PF3D7_0711700 (VAR)

Aliases : VAR

Description : SSF140924: No description available. Pfam domain(s): PF15447: N-terminal segments of PfEMP1, PF03011: PFEMP DBL domain, PF15445: "acidic terminal segments, variant surface antigen of PfEMP1", PF05424: Duffy binding domain, PF18562: Cysteine-Rich Interdomain Region 1 gamma.

Gene families : OG_01_0000012 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000012_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_0711700
Cluster	P. falciparum: Cluster_60

Target	Alias	Description	ECC score	Gene Family Method
PF3D7_0101700	VAR	No superfamily available. Pfam domain(s): PF15445:...	0.05	Orthofinderv1.1.8
PF3D7_0222900	VAR	No superfamily available. Pfam domain(s): PF15445:...	0.02	Orthofinderv1.1.8
PF3D7_0402800	No alias	SSF140924: No description available. Pfam domain(s):...	0.01	Orthofinderv1.1.8
PF3D7_0412900	VAR	SSF140924: No description available. Pfam domain(s):...	0.03	Orthofinderv1.1.8
PF3D7_0413400	VAR	SSF140924: No description available. Pfam domain(s):...	0.05	Orthofinderv1.1.8
PF3D7_0600100	VAR	SSF140924: No description available. Pfam domain(s):...	0.01	Orthofinderv1.1.8
PF3D7_0732100	VAR	No superfamily available. Pfam domain(s): PF15445:...	0.01	Orthofinderv1.1.8
PF3D7_1372900	VAR	No superfamily available. Pfam domain(s): PF15445:...	0.01	Orthofinderv1.1.8

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009405	pathogenesis	IEA	Interproscan predictions
BP	GO:0009405	pathogenesis	IEA	PlasmoDB
BP	GO:0009605	response to external stimulus	None	Extended
BP	GO:0009607	response to biotic stimulus	None	Extended
CC	GO:0016021	integral component of membrane	IEA	Interproscan predictions
CC	GO:0016021	integral component of membrane	IEA	PlasmoDB
CC	GO:0020002	host cell plasma membrane	TAS	PlasmoDB
BP	GO:0020013	modulation by symbiont of host erythrocyte aggregation	TAS	PlasmoDB
CC	GO:0020030	infected host cell surface knob	TAS	PlasmoDB
BP	GO:0020033	antigenic variation	TAS	PlasmoDB
BP	GO:0020035	cytoadherence to microvasculature, mediated by symbiont protein	TAS	PlasmoDB
BP	GO:0022407	regulation of cell-cell adhesion	None	Extended
BP	GO:0022610	biological adhesion	None	Extended
BP	GO:0030155	regulation of cell adhesion	None	Extended
CC	GO:0031224	intrinsic component of membrane	None	Extended
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033644	host cell membrane	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
CC	GO:0033655	host cell cytoplasm part	None	Extended
BP	GO:0034110	regulation of homotypic cell-cell adhesion	None	Extended
BP	GO:0034118	regulation of erythrocyte aggregation	None	Extended
BP	GO:0035821	modification of morphology or physiology of other organism	None	Extended
BP	GO:0043207	response to external biotic stimulus	None	Extended
BP	GO:0044003	modification by symbiont of host morphology or physiology	None	Extended
BP	GO:0044068	modulation by symbiont of host cellular process	None	Extended
CC	GO:0044217	other organism part	None	Extended
CC	GO:0044218	other organism cell membrane	None	Extended
CC	GO:0044279	other organism membrane	None	Extended
BP	GO:0044406	adhesion of symbiont to host	None	Extended
BP	GO:0044419	interspecies interaction between organisms	None	Extended
CC	GO:0044425	membrane part	None	Extended
MF	GO:0046789	host cell surface receptor binding	IEA	Interproscan predictions
MF	GO:0046789	host cell surface receptor binding	IEA	PlasmoDB
MF	GO:0046812	host cell surface binding	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
MF	GO:0050839	cell adhesion molecule binding	TAS	PlasmoDB
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051701	interaction with host	None	Extended
BP	GO:0051704	multi-organism process	None	Extended
BP	GO:0051707	response to other organism	None	Extended
BP	GO:0051805	evasion or tolerance of immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051807	evasion or tolerance of defense response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051809	passive evasion of immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051817	modification of morphology or physiology of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051832	avoidance of defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051834	evasion or tolerance of defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0052173	response to defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0052564	response to immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0065007	biological regulation	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0006163	purine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006164	purine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006811	ion transport	IEP	Predicted GO
BP	GO:0006812	cation transport	IEP	Predicted GO
MF	GO:0008324	cation transmembrane transporter activity	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009150	purine ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009152	purine ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009165	nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009259	ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009260	ribonucleotide biosynthetic process	IEP	Predicted GO
MF	GO:0015075	ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015077	monovalent inorganic cation transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015078	proton transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015318	inorganic molecular entity transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015399	primary active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015672	monovalent inorganic cation transport	IEP	Predicted GO
BP	GO:0015985	energy coupled proton transport, down electrochemical gradient	IEP	Predicted GO
BP	GO:0015986	ATP synthesis coupled proton transport	IEP	Predicted GO
CC	GO:0016469	proton-transporting two-sector ATPase complex	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
BP	GO:0019693	ribose phosphate metabolic process	IEP	Predicted GO
MF	GO:0019829	cation-transporting ATPase activity	IEP	Predicted GO
MF	GO:0022804	active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0022853	active ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0022890	inorganic cation transmembrane transporter activity	IEP	Predicted GO
CC	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	IEP	Predicted GO
BP	GO:0034220	ion transmembrane transport	IEP	Predicted GO
MF	GO:0036442	proton-exporting ATPase activity	IEP	Predicted GO
MF	GO:0042625	ATPase coupled ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEP	Predicted GO
MF	GO:0043492	ATPase activity, coupled to movement of substances	IEP	Predicted GO
CC	GO:0043657	host cell	IEP	Predicted GO
CC	GO:0044216	other organism cell	IEP	Predicted GO
MF	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	IEP	Predicted GO
CC	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046390	ribose phosphate biosynthetic process	IEP	Predicted GO
MF	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	IEP	Predicted GO
MF	GO:0046961	proton-transporting ATPase activity, rotational mechanism	IEP	Predicted GO
BP	GO:0072521	purine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072522	purine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0098655	cation transmembrane transport	IEP	Predicted GO
BP	GO:0098660	inorganic ion transmembrane transport	IEP	Predicted GO
BP	GO:0098662	inorganic cation transmembrane transport	IEP	Predicted GO
BP	GO:1901137	carbohydrate derivative biosynthetic process	IEP	Predicted GO
BP	GO:1901293	nucleoside phosphate biosynthetic process	IEP	Predicted GO
BP	GO:1902600	proton transmembrane transport	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR029210	PfEMP1_NTS	14	48
IPR008602	Duffy-antigen_binding	116	272
IPR008602	Duffy-antigen_binding	952	1177
IPR004258	DBL	1277	1324
IPR004258	DBL	1485	1617
IPR004258	DBL	636	798
IPR029211	PfEMP1_ATS	1733	2215

External Links

PlasmoDB	2654957
PlasmoDB	PF07_0048

PF3D7_0711700 (VAR)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation