PF3D7_1126000 (ThrRS)

Aliases : ThrRS

Description : SSF55681: No description available, SSF55186: "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily", SSF52954: No description available. Pfam domain(s): PF00587: "tRNA synthetase class II core domain (G, H, P, S and T)", PF07973: Threonyl and Alanyl tRNA synthetase second additional domain, PF03129: Anticodon binding domain.

Gene families : OG_01_0002696 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0002696_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1126000
Cluster	P. falciparum: Cluster_28

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_0922300	ThrRS	SSF55681: 20-02-2019, SSF55186: Threonyl/alanyl tRNA...	0.06	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEA	Interproscan predictions
MF	GO:0000166	nucleotide binding	IEA	PlasmoDB
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEA	Interproscan predictions
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEA	PlasmoDB
MF	GO:0004829	threonine-tRNA ligase activity	ISS	PlasmoDB
MF	GO:0004829	threonine-tRNA ligase activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	ISS	PlasmoDB
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005737	cytoplasm	IEA	PlasmoDB
CC	GO:0005829	cytosol	IDA	PlasmoDB
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006399	tRNA metabolic process	None	Extended
BP	GO:0006418	tRNA aminoacylation for protein translation	IEA	Interproscan predictions
BP	GO:0006418	tRNA aminoacylation for protein translation	IEA	PlasmoDB
BP	GO:0006435	threonyl-tRNA aminoacylation	ISS	PlasmoDB
BP	GO:0006435	threonyl-tRNA aminoacylation	IEA	PlasmoDB
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
CC	GO:0009536	plastid	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
CC	GO:0020011	apicoplast	IDA	PlasmoDB
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034660	ncRNA metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042493	response to drug	IDA	PlasmoDB
BP	GO:0043038	amino acid activation	None	Extended
BP	GO:0043039	tRNA aminoacylation	IEA	Interproscan predictions
BP	GO:0043039	tRNA aminoacylation	IEA	PlasmoDB
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140098	catalytic activity, acting on RNA	None	Extended
MF	GO:0140101	catalytic activity, acting on a tRNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000054	ribosomal subunit export from nucleus	IEP	Predicted GO
BP	GO:0000055	ribosomal large subunit export from nucleus	IEP	Predicted GO
BP	GO:0000245	spliceosomal complex assembly	IEP	Predicted GO
CC	GO:0000439	transcription factor TFIIH core complex	IEP	Predicted GO
MF	GO:0002161	aminoacyl-tRNA editing activity	IEP	Predicted GO
BP	GO:0002181	cytoplasmic translation	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0003743	translation initiation factor activity	IEP	Predicted GO
MF	GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	IEP	Predicted GO
MF	GO:0003872	6-phosphofructokinase activity	IEP	Predicted GO
MF	GO:0004156	dihydropteroate synthase activity	IEP	Predicted GO
MF	GO:0004177	aminopeptidase activity	IEP	Predicted GO
MF	GO:0004347	glucose-6-phosphate isomerase activity	IEP	Predicted GO
MF	GO:0004802	transketolase activity	IEP	Predicted GO
MF	GO:0004813	alanine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004815	aspartate-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004820	glycine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004822	isoleucine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004832	valine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005515	protein binding	IEP	Predicted GO
CC	GO:0005654	nucleoplasm	IEP	Predicted GO
CC	GO:0005665	RNA polymerase II, core complex	IEP	Predicted GO
CC	GO:0005730	nucleolus	IEP	Predicted GO
CC	GO:0005832	chaperonin-containing T-complex	IEP	Predicted GO
CC	GO:0005852	eukaryotic translation initiation factor 3 complex	IEP	Predicted GO
BP	GO:0005975	carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0006002	fructose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0006006	glucose metabolic process	IEP	Predicted GO
BP	GO:0006081	cellular aldehyde metabolic process	IEP	Predicted GO
BP	GO:0006090	pyruvate metabolic process	IEP	Predicted GO
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0006094	gluconeogenesis	IEP	Predicted GO
BP	GO:0006096	glycolytic process	IEP	Predicted GO
BP	GO:0006098	pentose-phosphate shunt	IEP	Predicted GO
BP	GO:0006109	regulation of carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEP	Predicted GO
BP	GO:0006405	RNA export from nucleus	IEP	Predicted GO
BP	GO:0006412	translation	IEP	Predicted GO
BP	GO:0006413	translational initiation	IEP	Predicted GO
BP	GO:0006419	alanyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006422	aspartyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006426	glycyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006428	isoleucyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006438	valyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006457	protein folding	IEP	Predicted GO
BP	GO:0006518	peptide metabolic process	IEP	Predicted GO
BP	GO:0006611	protein export from nucleus	IEP	Predicted GO
BP	GO:0006732	coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006733	oxidoreduction coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006739	NADP metabolic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006757	ATP generation from ADP	IEP	Predicted GO
BP	GO:0006761	dihydrofolate biosynthetic process	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
MF	GO:0008169	C-methyltransferase activity	IEP	Predicted GO
MF	GO:0008237	metallopeptidase activity	IEP	Predicted GO
MF	GO:0008238	exopeptidase activity	IEP	Predicted GO
MF	GO:0008443	phosphofructokinase activity	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009108	coenzyme biosynthetic process	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009132	nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009135	purine nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009166	nucleotide catabolic process	IEP	Predicted GO
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009185	ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
MF	GO:0009383	rRNA (cytosine-C5-)-methyltransferase activity	IEP	Predicted GO
BP	GO:0009396	folic acid-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0010322	regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IEP	Predicted GO
BP	GO:0010323	negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IEP	Predicted GO
BP	GO:0010563	negative regulation of phosphorus metabolic process	IEP	Predicted GO
BP	GO:0010565	regulation of cellular ketone metabolic process	IEP	Predicted GO
BP	GO:0010675	regulation of cellular carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0010677	negative regulation of cellular carbohydrate metabolic process	IEP	Predicted GO
CC	GO:0015934	large ribosomal subunit	IEP	Predicted GO
BP	GO:0016052	carbohydrate catabolic process	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
MF	GO:0016434	rRNA (cytosine) methyltransferase activity	IEP	Predicted GO
MF	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	IEP	Predicted GO
MF	GO:0016778	diphosphotransferase activity	IEP	Predicted GO
MF	GO:0016787	hydrolase activity	IEP	Predicted GO
MF	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	IEP	Predicted GO
BP	GO:0018130	heterocycle biosynthetic process	IEP	Predicted GO
MF	GO:0019200	carbohydrate kinase activity	IEP	Predicted GO
MF	GO:0019203	carbohydrate phosphatase activity	IEP	Predicted GO
BP	GO:0019216	regulation of lipid metabolic process	IEP	Predicted GO
BP	GO:0019319	hexose biosynthetic process	IEP	Predicted GO
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0019363	pyridine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Predicted GO
BP	GO:0019439	aromatic compound catabolic process	IEP	Predicted GO
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	IEP	Predicted GO
BP	GO:0019693	ribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019747	regulation of isoprenoid metabolic process	IEP	Predicted GO
BP	GO:0022613	ribonucleoprotein complex biogenesis	IEP	Predicted GO
CC	GO:0022625	cytosolic large ribosomal subunit	IEP	Predicted GO
MF	GO:0030544	Hsp70 protein binding	IEP	Predicted GO
CC	GO:0030684	preribosome	IEP	Predicted GO
MF	GO:0031369	translation initiation factor binding	IEP	Predicted GO
CC	GO:0031428	box C/D snoRNP complex	IEP	Predicted GO
BP	GO:0031503	protein-containing complex localization	IEP	Predicted GO
CC	GO:0032040	small-subunit processome	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0033750	ribosome localization	IEP	Predicted GO
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0034655	nucleobase-containing compound catabolic process	IEP	Predicted GO
BP	GO:0042866	pyruvate biosynthetic process	IEP	Predicted GO
BP	GO:0043043	peptide biosynthetic process	IEP	Predicted GO
MF	GO:0043139	5'-3' DNA helicase activity	IEP	Predicted GO
MF	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043604	amide biosynthetic process	IEP	Predicted GO
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0044085	cellular component biogenesis	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
CC	GO:0044391	ribosomal subunit	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044428	nuclear part	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
BP	GO:0045827	negative regulation of isoprenoid metabolic process	IEP	Predicted GO
BP	GO:0045833	negative regulation of lipid metabolic process	IEP	Predicted GO
BP	GO:0045912	negative regulation of carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0045936	negative regulation of phosphate metabolic process	IEP	Predicted GO
BP	GO:0046031	ADP metabolic process	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046364	monosaccharide biosynthetic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0046434	organophosphate catabolic process	IEP	Predicted GO
BP	GO:0046452	dihydrofolate metabolic process	IEP	Predicted GO
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Predicted GO
BP	GO:0046890	regulation of lipid biosynthetic process	IEP	Predicted GO
BP	GO:0046939	nucleotide phosphorylation	IEP	Predicted GO
MF	GO:0047334	diphosphate-fructose-6-phosphate 1-phosphotransferase activity	IEP	Predicted GO
MF	GO:0050308	sugar-phosphatase activity	IEP	Predicted GO
BP	GO:0051055	negative regulation of lipid biosynthetic process	IEP	Predicted GO
MF	GO:0051082	unfolded protein binding	IEP	Predicted GO
BP	GO:0051156	glucose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
BP	GO:0051640	organelle localization	IEP	Predicted GO
BP	GO:0051656	establishment of organelle localization	IEP	Predicted GO
MF	GO:0051879	Hsp90 protein binding	IEP	Predicted GO
MF	GO:0052689	carboxylic ester hydrolase activity	IEP	Predicted GO
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Predicted GO
BP	GO:0062012	regulation of small molecule metabolic process	IEP	Predicted GO
BP	GO:0062014	negative regulation of small molecule metabolic process	IEP	Predicted GO
BP	GO:0071071	regulation of phospholipid biosynthetic process	IEP	Predicted GO
BP	GO:0071072	negative regulation of phospholipid biosynthetic process	IEP	Predicted GO
BP	GO:0071426	ribonucleoprotein complex export from nucleus	IEP	Predicted GO
BP	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072525	pyridine-containing compound biosynthetic process	IEP	Predicted GO
CC	GO:0101031	chaperone complex	IEP	Predicted GO
BP	GO:1901292	nucleoside phosphate catabolic process	IEP	Predicted GO
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1903725	regulation of phospholipid metabolic process	IEP	Predicted GO
BP	GO:1903726	negative regulation of phospholipid metabolic process	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR012947	tRNA_SAD	458	506
IPR004154	Anticodon-bd	902	992
IPR002314	aa-tRNA-synt_IIb	609	788

External Links

PlasmoDB	810817
PlasmoDB	PF11_0270

PF3D7_1126000 (ThrRS)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation