PF3D7_1033400 (HAD1)

Aliases : HAD1

Description : SSF56784: HAD-like superfamily. Pfam domain(s): PF08282: haloacid dehalogenase-like hydrolase.

Gene families : OG_01_0002438 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002438_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1033400
Cluster	P. falciparum: Cluster_11

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_0517200	HAD1	SSF56784: HAD-like superfamily. Pfam domain(s): PF08282:...	0.12	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005737	cytoplasm	IDA	PlasmoDB
BP	GO:0006109	regulation of carbohydrate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009890	negative regulation of biosynthetic process	None	Extended
BP	GO:0009892	negative regulation of metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010322	regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	None	Extended
BP	GO:0010323	negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IDA	PlasmoDB
BP	GO:0010563	negative regulation of phosphorus metabolic process	None	Extended
BP	GO:0010565	regulation of cellular ketone metabolic process	None	Extended
BP	GO:0010675	regulation of cellular carbohydrate metabolic process	None	Extended
BP	GO:0010677	negative regulation of cellular carbohydrate metabolic process	None	Extended
BP	GO:0016311	dephosphorylation	IDA	PlasmoDB
MF	GO:0016787	hydrolase activity	IEA	PlasmoDB
MF	GO:0016788	hydrolase activity, acting on ester bonds	None	Extended
MF	GO:0016791	phosphatase activity	None	Extended
MF	GO:0019203	carbohydrate phosphatase activity	None	Extended
BP	GO:0019216	regulation of lipid metabolic process	None	Extended
BP	GO:0019220	regulation of phosphate metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0019747	regulation of isoprenoid metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031324	negative regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
BP	GO:0031327	negative regulation of cellular biosynthetic process	None	Extended
MF	GO:0042578	phosphoric ester hydrolase activity	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0045827	negative regulation of isoprenoid metabolic process	None	Extended
BP	GO:0045833	negative regulation of lipid metabolic process	None	Extended
BP	GO:0045912	negative regulation of carbohydrate metabolic process	None	Extended
BP	GO:0045936	negative regulation of phosphate metabolic process	None	Extended
BP	GO:0046890	regulation of lipid biosynthetic process	None	Extended
BP	GO:0048519	negative regulation of biological process	None	Extended
BP	GO:0048523	negative regulation of cellular process	None	Extended
MF	GO:0050308	sugar-phosphatase activity	IDA	PlasmoDB
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051055	negative regulation of lipid biosynthetic process	None	Extended
BP	GO:0051174	regulation of phosphorus metabolic process	None	Extended
BP	GO:0062012	regulation of small molecule metabolic process	None	Extended
BP	GO:0062014	negative regulation of small molecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0071071	regulation of phospholipid biosynthetic process	None	Extended
BP	GO:0071072	negative regulation of phospholipid biosynthetic process	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:1903725	regulation of phospholipid metabolic process	None	Extended
BP	GO:1903726	negative regulation of phospholipid metabolic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
BP	GO:0000122	negative regulation of transcription by RNA polymerase II	IEP	Predicted GO
MF	GO:0000339	RNA cap binding	IEP	Predicted GO
MF	GO:0002161	aminoacyl-tRNA editing activity	IEP	Predicted GO
BP	GO:0002181	cytoplasmic translation	IEP	Predicted GO
MF	GO:0003714	transcription corepressor activity	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0003743	translation initiation factor activity	IEP	Predicted GO
MF	GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	IEP	Predicted GO
MF	GO:0003872	6-phosphofructokinase activity	IEP	Predicted GO
MF	GO:0003938	IMP dehydrogenase activity	IEP	Predicted GO
MF	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IEP	Predicted GO
MF	GO:0004156	dihydropteroate synthase activity	IEP	Predicted GO
MF	GO:0004177	aminopeptidase activity	IEP	Predicted GO
MF	GO:0004347	glucose-6-phosphate isomerase activity	IEP	Predicted GO
MF	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	IEP	Predicted GO
MF	GO:0004385	guanylate kinase activity	IEP	Predicted GO
MF	GO:0004551	nucleotide diphosphatase activity	IEP	Predicted GO
MF	GO:0004590	orotidine-5'-phosphate decarboxylase activity	IEP	Predicted GO
MF	GO:0004618	phosphoglycerate kinase activity	IEP	Predicted GO
MF	GO:0004735	pyrroline-5-carboxylate reductase activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004815	aspartate-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004820	glycine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004827	proline-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004829	threonine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004832	valine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005198	structural molecule activity	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
CC	GO:0005622	intracellular	IEP	Predicted GO
CC	GO:0005742	mitochondrial outer membrane translocase complex	IEP	Predicted GO
CC	GO:0005829	cytosol	IEP	Predicted GO
CC	GO:0005832	chaperonin-containing T-complex	IEP	Predicted GO
CC	GO:0005840	ribosome	IEP	Predicted GO
CC	GO:0005852	eukaryotic translation initiation factor 3 complex	IEP	Predicted GO
CC	GO:0005854	nascent polypeptide-associated complex	IEP	Predicted GO
BP	GO:0005975	carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0006002	fructose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006090	pyruvate metabolic process	IEP	Predicted GO
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0006096	glycolytic process	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006163	purine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006164	purine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEP	Predicted GO
BP	GO:0006186	dGDP phosphorylation	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006412	translation	IEP	Predicted GO
BP	GO:0006413	translational initiation	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006422	aspartyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006426	glycyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006433	prolyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006435	threonyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006438	valyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006446	regulation of translational initiation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006458	'de novo' protein folding	IEP	Predicted GO
BP	GO:0006518	peptide metabolic process	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006560	proline metabolic process	IEP	Predicted GO
BP	GO:0006561	proline biosynthetic process	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0006732	coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006733	oxidoreduction coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006757	ATP generation from ADP	IEP	Predicted GO
BP	GO:0006761	dihydrofolate biosynthetic process	IEP	Predicted GO
BP	GO:0006807	nitrogen compound metabolic process	IEP	Predicted GO
MF	GO:0008097	5S rRNA binding	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008237	metallopeptidase activity	IEP	Predicted GO
MF	GO:0008238	exopeptidase activity	IEP	Predicted GO
MF	GO:0008443	phosphofructokinase activity	IEP	Predicted GO
MF	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009108	coenzyme biosynthetic process	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009132	nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009135	purine nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009151	purine deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009152	purine ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009165	nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009166	nucleotide catabolic process	IEP	Predicted GO
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009182	purine deoxyribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009185	ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009186	deoxyribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009200	deoxyribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009216	purine deoxyribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009260	ribonucleotide biosynthetic process	IEP	Predicted GO
CC	GO:0009331	glycerol-3-phosphate dehydrogenase complex	IEP	Predicted GO
MF	GO:0009383	rRNA (cytosine-C5-)-methyltransferase activity	IEP	Predicted GO
BP	GO:0009394	2'-deoxyribonucleotide metabolic process	IEP	Predicted GO
CC	GO:0015934	large ribosomal subunit	IEP	Predicted GO
CC	GO:0015935	small ribosomal subunit	IEP	Predicted GO
BP	GO:0016052	carbohydrate catabolic process	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
CC	GO:0016281	eukaryotic translation initiation factor 4F complex	IEP	Predicted GO
BP	GO:0016310	phosphorylation	IEP	Predicted GO
MF	GO:0016434	rRNA (cytosine) methyltransferase activity	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
BP	GO:0018130	heterocycle biosynthetic process	IEP	Predicted GO
MF	GO:0019200	carbohydrate kinase activity	IEP	Predicted GO
MF	GO:0019206	nucleoside kinase activity	IEP	Predicted GO
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0019363	pyridine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Predicted GO
BP	GO:0019439	aromatic compound catabolic process	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
BP	GO:0019637	organophosphate metabolic process	IEP	Predicted GO
BP	GO:0019692	deoxyribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0022625	cytosolic large ribosomal subunit	IEP	Predicted GO
CC	GO:0022627	cytosolic small ribosomal subunit	IEP	Predicted GO
BP	GO:0030150	protein import into mitochondrial matrix	IEP	Predicted GO
CC	GO:0030430	host cell cytoplasm	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
MF	GO:0031369	translation initiation factor binding	IEP	Predicted GO
CC	GO:0031428	box C/D snoRNP complex	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
MF	GO:0033677	DNA/RNA helicase activity	IEP	Predicted GO
MF	GO:0033679	3'-5' DNA/RNA helicase activity	IEP	Predicted GO
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0034641	cellular nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0034655	nucleobase-containing compound catabolic process	IEP	Predicted GO
BP	GO:0034660	ncRNA metabolic process	IEP	Predicted GO
BP	GO:0042493	response to drug	IEP	Predicted GO
MF	GO:0042802	identical protein binding	IEP	Predicted GO
MF	GO:0042803	protein homodimerization activity	IEP	Predicted GO
BP	GO:0042866	pyruvate biosynthetic process	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
BP	GO:0043043	peptide biosynthetic process	IEP	Predicted GO
MF	GO:0043139	5'-3' DNA helicase activity	IEP	Predicted GO
MF	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043230	extracellular organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043604	amide biosynthetic process	IEP	Predicted GO
BP	GO:0044238	primary metabolic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044267	cellular protein metabolic process	IEP	Predicted GO
BP	GO:0044270	cellular nitrogen compound catabolic process	IEP	Predicted GO
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
CC	GO:0044391	ribosomal subunit	IEP	Predicted GO
CC	GO:0044421	extracellular region part	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
BP	GO:0046031	ADP metabolic process	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046066	dGDP metabolic process	IEP	Predicted GO
BP	GO:0046168	glycerol-3-phosphate catabolic process	IEP	Predicted GO
BP	GO:0046390	ribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0046434	organophosphate catabolic process	IEP	Predicted GO
BP	GO:0046452	dihydrofolate metabolic process	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Predicted GO
BP	GO:0046700	heterocycle catabolic process	IEP	Predicted GO
BP	GO:0046939	nucleotide phosphorylation	IEP	Predicted GO
MF	GO:0047334	diphosphate-fructose-6-phosphate 1-phosphotransferase activity	IEP	Predicted GO
MF	GO:0051082	unfolded protein binding	IEP	Predicted GO
BP	GO:0051083	'de novo' cotranslational protein folding	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
MF	GO:0052689	carboxylic ester hydrolase activity	IEP	Predicted GO
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Predicted GO
BP	GO:0071704	organic substance metabolic process	IEP	Predicted GO
BP	GO:0072330	monocarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0072521	purine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072522	purine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072525	pyridine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0090407	organophosphate biosynthetic process	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
CC	GO:0098799	outer mitochondrial membrane protein complex	IEP	Predicted GO
CC	GO:0101031	chaperone complex	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
BP	GO:1901135	carbohydrate derivative metabolic process	IEP	Predicted GO
BP	GO:1901292	nucleoside phosphate catabolic process	IEP	Predicted GO
BP	GO:1901293	nucleoside phosphate biosynthetic process	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO
BP	GO:1901361	organic cyclic compound catabolic process	IEP	Predicted GO
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

No InterPro domains available for this sequence

External Links

PlasmoDB	810482
PlasmoDB	PF10_0325

PF3D7_1033400 (HAD1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation