PF3D7_0831700 (HSP70x)

Aliases : HSP70x

Description : SSF53067: No description available, SSF100920: "Heat shock protein 70kD, peptide-binding domain superfamily", SSF100934: "Heat shock protein 70kD, C-terminal domain superfamily". Pfam domain(s): PF00012: Hsp70 protein.

Gene families : OG_01_0000033 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000033_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0831700
Cluster	P. falciparum: Cluster_16

Target	Alias	Description	ECC score	Gene Family Method	Actions
PBANKA_0711900	HSP70	SSF53067: 20-02-2019, SSF100920: Heat shock protein...	0.07	Orthofinderv1.1.8
PBANKA_0914400	UIS24	SSF53067: 20-02-2019, SSF100920: Heat shock protein...	0.06	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IPI	PlasmoDB
MF	GO:0005524	ATP binding	IDA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	IDA	PlasmoDB
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
CC	GO:0020003	symbiont-containing vacuole	IDA	PlasmoDB
BP	GO:0020035	cytoadherence to microvasculature, mediated by symbiont protein	IMP	PlasmoDB
CC	GO:0020036	Maurer's cleft	IDA	PlasmoDB
BP	GO:0022610	biological adhesion	None	Extended
CC	GO:0030430	host cell cytoplasm	IDA	PlasmoDB
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0031072	heat shock protein binding	IDA	PlasmoDB
CC	GO:0031982	vesicle	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
CC	GO:0033655	host cell cytoplasm part	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043230	extracellular organelle	None	Extended
CC	GO:0044164	host cell cytosol	IDA	PlasmoDB
CC	GO:0044217	other organism part	None	Extended
BP	GO:0044406	adhesion of symbiont to host	None	Extended
CC	GO:0044421	extracellular region part	None	Extended
BP	GO:0051704	multi-organism process	None	Extended
CC	GO:0065010	extracellular membrane-bounded organelle	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
CC	GO:1903561	extracellular vesicle	RCA	PlasmoDB

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Type	GO Term	Name	Evidence	Source
CC	GO:0000323	lytic vacuole	IEP	Predicted GO
MF	GO:0000339	RNA cap binding	IEP	Predicted GO
MF	GO:0003688	DNA replication origin binding	IEP	Predicted GO
MF	GO:0003746	translation elongation factor activity	IEP	Predicted GO
MF	GO:0003872	6-phosphofructokinase activity	IEP	Predicted GO
MF	GO:0003924	GTPase activity	IEP	Predicted GO
MF	GO:0003938	IMP dehydrogenase activity	IEP	Predicted GO
MF	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004177	aminopeptidase activity	IEP	Predicted GO
MF	GO:0004190	aspartic-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004356	glutamate-ammonia ligase activity	IEP	Predicted GO
MF	GO:0004427	inorganic diphosphatase activity	IEP	Predicted GO
MF	GO:0004551	nucleotide diphosphatase activity	IEP	Predicted GO
MF	GO:0004619	phosphoglycerate mutase activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004821	histidine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004823	leucine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004828	serine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005381	iron ion transmembrane transporter activity	IEP	Predicted GO
CC	GO:0005764	lysosome	IEP	Predicted GO
CC	GO:0005767	secondary lysosome	IEP	Predicted GO
CC	GO:0005773	vacuole	IEP	Predicted GO
CC	GO:0005789	endoplasmic reticulum membrane	IEP	Predicted GO
CC	GO:0005829	cytosol	IEP	Predicted GO
BP	GO:0006002	fructose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006090	pyruvate metabolic process	IEP	Predicted GO
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0006096	glycolytic process	IEP	Predicted GO
BP	GO:0006163	purine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006164	purine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEP	Predicted GO
BP	GO:0006275	regulation of DNA replication	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006417	regulation of translation	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006427	histidyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006429	leucyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006434	seryl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006541	glutamine metabolic process	IEP	Predicted GO
BP	GO:0006542	glutamine biosynthetic process	IEP	Predicted GO
BP	GO:0006612	protein targeting to membrane	IEP	Predicted GO
BP	GO:0006613	cotranslational protein targeting to membrane	IEP	Predicted GO
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEP	Predicted GO
BP	GO:0006733	oxidoreduction coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006757	ATP generation from ADP	IEP	Predicted GO
BP	GO:0006846	acetate transport	IEP	Predicted GO
BP	GO:0006848	pyruvate transport	IEP	Predicted GO
BP	GO:0006857	oligopeptide transport	IEP	Predicted GO
MF	GO:0008028	monocarboxylic acid transmembrane transporter activity	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008237	metallopeptidase activity	IEP	Predicted GO
MF	GO:0008238	exopeptidase activity	IEP	Predicted GO
MF	GO:0008312	7S RNA binding	IEP	Predicted GO
MF	GO:0008324	cation transmembrane transporter activity	IEP	Predicted GO
MF	GO:0008443	phosphofructokinase activity	IEP	Predicted GO
MF	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	IEP	Predicted GO
BP	GO:0009084	glutamine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009132	nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009135	purine nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009165	nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009166	nucleotide catabolic process	IEP	Predicted GO
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009185	ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
MF	GO:0009678	hydrogen-translocating pyrophosphatase activity	IEP	Predicted GO
BP	GO:0010608	posttranscriptional regulation of gene expression	IEP	Predicted GO
MF	GO:0015075	ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015078	proton transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015091	ferric iron transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015093	ferrous iron transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015129	lactate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015293	symporter activity	IEP	Predicted GO
MF	GO:0015294	solute:cation symporter activity	IEP	Predicted GO
MF	GO:0015295	solute:proton symporter activity	IEP	Predicted GO
MF	GO:0015318	inorganic molecular entity transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015355	secondary active monocarboxylate transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015650	lactate:proton symporter activity	IEP	Predicted GO
BP	GO:0015711	organic anion transport	IEP	Predicted GO
BP	GO:0015724	formate transport	IEP	Predicted GO
BP	GO:0015727	lactate transport	IEP	Predicted GO
BP	GO:0015850	organic hydroxy compound transport	IEP	Predicted GO
BP	GO:0015893	drug transport	IEP	Predicted GO
BP	GO:0016052	carbohydrate catabolic process	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
MF	GO:0016211	ammonia ligase activity	IEP	Predicted GO
CC	GO:0016281	eukaryotic translation initiation factor 4F complex	IEP	Predicted GO
MF	GO:0016868	intramolecular transferase activity, phosphotransferases	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
MF	GO:0016880	acid-ammonia (or amide) ligase activity	IEP	Predicted GO
MF	GO:0019200	carbohydrate kinase activity	IEP	Predicted GO
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0019363	pyridine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0020005	symbiont-containing vacuole membrane	IEP	Predicted GO
CC	GO:0020020	food vacuole	IEP	Predicted GO
MF	GO:0022890	inorganic cation transmembrane transporter activity	IEP	Predicted GO
CC	GO:0030139	endocytic vesicle	IEP	Predicted GO
MF	GO:0030145	manganese ion binding	IEP	Predicted GO
CC	GO:0031410	cytoplasmic vesicle	IEP	Predicted GO
CC	GO:0032010	phagolysosome	IEP	Predicted GO
MF	GO:0033677	DNA/RNA helicase activity	IEP	Predicted GO
MF	GO:0033679	3'-5' DNA/RNA helicase activity	IEP	Predicted GO
BP	GO:0034220	ion transmembrane transport	IEP	Predicted GO
BP	GO:0034248	regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0034635	glutathione transport	IEP	Predicted GO
BP	GO:0034660	ncRNA metabolic process	IEP	Predicted GO
BP	GO:0035873	lactate transmembrane transport	IEP	Predicted GO
BP	GO:0042221	response to chemical	IEP	Predicted GO
BP	GO:0042493	response to drug	IEP	Predicted GO
BP	GO:0042866	pyruvate biosynthetic process	IEP	Predicted GO
BP	GO:0042891	antibiotic transport	IEP	Predicted GO
BP	GO:0042939	tripeptide transport	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
CC	GO:0043657	host cell	IEP	Predicted GO
CC	GO:0044216	other organism cell	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
CC	GO:0045335	phagocytic vesicle	IEP	Predicted GO
BP	GO:0046031	ADP metabolic process	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0046434	organophosphate catabolic process	IEP	Predicted GO
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Predicted GO
BP	GO:0046939	nucleotide phosphorylation	IEP	Predicted GO
MF	GO:0047334	diphosphate-fructose-6-phosphate 1-phosphotransferase activity	IEP	Predicted GO
BP	GO:0051052	regulation of DNA metabolic process	IEP	Predicted GO
BP	GO:0051181	cofactor transport	IEP	Predicted GO
MF	GO:0070001	aspartic-type peptidase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0071702	organic substance transport	IEP	Predicted GO
BP	GO:0072337	modified amino acid transport	IEP	Predicted GO
BP	GO:0072348	sulfur compound transport	IEP	Predicted GO
MF	GO:0072509	divalent inorganic cation transmembrane transporter activity	IEP	Predicted GO
MF	GO:0072510	trivalent inorganic cation transmembrane transporter activity	IEP	Predicted GO
BP	GO:0072521	purine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072522	purine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072525	pyridine-containing compound biosynthetic process	IEP	Predicted GO
CC	GO:0097619	PTEX complex	IEP	Predicted GO
CC	GO:0097708	intracellular vesicle	IEP	Predicted GO
BP	GO:0098656	anion transmembrane transport	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
BP	GO:1901292	nucleoside phosphate catabolic process	IEP	Predicted GO
BP	GO:1901293	nucleoside phosphate biosynthetic process	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
MF	GO:1901618	organic hydroxy compound transmembrane transporter activity	IEP	Predicted GO
BP	GO:1903825	organic acid transmembrane transport	IEP	Predicted GO
BP	GO:1905039	carboxylic acid transmembrane transport	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR013126	Hsp_70_fam	35	643

External Links

PlasmoDB	9221911
PlasmoDB	MAL7P1.228

PF3D7_0831700 (HSP70x)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation