PF3D7_0911900 (ICP)

Aliases : ICP

Description : SSF141066: Chagasin-like superfamily. Pfam domain(s): PF12628: "Falstatin, cysteine peptidase inhibitor".

Gene families : OG_01_0003663 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0003663_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0911900
Cluster	P. falciparum: Cluster_22

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0004857	enzyme inhibitor activity	None	Extended
MF	GO:0004866	endopeptidase inhibitor activity	None	Extended
MF	GO:0004869	cysteine-type endopeptidase inhibitor activity	IDA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005829	cytosol	IDA	PlasmoDB
BP	GO:0006928	movement of cell or subcellular component	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0030234	enzyme regulator activity	None	Extended
BP	GO:0030260	entry into host cell	IMP	PlasmoDB
MF	GO:0030414	peptidase inhibitor activity	None	Extended
CC	GO:0030430	host cell cytoplasm	IDA	PlasmoDB
CC	GO:0031982	vesicle	IDA	PlasmoDB
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
BP	GO:0040011	locomotion	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0044217	other organism part	None	Extended
BP	GO:0044409	entry into host	None	Extended
BP	GO:0044419	interspecies interaction between organisms	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0048870	cell motility	ISO	PlasmoDB
BP	GO:0051701	interaction with host	None	Extended
BP	GO:0051704	multi-organism process	None	Extended
BP	GO:0051806	entry into cell of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051828	entry into other organism involved in symbiotic interaction	None	Extended
MF	GO:0061134	peptidase regulator activity	None	Extended
MF	GO:0061135	endopeptidase regulator activity	None	Extended
MF	GO:0098772	molecular function regulator	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	IEP	Predicted GO
MF	GO:0000182	rDNA binding	IEP	Predicted GO
MF	GO:0003691	double-stranded telomeric DNA binding	IEP	Predicted GO
MF	GO:0003702	obsolete RNA polymerase II transcription factor activity	IEP	Predicted GO
MF	GO:0003743	translation initiation factor activity	IEP	Predicted GO
MF	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	IEP	Predicted GO
MF	GO:0004123	cystathionine gamma-lyase activity	IEP	Predicted GO
MF	GO:0004402	histone acetyltransferase activity	IEP	Predicted GO
MF	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	IEP	Predicted GO
MF	GO:0005509	calcium ion binding	IEP	Predicted GO
BP	GO:0006325	chromatin organization	IEP	Predicted GO
BP	GO:0006355	regulation of transcription, DNA-templated	IEP	Predicted GO
BP	GO:0006413	translational initiation	IEP	Predicted GO
BP	GO:0006534	cysteine metabolic process	IEP	Predicted GO
BP	GO:0006553	lysine metabolic process	IEP	Predicted GO
BP	GO:0006554	lysine catabolic process	IEP	Predicted GO
BP	GO:0006875	cellular metal ion homeostasis	IEP	Predicted GO
BP	GO:0006879	cellular iron ion homeostasis	IEP	Predicted GO
MF	GO:0008134	transcription factor binding	IEP	Predicted GO
MF	GO:0008271	secondary active sulfate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0008272	sulfate transport	IEP	Predicted GO
MF	GO:0008374	O-acyltransferase activity	IEP	Predicted GO
MF	GO:0008923	lysine decarboxylase activity	IEP	Predicted GO
BP	GO:0009063	cellular amino acid catabolic process	IEP	Predicted GO
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009068	aspartate family amino acid catabolic process	IEP	Predicted GO
BP	GO:0009889	regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0009892	negative regulation of metabolic process	IEP	Predicted GO
MF	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IEP	Predicted GO
CC	GO:0009986	cell surface	IEP	Predicted GO
BP	GO:0010468	regulation of gene expression	IEP	Predicted GO
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0010628	positive regulation of gene expression	IEP	Predicted GO
MF	GO:0010857	calcium-dependent protein kinase activity	IEP	Predicted GO
MF	GO:0015116	sulfate transmembrane transporter activity	IEP	Predicted GO
BP	GO:0016569	covalent chromatin modification	IEP	Predicted GO
BP	GO:0016570	histone modification	IEP	Predicted GO
BP	GO:0016573	histone acetylation	IEP	Predicted GO
MF	GO:0016846	carbon-sulfur lyase activity	IEP	Predicted GO
MF	GO:0017025	TBP-class protein binding	IEP	Predicted GO
BP	GO:0017148	negative regulation of translation	IEP	Predicted GO
BP	GO:0018205	peptidyl-lysine modification	IEP	Predicted GO
MF	GO:0018271	biotin-protein ligase activity	IEP	Predicted GO
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0019222	regulation of metabolic process	IEP	Predicted GO
CC	GO:0019898	extrinsic component of membrane	IEP	Predicted GO
CC	GO:0020005	symbiont-containing vacuole membrane	IEP	Predicted GO
CC	GO:0020009	microneme	IEP	Predicted GO
CC	GO:0020026	merozoite dense granule	IEP	Predicted GO
BP	GO:0021700	developmental maturation	IEP	Predicted GO
MF	GO:0022829	wide pore channel activity	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
CC	GO:0031226	intrinsic component of plasma membrane	IEP	Predicted GO
CC	GO:0031244	extrinsic component of cell outer membrane	IEP	Predicted GO
BP	GO:0031323	regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Predicted GO
CC	GO:0031410	cytoplasmic vesicle	IEP	Predicted GO
BP	GO:0032204	regulation of telomere maintenance	IEP	Predicted GO
BP	GO:0032205	negative regulation of telomere maintenance	IEP	Predicted GO
BP	GO:0032502	developmental process	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
CC	GO:0033647	host intracellular organelle	IEP	Predicted GO
CC	GO:0033648	host intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0034249	negative regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0035890	exit from host	IEP	Predicted GO
BP	GO:0035891	exit from host cell	IEP	Predicted GO
CC	GO:0042025	host cell nucleus	IEP	Predicted GO
BP	GO:0042966	biotin carboxyl carrier protein biosynthetic process	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
MF	GO:0043394	proteoglycan binding	IEP	Predicted GO
MF	GO:0043395	heparan sulfate proteoglycan binding	IEP	Predicted GO
MF	GO:0043565	sequence-specific DNA binding	IEP	Predicted GO
BP	GO:0043967	histone H4 acetylation	IEP	Predicted GO
BP	GO:0043981	histone H4-K5 acetylation	IEP	Predicted GO
BP	GO:0043982	histone H4-K8 acetylation	IEP	Predicted GO
BP	GO:0043983	histone H4-K12 acetylation	IEP	Predicted GO
BP	GO:0043984	histone H4-K16 acetylation	IEP	Predicted GO
BP	GO:0044053	translocation of peptides or proteins into host cell cytoplasm	IEP	Predicted GO
CC	GO:0044311	exoneme	IEP	Predicted GO
CC	GO:0044421	extracellular region part	IEP	Predicted GO
CC	GO:0044459	plasma membrane part	IEP	Predicted GO
CC	GO:0044462	external encapsulating structure part	IEP	Predicted GO
CC	GO:0046658	anchored component of plasma membrane	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
BP	GO:0046916	cellular transition metal ion homeostasis	IEP	Predicted GO
BP	GO:0048469	cell maturation	IEP	Predicted GO
BP	GO:0048523	negative regulation of cellular process	IEP	Predicted GO
BP	GO:0048869	cellular developmental process	IEP	Predicted GO
BP	GO:0050794	regulation of cellular process	IEP	Predicted GO
BP	GO:0051053	negative regulation of DNA metabolic process	IEP	Predicted GO
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051252	regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0052126	movement in host environment	IEP	Predicted GO
BP	GO:0052192	movement in environment of other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0055072	iron ion homeostasis	IEP	Predicted GO
BP	GO:0055076	transition metal ion homeostasis	IEP	Predicted GO
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0070897	transcription preinitiation complex assembly	IEP	Predicted GO
BP	GO:0072348	sulfur compound transport	IEP	Predicted GO
MF	GO:0080084	5S rDNA binding	IEP	Predicted GO
BP	GO:0080090	regulation of primary metabolic process	IEP	Predicted GO
CC	GO:0097619	PTEX complex	IEP	Predicted GO
CC	GO:0097708	intracellular vesicle	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901606	alpha-amino acid catabolic process	IEP	Predicted GO
MF	GO:1901682	sulfur compound transmembrane transporter activity	IEP	Predicted GO
BP	GO:1903506	regulation of nucleic acid-templated transcription	IEP	Predicted GO
BP	GO:1904356	regulation of telomere maintenance via telomere lengthening	IEP	Predicted GO
BP	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	IEP	Predicted GO
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:2001141	regulation of RNA biosynthetic process	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR024321	Prot_Inh_falstatin	241	413

External Links

PlasmoDB	813396
PlasmoDB	PFI0580c

PF3D7_0911900 (ICP)

Expression Profile

Co-expression Networks

Functional Annotation