PF3D7_1434600 (METAP2)

Aliases : METAP2

Description : SSF46785: Winged helix DNA-binding domain superfamily, SSF55920: Creatinase/aminopeptidase-like. Pfam domain(s): PF00557: Metallopeptidase family M24.

Gene families : OG_01_0001238 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001238_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1434600
Cluster	P. falciparum: Cluster_28

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1010200	METAP2	SSF55920: Creatinase/aminopeptidase-like, SSF46785:...	0.15	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004177	aminopeptidase activity	IEA	PlasmoDB
BP	GO:0006412	translation	ISS	PlasmoDB
BP	GO:0006417	regulation of translation	ISS	PlasmoDB
BP	GO:0006464	cellular protein modification process	ISS	PlasmoDB
BP	GO:0006508	proteolysis	IEA	PlasmoDB
BP	GO:0006518	peptide metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008235	metalloexopeptidase activity	ISS	PlasmoDB
MF	GO:0008235	metalloexopeptidase activity	IEA	PlasmoDB
MF	GO:0008237	metallopeptidase activity	None	Extended
MF	GO:0008238	exopeptidase activity	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0010608	posttranscriptional regulation of gene expression	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
BP	GO:0032268	regulation of cellular protein metabolic process	None	Extended
BP	GO:0034248	regulation of cellular amide metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0036211	protein modification process	None	Extended
BP	GO:0043043	peptide biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0043603	cellular amide metabolic process	None	Extended
BP	GO:0043604	amide biosynthetic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044267	cellular protein metabolic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051246	regulation of protein metabolic process	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000027	ribosomal large subunit assembly	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0003724	RNA helicase activity	IEP	Predicted GO
MF	GO:0003743	translation initiation factor activity	IEP	Predicted GO
MF	GO:0004004	ATP-dependent RNA helicase activity	IEP	Predicted GO
MF	GO:0004386	helicase activity	IEP	Predicted GO
MF	GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	IEP	Predicted GO
MF	GO:0004818	glutamate-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005488	binding	IEP	Predicted GO
CC	GO:0005681	spliceosomal complex	IEP	Predicted GO
CC	GO:0005684	U2-type spliceosomal complex	IEP	Predicted GO
CC	GO:0005730	nucleolus	IEP	Predicted GO
CC	GO:0005732	small nucleolar ribonucleoprotein complex	IEP	Predicted GO
CC	GO:0005852	eukaryotic translation initiation factor 3 complex	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006364	rRNA processing	IEP	Predicted GO
BP	GO:0006370	7-methylguanosine mRNA capping	IEP	Predicted GO
BP	GO:0006396	RNA processing	IEP	Predicted GO
BP	GO:0006397	mRNA processing	IEP	Predicted GO
BP	GO:0006424	glutamyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
MF	GO:0008026	ATP-dependent helicase activity	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
MF	GO:0008173	RNA methyltransferase activity	IEP	Predicted GO
MF	GO:0008174	mRNA methyltransferase activity	IEP	Predicted GO
MF	GO:0008186	RNA-dependent ATPase activity	IEP	Predicted GO
BP	GO:0009452	7-methylguanosine RNA capping	IEP	Predicted GO
BP	GO:0016070	RNA metabolic process	IEP	Predicted GO
BP	GO:0016071	mRNA metabolic process	IEP	Predicted GO
BP	GO:0016072	rRNA metabolic process	IEP	Predicted GO
BP	GO:0016556	mRNA modification	IEP	Predicted GO
BP	GO:0022607	cellular component assembly	IEP	Predicted GO
BP	GO:0022613	ribonucleoprotein complex biogenesis	IEP	Predicted GO
BP	GO:0022618	ribonucleoprotein complex assembly	IEP	Predicted GO
CC	GO:0030684	preribosome	IEP	Predicted GO
CC	GO:0030686	90S preribosome	IEP	Predicted GO
MF	GO:0031369	translation initiation factor binding	IEP	Predicted GO
CC	GO:0031428	box C/D snoRNP complex	IEP	Predicted GO
BP	GO:0032259	methylation	IEP	Predicted GO
MF	GO:0033677	DNA/RNA helicase activity	IEP	Predicted GO
MF	GO:0033678	5'-3' DNA/RNA helicase activity	IEP	Predicted GO
MF	GO:0033679	3'-5' DNA/RNA helicase activity	IEP	Predicted GO
CC	GO:0034457	Mpp10 complex	IEP	Predicted GO
BP	GO:0034462	small-subunit processome assembly	IEP	Predicted GO
BP	GO:0034470	ncRNA processing	IEP	Predicted GO
BP	GO:0034622	cellular protein-containing complex assembly	IEP	Predicted GO
BP	GO:0034660	ncRNA metabolic process	IEP	Predicted GO
BP	GO:0036260	RNA capping	IEP	Predicted GO
BP	GO:0042254	ribosome biogenesis	IEP	Predicted GO
MF	GO:0043142	single-stranded DNA-dependent ATPase activity	IEP	Predicted GO
BP	GO:0043933	protein-containing complex subunit organization	IEP	Predicted GO
BP	GO:0044085	cellular component biogenesis	IEP	Predicted GO
CC	GO:0044428	nuclear part	IEP	Predicted GO
CC	GO:0044452	nucleolar part	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
BP	GO:0065003	protein-containing complex assembly	IEP	Predicted GO
MF	GO:0070035	purine NTP-dependent helicase activity	IEP	Predicted GO
BP	GO:0071826	ribonucleoprotein complex subunit organization	IEP	Predicted GO
BP	GO:0071840	cellular component organization or biogenesis	IEP	Predicted GO
BP	GO:0080009	mRNA methylation	IEP	Predicted GO
BP	GO:0090304	nucleic acid metabolic process	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000994	Pept_M24	316	614

External Links

PlasmoDB	811909
PlasmoDB	PF14_0327

PF3D7_1434600 (METAP2)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation