PF3D7_1116700 (DPAP1)

Aliases : DPAP1

Description : SSF75001: "Cathepsin C, exclusion domain superfamily", SSF54001: Papain-like cysteine peptidase superfamily. Pfam domain(s): PF08773: Cathepsin C exclusion domain, PF00112: Papain family cysteine protease.

Gene families : OG_01_0002717 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002717_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1116700
Cluster	P. falciparum: Cluster_22

Type	GO Term	Name	Evidence	Source
CC	GO:0000323	lytic vacuole	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005764	lysosome	None	Extended
CC	GO:0005767	secondary lysosome	None	Extended
CC	GO:0005773	vacuole	None	Extended
BP	GO:0006508	proteolysis	IEA	Interproscan predictions
BP	GO:0006508	proteolysis	IEA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008234	cysteine-type peptidase activity	IEA	Interproscan predictions
MF	GO:0008234	cysteine-type peptidase activity	IEA	PlasmoDB
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
CC	GO:0020003	symbiont-containing vacuole	IDA	PlasmoDB
CC	GO:0020020	food vacuole	IDA	PlasmoDB
CC	GO:0030139	endocytic vesicle	None	Extended
CC	GO:0031410	cytoplasmic vesicle	None	Extended
CC	GO:0031982	vesicle	None	Extended
CC	GO:0032010	phagolysosome	None	Extended
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
CC	GO:0033655	host cell cytoplasm part	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042493	response to drug	IDA	PlasmoDB
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043230	extracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
CC	GO:0044217	other organism part	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
CC	GO:0044421	extracellular region part	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
CC	GO:0045335	phagocytic vesicle	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
CC	GO:0065010	extracellular membrane-bounded organelle	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
CC	GO:0097708	intracellular vesicle	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003700	DNA-binding transcription factor activity	IEP	Predicted GO
MF	GO:0003702	obsolete RNA polymerase II transcription factor activity	IEP	Predicted GO
MF	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	IEP	Predicted GO
MF	GO:0004123	cystathionine gamma-lyase activity	IEP	Predicted GO
MF	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	IEP	Predicted GO
MF	GO:0004620	phospholipase activity	IEP	Predicted GO
MF	GO:0004857	enzyme inhibitor activity	IEP	Predicted GO
MF	GO:0004866	endopeptidase inhibitor activity	IEP	Predicted GO
MF	GO:0004869	cysteine-type endopeptidase inhibitor activity	IEP	Predicted GO
MF	GO:0005488	binding	IEP	Predicted GO
MF	GO:0005509	calcium ion binding	IEP	Predicted GO
CC	GO:0005730	nucleolus	IEP	Predicted GO
CC	GO:0005829	cytosol	IEP	Predicted GO
BP	GO:0006338	chromatin remodeling	IEP	Predicted GO
BP	GO:0006355	regulation of transcription, DNA-templated	IEP	Predicted GO
BP	GO:0006417	regulation of translation	IEP	Predicted GO
BP	GO:0006534	cysteine metabolic process	IEP	Predicted GO
BP	GO:0006553	lysine metabolic process	IEP	Predicted GO
BP	GO:0006554	lysine catabolic process	IEP	Predicted GO
BP	GO:0006928	movement of cell or subcellular component	IEP	Predicted GO
MF	GO:0008134	transcription factor binding	IEP	Predicted GO
MF	GO:0008270	zinc ion binding	IEP	Predicted GO
MF	GO:0008374	O-acyltransferase activity	IEP	Predicted GO
MF	GO:0008923	lysine decarboxylase activity	IEP	Predicted GO
BP	GO:0009063	cellular amino acid catabolic process	IEP	Predicted GO
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009068	aspartate family amino acid catabolic process	IEP	Predicted GO
BP	GO:0009889	regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0009893	positive regulation of metabolic process	IEP	Predicted GO
MF	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IEP	Predicted GO
CC	GO:0009986	cell surface	IEP	Predicted GO
BP	GO:0010468	regulation of gene expression	IEP	Predicted GO
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010604	positive regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0010608	posttranscriptional regulation of gene expression	IEP	Predicted GO
BP	GO:0010628	positive regulation of gene expression	IEP	Predicted GO
MF	GO:0010857	calcium-dependent protein kinase activity	IEP	Predicted GO
BP	GO:0016054	organic acid catabolic process	IEP	Predicted GO
MF	GO:0016846	carbon-sulfur lyase activity	IEP	Predicted GO
MF	GO:0017025	TBP-class protein binding	IEP	Predicted GO
BP	GO:0017148	negative regulation of translation	IEP	Predicted GO
MF	GO:0018271	biotin-protein ligase activity	IEP	Predicted GO
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0019222	regulation of metabolic process	IEP	Predicted GO
CC	GO:0019898	extrinsic component of membrane	IEP	Predicted GO
CC	GO:0020005	symbiont-containing vacuole membrane	IEP	Predicted GO
CC	GO:0020009	microneme	IEP	Predicted GO
CC	GO:0020026	merozoite dense granule	IEP	Predicted GO
MF	GO:0022829	wide pore channel activity	IEP	Predicted GO
BP	GO:0030260	entry into host cell	IEP	Predicted GO
MF	GO:0030414	peptidase inhibitor activity	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
CC	GO:0031226	intrinsic component of plasma membrane	IEP	Predicted GO
CC	GO:0031244	extrinsic component of cell outer membrane	IEP	Predicted GO
BP	GO:0031323	regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Predicted GO
BP	GO:0032269	negative regulation of cellular protein metabolic process	IEP	Predicted GO
CC	GO:0033647	host intracellular organelle	IEP	Predicted GO
CC	GO:0033648	host intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0034248	regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0034249	negative regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0035890	exit from host	IEP	Predicted GO
BP	GO:0035891	exit from host cell	IEP	Predicted GO
BP	GO:0040011	locomotion	IEP	Predicted GO
CC	GO:0042025	host cell nucleus	IEP	Predicted GO
BP	GO:0042966	biotin carboxyl carrier protein biosynthetic process	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
MF	GO:0043394	proteoglycan binding	IEP	Predicted GO
MF	GO:0043395	heparan sulfate proteoglycan binding	IEP	Predicted GO
MF	GO:0043565	sequence-specific DNA binding	IEP	Predicted GO
BP	GO:0044053	translocation of peptides or proteins into host cell cytoplasm	IEP	Predicted GO
BP	GO:0044409	entry into host	IEP	Predicted GO
BP	GO:0044419	interspecies interaction between organisms	IEP	Predicted GO
CC	GO:0044459	plasma membrane part	IEP	Predicted GO
CC	GO:0044462	external encapsulating structure part	IEP	Predicted GO
BP	GO:0046395	carboxylic acid catabolic process	IEP	Predicted GO
CC	GO:0046658	anchored component of plasma membrane	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0046914	transition metal ion binding	IEP	Predicted GO
BP	GO:0048870	cell motility	IEP	Predicted GO
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051248	negative regulation of protein metabolic process	IEP	Predicted GO
BP	GO:0051252	regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0051701	interaction with host	IEP	Predicted GO
BP	GO:0051704	multi-organism process	IEP	Predicted GO
BP	GO:0051806	entry into cell of other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0051828	entry into other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0052126	movement in host environment	IEP	Predicted GO
BP	GO:0052192	movement in environment of other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Predicted GO
MF	GO:0061134	peptidase regulator activity	IEP	Predicted GO
MF	GO:0061135	endopeptidase regulator activity	IEP	Predicted GO
BP	GO:0070897	transcription preinitiation complex assembly	IEP	Predicted GO
BP	GO:0080090	regulation of primary metabolic process	IEP	Predicted GO
CC	GO:0097619	PTEX complex	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901606	alpha-amino acid catabolic process	IEP	Predicted GO
BP	GO:1903506	regulation of nucleic acid-templated transcription	IEP	Predicted GO
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:2001141	regulation of RNA biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR014882	CathepsinC_exc	28	158
IPR000668	Peptidase_C1A_C	371	676

External Links

PlasmoDB	810721
PlasmoDB	PF11_0174

PF3D7_1116700 (DPAP1)

Expression Profile

Co-expression Networks

Functional Annotation