PF3D7_0808200 (PMX)

Aliases : PMX

Description : SSF50630: Aspartic peptidase domain superfamily. Pfam domain(s): PF00026: Eukaryotic aspartyl protease.

Gene families : OG_01_0000105 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000105_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0808200
Cluster	P. falciparum: Cluster_2

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1222500	PMX	SSF50630: Aspartic peptidase domain superfamily. Pfam...	0.03	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004175	endopeptidase activity	None	Extended
MF	GO:0004190	aspartic-type endopeptidase activity	IMP	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006508	proteolysis	IDA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0030260	entry into host cell	IMP	PlasmoDB
BP	GO:0035890	exit from host	None	Extended
BP	GO:0035891	exit from host cell	IMP	PlasmoDB
BP	GO:0040011	locomotion	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
CC	GO:0044311	exoneme	IMP	PlasmoDB
BP	GO:0044409	entry into host	None	Extended
BP	GO:0044419	interspecies interaction between organisms	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0051701	interaction with host	None	Extended
BP	GO:0051704	multi-organism process	None	Extended
BP	GO:0051806	entry into cell of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051828	entry into other organism involved in symbiotic interaction	None	Extended
BP	GO:0052126	movement in host environment	None	Extended
BP	GO:0052192	movement in environment of other organism involved in symbiotic interaction	None	Extended
MF	GO:0070001	aspartic-type peptidase activity	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000182	rDNA binding	IEP	Predicted GO
MF	GO:0003691	double-stranded telomeric DNA binding	IEP	Predicted GO
MF	GO:0003743	translation initiation factor activity	IEP	Predicted GO
MF	GO:0003924	GTPase activity	IEP	Predicted GO
MF	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	IEP	Predicted GO
MF	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	IEP	Predicted GO
MF	GO:0004354	glutamate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	IEP	Predicted GO
MF	GO:0004866	endopeptidase inhibitor activity	IEP	Predicted GO
MF	GO:0004869	cysteine-type endopeptidase inhibitor activity	IEP	Predicted GO
MF	GO:0005509	calcium ion binding	IEP	Predicted GO
CC	GO:0005829	cytosol	IEP	Predicted GO
CC	GO:0005886	plasma membrane	IEP	Predicted GO
BP	GO:0006413	translational initiation	IEP	Predicted GO
BP	GO:0006553	lysine metabolic process	IEP	Predicted GO
BP	GO:0006554	lysine catabolic process	IEP	Predicted GO
BP	GO:0006928	movement of cell or subcellular component	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
MF	GO:0008271	secondary active sulfate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0008272	sulfate transport	IEP	Predicted GO
MF	GO:0008923	lysine decarboxylase activity	IEP	Predicted GO
BP	GO:0009068	aspartate family amino acid catabolic process	IEP	Predicted GO
BP	GO:0009892	negative regulation of metabolic process	IEP	Predicted GO
MF	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IEP	Predicted GO
CC	GO:0009986	cell surface	IEP	Predicted GO
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Predicted GO
MF	GO:0010857	calcium-dependent protein kinase activity	IEP	Predicted GO
MF	GO:0015116	sulfate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015698	inorganic anion transport	IEP	Predicted GO
BP	GO:0017148	negative regulation of translation	IEP	Predicted GO
MF	GO:0018271	biotin-protein ligase activity	IEP	Predicted GO
CC	GO:0020005	symbiont-containing vacuole membrane	IEP	Predicted GO
CC	GO:0020007	apical complex	IEP	Predicted GO
CC	GO:0020009	microneme	IEP	Predicted GO
CC	GO:0020026	merozoite dense granule	IEP	Predicted GO
CC	GO:0020039	pellicle	IEP	Predicted GO
BP	GO:0021700	developmental maturation	IEP	Predicted GO
MF	GO:0022829	wide pore channel activity	IEP	Predicted GO
MF	GO:0030414	peptidase inhibitor activity	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
CC	GO:0031226	intrinsic component of plasma membrane	IEP	Predicted GO
CC	GO:0031244	extrinsic component of cell outer membrane	IEP	Predicted GO
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0032204	regulation of telomere maintenance	IEP	Predicted GO
BP	GO:0032205	negative regulation of telomere maintenance	IEP	Predicted GO
BP	GO:0032502	developmental process	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
BP	GO:0034249	negative regulation of cellular amide metabolic process	IEP	Predicted GO
CC	GO:0042025	host cell nucleus	IEP	Predicted GO
BP	GO:0042966	biotin carboxyl carrier protein biosynthetic process	IEP	Predicted GO
MF	GO:0043394	proteoglycan binding	IEP	Predicted GO
MF	GO:0043395	heparan sulfate proteoglycan binding	IEP	Predicted GO
MF	GO:0043565	sequence-specific DNA binding	IEP	Predicted GO
CC	GO:0044310	osmiophilic body	IEP	Predicted GO
CC	GO:0044459	plasma membrane part	IEP	Predicted GO
CC	GO:0044462	external encapsulating structure part	IEP	Predicted GO
BP	GO:0044501	modulation of signal transduction in other organism	IEP	Predicted GO
CC	GO:0046658	anchored component of plasma membrane	IEP	Predicted GO
MF	GO:0046812	host cell surface binding	IEP	Predicted GO
BP	GO:0048469	cell maturation	IEP	Predicted GO
BP	GO:0048523	negative regulation of cellular process	IEP	Predicted GO
BP	GO:0048869	cellular developmental process	IEP	Predicted GO
BP	GO:0048870	cell motility	IEP	Predicted GO
BP	GO:0051053	negative regulation of DNA metabolic process	IEP	Predicted GO
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0052027	modulation by symbiont of host signal transduction pathway	IEP	Predicted GO
BP	GO:0052250	modulation of signal transduction in other organism involved in symbiotic interaction	IEP	Predicted GO
MF	GO:0061134	peptidase regulator activity	IEP	Predicted GO
MF	GO:0061135	endopeptidase regulator activity	IEP	Predicted GO
CC	GO:0070258	inner membrane pellicle complex	IEP	Predicted GO
CC	GO:0071944	cell periphery	IEP	Predicted GO
BP	GO:0072348	sulfur compound transport	IEP	Predicted GO
BP	GO:0075071	autophagy involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0075072	autophagy of symbiont cells involved in interaction with host	IEP	Predicted GO
BP	GO:0075109	modulation by symbiont of host receptor-mediated signal transduction	IEP	Predicted GO
MF	GO:0080084	5S rDNA binding	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO
MF	GO:1901682	sulfur compound transmembrane transporter activity	IEP	Predicted GO
BP	GO:1904356	regulation of telomere maintenance via telomere lengthening	IEP	Predicted GO
BP	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR033121	PEPTIDASE_A1	247	557

External Links

PlasmoDB	2655308
PlasmoDB	PF08_0108

PF3D7_0808200 (PMX)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation