PF3D7_1429900 (WRN)

Aliases : WRN

Description : SSF52540: P-loop containing nucleoside triphosphate hydrolase, SSF47819: HRDC-like superfamily, SSF46785: Winged helix DNA-binding domain superfamily. Pfam domain(s): PF00271: Helicase conserved C-terminal domain, PF00270: DEAD/DEAH box helicase, PF16124: RecQ zinc-binding, PF09382: RQC domain.

Gene families : OG_01_0000067 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000067_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1429900
Cluster	P. falciparum: Cluster_32

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0000166	nucleotide binding	IEA	PlasmoDB
CC	GO:0000781	chromosome, telomeric region	IDA	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	IEA	Interproscan predictions
MF	GO:0003676	nucleic acid binding	IEA	PlasmoDB
MF	GO:0003678	DNA helicase activity	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003824	catalytic activity	IEA	PlasmoDB
MF	GO:0004003	ATP-dependent DNA helicase activity	None	Extended
MF	GO:0004386	helicase activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IDA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	Interproscan predictions
BP	GO:0006260	DNA replication	IEA	PlasmoDB
BP	GO:0006281	DNA repair	IMP	PlasmoDB
BP	GO:0006281	DNA repair	IEA	Interproscan predictions
BP	GO:0006281	DNA repair	IEA	PlasmoDB
BP	GO:0006310	DNA recombination	IMP	PlasmoDB
BP	GO:0006310	DNA recombination	IEA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0006996	organelle organization	None	Extended
MF	GO:0008026	ATP-dependent helicase activity	None	Extended
MF	GO:0008026	ATP-dependent helicase activity	IEA	PlasmoDB
MF	GO:0008094	DNA-dependent ATPase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
BP	GO:0032392	DNA geometric change	None	Extended
BP	GO:0032508	DNA duplex unwinding	IDA	PlasmoDB
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043138	3'-5' DNA helicase activity	None	Extended
MF	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	IEA	Interproscan predictions
MF	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	IEA	PlasmoDB
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	IEA	PlasmoDB
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044422	organelle part	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044427	chromosomal part	None	Extended
CC	GO:0044446	intracellular organelle part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
MF	GO:0070035	purine NTP-dependent helicase activity	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
CC	GO:0098687	chromosomal region	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003777	microtubule motor activity	IEP	Predicted GO
MF	GO:0003916	DNA topoisomerase activity	IEP	Predicted GO
MF	GO:0005201	extracellular matrix structural constituent	IEP	Predicted GO
CC	GO:0005576	extracellular region	IEP	Predicted GO
CC	GO:0005581	collagen trimer	IEP	Predicted GO
CC	GO:0005871	kinesin complex	IEP	Predicted GO
BP	GO:0006265	DNA topological change	IEP	Predicted GO
BP	GO:0006268	DNA unwinding involved in DNA replication	IEP	Predicted GO
BP	GO:0006497	protein lipidation	IEP	Predicted GO
BP	GO:0006505	GPI anchor metabolic process	IEP	Predicted GO
BP	GO:0006506	GPI anchor biosynthetic process	IEP	Predicted GO
BP	GO:0006643	membrane lipid metabolic process	IEP	Predicted GO
BP	GO:0006661	phosphatidylinositol biosynthetic process	IEP	Predicted GO
BP	GO:0006664	glycolipid metabolic process	IEP	Predicted GO
BP	GO:0006817	phosphate ion transport	IEP	Predicted GO
BP	GO:0007018	microtubule-based movement	IEP	Predicted GO
BP	GO:0007049	cell cycle	IEP	Predicted GO
BP	GO:0007059	chromosome segregation	IEP	Predicted GO
BP	GO:0007155	cell adhesion	IEP	Predicted GO
MF	GO:0008017	microtubule binding	IEP	Predicted GO
BP	GO:0008654	phospholipid biosynthetic process	IEP	Predicted GO
BP	GO:0009247	glycolipid biosynthetic process	IEP	Predicted GO
MF	GO:0015631	tubulin binding	IEP	Predicted GO
BP	GO:0015698	inorganic anion transport	IEP	Predicted GO
BP	GO:0045017	glycerolipid biosynthetic process	IEP	Predicted GO
BP	GO:0046467	membrane lipid biosynthetic process	IEP	Predicted GO
BP	GO:0046474	glycerophospholipid biosynthetic process	IEP	Predicted GO
BP	GO:0046488	phosphatidylinositol metabolic process	IEP	Predicted GO
BP	GO:1903509	liposaccharide metabolic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR011545	DEAD/DEAH_box_helicase_dom	54	217
IPR032284	RecQ_Zn-bd	392	484
IPR001650	Helicase_C	285	378
IPR018982	RQC_domain	567	675

External Links

PlasmoDB	811860
PlasmoDB	PF14_0278

PF3D7_1429900 (WRN)

Expression Profile

Co-expression Networks

Functional Annotation