PBANKA_1003100 (PRPF8)

Aliases : PRPF8

Description : SSF53098: Ribonuclease H-like superfamily. Pfam domain(s): PF08084: PROCT (NUC072) domain, PF08083: PROCN (NUC071) domain, PF08082: PRO8NT (NUC069), PrP8 N-terminal domain, PF12134: PRP8 domain IV core, PF10596: U6-snRNA interacting domain of PrP8, PF10597: U5-snRNA binding site 2 of PrP8, PF10598: RNA recognition motif of the spliceosomal PrP8.

Gene families : OG_01_0001210 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001210_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pbe RNA-seq: PBANKA_1003100
Cluster	P. berghei: Cluster_4

Target	Alias	Description	ECC score	Gene Family Method	Actions
PF3D7_0405400	PRPF8	SSF53098: Ribonuclease H-like superfamily. Pfam...	0.05	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
BP	GO:0000375	RNA splicing, via transesterification reactions	None	Extended
BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	None	Extended
BP	GO:0000398	mRNA splicing, via spliceosome	IEA	Interproscan predictions
BP	GO:0000398	mRNA splicing, via spliceosome	IEA	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003723	RNA binding	IEA	Interproscan predictions
MF	GO:0003723	RNA binding	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006396	RNA processing	None	Extended
BP	GO:0006397	mRNA processing	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008380	RNA splicing	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
BP	GO:0016071	mRNA metabolic process	None	Extended
MF	GO:0017069	snRNA binding	None	Extended
MF	GO:0017070	U6 snRNA binding	IEA	Interproscan predictions
MF	GO:0017070	U6 snRNA binding	IEA	PlasmoDB
MF	GO:0030623	U5 snRNA binding	IEA	Interproscan predictions
MF	GO:0030623	U5 snRNA binding	IEA	PlasmoDB
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
MF	GO:0003677	DNA binding	IEP	Predicted GO
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Predicted GO
MF	GO:0004518	nuclease activity	IEP	Predicted GO
MF	GO:0004527	exonuclease activity	IEP	Predicted GO
MF	GO:0004532	exoribonuclease activity	IEP	Predicted GO
MF	GO:0004534	5'-3' exoribonuclease activity	IEP	Predicted GO
MF	GO:0004816	asparagine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005198	structural molecule activity	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
CC	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	IEP	Predicted GO
CC	GO:0005849	mRNA cleavage factor complex	IEP	Predicted GO
BP	GO:0006261	DNA-dependent DNA replication	IEP	Predicted GO
BP	GO:0006351	transcription, DNA-templated	IEP	Predicted GO
BP	GO:0006366	transcription by RNA polymerase II	IEP	Predicted GO
BP	GO:0006378	mRNA polyadenylation	IEP	Predicted GO
BP	GO:0006379	mRNA cleavage	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006421	asparaginyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0008033	tRNA processing	IEP	Predicted GO
MF	GO:0008409	5'-3' exonuclease activity	IEP	Predicted GO
BP	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009266	response to temperature stimulus	IEP	Predicted GO
BP	GO:0009405	pathogenesis	IEP	Predicted GO
BP	GO:0009408	response to heat	IEP	Predicted GO
BP	GO:0009628	response to abiotic stimulus	IEP	Predicted GO
MF	GO:0010181	FMN binding	IEP	Predicted GO
BP	GO:0016049	cell growth	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
MF	GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	IEP	Predicted GO
MF	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
CC	GO:0020002	host cell plasma membrane	IEP	Predicted GO
CC	GO:0030118	clathrin coat	IEP	Predicted GO
CC	GO:0030125	clathrin vesicle coat	IEP	Predicted GO
CC	GO:0030130	clathrin coat of trans-Golgi network vesicle	IEP	Predicted GO
CC	GO:0030132	clathrin coat of coated pit	IEP	Predicted GO
MF	GO:0030276	clathrin binding	IEP	Predicted GO
MF	GO:0030544	Hsp70 protein binding	IEP	Predicted GO
MF	GO:0031072	heat shock protein binding	IEP	Predicted GO
BP	GO:0031124	mRNA 3'-end processing	IEP	Predicted GO
MF	GO:0031369	translation initiation factor binding	IEP	Predicted GO
BP	GO:0031590	wybutosine metabolic process	IEP	Predicted GO
BP	GO:0031591	wybutosine biosynthetic process	IEP	Predicted GO
MF	GO:0032051	clathrin light chain binding	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
BP	GO:0032774	RNA biosynthetic process	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
BP	GO:0040007	growth	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
BP	GO:0043412	macromolecule modification	IEP	Predicted GO
BP	GO:0043631	RNA polyadenylation	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044451	nucleoplasm part	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
BP	GO:0048268	clathrin coat assembly	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
MF	GO:0070403	NAD+ binding	IEP	Predicted GO
CC	GO:0070847	core mediator complex	IEP	Predicted GO
CC	GO:0071013	catalytic step 2 spliceosome	IEP	Predicted GO
CC	GO:0071439	clathrin complex	IEP	Predicted GO
MF	GO:0097367	carbohydrate derivative binding	IEP	Predicted GO
BP	GO:0097659	nucleic acid-templated transcription	IEP	Predicted GO
MF	GO:0097747	RNA polymerase activity	IEP	Predicted GO
CC	GO:0098797	plasma membrane protein complex	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
CC	GO:1990229	iron-sulfur cluster assembly complex	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR012592	PROCN	892	1299
IPR021983	PRP8_domainIV	2314	2543
IPR019580	Prp8_U6-snRNA-bd	1980	2136
IPR012591	PRO8NT	365	516
IPR019581	Prp8_U5-snRNA-bd	1747	1879
IPR012984	PROCT	2825	2945
IPR019582	RRM_spliceosomal_PrP8	1484	1574

External Links

PlasmoDB	PB000225.00.0
PlasmoDB	PB000226.00.0
PlasmoDB	PB000736.01.0
PlasmoDB	PB000737.01.0
PlasmoDB	PB001033.02.0
PlasmoDB	PB100403.00.0
PlasmoDB	PB104011.00.0
PlasmoDB	PB300532.00.0
PlasmoDB	PB300843.00.0
PlasmoDB	PB300975.00.0
PlasmoDB	PBANKA_100310

PBANKA_1003100 (PRPF8)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation