PF3D7_1467300 (DXR)

Aliases : DXR

Description : SSF51735: NAD(P)-binding domain superfamily, SSF69055: "DXP reductoisomerase, C-terminal domain superfamily", SSF55347: No description available. Pfam domain(s): PF13288: DXP reductoisomerase C-terminal domain, PF08436: 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain, PF02670: 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Gene families : OG_01_0001858 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001858_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1467300
Cluster	P. falciparum: Cluster_10

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1330600	DXR	SSF55347: 20-02-2019, SSF69055: DXP reductoisomerase,...	0.02	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IEA	Interproscan predictions
MF	GO:0005515	protein binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006629	lipid metabolic process	None	Extended
BP	GO:0006720	isoprenoid metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008299	isoprenoid biosynthetic process	IEA	PlasmoDB
BP	GO:0008610	lipid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
CC	GO:0009536	plastid	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
CC	GO:0020011	apicoplast	IDA	PlasmoDB
MF	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	IEA	PlasmoDB
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044255	cellular lipid metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
MF	GO:0046872	metal ion binding	IEA	PlasmoDB
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050661	NADP binding	None	Extended
MF	GO:0050662	coenzyme binding	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	Interproscan predictions
BP	GO:0055114	oxidation-reduction process	IEA	PlasmoDB
MF	GO:0070402	NADPH binding	IEA	Interproscan predictions
MF	GO:0070402	NADPH binding	IEA	PlasmoDB
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000036	acyl carrier activity	IEP	Predicted GO
BP	GO:0000041	transition metal ion transport	IEP	Predicted GO
MF	GO:0000225	N-acetylglucosaminylphosphatidylinositol deacetylase activity	IEP	Predicted GO
MF	GO:0000234	phosphoethanolamine N-methyltransferase activity	IEP	Predicted GO
CC	GO:0000313	organellar ribosome	IEP	Predicted GO
MF	GO:0003689	DNA clamp loader activity	IEP	Predicted GO
MF	GO:0003909	DNA ligase activity	IEP	Predicted GO
MF	GO:0003911	DNA ligase (NAD+) activity	IEP	Predicted GO
MF	GO:0003998	acylphosphatase activity	IEP	Predicted GO
MF	GO:0004140	dephospho-CoA kinase activity	IEP	Predicted GO
MF	GO:0004170	dUTP diphosphatase activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004298	threonine-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004311	farnesyltranstransferase activity	IEP	Predicted GO
MF	GO:0004448	isocitrate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004602	glutathione peroxidase activity	IEP	Predicted GO
MF	GO:0004659	prenyltransferase activity	IEP	Predicted GO
MF	GO:0004825	methionine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005342	organic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005375	copper ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0005385	zinc ion transmembrane transporter activity	IEP	Predicted GO
CC	GO:0005622	intracellular	IEP	Predicted GO
CC	GO:0005663	DNA replication factor C complex	IEP	Predicted GO
CC	GO:0005743	mitochondrial inner membrane	IEP	Predicted GO
CC	GO:0005761	mitochondrial ribosome	IEP	Predicted GO
CC	GO:0005787	signal peptidase complex	IEP	Predicted GO
CC	GO:0005794	Golgi apparatus	IEP	Predicted GO
CC	GO:0005839	proteasome core complex	IEP	Predicted GO
BP	GO:0006102	isocitrate metabolic process	IEP	Predicted GO
BP	GO:0006259	DNA metabolic process	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006271	DNA strand elongation involved in DNA replication	IEP	Predicted GO
BP	GO:0006272	leading strand elongation	IEP	Predicted GO
BP	GO:0006431	methionyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006465	signal peptide processing	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0006518	peptide metabolic process	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0006778	porphyrin-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006779	porphyrin-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0006783	heme biosynthetic process	IEP	Predicted GO
BP	GO:0006784	heme a biosynthetic process	IEP	Predicted GO
BP	GO:0006807	nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0006811	ion transport	IEP	Predicted GO
BP	GO:0006829	zinc ion transport	IEP	Predicted GO
BP	GO:0006835	dicarboxylic acid transport	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
MF	GO:0008168	methyltransferase activity	IEP	Predicted GO
MF	GO:0008170	N-methyltransferase activity	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008495	protoheme IX farnesyltransferase activity	IEP	Predicted GO
MF	GO:0008509	anion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0008514	organic anion transmembrane transporter activity	IEP	Predicted GO
BP	GO:0008535	respiratory chain complex IV assembly	IEP	Predicted GO
MF	GO:0008897	holo-[acyl-carrier-protein] synthase activity	IEP	Predicted GO
BP	GO:0009056	catabolic process	IEP	Predicted GO
BP	GO:0009057	macromolecule catabolic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0015075	ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015140	malate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015318	inorganic molecular entity transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015367	oxoglutarate:malate antiporter activity	IEP	Predicted GO
MF	GO:0015556	C4-dicarboxylate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015711	organic anion transport	IEP	Predicted GO
BP	GO:0015740	C4-dicarboxylate transport	IEP	Predicted GO
BP	GO:0015742	alpha-ketoglutarate transport	IEP	Predicted GO
BP	GO:0015743	malate transport	IEP	Predicted GO
BP	GO:0015849	organic acid transport	IEP	Predicted GO
BP	GO:0016093	polyprenol metabolic process	IEP	Predicted GO
BP	GO:0016094	polyprenol biosynthetic process	IEP	Predicted GO
BP	GO:0016485	protein processing	IEP	Predicted GO
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Predicted GO
MF	GO:0016787	hydrolase activity	IEP	Predicted GO
BP	GO:0017004	cytochrome complex assembly	IEP	Predicted GO
BP	GO:0017062	respiratory chain complex III assembly	IEP	Predicted GO
BP	GO:0019348	dolichol metabolic process	IEP	Predicted GO
BP	GO:0019408	dolichol biosynthetic process	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
CC	GO:0019773	proteasome core complex, alpha-subunit complex	IEP	Predicted GO
CC	GO:0019866	organelle inner membrane	IEP	Predicted GO
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0022607	cellular component assembly	IEP	Predicted GO
BP	GO:0022616	DNA strand elongation	IEP	Predicted GO
CC	GO:0030134	COPII-coated ER to Golgi transport vesicle	IEP	Predicted GO
MF	GO:0030337	DNA polymerase processivity factor activity	IEP	Predicted GO
CC	GO:0031090	organelle membrane	IEP	Predicted GO
CC	GO:0031966	mitochondrial membrane	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0033013	tetrapyrrole metabolic process	IEP	Predicted GO
BP	GO:0033014	tetrapyrrole biosynthetic process	IEP	Predicted GO
BP	GO:0033108	mitochondrial respiratory chain complex assembly	IEP	Predicted GO
MF	GO:0033170	protein-DNA loading ATPase activity	IEP	Predicted GO
BP	GO:0034551	mitochondrial respiratory chain complex III assembly	IEP	Predicted GO
BP	GO:0034622	cellular protein-containing complex assembly	IEP	Predicted GO
BP	GO:0034641	cellular nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0035434	copper ion transmembrane transport	IEP	Predicted GO
BP	GO:0042168	heme metabolic process	IEP	Predicted GO
BP	GO:0042440	pigment metabolic process	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Predicted GO
BP	GO:0043933	protein-containing complex subunit organization	IEP	Predicted GO
BP	GO:0044248	cellular catabolic process	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044427	chromosomal part	IEP	Predicted GO
CC	GO:0044429	mitochondrial part	IEP	Predicted GO
CC	GO:0044432	endoplasmic reticulum part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
MF	GO:0044620	ACP phosphopantetheine attachment site binding	IEP	Predicted GO
BP	GO:0045017	glycerolipid biosynthetic process	IEP	Predicted GO
BP	GO:0046148	pigment biosynthetic process	IEP	Predicted GO
BP	GO:0046160	heme a metabolic process	IEP	Predicted GO
BP	GO:0046474	glycerophospholipid biosynthetic process	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
MF	GO:0046915	transition metal ion transmembrane transporter activity	IEP	Predicted GO
BP	GO:0046942	carboxylic acid transport	IEP	Predicted GO
MF	GO:0046943	carboxylic acid transmembrane transporter activity	IEP	Predicted GO
BP	GO:0048033	heme o metabolic process	IEP	Predicted GO
BP	GO:0048034	heme O biosynthetic process	IEP	Predicted GO
BP	GO:0051131	chaperone-mediated protein complex assembly	IEP	Predicted GO
MF	GO:0051192	prosthetic group binding	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
BP	GO:0055085	transmembrane transport	IEP	Predicted GO
BP	GO:0065003	protein-containing complex assembly	IEP	Predicted GO
MF	GO:0070003	threonine-type peptidase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0070070	proton-transporting V-type ATPase complex assembly	IEP	Predicted GO
BP	GO:0070071	proton-transporting two-sector ATPase complex assembly	IEP	Predicted GO
BP	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	IEP	Predicted GO
MF	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	IEP	Predicted GO
MF	GO:0070628	proteasome binding	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:1901575	organic substance catabolic process	IEP	Predicted GO
CC	GO:1905368	peptidase complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR026877	DXPR_C	357	476
IPR013644	DXP_reductoisomerase_C	227	323
IPR013512	DXP_reductoisomerase_N	80	212

External Links

PlasmoDB	812223
PlasmoDB	PF14_0641

PF3D7_1467300 (DXR)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation