PF3D7_1451400 (Sir2B)

Aliases : Sir2B

Description : SSF52467: DHS-like NAD/FAD-binding domain superfamily. Pfam domain(s): PF02146: Sir2 family.

Gene families : OG_01_0001797 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001797_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1451400
Cluster	P. falciparum: Cluster_47

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1315100	Sir2b	SSF52467: DHS-like NAD/FAD-binding domain superfamily....	0.04	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004407	histone deacetylase activity	None	Extended
MF	GO:0005488	binding	None	Extended
BP	GO:0006355	regulation of transcription, DNA-templated	IDA	PlasmoDB
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	None	Extended
MF	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	None	Extended
MF	GO:0017136	NAD-dependent histone deacetylase activity	ISS	PlasmoDB
MF	GO:0019213	deacetylase activity	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
MF	GO:0033558	protein deacetylase activity	None	Extended
MF	GO:0034979	NAD-dependent protein deacetylase activity	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051252	regulation of RNA metabolic process	None	Extended
MF	GO:0051287	NAD binding	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
MF	GO:0070403	NAD+ binding	IEA	Interproscan predictions
MF	GO:0070403	NAD+ binding	IEA	PlasmoDB
BP	GO:0080090	regulation of primary metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1903506	regulation of nucleic acid-templated transcription	None	Extended
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	None	Extended
BP	GO:2001141	regulation of RNA biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000177	cytoplasmic exosome (RNase complex)	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0003724	RNA helicase activity	IEP	Predicted GO
MF	GO:0003746	translation elongation factor activity	IEP	Predicted GO
MF	GO:0004004	ATP-dependent RNA helicase activity	IEP	Predicted GO
MF	GO:0004386	helicase activity	IEP	Predicted GO
MF	GO:0004518	nuclease activity	IEP	Predicted GO
MF	GO:0004527	exonuclease activity	IEP	Predicted GO
MF	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEP	Predicted GO
MF	GO:0004888	transmembrane signaling receptor activity	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006474	N-terminal protein amino acid acetylation	IEP	Predicted GO
BP	GO:0006892	post-Golgi vesicle-mediated transport	IEP	Predicted GO
BP	GO:0006896	Golgi to vacuole transport	IEP	Predicted GO
BP	GO:0007167	enzyme linked receptor protein signaling pathway	IEP	Predicted GO
BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEP	Predicted GO
MF	GO:0008026	ATP-dependent helicase activity	IEP	Predicted GO
MF	GO:0008186	RNA-dependent ATPase activity	IEP	Predicted GO
BP	GO:0009790	embryo development	IEP	Predicted GO
BP	GO:0009913	epidermal cell differentiation	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
BP	GO:0016070	RNA metabolic process	IEP	Predicted GO
MF	GO:0016433	rRNA (adenine) methyltransferase activity	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
MF	GO:0016788	hydrolase activity, acting on ester bonds	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
BP	GO:0017196	N-terminal peptidyl-methionine acetylation	IEP	Predicted GO
BP	GO:0018206	peptidyl-methionine modification	IEP	Predicted GO
MF	GO:0019199	transmembrane receptor protein kinase activity	IEP	Predicted GO
BP	GO:0030216	keratinocyte differentiation	IEP	Predicted GO
MF	GO:0030743	rRNA (adenosine-2'-O-)-methyltransferase activity	IEP	Predicted GO
BP	GO:0030855	epithelial cell differentiation	IEP	Predicted GO
CC	GO:0031248	protein acetyltransferase complex	IEP	Predicted GO
CC	GO:0031414	N-terminal protein acetyltransferase complex	IEP	Predicted GO
CC	GO:0031417	NatC complex	IEP	Predicted GO
MF	GO:0038023	signaling receptor activity	IEP	Predicted GO
CC	GO:0045095	keratin filament	IEP	Predicted GO
MF	GO:0070035	purine NTP-dependent helicase activity	IEP	Predicted GO
CC	GO:1902493	acetyltransferase complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003000	Sirtuin	53	147
IPR003000	Sirtuin	209	378

External Links

PlasmoDB	812071
PlasmoDB	PF14_0489

PF3D7_1451400 (Sir2B)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation