PF3D7_0404700 (DPAP3)

Aliases : DPAP3

Description : SSF75001: "Cathepsin C, exclusion domain superfamily", SSF54001: Papain-like cysteine peptidase superfamily. Pfam domain(s): PF08773: Cathepsin C exclusion domain, PF00112: Papain family cysteine protease.

Gene families : OG_01_0002747 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002747_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0404700
Cluster	P. falciparum: Cluster_20

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1002400	DPAP3	SSF75001: Cathepsin C, exclusion domain superfamily,...	0.16	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004177	aminopeptidase activity	IDA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006508	proteolysis	IEA	Interproscan predictions
BP	GO:0006508	proteolysis	IEA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008234	cysteine-type peptidase activity	ISM	PlasmoDB
MF	GO:0008234	cysteine-type peptidase activity	IEA	Interproscan predictions
MF	GO:0008234	cysteine-type peptidase activity	IEA	PlasmoDB
MF	GO:0008238	exopeptidase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
CC	GO:0020005	symbiont-containing vacuole membrane	IDA	PlasmoDB
BP	GO:0030260	entry into host cell	IMP	PlasmoDB
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
CC	GO:0033655	host cell cytoplasm part	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0044164	host cell cytosol	IDA	PlasmoDB
CC	GO:0044217	other organism part	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044409	entry into host	None	Extended
BP	GO:0044419	interspecies interaction between organisms	None	Extended
CC	GO:0044421	extracellular region part	None	Extended
CC	GO:0044422	organelle part	None	Extended
CC	GO:0044464	cell part	None	Extended
CC	GO:0045177	apical part of cell	IDA	PlasmoDB
BP	GO:0051701	interaction with host	None	Extended
BP	GO:0051704	multi-organism process	None	Extended
BP	GO:0051806	entry into cell of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051828	entry into other organism involved in symbiotic interaction	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0001791	IgM binding	IEP	Predicted GO
MF	GO:0003779	actin binding	IEP	Predicted GO
MF	GO:0004112	cyclic-nucleotide phosphodiesterase activity	IEP	Predicted GO
MF	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEP	Predicted GO
MF	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity	IEP	Predicted GO
MF	GO:0004143	diacylglycerol kinase activity	IEP	Predicted GO
MF	GO:0004721	phosphoprotein phosphatase activity	IEP	Predicted GO
MF	GO:0004722	protein serine/threonine phosphatase activity	IEP	Predicted GO
MF	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	IEP	Predicted GO
MF	GO:0004767	sphingomyelin phosphodiesterase activity	IEP	Predicted GO
MF	GO:0005515	protein binding	IEP	Predicted GO
CC	GO:0005792	obsolete microsome	IEP	Predicted GO
CC	GO:0005905	clathrin-coated pit	IEP	Predicted GO
CC	GO:0005952	cAMP-dependent protein kinase complex	IEP	Predicted GO
CC	GO:0005955	calcineurin complex	IEP	Predicted GO
BP	GO:0006470	protein dephosphorylation	IEP	Predicted GO
BP	GO:0006684	sphingomyelin metabolic process	IEP	Predicted GO
BP	GO:0006814	sodium ion transport	IEP	Predicted GO
BP	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IEP	Predicted GO
MF	GO:0008081	phosphoric diester hydrolase activity	IEP	Predicted GO
MF	GO:0008092	cytoskeletal protein binding	IEP	Predicted GO
MF	GO:0008603	cAMP-dependent protein kinase regulator activity	IEP	Predicted GO
BP	GO:0009214	cyclic nucleotide catabolic process	IEP	Predicted GO
CC	GO:0009986	cell surface	IEP	Predicted GO
MF	GO:0015298	solute:cation antiporter activity	IEP	Predicted GO
MF	GO:0015299	solute:proton antiporter activity	IEP	Predicted GO
MF	GO:0016788	hydrolase activity, acting on ester bonds	IEP	Predicted GO
MF	GO:0016791	phosphatase activity	IEP	Predicted GO
CC	GO:0019005	SCF ubiquitin ligase complex	IEP	Predicted GO
MF	GO:0019865	immunoglobulin binding	IEP	Predicted GO
CC	GO:0020008	rhoptry	IEP	Predicted GO
MF	GO:0030551	cyclic nucleotide binding	IEP	Predicted GO
MF	GO:0030553	cGMP binding	IEP	Predicted GO
BP	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
CC	GO:0031226	intrinsic component of plasma membrane	IEP	Predicted GO
BP	GO:0031399	regulation of protein modification process	IEP	Predicted GO
MF	GO:0031625	ubiquitin protein ligase binding	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
CC	GO:0033016	rhoptry membrane	IEP	Predicted GO
BP	GO:0040011	locomotion	IEP	Predicted GO
MF	GO:0042578	phosphoric ester hydrolase activity	IEP	Predicted GO
CC	GO:0043230	extracellular organelle	IEP	Predicted GO
MF	GO:0044389	ubiquitin-like protein ligase binding	IEP	Predicted GO
CC	GO:0044459	plasma membrane part	IEP	Predicted GO
MF	GO:0044877	protein-containing complex binding	IEP	Predicted GO
CC	GO:0045121	membrane raft	IEP	Predicted GO
BP	GO:0046069	cGMP catabolic process	IEP	Predicted GO
CC	GO:0046658	anchored component of plasma membrane	IEP	Predicted GO
MF	GO:0046789	host cell surface receptor binding	IEP	Predicted GO
MF	GO:0046812	host cell surface binding	IEP	Predicted GO
MF	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IEP	Predicted GO
BP	GO:0048870	cell motility	IEP	Predicted GO
BP	GO:0050746	regulation of lipoprotein metabolic process	IEP	Predicted GO
BP	GO:0050748	negative regulation of lipoprotein metabolic process	IEP	Predicted GO
MF	GO:0051015	actin filament binding	IEP	Predicted GO
CC	GO:0098589	membrane region	IEP	Predicted GO
CC	GO:0098857	membrane microdomain	IEP	Predicted GO
BP	GO:1903059	regulation of protein lipidation	IEP	Predicted GO
BP	GO:1903060	negative regulation of protein lipidation	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO
CC	GO:1990225	rhoptry neck	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000668	Peptidase_C1A_C	890	925
IPR000668	Peptidase_C1A_C	494	640
IPR000668	Peptidase_C1A_C	689	795
IPR014882	CathepsinC_exc	21	205

External Links

PlasmoDB	812449
PlasmoDB	MAL4P1.45
PlasmoDB	PFD0225c
PlasmoDB	PFD0230c

PF3D7_0404700 (DPAP3)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation