PF3D7_1030100 (PRP22)

Aliases : PRP22

Description : SSF52540: P-loop containing nucleoside triphosphate hydrolase, SSF50249: "Nucleic acid-binding, OB-fold". Pfam domain(s): PF00271: Helicase conserved C-terminal domain, PF04408: Helicase associated domain (HA2), PF07717: Oligonucleotide/oligosaccharide-binding (OB)-fold, PF00575: S1 RNA binding domain, PF00270: DEAD/DEAH box helicase.

Gene families : OG_01_0000023 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000023_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1030100
Cluster	P. falciparum: Cluster_9

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	IEA	Interproscan predictions
MF	GO:0003676	nucleic acid binding	IEA	PlasmoDB
MF	GO:0003724	RNA helicase activity	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004004	ATP-dependent RNA helicase activity	ISS	PlasmoDB
MF	GO:0004386	helicase activity	IEA	Interproscan predictions
MF	GO:0004386	helicase activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006396	RNA processing	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008026	ATP-dependent helicase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008186	RNA-dependent ATPase activity	None	Extended
BP	GO:0008380	RNA splicing	ISS	PlasmoDB
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0070035	purine NTP-dependent helicase activity	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140098	catalytic activity, acting on RNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0000182	rDNA binding	IEP	Predicted GO
BP	GO:0000245	spliceosomal complex assembly	IEP	Predicted GO
BP	GO:0000302	response to reactive oxygen species	IEP	Predicted GO
BP	GO:0000304	response to singlet oxygen	IEP	Predicted GO
BP	GO:0000375	RNA splicing, via transesterification reactions	IEP	Predicted GO
BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	IEP	Predicted GO
BP	GO:0000398	mRNA splicing, via spliceosome	IEP	Predicted GO
MF	GO:0003690	double-stranded DNA binding	IEP	Predicted GO
MF	GO:0004659	prenyltransferase activity	IEP	Predicted GO
MF	GO:0004661	protein geranylgeranyltransferase activity	IEP	Predicted GO
MF	GO:0004663	Rab geranylgeranyltransferase activity	IEP	Predicted GO
MF	GO:0004749	ribose phosphate diphosphokinase activity	IEP	Predicted GO
CC	GO:0005686	U2 snRNP	IEP	Predicted GO
CC	GO:0005739	mitochondrion	IEP	Predicted GO
CC	GO:0005968	Rab-protein geranylgeranyltransferase complex	IEP	Predicted GO
BP	GO:0006081	cellular aldehyde metabolic process	IEP	Predicted GO
BP	GO:0006098	pentose-phosphate shunt	IEP	Predicted GO
BP	GO:0006166	purine ribonucleoside salvage	IEP	Predicted GO
BP	GO:0006397	mRNA processing	IEP	Predicted GO
BP	GO:0006739	NADP metabolic process	IEP	Predicted GO
BP	GO:0006766	vitamin metabolic process	IEP	Predicted GO
BP	GO:0006767	water-soluble vitamin metabolic process	IEP	Predicted GO
BP	GO:0006904	vesicle docking involved in exocytosis	IEP	Predicted GO
BP	GO:0006979	response to oxidative stress	IEP	Predicted GO
BP	GO:0007584	response to nutrient	IEP	Predicted GO
MF	GO:0008270	zinc ion binding	IEP	Predicted GO
MF	GO:0008318	protein prenyltransferase activity	IEP	Predicted GO
MF	GO:0008478	pyridoxal kinase activity	IEP	Predicted GO
MF	GO:0008483	transaminase activity	IEP	Predicted GO
BP	GO:0008614	pyridoxine metabolic process	IEP	Predicted GO
BP	GO:0009110	vitamin biosynthetic process	IEP	Predicted GO
BP	GO:0009116	nucleoside metabolic process	IEP	Predicted GO
BP	GO:0009119	ribonucleoside metabolic process	IEP	Predicted GO
BP	GO:0009163	nucleoside biosynthetic process	IEP	Predicted GO
BP	GO:0009891	positive regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0009893	positive regulation of metabolic process	IEP	Predicted GO
BP	GO:0009991	response to extracellular stimulus	IEP	Predicted GO
BP	GO:0010035	response to inorganic substance	IEP	Predicted GO
BP	GO:0010557	positive regulation of macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010604	positive regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0010628	positive regulation of gene expression	IEP	Predicted GO
BP	GO:0016071	mRNA metabolic process	IEP	Predicted GO
MF	GO:0016740	transferase activity	IEP	Predicted GO
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEP	Predicted GO
MF	GO:0016769	transferase activity, transferring nitrogenous groups	IEP	Predicted GO
MF	GO:0016778	diphosphotransferase activity	IEP	Predicted GO
BP	GO:0016925	protein sumoylation	IEP	Predicted GO
BP	GO:0018205	peptidyl-lysine modification	IEP	Predicted GO
BP	GO:0018342	protein prenylation	IEP	Predicted GO
BP	GO:0018344	protein geranylgeranylation	IEP	Predicted GO
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	IEP	Predicted GO
MF	GO:0019842	vitamin binding	IEP	Predicted GO
BP	GO:0022406	membrane docking	IEP	Predicted GO
MF	GO:0030170	pyridoxal phosphate binding	IEP	Predicted GO
BP	GO:0031325	positive regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031328	positive regulation of cellular biosynthetic process	IEP	Predicted GO
BP	GO:0031667	response to nutrient levels	IEP	Predicted GO
BP	GO:0032446	protein modification by small protein conjugation	IEP	Predicted GO
BP	GO:0032784	regulation of DNA-templated transcription, elongation	IEP	Predicted GO
BP	GO:0032786	positive regulation of DNA-templated transcription, elongation	IEP	Predicted GO
BP	GO:0042278	purine nucleoside metabolic process	IEP	Predicted GO
BP	GO:0042364	water-soluble vitamin biosynthetic process	IEP	Predicted GO
BP	GO:0042451	purine nucleoside biosynthetic process	IEP	Predicted GO
BP	GO:0042455	ribonucleoside biosynthetic process	IEP	Predicted GO
BP	GO:0042816	vitamin B6 metabolic process	IEP	Predicted GO
BP	GO:0042819	vitamin B6 biosynthetic process	IEP	Predicted GO
BP	GO:0043094	cellular metabolic compound salvage	IEP	Predicted GO
BP	GO:0043101	purine-containing compound salvage	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
BP	GO:0043174	nucleoside salvage	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0045893	positive regulation of transcription, DNA-templated	IEP	Predicted GO
BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0046128	purine ribonucleoside metabolic process	IEP	Predicted GO
BP	GO:0046129	purine ribonucleoside biosynthetic process	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
BP	GO:0048278	vesicle docking	IEP	Predicted GO
BP	GO:0048518	positive regulation of biological process	IEP	Predicted GO
BP	GO:0048522	positive regulation of cellular process	IEP	Predicted GO
BP	GO:0051156	glucose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0051173	positive regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051254	positive regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0051640	organelle localization	IEP	Predicted GO
MF	GO:0070279	vitamin B6 binding	IEP	Predicted GO
MF	GO:0070280	pyridoxal binding	IEP	Predicted GO
MF	GO:0070281	pyridoxamine binding	IEP	Predicted GO
MF	GO:0070282	pyridoxine binding	IEP	Predicted GO
MF	GO:0070405	ammonium ion binding	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0097354	prenylation	IEP	Predicted GO
BP	GO:0140029	exocytic process	IEP	Predicted GO
BP	GO:0140056	organelle localization by membrane tethering	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
BP	GO:1901615	organic hydroxy compound metabolic process	IEP	Predicted GO
BP	GO:1901657	glycosyl compound metabolic process	IEP	Predicted GO
BP	GO:1901659	glycosyl compound biosynthetic process	IEP	Predicted GO
BP	GO:1901700	response to oxygen-containing compound	IEP	Predicted GO
BP	GO:1902680	positive regulation of RNA biosynthetic process	IEP	Predicted GO
BP	GO:1903508	positive regulation of nucleic acid-templated transcription	IEP	Predicted GO
MF	GO:1990837	sequence-specific double-stranded DNA binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001650	Helicase_C	831	962
IPR007502	Helicase-assoc_dom	1024	1111
IPR011709	DUF1605	1175	1251
IPR003029	S1_domain	328	395
IPR011545	DEAD/DEAH_box_helicase_dom	641	789

External Links

PlasmoDB	810451
PlasmoDB	PF10_0294

PF3D7_1030100 (PRP22)

Expression Profile

Co-expression Networks

Functional Annotation