PF3D7_1457500 (VPS4)

Aliases : VPS4

Description : SSF52540: P-loop containing nucleoside triphosphate hydrolase, SSF116846: MIT domain superfamily. Pfam domain(s): PF04212: MIT (microtubule interacting and transport) domain, PF17862: AAA+ lid domain, PF00004: ATPase family associated with various cellular activities (AAA), PF09336: Vps4 C terminal oligomerisation domain.

Gene families : OG_01_0001817 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001817_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1457500
Cluster	P. falciparum: Cluster_23

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1321200	VPS4	SSF116846: MIT domain superfamily, SSF52540: P-loop...	0.03	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005737	cytoplasm	IDA	PlasmoDB
BP	GO:0006810	transport	None	Extended
BP	GO:0006886	intracellular protein transport	ISS	PlasmoDB
BP	GO:0008104	protein localization	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0015031	protein transport	None	Extended
BP	GO:0015833	peptide transport	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	ISS	PlasmoDB
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033036	macromolecule localization	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042886	amide transport	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0045184	establishment of protein localization	None	Extended
BP	GO:0046907	intracellular transport	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0051641	cellular localization	None	Extended
BP	GO:0051649	establishment of localization in cell	None	Extended
BP	GO:0071702	organic substance transport	None	Extended
BP	GO:0071705	nitrogen compound transport	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000791	euchromatin	IEP	Predicted GO
MF	GO:0003919	FMN adenylyltransferase activity	IEP	Predicted GO
MF	GO:0003954	NADH dehydrogenase activity	IEP	Predicted GO
MF	GO:0004057	arginyltransferase activity	IEP	Predicted GO
MF	GO:0004140	dephospho-CoA kinase activity	IEP	Predicted GO
MF	GO:0004392	heme oxygenase (decyclizing) activity	IEP	Predicted GO
MF	GO:0004438	phosphatidylinositol-3-phosphatase activity	IEP	Predicted GO
MF	GO:0004596	peptide alpha-N-acetyltransferase activity	IEP	Predicted GO
MF	GO:0004767	sphingomyelin phosphodiesterase activity	IEP	Predicted GO
MF	GO:0005200	structural constituent of cytoskeleton	IEP	Predicted GO
MF	GO:0005484	SNAP receptor activity	IEP	Predicted GO
CC	GO:0005739	mitochondrion	IEP	Predicted GO
CC	GO:0005783	endoplasmic reticulum	IEP	Predicted GO
CC	GO:0005856	cytoskeleton	IEP	Predicted GO
BP	GO:0006108	malate metabolic process	IEP	Predicted GO
BP	GO:0006119	oxidative phosphorylation	IEP	Predicted GO
BP	GO:0006163	purine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006474	N-terminal protein amino acid acetylation	IEP	Predicted GO
BP	GO:0006629	lipid metabolic process	IEP	Predicted GO
BP	GO:0006643	membrane lipid metabolic process	IEP	Predicted GO
BP	GO:0006644	phospholipid metabolic process	IEP	Predicted GO
BP	GO:0006664	glycolipid metabolic process	IEP	Predicted GO
BP	GO:0006665	sphingolipid metabolic process	IEP	Predicted GO
BP	GO:0006684	sphingomyelin metabolic process	IEP	Predicted GO
BP	GO:0006787	porphyrin-containing compound catabolic process	IEP	Predicted GO
BP	GO:0006833	water transport	IEP	Predicted GO
BP	GO:0007010	cytoskeleton organization	IEP	Predicted GO
MF	GO:0008121	ubiquinol-cytochrome-c reductase activity	IEP	Predicted GO
MF	GO:0008137	NADH dehydrogenase (ubiquinone) activity	IEP	Predicted GO
MF	GO:0008519	ammonium transmembrane transporter activity	IEP	Predicted GO
MF	GO:0008914	leucyltransferase activity	IEP	Predicted GO
BP	GO:0009108	coenzyme biosynthetic process	IEP	Predicted GO
BP	GO:0009150	purine ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009247	glycolipid biosynthetic process	IEP	Predicted GO
BP	GO:0009259	ribonucleotide metabolic process	IEP	Predicted GO
CC	GO:0009986	cell surface	IEP	Predicted GO
BP	GO:0015791	polyol transport	IEP	Predicted GO
BP	GO:0015850	organic hydroxy compound transport	IEP	Predicted GO
CC	GO:0016021	integral component of membrane	IEP	Predicted GO
BP	GO:0016093	polyprenol metabolic process	IEP	Predicted GO
BP	GO:0016094	polyprenol biosynthetic process	IEP	Predicted GO
MF	GO:0016149	translation release factor activity, codon specific	IEP	Predicted GO
CC	GO:0016324	apical plasma membrane	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
BP	GO:0016598	protein arginylation	IEP	Predicted GO
MF	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IEP	Predicted GO
MF	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	IEP	Predicted GO
MF	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	IEP	Predicted GO
MF	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEP	Predicted GO
MF	GO:0016755	transferase activity, transferring amino-acyl groups	IEP	Predicted GO
BP	GO:0019348	dolichol metabolic process	IEP	Predicted GO
BP	GO:0019408	dolichol biosynthetic process	IEP	Predicted GO
BP	GO:0019637	organophosphate metabolic process	IEP	Predicted GO
CC	GO:0020004	symbiont-containing vacuolar space	IEP	Predicted GO
CC	GO:0031201	SNARE complex	IEP	Predicted GO
CC	GO:0031224	intrinsic component of membrane	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
CC	GO:0031248	protein acetyltransferase complex	IEP	Predicted GO
BP	GO:0031338	regulation of vesicle fusion	IEP	Predicted GO
CC	GO:0031414	N-terminal protein acetyltransferase complex	IEP	Predicted GO
CC	GO:0031415	NatA complex	IEP	Predicted GO
BP	GO:0033015	tetrapyrrole catabolic process	IEP	Predicted GO
MF	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	IEP	Predicted GO
MF	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	IEP	Predicted GO
MF	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	IEP	Predicted GO
BP	GO:0042044	fluid transport	IEP	Predicted GO
BP	GO:0042167	heme catabolic process	IEP	Predicted GO
MF	GO:0042578	phosphoric ester hydrolase activity	IEP	Predicted GO
MF	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity	IEP	Predicted GO
MF	GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IEP	Predicted GO
BP	GO:0044255	cellular lipid metabolic process	IEP	Predicted GO
CC	GO:0044425	membrane part	IEP	Predicted GO
CC	GO:0044459	plasma membrane part	IEP	Predicted GO
CC	GO:0045177	apical part of cell	IEP	Predicted GO
BP	GO:0046149	pigment catabolic process	IEP	Predicted GO
BP	GO:0046467	membrane lipid biosynthetic process	IEP	Predicted GO
BP	GO:0046488	phosphatidylinositol metabolic process	IEP	Predicted GO
CC	GO:0046658	anchored component of plasma membrane	IEP	Predicted GO
BP	GO:0046839	phospholipid dephosphorylation	IEP	Predicted GO
BP	GO:0046856	phosphatidylinositol dephosphorylation	IEP	Predicted GO
MF	GO:0048038	quinone binding	IEP	Predicted GO
MF	GO:0048039	ubiquinone binding	IEP	Predicted GO
CC	GO:0048471	perinuclear region of cytoplasm	IEP	Predicted GO
MF	GO:0050136	NADH dehydrogenase (quinone) activity	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051187	cofactor catabolic process	IEP	Predicted GO
BP	GO:0051475	glucosylglycerol transport	IEP	Predicted GO
BP	GO:0051604	protein maturation	IEP	Predicted GO
MF	GO:0052744	phosphatidylinositol monophosphate phosphatase activity	IEP	Predicted GO
MF	GO:0052866	phosphatidylinositol phosphate phosphatase activity	IEP	Predicted GO
BP	GO:0060627	regulation of vesicle-mediated transport	IEP	Predicted GO
CC	GO:0070258	inner membrane pellicle complex	IEP	Predicted GO
CC	GO:0098590	plasma membrane region	IEP	Predicted GO
MF	GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	IEP	Predicted GO
BP	GO:1901135	carbohydrate derivative metabolic process	IEP	Predicted GO
BP	GO:1901137	carbohydrate derivative biosynthetic process	IEP	Predicted GO
CC	GO:1902493	acetyltransferase complex	IEP	Predicted GO
BP	GO:1903509	liposaccharide metabolic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR015415	Vps4_C	353	415
IPR003959	ATPase_AAA_core	150	279
IPR007330	MIT	9	72

External Links

PlasmoDB	812130
PlasmoDB	PF14_0548

PF3D7_1457500 (VPS4)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation