016779 nucleotidyltransferase activity IEP Predicted GO
MF GO:0016874 ligase activity IEP Predicted GO
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Predicted GO
BP GO:0017144 drug metabolic process IEP Predicted GO
BP GO:0018130 heterocycle biosynthetic process IEP Predicted GO
MF GO:0019200 carbohydrate kinase activity IEP Predicted GO
BP GO:0019222 regulation of metabolic process IEP Predicted GO
BP GO:0019359 nicotinamide nucleotide biosynthetic process IEP Predicted GO
BP GO:0019362 pyridine nucleotide metabolic process IEP Predicted GO
BP GO:0019363 pyridine nucleotide biosynthetic process IEP Predicted GO
BP GO:0019438 aromatic compound biosynthetic process IEP Predicted GO
BP GO:0019439 aromatic compound catabolic process IEP Predicted GO
BP GO:0019637 organophosphate metabolic process IEP Predicted GO
BP GO:0019693 ribose phosphate metabolic process IEP Predicted GO
BP GO:0019752 carboxylic acid metabolic process IEP Predicted GO
CC GO:0022625 cytosolic large ribosomal subunit IEP Predicted GO
CC GO:0022627 cytosolic small ribosomal subunit IEP Predicted GO
MF GO:0030246 carbohydrate binding IEP Predicted GO
MF GO:0030371 translation repressor activity IEP Predicted GO
CC GO:0030532 small nuclear ribonucleoprotein complex IEP Predicted GO
MF GO:0030621 U4 snRNA binding IEP Predicted GO
CC GO:0030880 RNA polymerase complex IEP Predicted GO
BP GO:0031323 regulation of cellular metabolic process IEP Predicted GO
BP GO:0031325 positive regulation of cellular metabolic process IEP Predicted GO
BP GO:0031328 positive regulation of cellular biosynthetic process IEP Predicted GO
CC GO:0031982 vesicle IEP Predicted GO
BP GO:0032774 RNA biosynthetic process IEP Predicted GO
BP GO:0032784 regulation of DNA-templated transcription, elongation IEP Predicted GO
BP GO:0032786 positive regulation of DNA-templated transcription, elongation IEP Predicted GO
BP GO:0032787 monocarboxylic acid metabolic process IEP Predicted GO
BP GO:0033500 carbohydrate homeostasis IEP Predicted GO
MF GO:0033677 DNA/RNA helicase activity IEP Predicted GO
MF GO:0033678 5'-3' DNA/RNA helicase activity IEP Predicted GO
MF GO:0033679 3'-5' DNA/RNA helicase activity IEP Predicted GO
MF GO:0034062 5'-3' RNA polymerase activity IEP Predicted GO
BP GO:0034404 nucleobase-containing small molecule biosynthetic process IEP Predicted GO
MF GO:0034511 U3 snoRNA binding IEP Predicted GO
BP GO:0034641 cellular nitrogen compound metabolic process IEP Predicted GO
BP GO:0034645 cellular macromolecule biosynthetic process IEP Predicted GO
BP GO:0034654 nucleobase-containing compound biosynthetic process IEP Predicted GO
BP GO:0034655 nucleobase-containing compound catabolic process IEP Predicted GO
BP GO:0042221 response to chemical IEP Predicted GO
BP GO:0042493 response to drug IEP Predicted GO
BP GO:0042593 glucose homeostasis IEP Predicted GO
BP GO:0042866 pyruvate biosynthetic process IEP Predicted GO
BP GO:0043038 amino acid activation IEP Predicted GO
BP GO:0043039 tRNA aminoacylation IEP Predicted GO
BP GO:0043043 peptide biosynthetic process IEP Predicted GO
BP GO:0043094 cellular metabolic compound salvage IEP Predicted GO
BP GO:0043101 purine-containing compound salvage IEP Predicted GO
MF GO:0043142 single-stranded DNA-dependent ATPase activity IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
BP GO:0043174 nucleoside salvage IEP Predicted GO
CC GO:0043228 non-membrane-bounded organelle IEP Predicted GO
CC GO:0043232 intracellular non-membrane-bounded organelle IEP Predicted GO
BP GO:0043436 oxoacid metabolic process IEP Predicted GO
BP GO:0043484 regulation of RNA splicing IEP Predicted GO
BP GO:0043603 cellular amide metabolic process IEP Predicted GO
BP GO:0043604 amide biosynthetic process IEP Predicted GO
MF GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity IEP Predicted GO
BP GO:0044238 primary metabolic process IEP Predicted GO
BP GO:0044248 cellular catabolic process IEP Predicted GO
BP GO:0044249 cellular biosynthetic process IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
BP GO:0044270 cellular nitrogen compound catabolic process IEP Predicted GO
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Predicted GO
BP GO:0044281 small molecule metabolic process IEP Predicted GO
BP GO:0044283 small molecule biosynthetic process IEP Predicted GO
CC GO:0044391 ribosomal subunit IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044428 nuclear part IEP Predicted GO
CC GO:0044445 cytosolic part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
CC GO:0044451 nucleoplasm part IEP Predicted GO
MF GO:0045182 translation regulator activity IEP Predicted GO
BP GO:0045893 positive regulation of transcription, DNA-templated IEP Predicted GO
BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0046031 ADP metabolic process IEP Predicted GO
BP GO:0046034 ATP metabolic process IEP Predicted GO
BP GO:0046390 ribose phosphate biosynthetic process IEP Predicted GO
BP GO:0046394 carboxylic acid biosynthetic process IEP Predicted GO
BP GO:0046434 organophosphate catabolic process IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
BP GO:0046496 nicotinamide nucleotide metabolic process IEP Predicted GO
BP GO:0046700 heterocycle catabolic process IEP Predicted GO
BP GO:0046939 nucleotide phosphorylation IEP Predicted GO
MF GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity IEP Predicted GO
MF GO:0048029 monosaccharide binding IEP Predicted GO
BP GO:0051171 regulation of nitrogen compound metabolic process IEP Predicted GO
BP GO:0051173 positive regulation of nitrogen compound metabolic process IEP Predicted GO
BP GO:0051186 cofactor metabolic process IEP Predicted GO
BP GO:0051188 cofactor biosynthetic process IEP Predicted GO
BP GO:0051254 positive regulation of RNA metabolic process IEP Predicted GO
BP GO:0051260 protein homooligomerization IEP Predicted GO
BP GO:0051262 protein tetramerization IEP Predicted GO
BP GO:0051289 protein homotetramerization IEP Predicted GO
CC GO:0055029 nuclear DNA-directed RNA polymerase complex IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
BP GO:0060255 regulation of macromolecule metabolic process IEP Predicted GO
CC GO:0061695 transferase complex, transferring phosphorus-containing groups IEP Predicted GO
BP GO:0065003 protein-containing complex assembly IEP Predicted GO
BP GO:0071704 organic substance metabolic process IEP Predicted GO
BP GO:0072330 monocarboxylic acid biosynthetic process IEP Predicted GO
BP GO:0072521 purine-containing compound metabolic process IEP Predicted GO
BP GO:0072522 purine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072524 pyridine-containing compound metabolic process IEP Predicted GO
BP GO:0072525 pyridine-containing compound biosynthetic process IEP Predicted GO
BP GO:0080090 regulation of primary metabolic process IEP Predicted GO
MF GO:0090079 translation regulator activity, nucleic acid binding IEP Predicted GO
BP GO:0090304 nucleic acid metabolic process IEP Predicted GO
BP GO:0090407 organophosphate biosynthetic process IEP Predicted GO
CC GO:0097525 spliceosomal snRNP complex IEP Predicted GO
BP GO:0097659 nucleic acid-templated transcription IEP Predicted GO
MF GO:0097747 RNA polymerase activity IEP Predicted GO
CC GO:0120114 Sm-like protein family complex IEP Predicted GO
MF GO:0140098 catalytic activity, acting on RNA IEP Predicted GO
MF GO:0140101 catalytic activity, acting on a tRNA IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901137 carbohydrate derivative biosynthetic process IEP Predicted GO
BP GO:1901292 nucleoside phosphate catabolic process IEP Predicted GO
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
BP GO:1901361 organic cyclic compound catabolic process IEP Predicted GO
BP GO:1901362 organic cyclic compound biosynthetic process IEP Predicted GO
BP GO:1901564 organonitrogen compound metabolic process IEP Predicted GO
BP GO:1901566 organonitrogen compound biosynthetic process IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
BP GO:1901576 organic substance biosynthetic process IEP Predicted GO
BP GO:1902680 positive regulation of RNA biosynthetic process IEP Predicted GO
BP GO:1903508 positive regulation of nucleic acid-templated transcription IEP Predicted GO
CC GO:1903561 extracellular vesicle IEP Predicted GO
CC GO:1990234 transferase complex IEP Predicted GO
CC GO:1990904 ribonucleoprotein complex IEP Predicted GO
InterPro domains Description Start Stop
IPR004161 EFTu-like_2 270 352
IPR000795 TF_GTP-bd_dom 35 237
IPR015256 TIF2_gsu_C 364 453
PlasmoDB 811685
PlasmoDB PF14_0104