PF3D7_1454400 (APP)

Aliases : APP

Description : SSF53092: "Creatinase/Aminopeptidase P/Spt16, N-terminal", SSF55920: Creatinase/aminopeptidase-like. Pfam domain(s): PF00557: Metallopeptidase family M24, PF16189: Creatinase/Prolidase N-terminal domain, PF01321: Creatinase/Prolidase N-terminal domain, PF16188: C-terminal region of peptidase_M24.

Gene families : OG_01_0001808 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001808_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1454400
Cluster	P. falciparum: Cluster_25

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_1318100	APP	SSF53092: Creatinase/Aminopeptidase P/Spt16, N-terminal,...	0.02	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
CC	GO:0000323	lytic vacuole	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004177	aminopeptidase activity	IDA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005764	lysosome	None	Extended
CC	GO:0005767	secondary lysosome	None	Extended
CC	GO:0005773	vacuole	None	Extended
CC	GO:0005829	cytosol	IDA	PlasmoDB
BP	GO:0006508	proteolysis	IDA	PlasmoDB
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008235	metalloexopeptidase activity	None	Extended
MF	GO:0008237	metallopeptidase activity	None	Extended
MF	GO:0008238	exopeptidase activity	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009057	macromolecule catabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016787	hydrolase activity	IEA	Interproscan predictions
MF	GO:0016787	hydrolase activity	IEA	PlasmoDB
BP	GO:0019538	protein metabolic process	None	Extended
CC	GO:0020020	food vacuole	IDA	PlasmoDB
BP	GO:0020027	hemoglobin metabolic process	None	Extended
CC	GO:0030139	endocytic vesicle	None	Extended
BP	GO:0030163	protein catabolic process	None	Extended
CC	GO:0031410	cytoplasmic vesicle	None	Extended
CC	GO:0031982	vesicle	None	Extended
CC	GO:0032010	phagolysosome	None	Extended
BP	GO:0042540	hemoglobin catabolic process	TAS	PlasmoDB
MF	GO:0042802	identical protein binding	None	Extended
MF	GO:0042803	protein homodimerization activity	IDA	PlasmoDB
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044265	cellular macromolecule catabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
CC	GO:0045335	phagocytic vesicle	None	Extended
MF	GO:0046983	protein dimerization activity	None	Extended
MF	GO:0070006	metalloaminopeptidase activity	IDA	PlasmoDB
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
CC	GO:0097708	intracellular vesicle	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901565	organonitrogen compound catabolic process	None	Extended
BP	GO:1901575	organic substance catabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0004519	endonuclease activity	IEP	Predicted GO
MF	GO:0004521	endoribonuclease activity	IEP	Predicted GO
MF	GO:0004540	ribonuclease activity	IEP	Predicted GO
MF	GO:0005048	signal sequence binding	IEP	Predicted GO
CC	GO:0005739	mitochondrion	IEP	Predicted GO
CC	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	IEP	Predicted GO
CC	GO:0005852	eukaryotic translation initiation factor 3 complex	IEP	Predicted GO
BP	GO:0006325	chromatin organization	IEP	Predicted GO
BP	GO:0006396	RNA processing	IEP	Predicted GO
BP	GO:0006417	regulation of translation	IEP	Predicted GO
BP	GO:0006446	regulation of translational initiation	IEP	Predicted GO
BP	GO:0006479	protein methylation	IEP	Predicted GO
BP	GO:0006605	protein targeting	IEP	Predicted GO
BP	GO:0006626	protein targeting to mitochondrion	IEP	Predicted GO
BP	GO:0006839	mitochondrial transport	IEP	Predicted GO
BP	GO:0006986	response to unfolded protein	IEP	Predicted GO
MF	GO:0008170	N-methyltransferase activity	IEP	Predicted GO
BP	GO:0008213	protein alkylation	IEP	Predicted GO
MF	GO:0008276	protein methyltransferase activity	IEP	Predicted GO
MF	GO:0008419	RNA lariat debranching enzyme activity	IEP	Predicted GO
MF	GO:0008565	protein transporter activity	IEP	Predicted GO
MF	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	IEP	Predicted GO
BP	GO:0009266	response to temperature stimulus	IEP	Predicted GO
BP	GO:0009408	response to heat	IEP	Predicted GO
BP	GO:0009628	response to abiotic stimulus	IEP	Predicted GO
BP	GO:0010033	response to organic substance	IEP	Predicted GO
BP	GO:0010608	posttranscriptional regulation of gene expression	IEP	Predicted GO
MF	GO:0016273	arginine N-methyltransferase activity	IEP	Predicted GO
MF	GO:0016274	protein-arginine N-methyltransferase activity	IEP	Predicted GO
BP	GO:0016569	covalent chromatin modification	IEP	Predicted GO
BP	GO:0016570	histone modification	IEP	Predicted GO
BP	GO:0016571	histone methylation	IEP	Predicted GO
MF	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IEP	Predicted GO
MF	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
BP	GO:0022613	ribonucleoprotein complex biogenesis	IEP	Predicted GO
BP	GO:0030150	protein import into mitochondrial matrix	IEP	Predicted GO
MF	GO:0030943	mitochondrion targeting sequence binding	IEP	Predicted GO
BP	GO:0032259	methylation	IEP	Predicted GO
MF	GO:0033218	amide binding	IEP	Predicted GO
BP	GO:0033365	protein localization to organelle	IEP	Predicted GO
BP	GO:0034248	regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0034613	cellular protein localization	IEP	Predicted GO
BP	GO:0035966	response to topologically incorrect protein	IEP	Predicted GO
BP	GO:0042254	ribosome biogenesis	IEP	Predicted GO
MF	GO:0042277	peptide binding	IEP	Predicted GO
BP	GO:0043414	macromolecule methylation	IEP	Predicted GO
BP	GO:0044085	cellular component biogenesis	IEP	Predicted GO
CC	GO:0044455	mitochondrial membrane part	IEP	Predicted GO
BP	GO:0044743	protein transmembrane import into intracellular organelle	IEP	Predicted GO
BP	GO:0065002	intracellular protein transmembrane transport	IEP	Predicted GO
BP	GO:0070585	protein localization to mitochondrion	IEP	Predicted GO
BP	GO:0070727	cellular macromolecule localization	IEP	Predicted GO
BP	GO:0071806	protein transmembrane transport	IEP	Predicted GO
BP	GO:0072594	establishment of protein localization to organelle	IEP	Predicted GO
BP	GO:0072655	establishment of protein localization to mitochondrion	IEP	Predicted GO
CC	GO:0098798	mitochondrial protein complex	IEP	Predicted GO
CC	GO:0098800	inner mitochondrial membrane protein complex	IEP	Predicted GO
BP	GO:1990542	mitochondrial transmembrane transport	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000994	Pept_M24	482	695
IPR000587	Creatinase_N	135	265
IPR032416	Peptidase_M24_C	705	772

External Links

PlasmoDB	812099
PlasmoDB	PF14_0517

PF3D7_1454400 (APP)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation