PF3D7_1433500 (TOP2)

Aliases : TOP2

Description : SSF56719: "DNA topoisomerase, type IIA-like domain superfamily", SSF55874: Histidine kinase/HSP90-like ATPase superfamily, SSF54211: Ribosomal protein S5 domain 2-type fold. Pfam domain(s): PF00521: "DNA gyrase/topoisomerase IV, subunit A", PF01751: Toprim domain, PF16898: C-terminal associated domain of TOPRIM, PF02518: "Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase", PF00204: DNA gyrase B.

Gene families : OG_01_0001242 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0001242_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1433500
Cluster	P. falciparum: Cluster_12

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan predictions
MF	GO:0003677	DNA binding	IEA	PlasmoDB
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IDA	PlasmoDB
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEA	Interproscan predictions
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEA	PlasmoDB
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan predictions
MF	GO:0005524	ATP binding	IEA	PlasmoDB
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	RCA	PlasmoDB
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IDA	PlasmoDB
BP	GO:0006265	DNA topological change	IEA	Interproscan predictions
BP	GO:0006265	DNA topological change	IEA	PlasmoDB
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
MF	GO:0008094	DNA-dependent ATPase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
MF	GO:0061505	DNA topoisomerase II activity	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	IEP	Predicted GO
CC	GO:0000109	nucleotide-excision repair complex	IEP	Predicted GO
CC	GO:0000112	nucleotide-excision repair factor 3 complex	IEP	Predicted GO
BP	GO:0002028	regulation of sodium ion transport	IEP	Predicted GO
MF	GO:0004012	phospholipid-translocating ATPase activity	IEP	Predicted GO
MF	GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	IEP	Predicted GO
MF	GO:0004467	long-chain fatty acid-CoA ligase activity	IEP	Predicted GO
MF	GO:0005215	transporter activity	IEP	Predicted GO
MF	GO:0005539	glycosaminoglycan binding	IEP	Predicted GO
BP	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	IEP	Predicted GO
BP	GO:0006810	transport	IEP	Predicted GO
BP	GO:0006900	vesicle budding from membrane	IEP	Predicted GO
BP	GO:0008104	protein localization	IEP	Predicted GO
MF	GO:0008201	heparin binding	IEP	Predicted GO
MF	GO:0008565	protein transporter activity	IEP	Predicted GO
BP	GO:0009405	pathogenesis	IEP	Predicted GO
BP	GO:0010959	regulation of metal ion transport	IEP	Predicted GO
BP	GO:0015031	protein transport	IEP	Predicted GO
MF	GO:0015645	fatty acid ligase activity	IEP	Predicted GO
BP	GO:0015833	peptide transport	IEP	Predicted GO
BP	GO:0015917	aminophospholipid transport	IEP	Predicted GO
BP	GO:0016050	vesicle organization	IEP	Predicted GO
MF	GO:0016405	CoA-ligase activity	IEP	Predicted GO
MF	GO:0016877	ligase activity, forming carbon-sulfur bonds	IEP	Predicted GO
MF	GO:0016878	acid-thiol ligase activity	IEP	Predicted GO
CC	GO:0020005	symbiont-containing vacuole membrane	IEP	Predicted GO
CC	GO:0020007	apical complex	IEP	Predicted GO
CC	GO:0020009	microneme	IEP	Predicted GO
CC	GO:0020026	merozoite dense granule	IEP	Predicted GO
CC	GO:0030015	CCR4-NOT core complex	IEP	Predicted GO
BP	GO:0030260	entry into host cell	IEP	Predicted GO
BP	GO:0031204	posttranslational protein targeting to membrane, translocation	IEP	Predicted GO
CC	GO:0031207	Sec62/Sec63 complex	IEP	Predicted GO
CC	GO:0031410	cytoplasmic vesicle	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
BP	GO:0033036	macromolecule localization	IEP	Predicted GO
BP	GO:0033683	nucleotide-excision repair, DNA incision	IEP	Predicted GO
MF	GO:0033691	sialic acid binding	IEP	Predicted GO
BP	GO:0042000	translocation of peptides or proteins into host	IEP	Predicted GO
BP	GO:0042221	response to chemical	IEP	Predicted GO
BP	GO:0042493	response to drug	IEP	Predicted GO
BP	GO:0042886	amide transport	IEP	Predicted GO
CC	GO:0043230	extracellular organelle	IEP	Predicted GO
BP	GO:0043269	regulation of ion transport	IEP	Predicted GO
MF	GO:0043492	ATPase activity, coupled to movement of substances	IEP	Predicted GO
CC	GO:0043657	host cell	IEP	Predicted GO
BP	GO:0044053	translocation of peptides or proteins into host cell cytoplasm	IEP	Predicted GO
CC	GO:0044216	other organism cell	IEP	Predicted GO
CC	GO:0044217	other organism part	IEP	Predicted GO
BP	GO:0044255	cellular lipid metabolic process	IEP	Predicted GO
BP	GO:0044409	entry into host	IEP	Predicted GO
BP	GO:0044417	translocation of molecules into host	IEP	Predicted GO
BP	GO:0044419	interspecies interaction between organisms	IEP	Predicted GO
BP	GO:0044501	modulation of signal transduction in other organism	IEP	Predicted GO
BP	GO:0044766	multi-organism transport	IEP	Predicted GO
BP	GO:0045184	establishment of protein localization	IEP	Predicted GO
MF	GO:0046789	host cell surface receptor binding	IEP	Predicted GO
MF	GO:0046812	host cell surface binding	IEP	Predicted GO
BP	GO:0051179	localization	IEP	Predicted GO
BP	GO:0051234	establishment of localization	IEP	Predicted GO
BP	GO:0051260	protein homooligomerization	IEP	Predicted GO
BP	GO:0051701	interaction with host	IEP	Predicted GO
BP	GO:0051704	multi-organism process	IEP	Predicted GO
BP	GO:0051806	entry into cell of other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0051808	translocation of peptides or proteins into other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0051828	entry into other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0051836	translocation of molecules into other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0052027	modulation by symbiont of host signal transduction pathway	IEP	Predicted GO
BP	GO:0052250	modulation of signal transduction in other organism involved in symbiotic interaction	IEP	Predicted GO
BP	GO:0055088	lipid homeostasis	IEP	Predicted GO
BP	GO:0071702	organic substance transport	IEP	Predicted GO
BP	GO:0071705	nitrogen compound transport	IEP	Predicted GO
BP	GO:0075109	modulation by symbiont of host receptor-mediated signal transduction	IEP	Predicted GO
CC	GO:0097619	PTEX complex	IEP	Predicted GO
CC	GO:0097708	intracellular vesicle	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO
BP	GO:1902579	multi-organism localization	IEP	Predicted GO
CC	GO:1903561	extracellular vesicle	IEP	Predicted GO
CC	GO:1990225	rhoptry neck	IEP	Predicted GO
CC	GO:1990391	DNA repair complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR006171	TOPRIM_domain	494	595
IPR013506	Topo_IIA_bsu_dom2	321	461
IPR003594	HATPase_C	56	158
IPR031660	TOPRIM_C	610	734
IPR002205	Topo_IIA_A/C	737	1190

External Links

PlasmoDB	811898
PlasmoDB	PF14_0316

PF3D7_1433500 (TOP2)

Expression Profile

Co-expression Networks

Functional Annotation