PF3D7_1454700 (6PGD)

Aliases : 6PGD

Description : SSF48179: "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily", SSF51735: NAD(P)-binding domain superfamily. Pfam domain(s): PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase, PF00393: "6-phosphogluconate dehydrogenase, C-terminal domain".

Gene families : OG_01_0000374 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000374_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1454700
Cluster	P. falciparum: Cluster_48

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1318400	6PGD	SSF51735: NAD(P)-binding domain superfamily, SSF48179:...	0.05	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IDA	PlasmoDB
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IEA	Interproscan predictions
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005622	intracellular	ISO	PlasmoDB
CC	GO:0005829	cytosol	TAS	PlasmoDB
BP	GO:0006081	cellular aldehyde metabolic process	None	Extended
BP	GO:0006098	pentose-phosphate shunt	IDA	PlasmoDB
BP	GO:0006098	pentose-phosphate shunt	IEA	Interproscan predictions
BP	GO:0006098	pentose-phosphate shunt	IEA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006733	oxidoreduction coenzyme metabolic process	None	Extended
BP	GO:0006739	NADP metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0019362	pyridine nucleotide metabolic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042493	response to drug	IMP	PlasmoDB
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0046496	nicotinamide nucleotide metabolic process	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050661	NADP binding	IEA	Interproscan predictions
MF	GO:0050661	NADP binding	IEA	PlasmoDB
MF	GO:0050662	coenzyme binding	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051156	glucose 6-phosphate metabolic process	None	Extended
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	Interproscan predictions
BP	GO:0055114	oxidation-reduction process	IEA	PlasmoDB
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072524	pyridine-containing compound metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
CC	GO:0000015	phosphopyruvate hydratase complex	IEP	Predicted GO
BP	GO:0000045	autophagosome assembly	IEP	Predicted GO
BP	GO:0000122	negative regulation of transcription by RNA polymerase II	IEP	Predicted GO
BP	GO:0000154	rRNA modification	IEP	Predicted GO
MF	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	IEP	Predicted GO
MF	GO:0000287	magnesium ion binding	IEP	Predicted GO
BP	GO:0001678	cellular glucose homeostasis	IEP	Predicted GO
BP	GO:0001731	formation of translation preinitiation complex	IEP	Predicted GO
BP	GO:0002181	cytoplasmic translation	IEP	Predicted GO
BP	GO:0002253	activation of immune response	IEP	Predicted GO
BP	GO:0002684	positive regulation of immune system process	IEP	Predicted GO
MF	GO:0003714	transcription corepressor activity	IEP	Predicted GO
MF	GO:0004013	adenosylhomocysteinase activity	IEP	Predicted GO
MF	GO:0004017	adenylate kinase activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004222	metalloendopeptidase activity	IEP	Predicted GO
MF	GO:0004298	threonine-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IEP	Predicted GO
MF	GO:0004396	hexokinase activity	IEP	Predicted GO
MF	GO:0004448	isocitrate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004462	lactoylglutathione lyase activity	IEP	Predicted GO
MF	GO:0004576	oligosaccharyl transferase activity	IEP	Predicted GO
MF	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IEP	Predicted GO
MF	GO:0004634	phosphopyruvate hydratase activity	IEP	Predicted GO
MF	GO:0004731	purine-nucleoside phosphorylase activity	IEP	Predicted GO
MF	GO:0004743	pyruvate kinase activity	IEP	Predicted GO
MF	GO:0004784	superoxide dismutase activity	IEP	Predicted GO
MF	GO:0004791	thioredoxin-disulfide reductase activity	IEP	Predicted GO
MF	GO:0004807	triose-phosphate isomerase activity	IEP	Predicted GO
MF	GO:0004816	asparagine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004825	methionine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004839	ubiquitin activating enzyme activity	IEP	Predicted GO
MF	GO:0005310	dicarboxylic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005385	zinc ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005536	glucose binding	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
CC	GO:0005839	proteasome core complex	IEP	Predicted GO
CC	GO:0005850	eukaryotic translation initiation factor 2 complex	IEP	Predicted GO
CC	GO:0005887	integral component of plasma membrane	IEP	Predicted GO
CC	GO:0005956	protein kinase CK2 complex	IEP	Predicted GO
BP	GO:0005975	carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0005996	monosaccharide metabolic process	IEP	Predicted GO
BP	GO:0006006	glucose metabolic process	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006090	pyruvate metabolic process	IEP	Predicted GO
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0006094	gluconeogenesis	IEP	Predicted GO
BP	GO:0006096	glycolytic process	IEP	Predicted GO
BP	GO:0006102	isocitrate metabolic process	IEP	Predicted GO
BP	GO:0006148	inosine catabolic process	IEP	Predicted GO
BP	GO:0006152	purine nucleoside catabolic process	IEP	Predicted GO
BP	GO:0006163	purine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006164	purine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEP	Predicted GO
BP	GO:0006272	leading strand elongation	IEP	Predicted GO
BP	GO:0006421	asparaginyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006431	methionyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006487	protein N-linked glycosylation	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0006606	protein import into nucleus	IEP	Predicted GO
BP	GO:0006607	NLS-bearing protein import into nucleus	IEP	Predicted GO
BP	GO:0006627	protein processing involved in protein targeting to mitochondrion	IEP	Predicted GO
BP	GO:0006749	glutathione metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006757	ATP generation from ADP	IEP	Predicted GO
BP	GO:0006801	superoxide metabolic process	IEP	Predicted GO
BP	GO:0006829	zinc ion transport	IEP	Predicted GO
BP	GO:0006835	dicarboxylic acid transport	IEP	Predicted GO
BP	GO:0006913	nucleocytoplasmic transport	IEP	Predicted GO
BP	GO:0007033	vacuole organization	IEP	Predicted GO
MF	GO:0008170	N-methyltransferase activity	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008237	metallopeptidase activity	IEP	Predicted GO
CC	GO:0008250	oligosaccharyltransferase complex	IEP	Predicted GO
BP	GO:0008535	respiratory chain complex IV assembly	IEP	Predicted GO
BP	GO:0009056	catabolic process	IEP	Predicted GO
BP	GO:0009057	macromolecule catabolic process	IEP	Predicted GO
BP	GO:0009108	coenzyme biosynthetic process	IEP	Predicted GO
BP	GO:0009132	nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009135	purine nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009150	purine ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009152	purine ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009164	nucleoside catabolic process	IEP	Predicted GO
BP	GO:0009165	nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009166	nucleotide catabolic process	IEP	Predicted GO
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009185	ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009259	ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009260	ribonucleotide biosynthetic process	IEP	Predicted GO
MF	GO:0015140	malate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015367	oxoglutarate:malate antiporter activity	IEP	Predicted GO
MF	GO:0015556	C4-dicarboxylate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015740	C4-dicarboxylate transport	IEP	Predicted GO
BP	GO:0015742	alpha-ketoglutarate transport	IEP	Predicted GO
BP	GO:0015743	malate transport	IEP	Predicted GO
BP	GO:0016051	carbohydrate biosynthetic process	IEP	Predicted GO
BP	GO:0016052	carbohydrate catabolic process	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
MF	GO:0016209	antioxidant activity	IEP	Predicted GO
CC	GO:0016272	prefoldin complex	IEP	Predicted GO
BP	GO:0016310	phosphorylation	IEP	Predicted GO
MF	GO:0016433	rRNA (adenine) methyltransferase activity	IEP	Predicted GO
BP	GO:0016485	protein processing	IEP	Predicted GO
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEP	Predicted GO
MF	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	IEP	Predicted GO
MF	GO:0016740	transferase activity	IEP	Predicted GO
MF	GO:0016757	transferase activity, transferring glycosyl groups	IEP	Predicted GO
MF	GO:0016801	hydrolase activity, acting on ether bonds	IEP	Predicted GO
MF	GO:0016802	trialkylsulfonium hydrolase activity	IEP	Predicted GO
MF	GO:0016846	carbon-sulfur lyase activity	IEP	Predicted GO
MF	GO:0016860	intramolecular oxidoreductase activity	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
CC	GO:0017087	mitochondrial processing peptidase complex	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
MF	GO:0019200	carbohydrate kinase activity	IEP	Predicted GO
BP	GO:0019318	hexose metabolic process	IEP	Predicted GO
BP	GO:0019319	hexose biosynthetic process	IEP	Predicted GO
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019363	pyridine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019439	aromatic compound catabolic process	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
BP	GO:0019725	cellular homeostasis	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0019773	proteasome core complex, alpha-subunit complex	IEP	Predicted GO
CC	GO:0019774	proteasome core complex, beta-subunit complex	IEP	Predicted GO
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0022607	cellular component assembly	IEP	Predicted GO
MF	GO:0030246	carbohydrate binding	IEP	Predicted GO
BP	GO:0032787	monocarboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0033365	protein localization to organelle	IEP	Predicted GO
BP	GO:0033500	carbohydrate homeostasis	IEP	Predicted GO
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0034504	protein localization to nucleus	IEP	Predicted GO
BP	GO:0034613	cellular protein localization	IEP	Predicted GO
BP	GO:0034622	cellular protein-containing complex assembly	IEP	Predicted GO
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0034655	nucleobase-containing compound catabolic process	IEP	Predicted GO
BP	GO:0034656	nucleobase-containing small molecule catabolic process	IEP	Predicted GO
BP	GO:0034982	mitochondrial protein processing	IEP	Predicted GO
BP	GO:0042454	ribonucleoside catabolic process	IEP	Predicted GO
BP	GO:0042592	homeostatic process	IEP	Predicted GO
BP	GO:0042593	glucose homeostasis	IEP	Predicted GO
BP	GO:0042866	pyruvate biosynthetic process	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Predicted GO
MF	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	IEP	Predicted GO
BP	GO:0043933	protein-containing complex subunit organization	IEP	Predicted GO
BP	GO:0044248	cellular catabolic process	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Predicted GO
BP	GO:0044270	cellular nitrogen compound catabolic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
CC	GO:0044432	endoplasmic reticulum part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
CC	GO:0044613	nuclear pore central transport channel	IEP	Predicted GO
BP	GO:0046031	ADP metabolic process	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046102	inosine metabolic process	IEP	Predicted GO
BP	GO:0046130	purine ribonucleoside catabolic process	IEP	Predicted GO
BP	GO:0046364	monosaccharide biosynthetic process	IEP	Predicted GO
BP	GO:0046390	ribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0046434	organophosphate catabolic process	IEP	Predicted GO
BP	GO:0046700	heterocycle catabolic process	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
BP	GO:0046939	nucleotide phosphorylation	IEP	Predicted GO
MF	GO:0048029	monosaccharide binding	IEP	Predicted GO
BP	GO:0048584	positive regulation of response to stimulus	IEP	Predicted GO
BP	GO:0050778	positive regulation of immune response	IEP	Predicted GO
BP	GO:0051169	nuclear transport	IEP	Predicted GO
BP	GO:0051170	import into nucleus	IEP	Predicted GO
BP	GO:0051181	cofactor transport	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
BP	GO:0051260	protein homooligomerization	IEP	Predicted GO
BP	GO:0051262	protein tetramerization	IEP	Predicted GO
MF	GO:0051287	NAD binding	IEP	Predicted GO
BP	GO:0051289	protein homotetramerization	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
BP	GO:0051604	protein maturation	IEP	Predicted GO
MF	GO:0061608	nuclear import signal receptor activity	IEP	Predicted GO
BP	GO:0065003	protein-containing complex assembly	IEP	Predicted GO
MF	GO:0070003	threonine-type peptidase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0070727	cellular macromolecule localization	IEP	Predicted GO
BP	GO:0072330	monocarboxylic acid biosynthetic process	IEP	Predicted GO
MF	GO:0072509	divalent inorganic cation transmembrane transporter activity	IEP	Predicted GO
BP	GO:0072521	purine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072522	purine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0072523	purine-containing compound catabolic process	IEP	Predicted GO
BP	GO:0072525	pyridine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0072593	reactive oxygen species metabolic process	IEP	Predicted GO
BP	GO:0072594	establishment of protein localization to organelle	IEP	Predicted GO
BP	GO:0090407	organophosphate biosynthetic process	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
MF	GO:0140142	nucleocytoplasmic carrier activity	IEP	Predicted GO
BP	GO:1901137	carbohydrate derivative biosynthetic process	IEP	Predicted GO
BP	GO:1901292	nucleoside phosphate catabolic process	IEP	Predicted GO
BP	GO:1901293	nucleoside phosphate biosynthetic process	IEP	Predicted GO
BP	GO:1901361	organic cyclic compound catabolic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:1901575	organic substance catabolic process	IEP	Predicted GO
BP	GO:1901658	glycosyl compound catabolic process	IEP	Predicted GO
BP	GO:1905037	autophagosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR006114	6PGDH_C	178	468
IPR006115	6PGDH_NADP-bd	3	173

External Links

PlasmoDB	812102
PlasmoDB	PF14_0520

PF3D7_1454700 (6PGD)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation