PF3D7_0107800 (MRE11)

Aliases : MRE11

Description : SSF56300: No description available. Pfam domain(s): PF04152: Mre11 DNA-binding presumed domain.

Gene families : OG_01_0002310 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002310_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0107800
Cluster	P. falciparum: Cluster_41

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004518	nuclease activity	None	Extended
MF	GO:0004518	nuclease activity	IGI	PlasmoDB
MF	GO:0004519	endonuclease activity	IEA	Interproscan predictions
MF	GO:0004519	endonuclease activity	IEA	PlasmoDB
MF	GO:0004527	exonuclease activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IPI	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	Interproscan predictions
CC	GO:0005634	nucleus	IEA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006281	DNA repair	IMP	PlasmoDB
BP	GO:0006302	double-strand break repair	IEA	Interproscan predictions
BP	GO:0006302	double-strand break repair	IEA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016788	hydrolase activity, acting on ester bonds	None	Extended
MF	GO:0030145	manganese ion binding	IEA	Interproscan predictions
MF	GO:0030145	manganese ion binding	IEA	PlasmoDB
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
MF	GO:0001786	phosphatidylserine binding	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003677	DNA binding	IEP	Predicted GO
MF	GO:0003690	double-stranded DNA binding	IEP	Predicted GO
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Predicted GO
MF	GO:0004523	RNA-DNA hybrid ribonuclease activity	IEP	Predicted GO
MF	GO:0004540	ribonuclease activity	IEP	Predicted GO
MF	GO:0004594	pantothenate kinase activity	IEP	Predicted GO
MF	GO:0004661	protein geranylgeranyltransferase activity	IEP	Predicted GO
MF	GO:0004663	Rab geranylgeranyltransferase activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004823	leucine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004831	tyrosine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004839	ubiquitin activating enzyme activity	IEP	Predicted GO
MF	GO:0005088	Ras guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0005215	transporter activity	IEP	Predicted GO
MF	GO:0005324	long-chain fatty acid transporter activity	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
CC	GO:0005658	alpha DNA polymerase:primase complex	IEP	Predicted GO
CC	GO:0005829	cytosol	IEP	Predicted GO
CC	GO:0005968	Rab-protein geranylgeranyltransferase complex	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006097	glyoxylate cycle	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006427	histidyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006429	leucyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006437	tyrosyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006665	sphingolipid metabolic process	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008641	ubiquitin-like modifier activating enzyme activity	IEP	Predicted GO
CC	GO:0009536	plastid	IEP	Predicted GO
BP	GO:0010243	response to organonitrogen compound	IEP	Predicted GO
MF	GO:0010314	phosphatidylinositol-5-phosphate binding	IEP	Predicted GO
BP	GO:0010498	proteasomal protein catabolic process	IEP	Predicted GO
BP	GO:0010564	regulation of cell cycle process	IEP	Predicted GO
BP	GO:0015074	DNA integration	IEP	Predicted GO
MF	GO:0015399	primary active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	IEP	Predicted GO
CC	GO:0016234	inclusion body	IEP	Predicted GO
BP	GO:0016441	posttranscriptional gene silencing	IEP	Predicted GO
BP	GO:0016458	gene silencing	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
MF	GO:0016877	ligase activity, forming carbon-sulfur bonds	IEP	Predicted GO
MF	GO:0016887	ATPase activity	IEP	Predicted GO
BP	GO:0016925	protein sumoylation	IEP	Predicted GO
MF	GO:0017076	purine nucleotide binding	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
MF	GO:0017112	Rab guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0017137	Rab GTPase binding	IEP	Predicted GO
BP	GO:0018344	protein geranylgeranylation	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
MF	GO:0019948	SUMO activating enzyme activity	IEP	Predicted GO
CC	GO:0020011	apicoplast	IEP	Predicted GO
MF	GO:0022804	active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0022857	transmembrane transporter activity	IEP	Predicted GO
BP	GO:0030433	ubiquitin-dependent ERAD pathway	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
CC	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
BP	GO:0032196	transposition	IEP	Predicted GO
MF	GO:0032266	phosphatidylinositol-3-phosphate binding	IEP	Predicted GO
BP	GO:0032446	protein modification by small protein conjugation	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
MF	GO:0032555	purine ribonucleotide binding	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
MF	GO:0034061	DNA polymerase activity	IEP	Predicted GO
BP	GO:0034976	response to endoplasmic reticulum stress	IEP	Predicted GO
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
BP	GO:0036503	ERAD pathway	IEP	Predicted GO
BP	GO:0040029	regulation of gene expression, epigenetic	IEP	Predicted GO
BP	GO:0042391	regulation of membrane potential	IEP	Predicted GO
MF	GO:0042623	ATPase activity, coupled	IEP	Predicted GO
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
BP	GO:0043085	positive regulation of catalytic activity	IEP	Predicted GO
BP	GO:0043087	regulation of GTPase activity	IEP	Predicted GO
BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
CC	GO:0043190	ATP-binding cassette (ABC) transporter complex	IEP	Predicted GO
MF	GO:0043295	glutathione binding	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
MF	GO:0043492	ATPase activity, coupled to movement of substances	IEP	Predicted GO
BP	GO:0043547	positive regulation of GTPase activity	IEP	Predicted GO
BP	GO:0044093	positive regulation of molecular function	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
BP	GO:0046487	glyoxylate metabolic process	IEP	Predicted GO
MF	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IEP	Predicted GO
BP	GO:0051345	positive regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051881	regulation of mitochondrial membrane potential	IEP	Predicted GO
BP	GO:0055085	transmembrane transport	IEP	Predicted GO
BP	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	IEP	Predicted GO
BP	GO:0071897	DNA biosynthetic process	IEP	Predicted GO
MF	GO:0072341	modified amino acid binding	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
MF	GO:0097367	carbohydrate derivative binding	IEP	Predicted GO
CC	GO:0098533	ATPase dependent transmembrane transport complex	IEP	Predicted GO
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
MF	GO:1900750	oligopeptide binding	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO
BP	GO:1901698	response to nitrogen compound	IEP	Predicted GO
MF	GO:1901981	phosphatidylinositol phosphate binding	IEP	Predicted GO
CC	GO:1990229	iron-sulfur cluster assembly complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR007281	Mre11_DNA-bd	874	1115

External Links

PlasmoDB	MAL1P2.06
PlasmoDB	PFA0390w

PF3D7_0107800 (MRE11)

Expression Profile

Co-expression Networks

Functional Annotation