PF3D7_0420700 (VAR)

Aliases : VAR

Description : SSF140924: No description available. Pfam domain(s): PF15445: "acidic terminal segments, variant surface antigen of PfEMP1", PF18562: Cysteine-Rich Interdomain Region 1 gamma, PF15447: N-terminal segments of PfEMP1, PF03011: PFEMP DBL domain, PF05424: Duffy binding domain.

Gene families : OG_01_0000012 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000012_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0420700
Cluster	P. falciparum: Cluster_13

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009405	pathogenesis	IEA	Interproscan predictions
BP	GO:0009405	pathogenesis	IEA	PlasmoDB
BP	GO:0009605	response to external stimulus	None	Extended
BP	GO:0009607	response to biotic stimulus	None	Extended
CC	GO:0016021	integral component of membrane	IEA	Interproscan predictions
CC	GO:0016021	integral component of membrane	IEA	PlasmoDB
CC	GO:0020002	host cell plasma membrane	TAS	PlasmoDB
BP	GO:0020013	modulation by symbiont of host erythrocyte aggregation	TAS	PlasmoDB
CC	GO:0020030	infected host cell surface knob	TAS	PlasmoDB
BP	GO:0020033	antigenic variation	TAS	PlasmoDB
BP	GO:0020035	cytoadherence to microvasculature, mediated by symbiont protein	TAS	PlasmoDB
BP	GO:0022407	regulation of cell-cell adhesion	None	Extended
BP	GO:0022610	biological adhesion	None	Extended
BP	GO:0030155	regulation of cell adhesion	None	Extended
CC	GO:0031224	intrinsic component of membrane	None	Extended
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033644	host cell membrane	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
CC	GO:0033655	host cell cytoplasm part	None	Extended
BP	GO:0034110	regulation of homotypic cell-cell adhesion	None	Extended
BP	GO:0034118	regulation of erythrocyte aggregation	None	Extended
BP	GO:0035821	modification of morphology or physiology of other organism	None	Extended
BP	GO:0043207	response to external biotic stimulus	None	Extended
BP	GO:0044003	modification by symbiont of host morphology or physiology	None	Extended
BP	GO:0044068	modulation by symbiont of host cellular process	None	Extended
CC	GO:0044217	other organism part	None	Extended
CC	GO:0044218	other organism cell membrane	None	Extended
CC	GO:0044279	other organism membrane	None	Extended
BP	GO:0044406	adhesion of symbiont to host	None	Extended
BP	GO:0044419	interspecies interaction between organisms	None	Extended
CC	GO:0044425	membrane part	None	Extended
MF	GO:0046789	host cell surface receptor binding	IEA	Interproscan predictions
MF	GO:0046789	host cell surface receptor binding	IEA	PlasmoDB
MF	GO:0046812	host cell surface binding	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
MF	GO:0050839	cell adhesion molecule binding	TAS	PlasmoDB
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051701	interaction with host	None	Extended
BP	GO:0051704	multi-organism process	None	Extended
BP	GO:0051707	response to other organism	None	Extended
BP	GO:0051805	evasion or tolerance of immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051807	evasion or tolerance of defense response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051809	passive evasion of immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051817	modification of morphology or physiology of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051832	avoidance of defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051834	evasion or tolerance of defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0052173	response to defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0052564	response to immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0065007	biological regulation	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0020003	symbiont-containing vacuole	IEP	Predicted GO
CC	GO:0020036	Maurer's cleft	IEP	Predicted GO
MF	GO:0031072	heat shock protein binding	IEP	Predicted GO
CC	GO:0043230	extracellular organelle	IEP	Predicted GO
CC	GO:0044421	extracellular region part	IEP	Predicted GO
CC	GO:0065010	extracellular membrane-bounded organelle	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR029211	PfEMP1_ATS	1701	2152
IPR008602	Duffy-antigen_binding	126	279
IPR008602	Duffy-antigen_binding	934	1170
IPR029210	PfEMP1_NTS	20	55
IPR004258	DBL	1436	1576
IPR004258	DBL	656	805

External Links

PlasmoDB	812476
PlasmoDB	MAL4P1.194
PlasmoDB	PFD0995c

PF3D7_0420700 (VAR)

Expression Profile

Co-expression Networks

Functional Annotation