PBANKA_1011400 (TOP2)

Aliases : TOP2

Description : SSF55874: Histidine kinase/HSP90-like ATPase superfamily, SSF56719: DNA topoisomerase, type IIA-like domain superfamily, SSF54211: Ribosomal protein S5 domain 2-type fold. Pfam domain(s): PF01751: Toprim domain, PF00204: DNA gyrase B, PF16898: C-terminal associated domain of TOPRIM, PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, PF00521: DNA gyrase/topoisomerase IV, subunit A.

Gene families : OG_01_0001242 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001242_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pbe RNA-seq: PBANKA_1011400
Cluster	P. berghei: Cluster_29

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan predictions
MF	GO:0003677	DNA binding	IEA	PlasmoDB
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEA	Interproscan predictions
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	Interproscan predictions
BP	GO:0006265	DNA topological change	IEA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
MF	GO:0008094	DNA-dependent ATPase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
MF	GO:0061505	DNA topoisomerase II activity	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000808	origin recognition complex	IEP	Predicted GO
MF	GO:0003678	DNA helicase activity	IEP	Predicted GO
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Predicted GO
MF	GO:0003909	DNA ligase activity	IEP	Predicted GO
MF	GO:0003910	DNA ligase (ATP) activity	IEP	Predicted GO
MF	GO:0003917	DNA topoisomerase type I activity	IEP	Predicted GO
MF	GO:0004386	helicase activity	IEP	Predicted GO
MF	GO:0004529	exodeoxyribonuclease activity	IEP	Predicted GO
MF	GO:0004536	deoxyribonuclease activity	IEP	Predicted GO
MF	GO:0004672	protein kinase activity	IEP	Predicted GO
MF	GO:0005310	dicarboxylic acid transmembrane transporter activity	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
CC	GO:0005658	alpha DNA polymerase:primase complex	IEP	Predicted GO
CC	GO:0005694	chromosome	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006266	DNA ligation	IEP	Predicted GO
BP	GO:0006270	DNA replication initiation	IEP	Predicted GO
BP	GO:0006281	DNA repair	IEP	Predicted GO
BP	GO:0006298	mismatch repair	IEP	Predicted GO
BP	GO:0006333	chromatin assembly or disassembly	IEP	Predicted GO
BP	GO:0006468	protein phosphorylation	IEP	Predicted GO
BP	GO:0006793	phosphorus metabolic process	IEP	Predicted GO
BP	GO:0006796	phosphate-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
BP	GO:0006974	cellular response to DNA damage stimulus	IEP	Predicted GO
BP	GO:0007051	spindle organization	IEP	Predicted GO
BP	GO:0007052	mitotic spindle organization	IEP	Predicted GO
MF	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	IEP	Predicted GO
MF	GO:0008409	5'-3' exonuclease activity	IEP	Predicted GO
MF	GO:0008517	folic acid transmembrane transporter activity	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009187	cyclic nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009190	cyclic nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
MF	GO:0015238	drug transmembrane transporter activity	IEP	Predicted GO
MF	GO:0016301	kinase activity	IEP	Predicted GO
BP	GO:0016310	phosphorylation	IEP	Predicted GO
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	IEP	Predicted GO
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEP	Predicted GO
MF	GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	IEP	Predicted GO
MF	GO:0016849	phosphorus-oxygen lyase activity	IEP	Predicted GO
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	IEP	Predicted GO
MF	GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	IEP	Predicted GO
BP	GO:0018130	heterocycle biosynthetic process	IEP	Predicted GO
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Predicted GO
MF	GO:0030983	mismatched DNA binding	IEP	Predicted GO
BP	GO:0031497	chromatin assembly	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
BP	GO:0033554	cellular response to stress	IEP	Predicted GO
MF	GO:0034061	DNA polymerase activity	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Predicted GO
MF	GO:0035312	5'-3' exodeoxyribonuclease activity	IEP	Predicted GO
MF	GO:0042393	histone binding	IEP	Predicted GO
CC	GO:0042555	MCM complex	IEP	Predicted GO
CC	GO:0042575	DNA polymerase complex	IEP	Predicted GO
MF	GO:0042887	amide transmembrane transporter activity	IEP	Predicted GO
BP	GO:0043086	negative regulation of catalytic activity	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043625	delta DNA polymerase complex	IEP	Predicted GO
BP	GO:0044092	negative regulation of molecular function	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044427	chromosomal part	IEP	Predicted GO
CC	GO:0044454	nuclear chromosome part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
MF	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity	IEP	Predicted GO
BP	GO:0050896	response to stimulus	IEP	Predicted GO
BP	GO:0051095	regulation of helicase activity	IEP	Predicted GO
BP	GO:0051097	negative regulation of helicase activity	IEP	Predicted GO
BP	GO:0051103	DNA ligation involved in DNA repair	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051225	spindle assembly	IEP	Predicted GO
BP	GO:0051336	regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051716	cellular response to stimulus	IEP	Predicted GO
CC	GO:0061695	transferase complex, transferring phosphorus-containing groups	IEP	Predicted GO
BP	GO:0071897	DNA biosynthetic process	IEP	Predicted GO
MF	GO:0072349	modified amino acid transmembrane transporter activity	IEP	Predicted GO
BP	GO:0090307	mitotic spindle assembly	IEP	Predicted GO
MF	GO:0090482	vitamin transmembrane transporter activity	IEP	Predicted GO
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	IEP	Predicted GO
BP	GO:1905462	regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905463	negative regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905774	regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:1905775	negative regulation of DNA helicase activity	IEP	Predicted GO
CC	GO:1990234	transferase complex	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003594	HATPase_C	56	161
IPR002205	Topo_IIA_A/C	743	1196
IPR006171	TOPRIM_domain	500	605
IPR013506	Topo_IIA_bsu_dom2	325	467
IPR031660	TOPRIM_C	616	740

External Links

PlasmoDB	PB000671.01.0
PlasmoDB	PB300551.00.0
PlasmoDB	PB300632.00.0
PlasmoDB	PBANKA_101140

PBANKA_1011400 (TOP2)

Expression Profile

Co-expression Networks

Functional Annotation